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Leslie H. Lundahl, PhD

Assistant Professor
University Track:  Research-Educator
Room 202

Email:  llundahl@med.wayne.edu

Phone: 313.993.1374

Fax: 313.993.1372

Research:

Research Interests

Much of my research has focused on factors that affect the development of substance use disorders, particularly the physiological, behavioral, and subjective substrates of drug cue reactivity and craving as they relate to the maintenance of drug-taking behavior, and gender differences in physiological and behavioral responses to various substances (i.e., alcohol, nicotine, marijuana, and cocaine).  I am also interested in risk factors in the addictive process, such as family history of addiction, personality correlates, and psychiatric co-morbidity.  A more recent interest is in the neuropsychological and psychiatric sequelae of chronic MDMA, marijuana, and methamphetamine exposure.  Currently I am involved in developing laboratory models to test potential medications for treatment of cocaine and cannabis use disorders, and am starting to study the role of prenatal drug exposure in the development of adolescent substance use and other psychiatric disorders.

    Sigma Xi Research Presentation Award, 1991
    Student Travel Award, APA Science Directorate, 1992
    Dissertation Research Award, APA Science Directorate, 1994
    Livingston Fellowship Award, Department of Psychiatry, Harvard Medical School, 1996
    Early Career Award, College on Problems of Drug Dependence (CPDD), 2000
    National Institutes of Health (NIH) Loan Repayment Program Awardee, 2003 - 2005
    National Institutes of Health (NIH) Loan Repayment Program Awardee, 2005 - 2007

Selected Peer-Reviewed Publications

1.      Renshaw, P.F., Daniels, S.L., Lundahl, L.H., Rogers, V. & Lukas, S.E. (1999). Short-term treatment with citicholine (CDP-Choline)
          attenuates some measures of craving in cocaine-dependent subjects:  A preliminary report.  Psychopharmacology, 142, 132-138.

2.      Lundahl, L.H.,  Henningfield, J.E., &  Lukas, S.E.  (2000). Mecamylamine blockade of both positive and negative effects of IV nicotine in human volunteers.  Pharmacology, Biochemistry, & Behavior, 66, 637-643. 

3.      Lundahl, L.H. & Lukas, S.E. (2001). The impact of familial alcoholism on alcohol reactivity in female social drinkers. Experimental and Clinical Psychopharmacology, 9, 101-109.

4.      Kouri, E.M., Lundahl, L.H., Borden, K.M., McNeil, J. & Lukas, S.E. (2002). Effects of oral contraceptives on acute cocaine response in female volunteers.   Pharmacology, Biochemistry, & Behavior, 74, 173-180.

5.      Johanson, C.E., Frey, K., Lundahl, L.H., Keenan, P., Lockhart, N., Roll, J., Galloway, G., Koeppe, R. A., Kilbourn, M. R., Robbins, T., &  Schuster, C.R.  (2006). Cognitive function and nigrostriatal markers in abstinent methamphetamine abusers.  Psychopharmacology, 185, 327-338.

6.      Penetar, D.M., Looby, A.R., Su, Z., Lundahl, L.H., Erös-Sarnyai, M., McNeil, J.F., & Lukas, S.E. (2006). Benztropine pretreatment does not affect responses to acute cocaine administration in human volunteers. Human Psychopharmacology: Clinical and Experimental, 21, 549-559.

7.      Johanson, C.E., Lundahl, L.H., Lockhart, N. & Schubiner, H.E.  (2006). Intravenous cocaine discrimination in humans.  Experimental and Clinical Psychopharmacology, 14, 91-108. 

8.      Lundahl, L.H. & Lukas, S.E.  (2007). Negative cocaine effect expectancies are associated with subjective response to cocaine challenge in  recreational cocaine users. Addictive Behaviors, 32, 1262-1271.

9.      Durdle, H. Lundahl, L.H., Johanson, C.-E., & Tancer, M.E.  (In press).  Major Depression:  the relative contribution of gender, MDMA, and cannabis use.  Depression and Anxiety.

10.    Johanson, C.E., Lundahl, L.H., & Schubiner, H.E. (In press). Effects of oral cocaine on intravenous cocaine discrimination in humans. Experimental and Clinical Psychopharmacology.

 Book Chapter

1.      Lundahl, L.H. & Hopper, J. (September, 2007 release date).  Club Drugs.  In Handbook of Substance Use Disorders: A Treatment Guide.  J. Isaacson, T. Parran, Jr., D. Alford, and J. Hopper (Editors), Humana Press. 

