Department of Ophthalmology

Chair: Gary Abrams, MD
Kresge Eye Institute
(313) 577-1320

Articles, Patents, Intellectual Property

Ahuja RM, Chaturvedi, S, Eliott, D, Nishith, J, Puklin, JE, Abrams, GW.  Mechanisms of retinal arterial occlusive disease in African American and Caucasian patients.  Stroke 30/8:1506-1509, 1999.

Ames, JB, Dizhoor, AM, Ikura, M, Palczewski, K, Stryer, L.  Three-dimensional structure of guanylyl cyclase activating protein-2, a calcium-sensitive modulator of photoreceptor guanylyl cyclases.  J Biol Chem 274:19327-19337, 1999.

Berkowitz, BA, Kowluru, RA, Frank, RN, Kern, TS, Hohman, TC, Prakash, M.  Subnormal retinal oxygenation response precedes diabetic-like retinopathy.  Invest Ophthalmol Vis Sci 40:2100-2105, 1999.

Bhattacharya, M, Asselin, P, Hardy, P, Guerguerian, AM, Shi, H, Hou, X, Varma, DR, Bouayad, A, Fouron, JC, Clyman, RI, Chemtob, S.  Developmental changes in prostaglandin E2 receptor subtypes in porcine ductus arteriosus.  Circulation 100:1751-1756, 1999.

Bhattacharya, M, Peri, K, Ribeiro-da-Silva, A, Almazan, G, Shichi, H, Hou, X, Varma, DR, Chemtob, S.  Localization of functional prostaglandin E2 receptor EP3 and EP4 in the nuclear envelope.  J Biol Chem 274:15719-15724, 1999.

Dizhoor, AM, Hurley, JB.  Regulation of photoreceptor membrane guanylyl cyclases by guanylyl cyclase activator proteins.  Methods 19:521-531, 1999.

Ernest, P, Rhem, M, McDermott, ML, Domash, D, et al.  The mechanism of catastrophic thermal wound injury during phacoemulsification.  J Cat Refrac Surg (in press).

Esco, M, Kurpakus, M, McDermott, ML.  Heterogeneity of Laminin-5 synthesis in response to hypoxia in human corneal epithelium.  Invest Ophthalmol Vis Sci (in press).

Frank, RN, Amin, RH, Puklin, JE.  Antioxidant enzymes in the macular retinal pigment epithelium of eyes with neovascular age-related macular degeneration.  Am J Ophthalmol 127(6):694-709, 1999.  

Gordon, MO, Kass, MA for the OHTS Group.  The Ocular Hypertension Treatment Study. Design and baseline description of the participants.  Arch Ophthalmol 117:573-583, 1999.

Henry, DN, Frank, RN, Hootman, SR, Rood, SE, Heilig, CW, Busik, JV.  Glucose specific regulation of aldose reductase in human retinal pigment epithelial cells in vitro.  Invest Ophthalmol Vis Sci (in press).

Hidalgo, JA, Alangaden GJ, Eliott D, Akins, RA, Vazquez, JA.  Diagnosis of fungal endophthalmitis by detection of candida albicans DNA in vitreous specimens using a species-specific PCR assay.  Journal of Infectious Disease (in press).

Kachi, S, Nishizawa, Y, Olshevskaya, E, Yamazaki, A, Miyake, Y, Wakabayashi, T, Dizhoor, A, Usukura, J.  Detailed localization of photoreceptor guanylate cyclase activating protein-1 and -2 in mammalian retinas using light and electron microscopy.  Exp Eye Res 68:465-473, 1999.

Kraft, SP, Nabi, NU, Wilson, ME, Roarty, JD, et al.  Bilateral idiopathic Brown’s Syndrome with delayed onset in the second eye.   Journal of the American Association of Pediatric Ophthalmology (in press).

Krylov, DM, Niemi, GA, Dizhoor, AM, Hurley, JB.  Mapping sites in guanylyl cyclase activating protein-1 required for regulation of photoreceptor membrane guanylyl cyclases.  J Biol Chem 274:10833-10839, 1999.

