Department of Neurology

Chair: Robert Lisak, MD
6E University Health Center
(313) 577-1242

Articles Published

Ahuja R, Chaturvedi S, Joshi N, Elliot D, Abrams G, Puklin J. Mechanisms of retinal arterial occlusive disease in African American and Caucasian patients. Stroke, 30:1506-1509, 1999.

Balabanov R, Beaumont T, Dore-Duffy P. Role of central nervous system microvascular pericytes in activation of antigen-primed splenic T-lymphocytes. J Neurosci Res, 55:578-587, 1999.

Boullerne AI, Nedelkoska L, Benjamins JA. Synergism of nitric oxice and iron in killing the transformed murine oligodendrocyte cell line N20.1. J Neurochem, 72:1050-1060, 1999.

Carhuapoma JR, DÕOlhaberriague L, Levine SR: Moyamoya syndrome associated with Sneddon’s Syndrome and antiphospholipid-protein antibodies. J Stroke Cerebrovasc Dis, 8:51-56, 1999.

Chaturvedi S, Adams HP, Woolson RF. Circadian variation in ischemic stroke subtypes. Stroke, 30:1793-1795, 1999.

Chaturvedi S, Dzieczkowski J. Protein S deficiency, activated protein C resistance, and sticky platelet syndrome in a young woman with bilateral strokes. Cerebrovasc Dis, 9:127-130, 1999.

Chaturvedi S, Joshi N, Dzieczkowski J. Activated protein C resistance in young African American patients with ischemic stroke. J Neurol Sci, 163:137-139, 1999.

Chaturvedi S, Lukovits T, Chen W, Gorelick PB. Ischemia in the territory of a hypoplastic vertebrobasilar system. Neurology, 52:980-983, 1999.

Cheng H-L, Shy ME, Feldman EL Regulation of insulin like growth factor binding protein 5 expression during Schwann cell differentiation. Endocrinology, 140: 4478-4485, 1999.

Chugani DC, Muzik O, Behen ME, Rothermel RD, Lee J, Chugani HT.  Developmental changes in brain serotonin synthesis capacity in autistic and non-autistic children.  Ann Neurol, 45:287-295, 1999.

Chugani DC, Niimura K, Chaturvedi S, Muzik O, Fakhouri M, Lee ML, Chugani HT.  Increased brain serotonin synthesis in migraine. Neurology, 53:1473-1479, 1999.

Clark WM, Wissmna S, Albers GW, Jhamandas JH, Madden KP, Hamilton S, for the ATLANTIS Study Investigators (SRLevine, local site principal investigator): Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: A randomized controlled trial. JAMA, 282:2019-2026, 1999.

Clifford DB, Yiannoutsos C, Glicksman M, Simpson DM, Singer EJ, Piliero PJ, Marra CM, Francis GS, McArthur JC, Tyler KL, Tselis AC, Hyslop NE. HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy. Neurology, 52:623-625, 1999.

Coplin WM, Avellin AM, Kim DK, Winn HR, Grady MS, Bacterial meningitis associated with lumbar drains: a retrospective cohort study. J Neurol Neurosurgy Psychaiat, 67:468-473, 1999.

Coplin WM, Longstreth WT, Jr, Lam AM, Chandler WL, Maybert TS, Fine JS, Winn HR. Cerebral spinal fluid creatinine kinase-BB isoenzyme activity and outcome after subarachnoid hemorrhage. Arch Neurol, 56:1348-1352, 1999.

da Silva EA, Muller RA, Chugani DC, Shah J, Shah A, Watson C, Chugani HT. Brain activation during intermittent photic stimulation:  A [150]-water PET study on photosensitive. Epilepsy, 40:17-22, 1999.

Dickson DW, Lin W-K, Hardy J, Farrer M, Menta N, Vitti R, Mark M, Zimmerman T, Golbe L, Sage J, DÕAmato C, Sima AAF, Albin R, Gilman S, Yen S-H:  Widespread alterations in alpha-synuclein in multiple system atrophy.  Am. J. Path 155: 1241-1251, 1999.

Dore-Duffy P, Balabanov R, Beaumont T, Hritz MA, Harik SI, LaManna J. Endothelial activation following prolonged hypobaric hypoxia. Microvasc Res, 57: 75-85, 1999.

Ford BD, Loeb JA, Fischbach, GD. Neuregulin stimulates DNA synthesis in embryonic chick heart cells.  Dev Biol, 214:139-150, 1999.

Garbern J, Cambi F, Lewis RA, Shy ME, Sima A, Kraft G, Vallat JM, Bosch EP, Hodes ME, Dlouhy S, Raskind W, Bird T, Macklin W, Kamholz J. Peripheral neuropathy caused by proteolipid protein gene mutations. Ann N Y Acad Sci, 883:351-365, 1999.

Garbern J, Lewis R, Bosch EP, Sima AAF, Shy ME, Menichella D, Vallat JM, Cambi F, Kamholz J.  Peripheral neuropathy caused by mutation of the proteolipid protein gene.  Ann New York Acad Sci 883: 351-365, 1999.

Goldberg SH, Albright AV, Lisak RP, Gonzalez-Scarano F.  Polymerase chain reaction analysis of human herpes virus-6 sequences in the sera and cerebrospinal fluid of patients with multiple sclerosis. J Neurovirol, 5:134-139, 1999.

Grotta JC, Chiu D, Lu M, Patel S, Levine SR, Tilley BC, Brott TG, Clarke EC Jr., Lyden PD, Kothari R, Frankel M, Lewandowski CA, Libman R, Kwiatkowki T, Broderick JP, Marler JR, Corrigan J, Huff S, Mitsias P, Talati S, Tanne D, and the NINDS rt-PA Stroke Trial Study Group. Agreement and variability in the interpretation of early CT changes in stroke patients qualifying for intravenous rtPA therapy. Stroke, 30:1528-1533, 1999.

Jani A, Menichella D, Jiang H, Chbihi T, Acsadi G, Kamholz J, Shy ME. Overcoming cellular immunity to prolong adenoviral-mediated gene expression in sciatic nerve. Ann NY Acad Sci, 883:397-414, 1999.

