Department of Radiation Oncology

Interim Chair: Jeffrey Forman, MD
1st Level University Health Center
(313) 745-9191  

Articles, Patents and Intellectual Property

Aref A, Mohammad R, Yudelev M, Choudhuri R, Strowbridge A, Orton C, Al-Katib A.  Radiobiological Characterization of Two Human Chemotherapy-Resistant Intermediate Grade Non-HodgkinÕs Lymphoma Cell Lives.  Radiat. Oncol. Invest. 7:158-162, 1999.

Aref A, Narayan S, Tekyi-Mensah S, Varterasian M, Dan M, Eilender D, Karanes C, Al-Katib A,  Value of radiation therapy in the management of chemoresistant intermediategrade non-hodgkinÕs lymphoma.  Radiation Oncology Investigations 7:186-191, 1999.

Bohm, TD, DeLuca, PM, Cox, LJ, Maughan, RL, Jones, DTL and Lennox, A.  Monte Carlo calculations to characterize the source for neutron therapy facilities. Medical Physics, 26: 783-792, 1999.

Burmeister J, Kota Cand Maughan RL.  Pair miniature tissue-equivalent proportional counters for dosimetry in high flux epithermal neutron capture therapy beams.  Nucl Instrum Methods Phys A422: 606-610, 1999.

Burmeister J, Kota C and Maughan RL.  Dosimetry of the boron neutron capture reaction for BNCT and BNCEFNT.  Strahlentherapie und Onkol 175 (Supl. 2):115-118, 1999.

Burmeister J, Kota C, Maughan RL and Yudelev M.  Paired Mg and Mg(B) ionization chambers for measurement of boron neutron capture dose in neutron beams.  Med Phys 26: 2482-2487, 1999.

Chuba PJ, Maughan RL, Forman JD:  Three dimensional conformal neutron radiotherapy for prostate cancer. Strahlenther Onkol 1999; 175:  Suppl II: 79-81.

Fontanesi JN, Chuba PJ, Rivard M, Benda R, Rector FE, Farmer DL.  Pediatric brachytherapy:  The Barbara Ann Karmanos Cancer Institute experience using Californium-252.  J Brachytherapy Int, 15:37-41, 1999.

Forman JD, Keole S, Bolton S, Tekyi-Mensah S,  Association of prostate size with urinary morbidity following mixed conformal neutron and photon irradiation.  Intl Fournal of Radiation Oncology, Biology, Physics.  45(4):871-875, 1999.

Gao X and Honn KV.  Upregulation of the oncogene MDM-2 and down regulation of the putative tumor suppressor gene DCC by an arachidonate metabolite, 12(S)-HETE, in human cancer cells.  Pathol. Oncol. Res. (in press)

Hart KB, Wood DP, Tekyi-Mensah SE, Porter AT, Pontes JE, Forman JD.  The impact of race on biochemical disease-free survival in early-stage prostate cancer patients treated with surgery or radiation therapy.  Intl Journal of Radiation Oncology, Biology, Physics.  45(5): 1235-1238, 1999.

Kocheril SV, Grignon D, Wang CY, Maughan RL, Montecillo EJ, Talati B, Tekyi-Mensah S, Pontes JE and Hillman GG.  Responsiveness of human prostate carcinoma bone tumors to interleukin-2 therapy in a mouse xenograft tumor model.  Cancer Detection and Prevention, 23:408-416, 1999.

Kota, C, Maughan, RL, Tattum, D and Beynon, TD. Low pressure tissue equivalent proportional counters for dosimetry in BNCT and BNCEFNT. Medical Physics (in press).

Leibel SA and the Expert Panel on Radiation Oncology.  ACR Appropriateness Criteria.  Int J Radiat Oncol Biol Phys, 41(1):125-168, 1999.

Maughan, RL.  Designing an optical distance indicator for a radiation therapy accelerator. Medical Physics, 26: 236-238, 1999.

Maughan, RL, Chuba, P, Porter, AT, Ben-Josef, E, Lucas, DR and Bjarngard, BE.  Mass energy-absorption coefficients and mass collision stopping powers for electrons in tumors of various histologies. Medical Physics, 26: 472-477, 1999.

Maughan RL, Yudelev M, Kota C, Burmeister J, Porter AT, Forman JD, Blosser H., Blosser E and Blosser G.  Neutron radiation therapy:  application of advanced technology to the treatment of cancer. Nucl Phys A654:1068-1071, 1999.