Published Proceedings of Conference and Symposia (last 5 years)

1.      Raiter, J.A., Lundahl, L.H., Johanson, C.E., & Tancer, M.E. (2003).  Neuropsychological and personality function in light and heavy MDMA users.  Problems of Drug Dependence 2003: Proceedings of the 65th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc.
 http://www.cpdd.vcu.edu/Pages/Meetings/MeetProgAbSearchAll.html

2.      Lundahl, L.H., Raiter, J.A, , Berardi, K., Aubie, C., & Johanson, C-E. (2003). Marijuana cue-induced craving in young adult cannabis abusers. Problems of Drug Dependence 2003: Proceedings of the 65th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc. (paper presentation)
 http://www.cpdd.vcu.edu/Pages/Meetings/MeetProgAbSearchAll.html

3.      Lockhart, N., Lundahl, L.H., Schubiner, H., & Johanson, C-E. (2004).  Intravenous cocaine discrimination in humans. Problems of Drug Dependence 2004: Proceedings of the 66th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc.         http://www.cpdd.vcu.edu/Pages/Meetings/MeetProgAbSearchAll.html

4.      Lundahl, L.H., Keenan, P., Schuster, C.R., & Johanson, C.E.   (2004).  Neurocognitive function in chronic high dose methamphetamine users following long term abstinence.  Problems of Drug Dependence 2004: Proceedings of the 66th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc.         http://www.cpdd.vcu.edu/Pages/Meetings/MeetProgAbSearchAll.html

5.      Frey, K.A., Schuster, C.R., Johanson, C.E., Lundahl, L.H., Keenan, P., Lockhart, N.,  Koeppe, R.A., & Kilbourn, M.R.  (2004).  Effects of chronic high dose methamphetamine in long-term abstinent methamphetamine abusers on striatal dopamine assessed with PET.  Problems of Drug Dependence 2004: Proceedings of the 66th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc.
http://www.cpdd.vcu.edu/Pages/Meetings/MeetProgAbSearchAll.html

6.      Lundahl, L.H., Aubie, C., Berardi, K., Johanson, C.E., & Tancer, M.E. (2005).  Cognitive function and mood symptoms in light and heavy MDMA users who abuse cannabis. Problems of Drug Dependence 2005: Proceedings of the 67th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc. (paper presentation)         http://www.cpdd.vcu.edu/Pages/Meetings/MeetProgAbSearchAll.html

7.      Lockhart, N., Schubiner, H., Lundahl, L.H., & Johanson, C.E. (2005).  The ability of oral cocaine to block the discriminative stimulus effects of intravenous cocaine in humans. Problems of Drug Dependence 2005: Proceedings of the 67th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc.
http://www.cpdd.vcu.edu/Pages/Meetings/MeetProgAbSearchAll.html

8.      Johanson, C-E., Lundahl, L.H., & Schubiner, H. (2006).  D-amphetamine blocks some subjective effects of intravenous cocaine in humans. Problems of Drug Dependence 2006: Proceedings of the 68th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc.
http://www.cpdd.vcu.edu/Pages/Meetings/MeetProgAbSearchAll.html

9.      Lundahl, L.H., Cederlind, L., Johanson, C-E., & Tancer, M.E. (2006).  Cue-reactivity for medications development:  Specificity of the model. Problems of Drug Dependence 2006: Proceedings of the 68th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc.
http://www.cpdd.vcu.edu/Pages/Meetings/MeetProgAbSearchAll.html

10.    Durdle, H., Lundahl, L.H., Johanson, C-E., & Tancer, M.E. (2006).  Major Depression:  Contributions of gender, MDMA and cannabis use. Problems of Drug Dependence 2006: Proceedings of the 68th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc.
http://www.cpdd.vcu.edu/Pages/Meetings/MeetProgAbSearchAll.html

11.    Lundahl, L.H., Cederlind, L., & Johanson, C.-E. (2007).  Oral THC attenuates cue-induced marijuana craving in cannabis-dependent humans. Problems of Drug Dependence 2007: Proceedings of the 69th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc. (paper presentation)

12.    Sander, L., Milosevic, A., Lundahl, L.H., Durdle, H., Johanson, C.-E., & Tancer, M.E. (2007).  Do exclusionary criteria in MDMA studies create misrepresentative samples? Problems of Drug Dependence 2007: Proceedings of the 69th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc.

13.    Lundahl, L.H., Jacobson, S.W., Dodge, N.C., Sokol, R.J., & Jacobson, J.L. (In press).  Relation of early adolescent alcohol use to prenatal alcohol exposure. Alcoholism:  Clinical and Experimental.

Research Support

“Cue Reactivity Model/Pharmacological. Intervention in Cannabis Use” (Leslie H. Lundahl, PI), Agency:  NIH/NIDA.   Funding Period: Sept, 2004 – July, 2006.  Purpose:  To develop and test a laboratory model of marijuana craving to test medications for use in treatment of marijuana abuse and dependence.

"Biobehavioral Studies of Opioid Drug-Seeking Behavior" (Mark Greenwald, PI), Agency:  NIH/NIDA. Funding period: September,        2003 – May, 2008. Purpose: Examine environmental factors that influence drug-seeking behavior in opioid-dependent humans.

“Reducing Cocaine/Heroin Abuse with SR-Amphetamine and Buprenorphine” (Mark Greenwald, PI), Agency:  NIH/NIDA. Fundingperiod:  September, 2006 – June, 2009.  Purpose:    To determine in cocaine/heroin-dependent volunteers whether maintenance on sustained release oral d-amphetamine with buprenorphine sublingual tablet is safe and well tolerated, decreases cocaine choice in a human laboratory polydrug abuse model (Study 1), and protects against relapse (Study 2).                           