Jani A, Menichella D, Jiang H, Chbihi T, Acsadi G, Shy ME, Kamholz J. Modulation of cell-mediated immunity prolongs adenovirus-mediated transgene expression in sciatic nerve. Hum Gene Ther, 10:787-800, 1999.

Juhasz C, Nagy F, Muzik O, Watson C, Shah J, Chugani HT. [11C]-Flumazenil PET in patients with epilepsy with dual pathology.  Epilepsia, 40:566-574, 1999.

Juhasz C, Nagy F, Watson C, da Silva EA, Muzik O, Chugani DC, Shah J, Chugani HT. Glucose and [11C]flumazenil positron emission tomography abnormalities of thalamic nuclei in temporal lobe epilepsy.  Neurology, 53:2037-2045, 1999.

Kamholz J, Awatramani R, Menichella D, Jiang H, Xu W, Shy ME. Regulation of myelin-specific gene expression: relevance to CMT1. Ann New York Acad Sci, 883:91-108, 1999.

Koffman B Junck L, Elias SB, Feit HW, Levine SR. Polyradiculopathy in sarcoidosis. Muscle & Nerve, 22:608-613, 1999.

Koo B:  Vigabatrin in the treatment of infantile spasms. Ped Neurol 20:106-110, 1999.

Krajewski K, Turansky C, Lewis RA, Garbern J, Hinderer S, Kamholz J, Shy ME. Correlation between weakness and axonal loss in patients with CMT 1A. Ann New York Acad. Sci, 883:490-493, 1999.

Kwiatkowski TG, Libman RB, Frankel M, Tilley BC, Morgenstern LB, Lu M, Broderick JP, Lewandowski CA, Marler JR, Levine SR, Brott T, for the NINDS rt-PA Stroke StudyGroup. Effects of tissue plasminogen activator for acute ischemic stroke at one year. New Engl J Med, 340:1781-1787, 1999.

Lewandowski CA, Frankel M, Broderick J, Tomsick TA, Broderick J, Frey J, Clark W, Starkman S, Grotta J, Spilker J, Khoury J, Brott T, and the EMS Bridging Trial Investigators (SR Levine, member of EMS Bridging Trial). Combined intravenous and intra-arterial rt-PA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging Trial. Stroke, 30:2598-2605, 1999. 

Lewis RA, Shy ME. Electrodiagnostic findings in CMTX: a disorder of the Schwann cell and peripheral nerve myelin, Ann New York Acad Sci, 883:504-508, 1999.

Li LM, Cendes F, Andermann F, Watson C, Fish DR, Cook MJ, Dubeau F, Duncan JS, Shorvon SD, Berkovic SF, Free S, Olivier A, Harkness W, Arnold DL. Surgical outcome in patients with epilepsy and dual pathology.  Brain, 122:799-805, 1999.

Loeb JA, Khuranna TS, Robbins J, Yee AG, Fischbach, GD. Expression patterns of transmembrane and released forms of neuregulin during spinal cord and neuromuscular synapse development. Development, 126:781-791, 1999.

Lyden P, Lu M, Jackson C, Marler J, Kothari R, Brott T, Zivin J, and the NINDS t-PA Stroke Trial Investigators, (SR Levine, member of NINDS rt-PA Stroke Study Group). Underlying structure of the National Institutes of Health Stroke Scale. Results of a factor analysis. Stroke, 30:2347-2354, 1999.

Maiese K, Ahmad I, TenBroeke M, Gallant J. Metabotropic glutamate receptors independently modulate neuronal intracellular calcium. J Neurosci Res 55:472-485, 1999.

Maiese K, Vincent A M. Group I metabotropic receptors down-regulate nitric oxide induced caspase-3 activity in rat hippocampal neurons. Neurosci Lett 264:17-20, 1999.

Menichella DM, Xu W, Jiang H, Sohi J, Vallat JM, Baron P, Kamholz J, Shy ME. The absence of myelin P0 protein produces a novel molecular phenotype in Schwann cells. Ann New York Acad Sci, 883:281-294, 1999.

Muller RA, Behen ME, Rothermel RD, Chugani DC, Muzik O, Mangner TJ, Chugani HT. Brain mapping of language and auditory perception in high-functioning autistic adults:  a PET study.  J Autism Dev. Disorders, 29:19-31, 1999.

Muller RA, Behen ME, Rothermel RD, Muzik O, Chakraborty PK, Chugani HT. Brain organization for language in children, adolescents, and adults with left hemisphere lesion: A PET study. Progressive Neuro-Psychopharmacology & Biology Psychiatry, 23:657-668, 1999.

Muller RA, Rothermel RD, Behen ME, Muzik O, Chakraborty PK, Chugani HT. Language organization in patients with early and late left-hemisphere lesions: A PET Study.  Neuropsychologia, 37:545-557, 1999.

Muzik O, Janisse J, Ager J, Shen C, Chugani DC, Chugani HT. A mathematical model for the analysis of cross-sectional brain glucose metabolism data in children. Progressive Neuro-Psychopharmacology & Biology Psychiatry, 23:589-600, 1999.

Nagy F, Chugani DC, Juhasz C, da Silva EA, Muzik O, Kupsky W, Canady A, Watson C, Shah J, Chugani HT.  Altered in vitro and in vivo flumazenil binding in human epileptogenic neocortex.  J Cerebral Blood Flow and Metabolism, 19:939-947, 1999.

Niimura K, Chugani DC, Muzik O, Chugani HT. Cerebellar reorganization following cortical injury in humans:  Effects of lesion size and age. Neurology, 52:4;792-797, 1999.

Pareyson D, Menichella D, Botti S, Sghirlanzoni A, Fallica E, Mora M,       Ciano C, Shy ME, Taroni F, Heterozygous null mutation in the P0 gene associated with mild Charcot Marie Tooth Disease. Ann New York Acad Sci, 883:477-481, 1999.

Pegoraro E, Marks H, Garcia CA, Crawford T, Mancias P, Connolly AM, Fanin M, Martinello F, Trevisian CP, Angellini C, Stella A, Scavina M, Mink RL, Servidei S, Boneman C, Bertorini T, Acsadi G, Thompson CE, Gagnon D, Hoganson G, Carver V, Hoffman EP.  Congenital muscular dystrophy (CMD) due to pimary merosin (laminin a2) gene mutations: Genotype/phenotype studies of 22 patients.  Neurology, 51:101-110, 1998.