Narayana V, Orton CG. ÒPulsed brachytherapy:  A Formalism to Account for the Variation in Dose Rate of the Stepping Source.Ó  Medical Physics 26, 161-165, 1999.

Nag S., Orton C, Young D, Erickson B.  ÒThe American Brachytherapy Society Survey of Brachytherapy Practice for Carcinoma of the Cervix in the United States.Ó  Gynecologic Oncology 73, 111-118, 1999.

Nie D, Tang K, Szekeres K, Trikha M and Honn KV.  Eicosanoid regulation of angiogenesis:  Role of endothelial arachidonate 12-lipoxygenase.  Blood 95(7): 2-7, 1999.

Nishisaka N, Maini A, Kinoshita Y, Yasumoto R, Jones RF, Morse P, Hillman GG, Wang CY and Haas GP.  Immunotherapy for Lunc Metastases of Murine Renal Cell Carcinoma:  Synergy between Radiation and Cytokine-Producing Tumor Vaccines.  J Immunotherapy 22:308-314, 1999

Porter A., Aref A, Chodounski Z, Elzaway, A, Manatrakul N., Ngoma T, Orton C, VanÕt Hooft E, Sikora K.  ÒA Global Strategy for Radiotherapy:  A WHO Consultation.  Clinical Oncology 11:368-370, 1999.

Rivard MJ, Wierzbicki JG, Van den Heuvel F, Martin RC, and McMahon RR.  Clinical brachytherapy with neutron emitting Cf-252 sources and adherence to AAPM TG-43 dosimetry protocol.  Medical Physics, 26:1, 87-96, 1999.

Schmidt R, Kota K, Yudelev M., Maughan, RL and Wanwilairet S.  Experimental determination of the thermal flux around two different types of high intensity 252Cf source. Medical Physics, 26: 83-86, 1999.

Tang K, Finley RL, Nie D and Honn KV.  Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.  Biochemistry.  (in press)

Tang K, Nie D, Cai Y and Honn KV.  The b4 integrin subunit rescues A431 cells from apoptosis through a PI3K/Akt kinase signaling pathway.  Biochem. And Biophys. Res. Comm. 264: 127-132, 1999.

Tiguert R, Forman JD, Hussain M, Wood DP.  Radiation therapy for a rising PSA level after radical prostatectomy.  In press:  Seminars in Urologic Oncology, 17(3); August 1999.

Timar J, Raso E, Dome B, Li L, Grignon D, Nie D, Honn KV and Hagmann W.  Expression, subcellular localization and putative function of platelet-type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potenetial.  IntÕl J. Cancer (in press)

Van den Heuvel F, Han I, Chungbin S, Strowbridge A, and Ragan DP.  Development and clinical implementation of an enhanced display algorithm for use in networked electronic portal imaging.  Int. J. Radiation Oncology Biol. Phys., 45:4, 1041-1053, 1999.

Velasco J, Tekyi-Mensah S, Bolton S, Forman JD.  Post-neoadjuvant hormone PSA levels and prognosis in locally advanced prostate cancer.  Urology, 54:325-328, 1999.

Videtic GMM, Gaspar K, Zamorano L, Fontanesi J, Levin KJ, Kupsky WL, Tekyi-Mensah S.  I-125 implants in the primary treatment of malignant gliomas (MG): Survival comparison using the RTOG Recursive partitioning analysis (RPA).  Int J Rad Oncol Biol Phys, 42(1): Supplement; p.267 (2080), September, 1998.

Videtic GMM, Levin KJ, Zamorano L, Kupsky WJ.  Adjuvant gamma-knife radiosurgery for a resected suprasellar pituitary adenoma with atypical immunohistochemistry:  Case report.  J Radiosurgery, 2(1): 33-39; 1999.

Videtic GMM, Gaspar L, Zamorano L, Tekyi-Mensah S, Garzon A, Levin KJ, Diaz F.  Gamma knife radiosurgery for brainstemlesions:  The Wayne State University experience.  J. Radiosurgery, 2(3): 135-139, 1999.

Videtic GMM, Gaspar L, Zamorano L, Fontanesi J, Levin KJ, Kupsky W, Tekyi-Mensah S.  Use of the RTOG recursive partitioning analysis to validate the benefit of iodine-125 implants in the primary treatment of malignant gliomas.  Int J Rad Oncol Biol Phys 45(3):687-692, 1999.

