Li Li
Biography
Li Li received her BS degree from the University of Science and Technology of China (USTC) and her Ph.D in Molecular Biology and Biochemistry from the University of Texas GSBS at Houston. She is now a professor at Wayne State University. Her research interests are centered on the molecular mechanisms that drive smooth muscle dedifferentiation; specifically, on signal pathways and transcription regulatory networks during extracellularmatrix (ECM)-cytoskeleton interaction. This process is critical for the pathogenesis of aortic aneurysms and atherosclerosis in response to genetic and metabolic stresses.
Education
* University of Science and Technology of China (USTC), Hefei, China B.S. 07/1985 Cell Biology
* University of Texas Graduate School of Biomedical Sciences (GSBS), Houston, TX Ph.D. 10/1991 Biochemistry and Molecular Biology
* University of Texas Southwestern Medical Center. Dallas, TX Postdoctor 07/1996 Mol Dev Biology
Research
*Research Objectives*: To identify biomarkers and signaling pathways that can aid in the diagnosis, understand the pathogenesis, and inform the treatment of aortic aneurysms.
* Molecular Mechanisms in Marfan Syndrome*: Exploring vascular remodeling and the pathways leading to aneurysm rupture, focusing on the interplay between the cytoskeleton and the extracellular matrix (ECM) and their impact on gene regulation.
*Research Approach*: Utilizing bioinformatics tools to workout the molecular mechanisms of oxidative stress, inflammation, vascular smooth muscle cell (VSMC) dedifferentiation, and wall degeneration. Our approach includes testing potential therapeutic targets in aneurysm mouse models to advance drug discovery.
Publications
- Jianbin Shen*, Donghong Ju, Shichao Wu*, Jiawei Zhao, Lucynda Pham*, Alejandro Ponce*, Maozhou Yang, Hui J. Li, Kezhong Zhang, Zhe Yang, Youming Xie, Li Li SM22α deficiency: promoting vascular fibrosis via SRF-SMAD3-mediated activation of Col1a2 transcription following arterial injury (2024) Cardiovascular Therapeutics (submitted) doi: https://doi.org/10.21203/rs.3.rs-3941602/v1.
- Donghong Ju, Shichao Wu, Li Li, Youming Xie Ubiquitylation-independent cotranslational degradation of dihydrofolate reductase and ubiquitin (2024) Biochem Biophys Res Commun 702:149651.
- S. Seeburun, S. Wu, D. Hemani, L. Pham, D. Ju, Y. Xie, P. Kata, Li Li, Insights into elastic fiber fragmentation: Mechanisms and treatment of aortic aneurysm in Marfan syndrome, Vascular Pharmacology (2023) 153:107215, PMID: 37640090 (highlighted on the cover) https://authors.elsevier.com/sd/article/S1537-1891(23)00075-7.
- Donghong Ju, Li Li, Youming Xie (2023) Homeostatic regulation of ribosomal proteins by ubiquitin-independent cotranslational degradation. Proc Natl Acad Sci U S A 120(30): e2306152120.
- Kim H, Wei J, Song Z, Mottillo E, Samavati L, Zhang R, Li L, Jena BP, Lin JD, Fang D, Zhang K. Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program. Mol Metab.. 07/2021;49:101192. doi: 10.1016/j.molmet.2021.101192.
- Li, H., H. Nguyen, S. P. Meda Venkata, J. Y. Koh, A. Kowluru, L. Li, N. F. Rossi, W. Chen and J. M. Wang (2021). "Novel Role of GPR35 (G-Protein-Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure." Hypertension 78(3): 816-830.
- Zheng JP, He X, Liu F, Yin S, Wu S, Yang M, Zhao J, Dai X, Jiang H, Yu L, Yin Q, Ju D, Li C, Lipovich L, Xie Y, Zhang K, Li HJ, Zhou J, Li L. (2020) YY1 directly interacts with myocardin to repress the triad myocardin/SRF/CArG box-mediated smooth muscle gene transcription during smooth muscle phenotypic modulation. Sci Rep. 10:21781. doi: 10.1038/s41598-020-78544-3.
Office address
Li Li, Ph.D
Professor
Department of Internal Medicine
Center for Mol. Medicine &Genetics
Karmano Cancer Institute
Wayne State University
Detroit MI 48201
Phone: 313-577-8749
email: lili@med.wayne.edu