Clinical Electrophysiology lab
Lab
2751 E. Jefferson
Detroit, MI 48207
The P50 and N100 auditory evoked response (EP) have been used to examine the ability of the brain to inhibit incoming irrelevant sensory input (sensory gating) in healthy
and psychopathological populations. Several studies have shown that P50 sensory gating is consistently deficient in schizophrenic patients. Failure of sensory gating has been
proposed as a fundamental pathophysiological aberration leading to the development of psychotic symptoms. Therefore, a clear definition of the anatomical sources of the P50 and N100 is
important to fully understand the implications of sensory gating deficiency in schizophrenia. The goal of the study is to map the function of sensory gating into the different parts
of the brain. All patient recruitment and data collection are performed at the Department of Epilepsy, University of Bonn, Germany. Data analysis is performed at the Clinical Electrophysiology
Laboratory.
of Sensory Gating