Patents

Wayne State University Invention File 98-447:  Renal Cell Carcinoma Cell Line for Establishing an Experimental Renal Tumor Model., Gilda Hillman

Wayne State University Invention File 98-448:  Prostate Carcinoma Cell Lines for Establishing an Experimental Metastatic Prostate Tumor Model, Gilda Hillman

Wayne State University Invention File 98-449:  Cell Lines for Establishing an Experimental Bone Metastatic Prostate Tmor Model, Gilda Hillman

Books, Chapters and Reviews

Bradley, PD, Rosenfeld, AB, Allen, BJ, Kota, C, Maughan, RL, Yudelev, Y, Coderre, J and Capela, J.  Application of silicon diode arrays for microdosimetry in BNCT and FNT. In Frontiers in Neutron Capture Therapy the proceedings of the Eighth International Symposium on Neutron Capture Therapy for Cancer, (MF Hawthorne and RJ Wiersema, eds.) Plenum Publishing, New York (in press).

Brenner D., Dale R., Orton CG, Fowler J.  ÒModeling HDR, LDR and PDR.Ó  In:  Brachytherapy, Joslin, Hall and Flynn (Eds.), Chapman and Hall, London  (In Press).

Burmeister, J, Kota,C and Maughan,RL. Microdosimetric studies at several BNCT facilities using miniature tissue equivalent proportional counters. In Frontiers in Neutron Capture Therapy the proceedings of the Eighth International Symposium on Neutron Capture Therapy for Cancer, (MF Hawthorne and RJ Wiersema, eds.) Plenum Publishing, New York (in press).

Burmeister, J, Kota, C, Maughan, RL and Yudelev, M. Characterization of modified fast neutron beam for boron neutron capture enhancement of fast neutron therapy. In Frontiers in Neutron Capture Therapy the proceedings of the Eighth International Symposium on Neutron Capture Therapy for Cancer, (MF Hawthorne and RJ Wiersema, eds.) Plenum Publishing, New York (in press).

Forman, JD, Tekyi-Mensah, S, Caudrelier, JM, Falquez, R, Velasco, J, Porter AT and Maughan, RL. Neutron radiation in the management of localized and locally advanced prostate cancer. In Radiotherapeutic Management of Carcinoma of the Prostate. (AD Amico and G. Hank, eds.).  Chapman and Hall, 73-89, 1999.

Gao X and Honn KV.  Molecular biology of prostate cancer:  Tumor suppressor genes.  In: Advances in Oncobiology in Prostate Cancer.  DP Wood and KV Honn, Eds.), JAI Press, Greenwich, 1999.

Gao X and Honn KV.  Tumor markers for prostate cancer.  In: Advances in Oncobiology in Prostate Cancer, (DP Wood and KV Honn, Eds.), JAI Press, Greenwich, 1999.

Hillman GG, Triest JA, Cher ML, Kocheril SV and Talati BR.  Prospects of Immunotherapy for the Treatment of Prostate Carcinoma-A Review.  Cancer Detection and Prevention, 23:333-342, 1999.

Kota, C, Burmeister,J, Maughan, R, Levin, K, Chuba, P, Gaspar, L and Forman,JD. Treatment planning for boron neutron capture enhanced fast neutron therapy. In Frontiers in Neutron Capture Therapy the proceedings of the Eighth International Symposium on Neutron Capture Therapy for Cancer, (MF Hawthorne and RJ Wiersema, eds.) Plenum Publishing, New York (in press).

Kota, C, Burmeister, J and Maughan, RL. Utility of measured microdosimetric single event spectra in interpreting quality of radiation fields used in BNCT and BNCEFNT. In Frontiers in Neutron Capture Therapy the proceedings of the Eighth International Symposium on Neutron Capture Therapy for Cancer, (MF Hawthorne and RJ Wiersema, eds.) Plenum Publishing, New York (in press).

Maughan, RL, Kota, C, Burmeister, J, Levin, KJ, Chuba, PJ, Gaspar, LE and Forman, JD. Progress towards boron neutron capture enhancement of fast neutron therapy at the Harper Hospital neutron therapy facility. In Frontiers in Neutron Capture Therapy the proceedings of the Eighth International Symposium on Neutron Capture Therapy for Cancer, (MF Hawthorne and RJ Wiersema, eds.) Plenum Publishing, New York (in press).

Maughan, RL and Yudelev, M Neutron Therapy. In Modern Technology of Radiation Oncology, (J. Van Dyk, ed) Medical Physics Publishing, Madison pp. 871-917, 1999.