Martin, DF, Kuppermann, BD, Wolitz, RA, Palestine, LI, Robinson, CA.  Roche Ganciclovir Study Group: Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant.  The New England Journal of Medicine, 340:1063-1070, 1999.

Moroi, SE, Gottfredsdottir, MS, Steingart, MT, Elner, SG, Lee, CM, Schertzer, RM, Abrams, GW, Johnson, MW.  Cystoid macular edema associated with latanoprost therapy in a case series of patients with glaucoma and ocular hypertension.  Ophthalmol 106(5): 1024-1029, 1999. 

Morris, DA, Peracha, MO, Shin, DH, Kim, C, Cha, SC, Kim YY.   Risk factors for early filtration failure requiring suture release after primary glaucoma triple procedure with adjunctive mitomycin.  Arch Ophthalmol 117:1149-1154, 1999. 

Murphy, PL, as a member of the COMS Quality of Life Study Group.  Quality of life assessment in the collaborative ocular melanoma study: design and methods.  Ophthalmic Epidemiol  6(1)5-17, 1999.

Murphy, PL, as a member of the Early Treatment Diabetic Retinopathy Study Group.  Impaired color vision associated with diabetic retinopathy.  Report no. 15,  Am J Ophthalmol 128(5):612-617, 1999.

Murphy, PL, as a member of the Early Treatment Diabetic Retinopathy Study Group.  Causes of severe visual loss in the early treatment diabetic retinopathy study.  ETDRS report no. 24.  Am J Ophthalmol 127(2):137-141, 1999. 

Newland, TJ, McDermott, ML, Eliott, D, Hazlett, LD, Apple, DJ, Lambert, RJ.  Experimental neodymium:YAG lser damage to acrylic, PMMA, and silicone intraocular lens materials.  J Cat Refrac Surg, 25(1):72-76, 1999.

Olshevskaya, EV, Boikov, S, Ermilov, A, Krylov, D, Hurley, JB, Dizhoor, AM.  Mapping function domains of the guanylate cyclase regulator protein, GCAP-2.  J Biol Chem 274:10823-10832, 1999.

Olshevskaya, EV, Ermilov, AN, Dizhoor, AM.  Dimerization of guanylyl cyclase-activating protein and a mechanism of photoreceptor guanylyl cyclase activation.  J Bio Chem 274:25583-25587, 1999.

Qian, W, Amin, RH, Shichi, H.  Cytotoxic metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, produces cataract in DBA2 mice.  J Ocular Pharmacol Therapeut.  15:537-545, 1999.

Qian, W, Shichi, H.  Acetaminophen produces cataract in DBA2 mice by Ah receptor-independent induction of CYP1A2.  J Ocular Pharmacol Therapeut.  (in press).

Ren J, Shin DH, Chung, HS, Birt, C, Glover, B, Juzych, MS, Hughes, BA, Kim, C.  Efficacy of apraclonidine 1+ versus pilocarpine 4% for prophylaxis of intraocular pressure spike after argon laser trabeculoplasty.  Ophthalmol 106:1135-1139, 1999.

Shin, DH and the Brinzolamide Adjunctive Therapy Study Group.  Adjunctive therapy with Brinzolamide 1% ophthalmic suspension (AZOPT() in patients with primary open-angle glaucoma or ocular hypertension maintained on timolol therapy.  Surv Ophthalmol (in press).

Shin, DH, Glover, BK, Cha, SC, Kim, YY, Kim, C, Nguyen, KD.  Long-term brimonidine therapy in glaucoma patients with apraclonidine allergy.  Am J Ophthalmol 127: 511-515, 1999.

Shin, DH, McCracken, M, Bendel, RE, Pearlman, R, Juzych, MS, Hughes, BA, Schulz, LL, Kim, C, Baek, NH.  The additive effect of latanoprost to maximum-tolerated medications with low-dose, high-does, or no pilocarpine therapy.  Ophthalmol 106:386-390, 1999. 

Tervo, T, Vesaluoma, M, Weiss, JS, Linna, T.  Confocal microscopy of a family with SchnyderÕs crystalline dystrophy.  Ophthalmology, 106:944-951, 1999.

