A researcher with the Wayne State University School of Medicine’s Kresge Eye Institute was awarded $5,000 from the Alliance for Vision Research to explore the role of a regulatory protein in the development of diabetic retinopathy.
Research associate Manish Mishra, Ph.D., works in the lab of Renu Kowluru, Ph.D., a professor of Ophthalmology, and of the Department of Internal Medicine’s Division of Endocrinology, Diabetes and Metabolism.
The project, “Novel role of PARP-1 in regulation of MMMP-9 in diabetic retinopathy,” would provide new insight into the molecular mechanism of pathogenesis of diabetic retinopathy.
Diabetic retinopathy is the most common diabetic eye disease, according to the American Academy of Ophthalmology, and occurs when blood vessels in the retina change. The vessels swell and leak fluid or close off completely. In some cases, abnormal new blood vessels grow on the retina surface. The condition can cause permanent blindness.
“The main objective of this proposal is to understand the novel role of poly (ADP-ribose) polymerase 1 in regulating matrix metalloproteinase-9, an enzyme implicated in mitochondrial damage, in the development of retinopathy. Our research is expected to identify targets for future therapeutic interventions to prevent or retard this sight-threatening disease,” Dr. Mishra said.
The project was chosen for its high relevance, direct correlation and significance in context with the development of diabetic retinopathy.
“The outcome will provide intriguing information about the mechanism of disease development and identify novel therapeutic targets,” he said.
This is Dr. Mishra’s first award from the Alliance for Vision Research, a Michigan nonprofit whose mission is to restore, preserve and improve vision by providing support to state vision researchers and organizations.