Maughan, RL, Yudelev, M, Porter, AT, Forman, JD, Blosser, HG, Blosser, EB and Blosser, GF. Neutron radiation therapy with the Harper Hospital superconducting cyclotron: six years operating experience. In the Proceedings of the 15th Conference on Cyclotrons and their Applications.( E Baron and M Lieuvin, eds.) Institute of Physics Publishing, Bristol pp 141-144, 1999.

Nie D, Hillman GG, Geddes T, Tang K, Pierson C, Grignon DJ and Honn KV.  Platelet-type 12-lipoxygenase regultes angiogenesis in human prostate carcinoma.  In:  Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury 4.  Advances in Experimental Medicine and Biology.  Plenum Press, New York, 1999

Nie D, Tang K, Szekeres K, Li L, and Honn, KV.  Eicosanoid regulation of angiogenesis in human prostate carcinoma and its therapeutic implications.  In:  Annals N.Y. Acad. Science (in press).

Nie D, Tang K, Szekeres K, Trikha M and Honn KV.  The Role of Eicosanoids in Tumor Growth and Metastasis.  In:  Advances in Eicosanoid Res.  (in press)

Orton CG.  Emerging New Technologies in Radiation Oncology  In:  Advances in Medical Physics, Rehani, M.M. (ed.), Jaypee Bors., New Delhi, 1999.

Rivard MJ, Yudelev M, Van den Heuvel F, Wierzbicki JF, Martin RC, and McMahon RR. 252Cf mixed-field dosimetry for a variety of source geometries and phantom materials for clinical brachytherapy:  comparison of experimental and calculative results.  8th Intl. Symp. on Neutron Capture Therapy for Cancer, edited by MF Hawthorne, RJ Wiersema, Plenum Press, New York.  (accepted)

Rosenfeld, AB, Kaplan, GI, Carolan, MG, Allen, BJ, Coderre, J, Maughan, RL, Kota, C., Yudelev, Y, Khivrich, VI and Litovchenko, PG. Semiconductor detectors for thermal neutron flux measurements in phantoms used for epithermal BNCT and fast neutron therapy. In Frontiers in Neutron Capture Therapy the proceedings of the Eighth International Symposium on Neutron Capture Therapy for Cancer, (MF Hawthorne and RJ Wiersema, eds.) Plenum Publishing, New York (in press).

Tang K and Honn KV.  Apoptosis and Prostate Cancer.  In: Advances in Oncobiology in Prostate Cancer, (DP Wood and KV Honn, Eds.), JAI Press, Greenwich, 1999.

Tang K, Nie D and Honn KV.  Role of autocrine motility factor in a 12-lipoxygenase dependent anti-apoptotic pathway.  In: Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury 4.  Advances in Experimental Medicine and Biology, Plenum Press, New York, 1999.

Timar J, Raso E, Honn KV and Hagmann W.  12-lipoxygenase expression in human melanoma cell lines.  In:  Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury 4.  Advances in Experimental Medicine and Biology.  Plenum Press, New York, 1999.

Trikha M and Honn KV.  Integrins in Prostate Cancer,  In:  Advances in Oncobiology in Prostate Cancer, (DP Wood and KV Honn, Eds.), JAI Press, Greenwich, 1999.

Wood DP and Honn KV.  Introduction and Background.  Advances in Oncobiology in Prostate Cancer, Vol 3. (D.P. Wood and K.V. Honn, Eds.), JAI Press, Greenwich, 264 pp., 1999

Abstracts, Letters to the Editor and Articles in Non-Refereed Journals 

Abadir R. and Orton, CG.  ÒRadiotherapy for Small Cell Lung and Cancer.Ó  New England J. Med. 340, 2002-2003, 1999.

Aref A, Thornton D, Youssef E, He T, Tekyi-Mensah S, Denton L, Ezzell G,  Dosimetric improvements following 3-D planning of tangential breast irradiation.  Proceedings of the European Cancer Conference, ECCO 10, Vienna #314.  The European Journal of Cancer, 35(4):314, 1999.

Binns, PJ, DeLuca, PM, Maughan, RL and Kota, C. Reply to Comments on ÒDirect determination of kerma for a d(48.5)+Be therapy beam.Ó  Phys Med Biol, 44: L14, 1999.

Burmeister J., Kota C., Maughan RL.  Miniature proportional counter microdosimetry measurements in clinical BNCT beams.  Med Phys 26: 1120, 1999.

Chuba, PJ, Forman, JD, Maughan, R, Bolton, S, Tekyi-Mensa, S. Neoadjuvant hormone therapy and radiation dose escalation in patients with intermediate and high risk prostate cancer.  Int J Radiat Oncol Biol Phys 45(suppl.): 358, 1999.