Price RW, Yiannoutsos C, Clifford DB, Zaborski L, Tselis AC, Sidtis JJ, Cohen B, Hall C, Erice A, Henry K, for the ACTG and NeuroAIDS Research Consortium 811 and 810 Study Team. Neurologic outcomes in late HIV infection: adverse impact of neurological impairment on survival and protective effect of antiviral therapy. AIDS, 13:1677-1685, 1999.

Ragheb, S, Bealmear B, Lisak, RP. Cell-surface expression of lymphocyte activation markers in myasthenia gravis. Autoimmunity, 3:55-66, 1999.

Rajkumar V, Choudhury L, Ragatzki P, Sima AAF, Levy J:  Hypercoagulability and microvascular disease in diabetic muscle infarction, new implications for therapy.  Endocrinology 11:57-60, 1999.

Reynolds EM, Thompson IM, Nigro MA, Kupsky WJ, Klein MD. Muscle and nerve biopsy in the evaluation of neuromuscular disorders:  The surgeonÕs perspective.  J Pediatric Surgery, 34:588-590, 1999.

Rhoney DH, Coplin WM, Zaran FK, Brish LK, Weingarten CM. Urokinase activeity after freezing: Implication for thrombolysis in introventricular hemorrhage. Am J Heath Syst Pharm. 56:204702051, 1999.

Shah AK, Freij W. Dramatic headache relief after sumatriptan in a patient with pituitary macroadenoma. Headache, 39:443-445, 1999.

Shah AK, Whitty JE. Brain MRI in peripartum seizures: Usefulness of combined T2 and diffusion weighted MR imaging. J. Neurol Sci 166:122-125, 1999.

Shah AK. Cyclosporine A neurotoxicity among bone marrow transplant recipients. Clin Neuropharm, 2:67-73, 1999.

Sima AAF, DÕAmato C, Foster NL:  Neuropathology of chromosome 17-linked dementia.  Dementia & Geriatric Cognitive Disorders 10: 61-63, 1999.

Studzinski DM, Callahan RE, Benjamins JA. Increased intracellular calcium alters myelin gene expression in the N20.1 oligodendroglial cell line. J Neurosci Res, 57:633-642, 1999.

Tanne D, Bates VE, Verro P, Kasner SE, Binder JR, Patel SC, Mansbach HH, Daley S, Schultz LR, Karanjia PN, Scott P, Dayno JM, Vereczkey-Porter K, Benesch C, Book D, Coplin WM, Dulli D, Levine SR, for the t-PA Stroke Survey Group (S. Chaturvedi, participant). Initial clinical experience with IV tissue plasminogen activator for acute ischemic stroke. A multicenter survey. Neurology, 53:424-427, 1999.

Tanne D, DÕOlhaberriague L, Schultz LR, Salowich-Palm L, Sawaya KL, Levine SR. Anticardiolipin antibodies and their associations with cerebrovascular risk factors. Neurology, 52:1368-1373, 1999.

Tiguert R, Lewis RA, Gheiler EL, Tefilli MV, Gudziak MR. Case report: Acute urinary retention secondary to IsaacÕs syndrome. Neurourol Urodyn, 18:113-114, 1999.

Videtic GMM, Gaspar LE, Zamorano L, Levin KJ, Kupsky WJ, Tekyi-Mensuh S. Use of the RTOG recursive partitioning analysis to validate the benefit of iodine-125 implants in the primary treatment of malignant gliomas. Int J Radiation Oncol Biol Phys, 45:687-692, 1999.

Videtic GMM, Levin KJ, Zamorano L,Kupsky WJ. Adjuvant gamma-knife radiosurgery for a resected suprasellar pituitary adenoma with atypical immunohistochemistry: Case report. J Radiosurgery 2:33-39, 1999.

Vinas FC, Ferris D, Kupsky WJ, Dujovny M. Evaluation of expanded polytetrafluroethylene (ePTFE) versus polydioxanone (PDS) for the repair of dura mater defects. Neuro Res 21:262-268, 1999.

Vincent A M, Maiese K. Temporal analysis of apoptosis in living neurons. J Histochem Cytochem 47:661-672, 1999.

Vincent A M, TenBroeke M, Maiese K. Metabotropic glutamate receptors prevent programmed cell death through the modulation of neuronal endonuclease activity and intracellular pH. Exp Neurol 155:79-94, 1999.

Vincent A M, TenBroeke M, Maiese K. Neuronal intracellular pH directly mediates nitric oxide-induced programmed cell death. J Neurobiol 40:171-184, 1999.

Wilner HI, Vinas F, Duffy C, Kupsky WJ, Guthikonda M. Magnetic resonance imaging of intracranial plasmocytic granuloma. Skull Base Surgery, 9:265-270, 1999.

Woo D, Broderick JP, Kothari RU, Lu M, Brott T, Lyden PD, Marler JR, Grotta JC; for the NINDS rt-PA Stroke Study Group, (SR Levine, member of NINDS rt-PA Stroke Study Group). Does the National Institutes of Health Stroke Scale left hemisphere strokes? Stroke, 30:2355-2359, 1999.

X-M Tang, Beesley JS, Grinspan JB, Seth P, Kamholz J, Cambi F. Cell cycle arrest induced by ectopic expression of p27 is not sufficient to promote oligodendrocyte differentiation. J Cell Biochem, 76:270-279, 1999.

Articles In Press

Aldape K, Simmons ML, Davis RL, Miike R, Wiencke J, Barger G, Lee M, Chen P, Wrensch M. Diagnostic discrepancies in neuroepithelial neoplasms: The San Franciso Bay Area Adult Glioma Study. Cancer (in press).

Chaturvedi S, St. Pierre E, Bertasio B. Availability of cerebral angioplasty expertise at major medical centers in the United States. Neuroradiology, (in press).

Clark L., Foster N., Sima AAF, Williamson K. A survey of polymorphisms and mutations in the microtubule Ð associated protein tau gene in sporadic fronto-temporal dementia and progressive supranuclear palsy.  Am J Hum Genetics (in press).