Thompason, JT, Smiddy, WE, Williams, GA, Sjaarda, RN, Flynn, HW, Margherio, RR, Abrams, GW.  Comparison of recombinant transforming growth factor-beta-2 and placebo as an adjunctive agent for macular hole surgery.  Ophthalmol 105(4): 700-706, 1999. 

Yu, H, Olshevskaya, E, Duda, T, Seno, K, Hayashi, F, Sharma, RK, Dizhoor, AM, Yamazaki, A.  Activation of retinal guanylyl cyclase-1 by Ca2+-binding proteins involves its dimerization.  J Biol Chem 274:15547-15555, 1999. 

Zalloum, JN, Ahuja, RM, Weiss, JS.  Assessment of corneal decompensation in eyes having undergone Molteno shunt procedure compared to eyes having undergone trabeculectomy.  J CLAO, 25:57-60, 1999.

Books, Chapters and Reviews

Abrams, GW, Gentile, RC.  Vitrectomy.  In: Retina-Vitreous-Macula  (DR Guyer, LA Yannuzzi, S Chang, J Shields, WR Green, eds.)  W.B. Saunders Co, Philadelphia, pp. 1298-1319, 1999.

Eliott, D.  BiettiÕs crystalline dystrophy.  In: Retina-Vitreous-Macula  (DR Guyer, LA Yannuzzi, S Chang, J Shields, WR Green, eds.)  W.B. Saunders Co, Philadelphia, pp. 1037-1049, 1999. 

Eliott, D, Lee, MS, Abrams, GW.  Proliferative diabetic retinopathy: principles and techniques of surgery.  In: Retina 3rd ed. (SJ Ryan, ed.)  CV Mosby, St. Louis (in press).

Eliott, D, Schachat, AP.  Combined hamartoma of the retina and retinal pigment epithelium.  In: Retina 3rd ed.  (SJ Ryan, ed.)  CV Mosby, St. Louis  (in press).

Frank, RN.  Etiologic mechanisms in diabetic retinopathy.  In: Retina, 3rd ed.  (SJ Ryan, ed.)  CV Mosby, St. Louis (in press).

Hurley, JB, Dizhoor, AM.  Heterologous expression and assay of photoreceptor guanylyl cyclases and guanylyl cyclase activator proteins.  In: Methods in Enzymology.  Vertebrate Phototransduction and the Visual Cycle, Part A (in press).

Juzych, MS, Bendel, RE.  Principles and complications of medical therapy of glaucoma.  In: Clinical Pathways in Glaucoma.  Thieme Publishers, New York (in press).

Lee, M, Abrams, GW.  Membrane removal in proliferative vitreoretinopathy.  In: Atlas of vitreoretinal surgery, (G Paymen ed.) Martin Dunitz Ltd.  (in press).

Lee, M, Abrams, GW.  Membrane dissection in proliferative diabetic vitreoretinopathy.  In: Atlas of vitreoretinal surgery, (G Paymen ed.) Martin Dunitz Ltd. (in press).

McDermott, ML.  Corneal endothelium.  In: Ophthalmology, (M Yanoff, J Duker, eds.) Mosby International, London, pp. 1-10, 1999.

McDermott, ML.  Corneal stromal wound healing.  In: Corneal Surgery, (FS Brightbill, ed.) Mosby-Year Book, Inc., St. Louis, pp. 40-48, 1999.

McDermott, ML, Tu, EY.  Corneal pigmentation.  In: Decision Making in Ophthalmology, 2nd edition, (WA van Heuven, JT Zwaan, eds.) Mosby, St. Louis (in press).

McDermott, ML, Tu, EY.  Corneal crystals.  In: Decision Making in Ophthalmology, 2nd edition, (WA van Heuven, JT Zwaan, eds.)  Mosby, St. Louis (in press).

McDermott, ML, Tu, EY.  Punctate corneal staining.  In: Decision Making in Ophthalmology, 2nd edition, (WA van Heuven, JT Zwaan, eds.) Mosby, St. Louis (in press).

Robin, AL, Juzych, MS.  Argon laser trabeculoplasty.  In: Essentials of Glaucoma.  Thieme Publishers, New York (in press).

