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IMPORTANT POINTS & DISCOVERIES
- Development of the first approach for pathway analysis that considers factors such as: the topology of the pathways, position of each individual genes on each pathway, and type of interactions between genes
- This approach was implemented first as a web tool (Pathway-Express) part of the Onto-Tools suite maintained by Dr. Draghici's laboratory and later as a Bioconductor package, called SPIA (Signaling Pathway Impact Analysis), currently maintained by Dr. Tarca
- Software package nnNorm (normalization of two-channel microarray data based on robust neural nets) has been previously developed and is currently maintained by Dr. Adi L. Tarca as part of the same Bioconductor project
- These software tools are used to analyze all microarray data generated by the PRB researchers, as well as by hundreds of users worldwide (nnNorm download statistics, SPIA download statistics)
- Dr. Sorin Draghici, is the director of the Intelligent Systems and Bioinformatics Laboratory that developed the Onto-tools, which is a collection of bioinformatics web-based software tools used by over 10,000 users worldwide