Glauser TA, Nigro MA, Sachdeo R, Bonet HB, Weinstein S, Abou-Khalil B, Frank M, Grinspan A. TG, Betts T, Kerrigan J, Geoffroy G, Jacobs T, Mesenbrink P, Kramer L, DÕSouza J, and the Trileptal Pediatric Group.  Adjunctive therapy with Oxcarbazepine in children with inadequately controlled partial seizures:  A multinational, multicenter, randomized, double-blind, placebo-controlled, parallel trial. Neurology, (in press).

Hall KE, Sima AAF, Wiley J. Impaired regulation of the inhibitory G protein: calcium channel complex contributes to elevated neuronal calcium influx in diabetes mellitus.  J Phys. London, (in press).

Jean-Guillaume D, Awatramani R, Lee A, Mason LM, Lintner RN, Kendler A, Kamholz J, Raine CS, Dyer CA.  GFAP-positive non-myelinating oligodendrocytes in normal and pathologic adult brain.  J Neurosci Res, (in press).

Juhasz C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT. The relationship between EEG and PET abnormalities in clinical epilepsy. Clin Neurophys, (in press).

Kamholz J, Menichella D, Jani A, Garbern J, Lewis, Krajewski K, RA, Lilien J, Scherer S, Shy ME. Charcot-Marie-Tooth disease type 1: molecular pathogenesis to gene therapy.  Brain, (in press).

Khan OA, Rothman MI. Reversibility of acute demyelinating lesions in relapsing-remitting multiple sclerosis. JPMA, (in press).

Krajewski K, Lewis R, Fuerst D, Turansky C, Hinderer S, Garbern J, Kamholz J, Shy M. Neurological dysfunction and axonal degeneration in CMT 1A. Brain, (in press).

Lewis RA, Shy ME, Sumner AJ. Electrophysiologic features of inherited demyelinating neuropathies: a reappraisal. Muscle & Nerve, (in press).

Maiese K, Lin S-H, Vincent A M Dual pathways of free radical injury in vascular endothelial cells:  Loss of nuclear DNA integrity and membrane asymmetry during enhanced cysteine protease activity.  Proceedings of the 6th Keio International Symposium for Life Sciences and Medicine (in press).

Maiese K, Vincent A M. Membrane asymmetry and DNA degradation: Functionally distinct determinants of neuronal programmed cell death. J Neurosci Res (Rapid Publication) (in press).

Maiese K, Vincent A M. Critical temporal modulation of neuronal programmed cell injury. Cell Mol Neurobiol (in press).

Muzik O, da Silva EA, Juhasz C, Chugani DC, Shah J, Nagy F, Stockhausen H, Herholz K, Canady A, Gates J, Frost M, Ritter F, Watson C, Chugani HT.  Intracranial electrophysiological significance of flumazenil and glucose PET abnormalities in children with extratemporal lobe epilepsy. Neurology, (in press).

Nagy F, Chugani DC, da Silva EA, Kupsky W, Canady A, Watson C, Juhasz C, Muzik O, Shah J, Chugani HT.  Comparison of in vivo and in vitro flumazenil binding in human neocortex. Epilepsia, (in press).

Nikhar N, Shah J, Tselis A, Lewis RA. Primary neurosarcoidosis: a diagnostic and therapeutic challenge. Neurologist, (in press).

Noseworthy JH, Wolinsky JS Lublin FD, Whitaker JN, Linde A, Gjorstrup P, Sullivan HC, and the North American Linomide Trialists (Lisak, RP ,PI for WSU Linomide Trialists). Linomide in relapsing and secondary progressive MS: I. Trial design and clinical results. Neurology, (in press).

Selcen D, Kupsky WJ, Benjamins D, Nigro MA. Myopathy with muscle spindle excess: A new congenital neuromuscular syndrome? Muscle & Nerve, (in press).

Selcen D, Nigro MA. High-dose intravenous immunoglobulin therapy in juvenile myasthenia gravis. Ped Neurol, (in press)

Selcen D, Seidman S, Nigro MA. Otocerebral anomalies associated with topical tretinoin use.  Brain & Development, (in press).

Shah AK, Tselis A, Mason B. Acute disseminated encephalomyelitis in a pregnant woman successfully treated with plasmapheresis. J Neurol Sci, (in press).

Sundkvist G, Dahlin L-B, Eriksson KF, Lindgärde F, RosŽn I, Lattimer SA, Sima AAF, Greene DA. Sorbitol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance.  Diabetes Medicine (in press)

Xu W, Manichella D, Jiang H, Vallat J-M, Lilien J, Kamholz J, Shy ME. P0 is involved in the regulation of myelin gene expression and myelin morphogenesis. J Neurosci Res, (in press).

Books, Chapters and Reviews

Aboussouan L, Lewis RA. Editorial: Sleep, Respiration and ALS.  J Neurol Sci, 164:1-2, 1999.

Barfield E, Kamath S, Chaturvedi S. High prevalence of dementia among African American patients in a stroke rehabilitation unit. In: Proceedings of the 1st International Conference on Vascular Dementia. Bologna: Monduzzi Editore, 77-80, 1999

Cendes F, Li LM, Andermann F, Watson C, Fish DR, Shorvon SD, Dubeau F, Arnold DL. Dual pathology and its clinical relevance.  In: Plasticity and Epilepsy: Dynamic aspects of brain function, (H Stefan, F Andermann, SD Shorvon, P Chauvel, eds.), Lippincott Williams and Wilkins Publishers, Philadelphia, PA, Chapter 17, 1999.

Charcot-Marie-Tooth disorders. Ann New York Acad Sci (ME Shy, J Kamholz, RE Lovelace, eds.), Volume 883, 1999.

Chaturvedi S, Hickenbottom S, Levine SR. Ischemic stroke prevention. Current Treatment Options in Neurology, 1:113-125, 1999.

Chaturvedi S. Current status of carotid stenting. Stroke Clinical Updates, 9:5, National Stroke Association, 1999.

Chaturvedi S. Is carotid endarterectomy appropriate for asymptomatic stenosis? No. Arch Neurol, 56:879-881, 1999.

Chaturvedi S. Public health impact of carotid endarterectomy. Neuroepidemiology, 18:15-21, 1999.

Chugani HT. Metabolic Imaging: A window on brain development and plasticity.  In: Neuroscientist (S Waxman, CM Becker, WE Bunney, TN Byrne, CG Gross, M Ito, E Nestler eds). 5:1-2, 1999.