Shichi, H.  Molecular biology of vision.  In: Basic Neurochemistry: Molecular, Cellular and Medical Aspects, (GJ Siegel, BW Arganoff, RW Albers, SK Fisher, MD Uhler, eds.), Lippincott-Raven, Philadelphia, pp. 971-987, 1999.

Tu, EY, McDermott, ML.  Corneal hypesthesia.  In: Decision Making in Ophthalmology, 2nd edition, (WA van Heuven, JT Zwaan, eds.)  Mosby, St. Louis (in press).

Weiss, JS, Spagnolo, B.  Crystalline dystrophy. In: eMedicine Ophthalmology Textbook,  (Roy, Hampton, ed.), 1999.

Weiss, JS.  SchnyderÕs corneal dystrophy.  In: Ophthalmic Pathology, (Klintworth, ed.), 1999.

Weiss, JS.  SchnyderÕs dystrophy.  In: Current Ocular Therapy,  (FT Fraunfelder, FH, Roy, ed.), Saunders Col., Philadelphia (in press).

Abstracts, Letters to the Editor, Articles in Non-refereed Journals

Abdel-Dayen, H, Trese, M, Roarty, JD, et al.  Preservation of visual acuity in macular and papillary retinoblastoma tumor treated with thermochemotherapy and radioactive plaque: A photo essay.  American Academy of Ophthalmology Annual Meeting, 1999.

Amin, RH, Frank, RN, Heilig, C.  Short term diabetic mice upregular vascular endothelial growth factor (VEGF) protein in retinal neurons.  Invest Ophthalmol Vis Sci 40:S370, 1999.

Barrow, DY, Cha, SC, Shin, DH, Chung, HS, Lee, D, Birt, CM.  Efficacy of brimonidine 0.2% topical eye medication in post-argon laser trabeculoplasty intraocular pressure spike prophylaxis.  Invest Ophthalmol Vis Sci 40(S): 515, 1999.

Bednarski, MA, Achtenberg, J, and the Ocular Hypertension Treatment Study (OHTS) Group.  Delivering coordinating center reports to clinics via the world wide web.  Controlled Clin Trials 20(2S): 60S, 1999.

Dizhoor, AM, Ikura, M, Stryer, L, Ames, JB.  Three-dimensional structure of regulatory domains of GCAP-2 determined by NMR spectroscopy and directed mutagenesis.  Invest Ophthalmol Vis Sci 40, 1999.

Esco, MA, McDermott, ML, Kurpakus, MA.  Effects of hypoxia on human corneal epithelial cell-cell and cell-matrix adhesion.  Invest Ophthalmol Vis Sci 40(suppl), 1999.

Feuer, WJ, Parrish, RK, Wells, MC, Schiffman, JC, Kass, MA, Gordon, MO, and Ocular Hypertension Treatment Study (OHTS) Group.  Reproducibility of reading of optic disc cup/disc ratio in the Ocular Hypertension Treatment Study (OHTS).  Invest Ophthalmol Vis Sci 40(S):283, 1999.

Frank, RN, Grunberger, G.  Cancer in a patient receiving IGF-1 cotherapy for blood glucose control in diabetes.  Diabetes Care (in press).

Gentile, RC, Eliott D, Lee, M, Puklin JE, Abrams GW.  Central serous chorioretinopathy in African-American patients.  Invest Ophthalmol Vis Sci 40/4:S485, 1999.

Henry DN, Busik, JV, Olson, LK, Greenidge, CA, Heilig, CW, Frank, RN.  Accelerated glucose exchange increases glucose entry into cells of the blood-retinal barrier (BRB) in vitro.  Invest Ophthalmol  Vis Sci 40:S484, 1999.

Iskander, NG, Ahee, JA, Ramirez, JA, Shin, DH, Kim, C, Kim, YY.  Long-term intraocular pressure control and visual field changes after primary glaucoma triple procedure with and without mitomycin C.  Invest Ophthalmol Vis Sci 40(S): 4, 1999.  

Keltner, JL, Johnson, CA, Spurr, JO, Kass, MA, Gordon, MO, and the Ocular Hypertension Treatment Study (OHTS) Group.  Classification of visual field abnormalities in the Ocular Hypertension Treatment Study (OHTS).  Invest Ophthalmol Vis Sci 40(S): 69, 1999.