Forman JD, Tekyi-Mensah S, Bolton SE, Prokop S, Chuba PJ, Ben-Josef E, Porter AT, Maughan RL.  Conformal sequential neutron-photon vs photon-neutron irradiation in organ confined prostate cancer:  results of a randomized prospective trial.  Int J Radiat Oncol Biol Phys 45(suppl):168, 1999.

Forman JD, Tekyi-Mensah S, Maughan RL, Chuba PJ, Porter AT.  Phase II & III evaluation of conformal mixed neutron and photon irradiation in localized prostate cancer.  Proceedings of ASCO #1225, Volume 18, 1999.

Kim HE, Krup MA, Han I, Ensley J, Kim H-RC.  Synergistic cytotoxicity by cis-platinum and neutron irradiation in human head and neck squamous cancer cells.  The European Journal of Cancer 35:S187, 1999.

Maughan RL, Kota C, Burmeister, Forman JD. Dosimetry studies for boron neutron capture therapy and the feasibility of boron neutron capture enhanced fast neutron therapy at the Gershenson Radiation Oncology Center.  Presented at the Joint Meeting of the Proton Therapy Cooperative Group XXX/European Hadron Therapy Group/ European Clinical Heavy Particle Dosimetry Group, Cape Town, South Africa, April 12-15, 1999.

Maughan RL, Yudelev M, Forman JD.  Design considerations for a computer controlled multi-leaf collimator for the Harper Hospital fast neutron therapy facility.  Presented at the Joint Meeting of the Proton Therapy Cooperative Group XXX/European Hadron Therapy Group/ European Clinical Heavy Particle Dosimetry Group, Capte Town, South Africa, April 12-15, 1999.

Nie D, Chen Y, Tang K, Hanna K, Nemeth J, Hillman GG, Cher M, Grignon D, and Honn KV.  Arachidonate 12-lipoxygenase enhances the metastatic potential of human prostate cancer cells.  90th Annual Meeting of the American Association for Cancer Research (AACR), Philadelphia, 1999.

Rakozy C, Gheiler E, Tiguert R, Sarkar FH, Sakr W, Pontes JE, Wood DP, Forman JD, Grignon.  Cell-cycle and apoptosis related markers may predict time to recurrence and clinical outcome in patients with recurrent prostatic carcinoma after radiation failure.  Presented (in part) at the 88th Annual Meeting of the United States and Canadian Academy of Pathology in San Francisco, CA.  March, 1999.

Schmidt, R, Maughan, RL, Yudelev, M and Kota, C. Response to Comment on ÓExperimental determination of the thermal neutron flux around  2 different types of high intensity 252Cf source .Ó Medical Physics, 26: 2039-2040, 1999.

Shields AF, Ahmed S, Zalupski MM, Muzik O, Forman JD, Lawhorn-Crews JM, Arlauskas P, Philip PA, Soulen RL, Vaitkevicius VK.  FDG-PET evaluation of pancreatic cancer treatment.  Presented at the Annual Meeting of the Society of Nuclear Medicine Convention, Los Angeles, California, June, 1999.

Van den Heuvel F, Han I, Strowbridge A, Chungbin SJ, Ragan DP. Determination of clinically relevant setup errors for daily electronic portal imaging analysis.  Med. Phys. 26:6, 1159, 1999.

Van den Heuvel F, Strowbridge A, Han I, Chungbin SJ, Ragan DP.  A comparative analysis of electronic portal image quality for patients receiving whole pelvic irradiation.  Eur. J. Cancer 35 (Supp 4), 94, 1999.

Yap J, Tekyi-Mensah S, Forman JD.  Hyperfractionated photon dose escalation in locally advanced prostate cancer.  IntÕl Journal of Radiation Oncology, Biology, Physics.  45(3): 2159, 1999.

Youssef E, Aref A, Chuba P, Kim H, Wilseck J, Adsay V, Arden R, Jacobs J.  Incidence of occult lymph node metastases in clinically and CT staged N0 neck in patients with oropharyngeal carcinoma.  Presented at the European Cancer Conference (ECCO 10), Vienna, Austria, September 12-16, 1999.

Youssef E, Tekyi-Mensah S, Bolton S, Forman JD.  The prognostic significance of changes in the PSA level during the course of therapeutic post-prostatecomy irradiation.  Intl Journal of Radiation Oncology, Biology, Physics.  45(3):1007, 1999.