Garbern J, Cambi F, Shy ME, Kamholz J. The molecular pathogenesis of Pelizaeus-Merzbacher disease. Arch Neurol, 56:1210-1214, 1999.

Gorman M. Migraine and cerebral blood flow. Sem Headache Manag, 4:6-10, 1999.

Gorman MJ, Levine SR. Stroke care early in the 21st century. J Stroke Cerebrovasc Dis #:1-4, 1999.

Gorman M. MollaretÕs meningitis. In: Neurobase, (S Gilman, GW Goldstein, SG Waxman, eds). Arbor Publishing Corp, San Diego, CA 1997. Updated in 1999.

Juhasz C, Chugani DC, Chugani HT. A PET a normalis agy fejlodesenek es gyermekkori neuropszichiatriai korkepeknek a vizsgalataban.  Rudolph C, (ed).  In:  Magyar Tudomany:  A Pozitron Emisszios Tomografia (PET) A Vilagban es Magyaroszagon.  Oktober/Kulonszam, 1999.

Kapen S. Sleep disorders associated with stroke. In Neurobase.  7th Edition (S Gilman, GW Goldstein, SG Waxman eds). La Jolla, CA, Arbor Publishing Corp., 1999. 

Khan OA. Pain related to multiple sclerosis. National Multiple Sclerosis Society. Key Note Issues. April 1999

Khan OA. Prognosis in Multiple Sclerosis. National Multiple Sclerosis Society. Key Note Issues. September 1999.

Levine SR, Gorman MJ. ÒTelestrokeÓ: The application of telemedicine for stroke. Stroke, 30:464-469, 1999.

Lewis RA, Sumner AJ. Electrophysiologic features of inherited demyelinating neuropathies: a reappraisal. Ann NY Acad Sci, 883:321-335, 1999.

Lisak, RP. Treatment of myasthenia gravis. In: Current Treatment Options in Neurology. 1:239-242, 1999

Maiese K. Brain herniation. In: Neurobase, 5th Ed. (S Gilman, GW Goldstein, SG Waxman, eds). La Jolla, CA: Arbor Publishing Corp., 1999.

Maiese K. Hypoxic-ischemic encephalopathy. In: Neurobase, 5th Ed. (S Gilman, GW Goldstein, SG Waxman, eds) La Jolla, CA: Arbor Publishing Corp., 1999.

Maiese K. Metabolic coma. In: Neurobase, 5th Ed. (S Gilman, GW Goldstein, SG Waxman eds).  La Jolla, CA: Arbor Publishing Corp., 1999.

Maiese K. Neurodegeneration: A view from within the neuron. In: Recent Research Developments in Neurochemistry, (S G Pandalai. ed).  Trivandrum, India:  Research Signpost, Recent Re. Devel. Neurochem., 2: 403-422, 1999.

Maiese K. Nitric Oxide: Cellular and molecular pathways of protection in stroke.  In: Stroke Therapy: Basic, Preclinical, and Clinical Directions, (L P Miller, ed). Wiley - Liss, Inc., 219-244, 1999.

Maiese K. Persistent vegetative state. In: Neurobase, 5th Ed. (S Gilman, GW Goldstein, SG Waxman, eds). La Jolla, CA: Arbor Publishing Corp., 1999.

Maiese K. Sequelae of cardiac arrest. In: Neurobase, 5th Ed. (S Gilman, GW Goldstein, SG Waxman, eds). La Jolla, CA: Arbor Publishing Corp., 1999.

Mayer SA, Coplin WM, Raps EC. Cerebral edema, intracranial pressuren and herniation syndromes. J. Stroke Cerbrovasc Dis, 8;183-191, 1999.

Nigro MA.  Periodic Paralyses. Chapter 15:  Muscles. Gellis & KaganÕs Current Pediatric Therapy, 16th Edition.  WB Saunders, 951-952, 1999.

Nigro MA. Chapter 175: The floppy Infant.  Ambulatory Pediatric Care, 3rd Edition. Lippincott-Raven, 758-764, 1999.

Nikhar N, Shah AK: POEMS syndrome. Neurobase (An electronic database). First 1999 edition, Arbor Publishing.

Schenk MJ, Chaturvedi S, Thompson D, Gorelick PB. Antiplatelet and anticoagulant therapy in stroke prevention in African-Americans. In: Stroke in Blacks: A Guide to Management and Prevention (RF Gillum, PB Gorelick, ES Cooper, eds). Basel: Karger,167-179, 1999.

Shafrir E, Sima AAF. Diabetic animals for research into the complications: a general overview, In: Frontiers in animal diabetes research: chronic complications, (Sima AAF, Shafrir, eds). Harwood Acad. Publ, Amsterdam 1999 pp 1-42.

Shy ME, Kamholz J, Lovelace RE. Introduction to the third international symposium on Charcot-Marie-Tooth disorders, Ann New York Acad Sci, 883:xv-1, 1999.

Sima A.A.F. Diabetic neuropathy Ð the present and the future. Adv in Clin Neurosci, (Sinha KK, Chandra P eds). Vol 8, pp 275-299, 1998.

Sima AAF (Editor-in-Chief). Book series:  Frontiers in Animal Diabetes Research (2 volumes per year), Harwood Academic Publishers, Amsterdam

Sima AAF. Diabetic Neuropathy Ð The Utility of Nerve Biopsy, In Clinical Neurophysiology: From Receptors to Perception, Comi G , Lücking CH, Kimura J, Rossini PM (ed) Elsevier Science, Amsterdam, Chapter 64, pp 525-533, 1999.

Sima AAF, Sugimoto K. Experimental diabetic neuropathy-an update. Diabetologia, 42:773-788, 1999.

Sripathi N, Gorman M, Ramadan NM. The patient with migraine and transient motor weakness. In: Advanced Therapy of Headache. (Rapoport AM, Sheftell FD, Purdy RA, eds). Hamilton, BC Decker Inc. 1999.

Tselis A. Book review of Said G, Saimot AG, Lacroix C and Tardieu M. Neurological Complications of HIV and AIDS. WB Saunders, Publisher. New York. 1997. Neurology, 52:1304, 1999.

Tselis A. Book review of Scientific American Molecular Neurology, (Martin JB, ed). Scientific American, Inc, Publisher, 1998. Chemistry and Industry, Number 14; 555, July 19, 1999.

