Isaac J. Powell, M.D., Associate Professor, Department of Urology Wayne State University and Karmanos Cancer Institute, Chief of Urology at the Veterans Administration Hospital of Detroit.

Clinical Interests: Urologic Oncology (Urologic Cancer) and Cancer Genetics.

Special Interests: The focus of my research is on the many ways prostate cancer impacts African Americans in comparison to other ethnic groups. My past research has included community-based education, health care behavior modification, and early detection study of prostate cancer among African American men. As a protocol director for the Southwest Oncology Group (SWOG), I have completed a study investigating neoadjuvant hormonal therapy for locally advanced prostate cancer. Currently my research is directed toward ethnic differences in the biology/genetics of prostate cancer. I am Principal Investigator of a nation-wide consortium of recruitment centers (medical centers) whose goal is to recruit families to examine hereditary prostate cancer among African Americans. We recently published our initial results of 4 or 5 regions in the genome where genes responsible for hereditary prostate cancer may be found. In collaboration with others at our institution and other institutions across the country, we are examining androgen-related gene variations (genes responsible for the male hormone production).  We have identified one the genetic variations that appears to be associated with aggressive prostate cancer. We are also studying epigenetic factors (environmental factors that impact on genes) such as diet and inflammation in correlation to clinical outcome. Cancer is a genetic disease, and genetic research has to be apart of the search for a cure.

Medical Training
Internship, Henry Ford Hospital, Detroit, Michigan, 1969-1970
General Surgery Residency, Henry Ford Hospital, Detroit, Michigan, 1970-1971
Urology Residency, Henry Ford Hospital, Detroit, Michigan, 1971-1974

Education
University of Michigan, Ann Arbor, Michigan: B.S. in Zoology, 1962
Howard University Graduate School, Washington, DC: M.S. in Embryology, 1965
Indiana University Medical School, Indianapolis, Indiana: M.D., 1969

Selected Publications

  • Powell IJ, Heilbrum L, Littrup P, et al: Outcome of African American Men screened for prostate cancer the DEED (Detroit Education and Early Detection) study. Journal of Urology, Vol. 158, 146-149, July 1997.
  • Powell IJ, Tangen M, Miller G, Lowe B, Haas G, Carroll PR: Neoadjuvant Therapy Prior to Radical Prostatectomy for Clinical T3/T4 Carcinoma of the Prostate (5 Year Follow-Up, Phase II Swog Study 9109) Journal of Urology 168:2016-2019, 2002
  • Powell IJ, Banerjee M, Novallo M, Sakr W, Grignon D, Wood DP, Pontes JE:  Prostate cancer biochemical recurrence stage for stage is more frequent among African American versus Caucasian men with locally advanced but not organ confined disease.  Urology, Vol 55, 246-251, February 2000.
  • Powell IJ, Carpten J, Dunston G, Kittles R, Bennett J, Hoke G, Pettaway C, Weinrich S, Vijayakumar S, Ahaghotu CA, Boykin W, Mason T, Royal C, Baffoe-Bonnie A, Bailey-Wilson J, Berg K, Trent J, Collias F:  African American hereditary prostate cancer study:  a model for genetic research.  Journal National Medical Society 93: 120-123, 2001.
  • Powell IJ, Dey J, Pontes EJ, Cher ML, Sakr W, Wood DP:  Disease free survival of local prostate cancer among African Americans and Caucasians:  A multivariable analysis of race/ethnicity as an independent variable.  Urology, 59: 907-912, 2002
  • Powell IJ, Banerjee M, Bianco FJ, Wood DP Jr., Dey J, Lai Z, Heath M, Pontes EJ: The Effect of Race/Ethnicity on Prostate Cancer Treatment Outcome is Conditional: A Review of Wayne State University Data. Journal of Urology 171:1508-1512, 2004.
  • I.J. Powell, J.Y, Zhou, Y. Sun, W.A Sakr, N.P. Patel, L. K. .Heilbrun, and R.B.Everson: CYP3A4 Genetic Variant and Disease Free Survival Among Caucasian and African American Men After Radical Prostatectomy. Journal of Urology 172(5, Part 1 of 2), 1848 -1852, November, 2004.
  • Baffoe-Bonnie A, Kittles RA, Gillanders E, Ou L, George A, Ahaghotu C, Bennett J, Boykin W, Hoke G, Mason T, Pettaway C, Vijayakumar S, Weinrich S, Jones MP, Lockwood E, Klaric M, Faruque M, Royal C, Trent JM, Berg K, Collins FS,  Fubert-Harris P, Bailey-Wilson JE,  Dunston G,  Powell I, Carpten JD: Genome-wide Linkage of 77 Families from the African American Hereditary Prostate Cancer Study (AAHPC). Prostate Oct 9, 2006.
  • Isaac J. Powell: Epidemiology and Pathophysiology of Prostate Cancer in African American Men. Review Article. Journal of Urology Vol. 177; February 2007.

Clinical Office Address:
Detroit-Barbara Ann Karmanos Cancer Center
4100 John R
Detroit, MI 48101
Phone: (800) KARMANO (527-6266)
Fax: 313-966-8207

Academic Address:
Department of Urology
4201 St Antoine - 7C UHC
Detroit, MI 48201
Telephone:  (313) 577-5222
Fax:  (313) 577-5217


ipowell@med.wayne.edu


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