Kennedy, A, Frank RN.  High glucose decreases hypoxic upregulation of VEGF in cultured retinal cells; effects of an aldose reductase inhibitor, aminoguanidine, and an antioxidant.  Invest Ophthalmol Vis Sci 40:S162, 1999.

MacKersie, DL, Ober, MD, Shin, DH, Cha, SC, Juzych, MS, Baek, NH.  Comparative study on asymmetry of visual field defects in normal-tension versus high-tension primary open-angle glaucoma patients.  Invest Ophthalmol Vis Sci 40(S):778, 1999.

Morris, PA, Wilder, AK, Bednarski, MA, Gordon, MO, and the Ocular Hypertension Treatment Study (OHTS) Group.  Accessing SAS reports by the central coordinators via the world wide web.  Controlled Clin Trials 20(2S): 68S, 1999.

Nootheti, P, Kim, C, Shin, DH, Morris, DA, Juzych, MS, Hughes, BA.  Prospective, open-label Cosopt replacement therapy for concomitant topical B-blocker and carbonic anhydrase inhibitor in a clinical practice setting.  Invest Ophthalmol Vis Sci 40(S):186, 1999.

Nootheti, P, Shin, DH, Morris, DA, Kim, C, Hughes, BA, Birt, CM.  Cosopt replacement therapy for concomitant beta-blocker and carbonic anhydrase inhibitor.  Ophthalmology 106(S): 159, 1999. 

Ober, MD, Lemon, LC, Shin, DH, Nootheti, P, Cha, SC.  A long-term comparative study of silicone versus acrylic intraocular lens in phaco-trabeculectomy.  Ophthalmology 106(S): 256, 1999.

Peracha, M, Kim, C, Shin, DH, Morris, DA, Nootheti, P, Ren, J.  The efficacy of suture release for early filtration failure following trabeculectomy.  Invest Ophthalmol Vis Sci 40(S): 5, 1999.

Ramocki, JM.  Evaluating the protective capabilities of soft contact lens coverage during rejuvenation laser treatment with Erbium and CO2 pulse lasers in preventing accidental corneal burns.  CLAO Annual Meeting (in press).

Ramocki, JM, Shin, DH, Glover, BK, Morris, DA, Kim, YY.  Foldable posterior chamber lens implantation in the absence of capsular and zonular support.  Am J Ophthalmol 127: 213-216, 1999

Reno, JB, Rabban, UJ, Shin, DH, Schulz, LL, Kim, C, and SLT Study Group.  A retrospective comparison of selective laser trabeculoplasty versus argon laser trabeculoplasty in chronic open-angle glaucoma patients.  Invest Ophthalmol Vis Sci 40(S): 270, 1999.

Shin, D, Garadi, R, Silver, LH, Ratliff, M, von Tress, M and the Timolol Gel Forming Solution Study Groups.  Timolol gel forming solution (0.25% and 0.5%): A new once-daily formation of timolol maleate for the reduction of elevated intraocular pressure.  Invest Ophthalmol Vis Sci 40(S): 513, 1999. 

Shokoohi, KK, Shin, DH, Eliott, D, Zwas, F, Juzych, MS, Hughes BA.  Antiphospholipid antibodies in patients with normal tension glaucoma.  Invest Ophthalmol Vis Sci 40/4:S64, 1999.

Singh, AK, Shichi, H.  Se-independent glutathione peroxidase (GPX) activities in bovine ocular tissues.  Invest Ophthalmol Vis Sci. 40(Suppl):12, 1999.

Wilder, AK, Morris, PA, Gordon, MO, and the Ocular Hypertension Treatment Study (OHTS) Group.  Offering continuation education credits at clinic coordinating meeting.  Controlled Clin Trials 20(2S): 67S, 1999.

Zenzen, CT, Cha, SC, Wierenga, CM, Shin, DH, Nootheti, P, Hughes, BA.  Comparative study of filtration outcome between primary trabeculectomy and primary glaucoma triple procedure with and without adjunctive mitomycin C.  Invest Ophthalmol Vis Sci 40(S): 967, 1999.