Tselis, AC, Lisak, RP. Multiple sclerosis. Therapeutic update.  Arch Neurol, 56:277-280, 1999

Books, Chapters and Reviews In Press

Clinical Approach to Antiphospholipid Antibodies, (SR Levine, RL Brey, eds). Butterworth-Heinneman, Waltham, MA, (in press).

Garbern J. Pelizaeus-Merzbacher disease. Geneclinics:  HYPERLINK Òhttp://www.geneclinics.orgÓ #http://www.geneclinics.org  (in press).

Guyot, AM. Early Studies of Thrombolytic Therapy for Stroke. In: Thrombolytic Therapy, (PD Lyden, ed). (in press)

Guyot, AM. Pre-Clinical Testing of Thrombolytic Stroke. In: Thrombolytic Therapy, (PD Lyden, ed). (in press).

Lewis RA, Shy ME, Sumner AJ. Electrophysiologic features of inherited demyelinating neuropathies: a reappraisal in the era of molecular genetics. Muscle & Nerve, (in press). 

Lewis RA. Multifocal neuropathies. In: Intravenous immunoglobulin in the treatment of neurological disorders. (G Said, ed). Martin Dunitz, ltd. (in press).

Lisak, RP, Mendell, JR. Neuropathies in collagen vascular diseases, In: Handbook of Peripheral Neuropathies. (JR Mendell, JW Griffin, eds.), Marcel Dekker, New York, (in press).

Lisak, RP. Type I interferons and chronic inflammatory demyelinating polyneuropathy: Treatment or cause. Muscle & Nerve, (in press).

Maiese K, Caronna JJ. Evaluating the outcome of ischemic cerebral injury.  In:  Principles and Practice of Neurocritical Care, (DF Hanley ed). Baltimore: Williams and Wilkins, (in press).

Maiese K, Caronna JJ. Coma. In: The High Risk Patient: Management of the Critically Ill, eds. E.D. Sivak, T. Higgins and A. Seiver. Philadelphia: Lea and Febiger, (in press).

Maiese K. Dynamic Modulation of Molecular Neurodegeneration:  Transformation into Neuroprotection.  Histology and Histopathology (in press).

Maiese K. The Quarterly Review of Biology, SUNY. ÒCerebral Ischemia: Molecular and Cellular PathophysiologyÓ, ed. Wolfgang Walz (in press).

Maiese K. The Quarterly Review of Biology, SUNY. ÒNeuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy,Ó (F W Van Leeuwen, A Salehi, R J Giger, A J G D Holtmaat, J Verhaagen eds) (in press).

Moorjani BH. Neonatal injury in child abuse. In: Emedicine, (RO Rust ed). (in press)

Shah AK. Myasthenia Gravis. eMedicine Neurology Online Reference. Emedicine Inc, St. Pete Beach, (in press).

Shah AK. Preeclampsia and Eclampsia. eMedicine Neurology Online Reference. Emedicine Inc, St. Pete Beach, (in press).

Shah JR, Chugani DC, Chugani HT. Diagnostic positron emission tomography. In: Intractable focal epilepsy: medical and surgical treatment, (Oxbury, Polkey, Duchowny, eds.), W.B.Saunders, London, (in press).

Shy ME, Kamholz J. Hereditary Neuropathies. Neurobase, (in press).

Shy ME, Lewis RA. Inherited Neuropathies. In: Neuroscular Diseases, (R Pourmand, ed).Buttermworth-Heinemann, (in press).

Shy ME. Axonal loss in inherited demyelinating neuropathies; lessons from PMP-22 mutant mice. Neurology Network Commentary, (in press).

Sima AAF, Shafrir E. A primer to animal models of diabetes.  Harwood Academic Publishers, Amsterdam, (in press).

Sima AAF. Neuro-Pathology in Pearls of Wisdom, Boston Medical Publishing Inc., Lincoln, NE, (in press).

Abstracts Published

Acsadi G, Jani A, Anguelov R, Shy ME. Gene therapy for motor neuron diseases by adenoviral gene transfer.  J Hum Gen, 65(S):1728A, 1999.

Albers GW. The STARS Investigators (SR Levine, investigator): Prospective, monitored, multicenter, post-approval experience with intravenous t-PA for treatment of acute stroke: The Standard Treatment with Activase to Reverse Stroke (STARS) Study. Stroke, 30:244, 1999.

Anguelov R, Jani A, Garbern J, Kamholz J, Shy ME, Acsadi G. GDNF gene transfer into lower motor neurons in vivo: The potential of gene therapy for SMA and ALS. Soc Neurosci Abstr, 25:734.13, 1999.

Asano E, Chugani DC, Muzik O, Shen C, Juhaz C, Canady A, Shah JR, Shah AK, Watson C, Chakraborty PK, Mangner TJ, Chugani HT. Epileptogenic lesions in children with Tuberous Sclerosis complex studied with a-[11C] methyl-L-tryptophan and 2-deoxy-2[18F]fluoro-D-glucose positron emission tomography and magnetic resonance imaging. Epilepsia, 40(suppl 7):188, 1999.

Benjamins JA, Nedelkoska L, Studzinski DM, Callahan RE. Differential regulation of levels of myelin protein genes in mature oligodendrocytes: Mode of calcium entry matters. J Neurochem 72:(Suppl.) S13A, 1999.

Cambi F, Garbern J, Shy M, Kamholz J. X-linked spasticity syndromes caused by mutations in the PLP gene. J Neurochem, 72:S17, 1999.

Cendes F, Li LM, Watson C, Andermann F, Dubeau F, Arnold DL. Scalp EEG recordings in temporal lobe epilepsy: Relationship to hippocampal atrophy. Neurology, 52 (Suppl 2):A160, 1999.

Chaturvedi S, Aggarwal R, Murugappan A. Results of carotid endarterectomy with prospective neurologist follow-up. Ann Neurol, 46:506, 1999.

Chaturvedi S, Joshi N. Dangers of intraarterial thrombolysis in acute stroke with early CT change. J Neuroimaging; 9:52, 1999.

Chugani HT, Juhasz C, Behen ME.  Children with epilepsy and aggression:  a distinct pattern of positron emission tomography glucose metabolism.  Ann Neurol, 46:3, 1999.

