Frank A. Baciewicz, Jr., M.D.
Chenicheri Balakrishnan, M.D.
Ramesh Babu Batchu, Ph.D
Alfred Baylor, M.D.
Keiva L. Bland, M.D.
David L. Bouwman, M.D.
O.W. Brown, M.D.
Lawrence N. Diebel, M.D.
Heather Dolman, M.D.
David A. Edelman, M.D.
Ali Elhorr, M.D.
Mohamed Gazayerli, M.D.
Ruben Gomez, M.D.
David Gorski, M.D.
Kenneth Granke, M.D.
Scott Gruber, M.D.
Eti Gursel, M.D.
M. Salik Jahania, M.D.
Einas Joseph, M.D.
Mary Ann Kosir, M.D.
Scott Laker, M.D.
Anna M. Ledgerwood, M.D.
Charles E. Lucas, M.D.
Guillermina Nava, M.D.
Yevgeniy Rits, M.D.
Jeffrey Rubin, M.D.
Arlene A. Rozzelle, M.D.
Walter Salwen, M.D.
Vishwanath M. Sardesai, Ph.D.
Allen Silbergleit, M.D., Ph.D.
Yvan Silva, M.D.
Christopher Steffes, M.D.
Larry W. Stephenson, M.D.
Choichi Sugawa, M.D.
Steven D. Tennenberg, M.D.
James G. Tyburski, M.D.
Donald W. Weaver, M.D.
John D. Webber, M.D.
Matthew Weiner, M.D.
Miguel S. West, M.D.
Michael T. White, M.D.
Robert F. Wilson, M.D.

Title:
Associate Professor of Surgery
WSU III Clerkship Director

Office Address:
Harper University Hospital
Professional Building
Suite 400
Detroit, MI 48201

Phone:
313- 745-8770

Fax:
313-993-0595

Email:
csteffes@med.wavne.edu

Specialty:
General Surgery

Clinical Interest:
Oncologic, gastrointestinal, trauma, hepatobiliary, bariatric, laparoscopic and general surgery
Laparoscopic bariatric surgery
Image guided hepatic ablative procedures (radiofrequency ablation, cryosurgery)

Research Interest:
Microvascular response to inflammation, trauma and shock. Specifically we look at the microvascular events of pericytes and microvascular endothelial cells of the lung. Current experimentation centers around apoptosis of pericytes, mediator induced leakage of invitro pericyteendothelial cocultures, and mechanisms of regulation of pericyte contractility, all in response to an inflammatory environment.

Board Certification:
American Board of Surgery, 1994

Education:
1974-1978
Gale-Ettrick-Trempealeau High School
Galesville, Wisconsin

1978-1982
Cornell University
Ithaca, New York
B.S. - Electrical Engineering

1982-1986
University of Wisconsin
Madison School of Medicine
Madison, Wisconsin
M.D.

Training:
1986-1993
Wayne State University Detroit, Michigan
General Surgery

1989-1991
(Research)
Bovill Surgical Research Fellow
Wayne State University School of Medicine
Department of Biochemistry

Selected Publications:

Speyer C, Steffes C, Tyburski J, Ram J. Lipopolysaccharide induces relaxation in lung pericytes by an iNOS-independent mechanism. Amer J Physiology, 5:278, L880-L887, 2000.

Kerkar S, Speyer C, Tyburski J, Steffes C: Reactive oxygen metabolites induce a biphasic contractile response in microvascular lung pericytes. J Trauma. 51:3, 440-445, 2001.

Dente C, Steffes C, Speyer C, Tyburski J. Pericytes augment the capillary barrier in in-vitro cocultures. J Surg Research. 97:1,85-91,2001.

Speyer C, Steffes C, Tyburski J, Homan R, Ram J. Lipopolysaccharide-induced secretory phospholipase A2 activity in pericytes: a possible mechanism for mediating relaxation. Microvasc Research. 63:2, 239-242-2002.

Williams M, Kerkar S, Tyburski J, Steffes C, Carlin A, Wilson R: The role of cAMP and cGMPdependent protein kinase pathways in hydrogen peroxide induced contractility of microvascular lung pericytes. J Trauma. Soon to be published.