“Bases of ADHD in Fetal Drug or Alcohol Exposure” (Malcolm Avison, PI: Sandra W. Jacobson, Site PI).  Agency:  NIH/NIDA.  Funding period:  Sept, 2005 – August, 2008.  Purpose:  1) To use fMRI to confirm that idiopathic, PNCE and PNAE ADHD subjects in this cohort have a functional impairment in fronto-striatal circuits, and that additional circuit dysfunctions contribute to behavioral deficits in PNAE; 2) To test the hypothesis that the circuit defect in PNCE ADHD is postsynaptic and therefore unresponsive to methylphenidate; 3) To use structural MRI and DTI to examine the contribution of structural abnormalities to the functional and behavioral deficits; 4)To identify the neural correlates of dyscalculia in PNAE subjects, and test their ability to distinguish PNAE- from idiopathic and PNCE-associated ADHD; 5) To test the hypothesis that prenatal exposure to alcohol or cocaine increases the risk of heavy episodic drinking during adolescence and that this increased risk is mediated by abnormalities in brain circuitry that are manifest in ADHD.

“Effect of Three Dose Ratios of Fentanyl and Naloxone in Opioid-Dependent Volunteers”  (Mark Greenwald, PI), contract with BioDelivery Sciences International Inc. Funding Period:  April, 2006 – June, 2007.  Purpose:  To determine the dose range over which IV naloxone administered in combination with IV fentanyl, would precipitate opioid withdrawal signs and symptoms and attenuate any pleasurable effects from intravenous fentanyl injection in subjects with a moderate level of opioid dependence.                        

“A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study of Probuphine^® in Patients with Opioid Dependence” (Mark Greenwald, site PI), contract with Titan Pharmaceuticals, Inc. Funding period:  January, 2007 – December, 2007. Purpose: To determine the safety and efficacy of a buprenorphine implant for treating opioid-dependent patients.

Currently Active HIC-Approved Studies

1.      Cue Reactivity Model for Assessing Pharmacologic Intervention in Treatment of Cannabis Use Disorders:  Study 1:  Specificity of Cue-Induced Craving for Marijuana.

2.      Cue Reactivity Model for Assessing Pharmacologic Intervention in Treatment of Cannabis Use Disorders:  Study 2:  Effects of Pretreatment with Oral THC on Marijuana Cue-Reactivity.

3.      Assessing the discriminative stimulus properties of smoked marijuana:  Establishing the Sensitivity and Specificity of the Model.

TEACHING

 Seminars Taught in Past 5 Years   

         Psychiatric Co-Morbidity:  Dual Diagnosis
         Issues in Adolescent Drug Use
         Risk Factors in Adolescent Substance Use
         Treatment Interventions for Adolescent Substance Abusers
         Introduction to Club Drugs
         Psychodynamic and Interpersonal Therapy Treatment Approaches for Substance Abuse
         The Tarasoff Ruling and the Duty to Protect
         Assessing Dangerousness in Tarasoff-Type Situations
         The Treatment Plan as a Clinical Tool in Psychotherapy
         Transference and Countertransference in the Therapeutic Relationship
         Assessing Suicidality and the Use of No-Suicide Contracting
         Substance Use Disorders and Neuropsychological Impairment
         Dual Diagnosis:  Issues in Assessment and Treatment
         Co-Occurring Psychiatric and Substance Use Disorders: Epidemiology and Issues in Diagnosis

Clinical Supervision
         Individual, Couples, and Group Psychotherapy
         Clinical Assessment and Diagnostic Interviewing
         Neuropsychological Assessment

Invited Presenter at Workshops
         Methamphetamine:  The Problem, the Challenge, and Interventions
         Methamphetamine:  Assessment, Diagnosis and Interventions
         The Mental Health Challenges of the University Student:  Alcohol and Drug Abuse
         Evidence-Based Treatment for Methamphetamine Dependence
         Overview of Addictions
         Screening, Assessment and Diagnoses of Co-Occurring Disorders
         Therapeutic Interventions for Use in Populations with Co-Occurring Psychiatric and Substance Use Disorders

SERVICE

Grant Review/Service

          Ad-hoc Committee for Scientific Review
          Small Business Innovation Research/Small Business Technology Transfer Research
          National Institutes of Health (NIH)
          Washington, DC
          October 2002 to Present

          Ad-hoc Committee for Scientific Review
          NIH/NIAAA (Special Emphasis Panel)
         October 2003- present

          Federal Government Advisory Committee Service:  Ad hoc consultant to the Division of
          Treatment  Research and Development on Medications Development for Cannabis Dependence
          NIH/NIDA, March 2004

          Human Subjects Committee
          College on Problems of Drug Dependence
          June, 2007 – June, 2009

Journal Reviewer

          Addictive Behaviors                                                      1999-present
       Experimental and Clinical Psychopharmacology                    2001-present
       Journal of Anxiety and Depression                                   2002-present
       Drug and Alcohol Dependence                                         2003-present