Chugani HT.  Infantile spasms, dysphasia and autism:  relationship to bitemporal abnormalities.  J Child Neurology, 14:5, 1999.

Clark WM, Albers GW, for the ATLANTIS Stroke Study Investigators (SR Levine, investigator). The Atlantis rt-PA (Alteplase) Acute Stroke Trial: Final results. Stroke, 30:234, 1999.

Coplin WM, Policherla PN, Vinas FC, Wilsek JM, Johnson, II RR, King PK, Rengachary SS. Early decompressive craniectomy for severe traumatic brain injury: A preliminary feasibility study. American Association of Neurological Surgeons 67th Annual Meeting. Abstract #1404:231, 1999.

Coplin WM, Tipps LB, Basham MC, Murry KR, Michael DB, Rhoney DH. Relation of computed tomographic findings to seizure occurrence after aneurismal subarachnoid hemorrhage: Implcations for prophylactic anticonvulsant prescription. Neurology, 52(Suppl 2):A102-A103, 1999.

Cullen NK, Coplin WM, Policherla PN, Vinas FC, Zafonte RD, Millis SR, Rengachary SS. Functional outcome after early decompressive craniectomy: Preliminary results. Association of Academic Physiatrists, 1999.

D’Olhaberriague L, Joshi N, Mitsias P, Coplin W, Lewandowski C, Patel SC, Chaturvedi S, Levine SR: Tissue plasminogen activator in acute stroke patients with an unruptured brain aneurysm. Cerbrovasc Dis, 9(suppl 1):125, 1999.

D’Olhaberriague L, Welch KMA, Mitsias P, Patel SC, Nagesh V, Tanne D, Nelson J, Aggarwal R, Levine SR, Chopp M: DWI may facilitate stroke prognosis: A comparative study with CT and clinical and laboratory data. Neurology, 52(Suppl 2):A365, 1999.

da Silva EA, Muller R-A, Chugani DC, Shah J, Shah A, Watson C, Chugani HT. Brain activation during intermittent photic stimulation: A [15O]-water PET study on photosensitive epilepsy. Epilepsia, 40(suppl 4):17-22, 1999.

Demchuk AM, Tanne D, Kasner SE, Schultz L, Grond M, HansonS, Hamilton S, Buchan AM, Wang DZ, Wechsler LR, Zweifler R, Levine SR, and t-PA in Acute Stroke Collaborators. A multinational multicenter investigation to identify predictors of good outcome after open label t-PA treatment in acute ischemic stroke. Neurology, 52(Suppl 2):A537, 1999.

Dore-Duffy P, Balabanov R. Functional differentiation of CNS microvascular pericytes in response to T1 and T2 cytokines. Proceedings of Brain 99, J. Cerebral Blood Flow Metab, 19:741, 1999.

Dore-Duffy P, Balabanov R. HIV Tat protein activates CNS microvascular pericytes and induces differentiation to the migrating phenotype. Neurology, 52(Suppl 2):A189, 1999.

England G, Zamorano L, Gaspar L, Barger G, Levine K, Diaz F:  Use of the gamma knife for the treatment of grade IV recurrent astrocytoma (glioblastoma multiforme). The American Association of Neurological Surgeons 1999 Annual Meeting Poster Program, p.198, 1999.

Foster NL, Moura V, Gelb DJ, Sima AAF. Consensus clinical criteria have limited ability to distinguish dementia with Lewy Bodies and AlzheimerÕs Disease.  Neurology, 52(Suppl 2);A476, 1999.

Garbern JY, Heng HHQ, Wu R-P, Ye CJ, Awatraman R, Kamholz J. The human GTX gene maps to 10q26, a region often deleted in gliomas. American Society for Human Genetics, 65, Program Nr:1022, 1999.

Glauser TA, Nigro M, Sachdeo R, Bonet HB, Weinstein S, About-Khalil B, Frank M, Jacobs T, Mesenbrink P, DÕSouza J.  Safety and efficacy of Oxcarbazepine as adjunctive therapy in children with inadequately controlled partial seizures.  Neurology, 52 (suppl 2):A392, 1999.

Grotta J, Chiu D, Lu M, Patel S, Levine S, Tilley B, Brott T, Haley C, Lyden P, Kothari R, Frankel M, Lewandowski C, Libman R, Marler J, Kwiatkowski T, and the NINDS rt-PA Stroke Study Group: Agreement and variability interpreting early CT changes in stroke patients qualifying for intravenous rtPA therapy. Neurology, 52 (Suppl 2):A454, 1999.

Jacobs BS, Sacco RL, Liu RC, Boden-Albala B, Benson R, Pablos-Mendez. Higher dietary intake of vitamin B6 is associated with a lower risk of ischemic stroke. Cerebrovascular Diseases 9(suppl 1):63, 1999.

Jacobs BS, Sacco RL, Liu RC, Boden-Albala B, Benson R, Pablos-Mendez.  Low dietary intake of vitamin B6 is associated with an increased risk of ischemic stroke. Stroke 30(1):252, 1999.

Jacobs, LR and the CHAMPS Study Group (Lisak, RP and Tselis, AC member). A profile of patients at high risk of developing clinically definite multiple sclerosis (CDMS). The first report of the CHAMPS Study. Neurology, 52(Suppl 2):A495, 1999.

Joshi N, Zvartau-Hind M, Wilseck J, Chaturvedi S. Moyamoya-like vasculopathy in association with anticardiolipin antibodies and hyperthyroidism. J Neuroimaging, 9:60, 1999.

Juhasz C, da Silva EA, Watson CE, Muzik O, Shah J, Chugani DC, von Stockhausen H-M, Chugani HT.  Comparison of [11C] Flumazenil and glucose PET abnormalities in patients with epilepsy and brain lesions.  Neurology, 52(Suppl 2):A58, 1999.

Juhasz C, Muzik O, Chugani DC, Shah J, Canady A, Shah A, Watson C, Gates J, Frost M, Ritter F, Chugani HT. Non-resected [11C]flumazenil PET abnormalities predict poor outcome in extratemporal lobe epilepsy surgery. Epilepsia, 40(suppl 7):216, 1999.

Kaddurah AK, Juhasz C, Chugani HT. Predilection of frontotemporal cortex involvement in early rasmussenÕs syndrome:  a positron emission tomographic study. Ann Neurol, 46:3, 1999.

Kapen S, Khurshid M.  REM latencies in stroke patients.  Neurology, 52(Suppl 2):A79, 1999.

Khan OA, Tselis AC, Garbern J, Kamholz J, Lisak RP. Clinical profile of relapsing multiple sclerosis in African-Americans: Impact of immunomodulating therapy on disease course. Ann Neurol, 46:471, 1999.

Khan OA, Tselis AC, Kamholz J, Garbern J, Lewis RA, Lisak RP. Works in progress. A prospective, controlled, open-label trial comparing the effect of Avonex, Betaseron, Copaxone on the relapse rate in patients with multiple sclerosis. Ann Neurol, 46:938, 1999.

Koo B, Canady A, Rothermel R.  Transcranial cortical magnetic stimulation in children:  a non-invasive method for localization of functional cortical motor cortex in epilepsy surgery candidates.  Ann Neurol, 46:3;523, 1999.

Krajewski K, Shein N, Watson C, Fuerst D, Kamholz J, Garbern J, Shah J, Shah A, Chugani HT. The genetics of hippocampal sclerosis. Epilepsia, 40(suppl.7):234, 1999.

Leurgans SE, Chaturvedi S, Raman R, Gorelick PB. Cardiac disease and stroke subtype in African American patients. Neurology, 52(Suppl 2):A506, 1999.

Levine SR, Brey RL, Tilley BC, Thompson JLP, Sacco RL, Triplett DA, Costigan T, Mohr JP, and the WARSS-APASS Collaborative Study Investigators (Chaturvedi, S, investigator). The WARSS-APASS Collaborative Study: A prospective, multicenter study of the significance of antiphospholipid antibodies in a large, ischemic stroke cohort. J Autoimmunity, Supplement:38, 1999.

Lewis R, Shy ME. Electrodiagnostic findings in CMTX: a disorder of the Schwann cell and peripheral nerve myelin. Neurology, 52(suppl 2):A74, 1999.

Lin S-H, Vincent A, Shaw T, Wright J, Maiese K. Group I metabotropic receptors selectively down-regulate nitric oxide induced CPP32 activity. Soc. Neurosci. Abstr., 25 (Part 1):1060, 1999.

Lisak RP, Bealmear B, Skoff AM, Benjamins JA. Identification of cytokines that inhibit galactolipid expression by Schwann cells (SC). Neurology, 52 (Suppl 2):A338, 1999.

Lisak, RP, Bealmear, B, Benjamin, JA, Skoff, A. Tumor necrosis factor-a((TNF-a) upregulation of intracellular adhesion molecule-1 by Schwann cells is predominately mediated by TNF receptor type 1. Soc Neurosci Abstr, 25:294, 1999

Lisak, RP. Chronic inflammatory demyelinating polyneuropathy. J Autoimmunity, (Suppl) 17, 1999.

Lublin FD and The Hu23F2G Group (Khan O, member). A phase II Trial of Anti-CD 11/CD18 Monoclonal Antibody in acute exacerbations of multiple sclerosis. Neurology, 52(suppl 2):A290-A291, 1999.

Maniar SV, Nikhar NK, Lewis RA. Miller Fisher syndrome and polyneuritis cranialis are to be part of a larger spectrum of cranial neuropathies in acute inflammatory polyradiculoneuropathy. Neurology, 52(suppl 2):A84-85, 1999.

Marler JR, Tilley BC, Lu M, Brott T, Lyden P, Broderick JP, Grotta J, Levine SR, Frankel M, Horowitz S, Kwiatkowski T, the NINDS rt-PA Stroke Study Group: Earlier treatment associated with better outcome in the NINDS TPA Stroke Study. Stroke, 30:244, 1999.

Mohamed IS, Asano E, Chugani DC, Muzik O, Chugani HT. Cerebral glucose metabolism in patients with angelmanÕs syndrome. Ann Neurol, 46:3, 1999.

Moore GJ, da Silva EA, Watson C. Normalization of neurochemical abnormalities in the unoperated temporal lobe following neurosurgery for unilateral temporal lobe epilepsy. Proceedings ISMRM, 7:1178, 1999.

Nedelkoska L, Benjamins JA, Elferink L. Proteolipid protein co-localizes with sites of WGA-binding and endocytosis on membrane sheets of mature oligodendrocytes. J Neurochem, 72(Suppl):S16A, 1999.

Parchi P, Capellari S, Brown P, Sima AAF, Mikol J, Gray F, Frosch MP, Trojanowski JQ, Vital C, Ghetti B, Giese A, Kretzschmar HA, Gambetti P.  Molecular and clinico-pathologic phenotypic variability in genetic Creutzfeldt-Jakob Disease.  Neurology, 52(Suppl 2):A323, 1999.

Ragheb, S, Abramczk, S, Lisak, RP. Effect of treatment of patients with glatiramer acetate (Copolymer-1`; Cop-1) on the proliferative response of peripheral blood mononuclear cells (PBMC) to glatiramer acetate in vitro. Ann Neurol, 46:457, 1999.

Rhoney DH, Tran A, Murry KR, Coplin WM. Effect of nimodipine dosage adjustments for patients experiencing hypotension after aneurysmal subarachnoid hemorrhage. Neurology, 52(Suppl 2):A60-A61, 1999.

Rogers LR, Cassells LJ, Klein J, Lewis R, Dansey R. Severe lumbosacral polyradiculoneuropathy after high dose chemotherapy and stem cell transplant for breast cancer. Neurology, 52(suppl 2):A199, 1999.

Selcen D, McCormick E, Michon AM, Nigro MA. N-Acetylcystine in FredreichÕs Ataxia. Ann Neurol, 46:536, 1999.

Shah AK, Whitty J. Characteristics of headache in women with eclampsia. Neurology, 52(suppl 2):A285-86, 1999.

Shaw T, Moon B-K, Wright J, Maiese K. The transcription factor E2F directs attempted cell cycle induction during neuronal programmed cell death. Soc. Neurosci. Abstr., 25(Part 1):793, 1999.

Shy ME, Jiang H, Xu G, Sima AAF.  Delayed initiation of regeneration in diabetic nerve is preceded by attenuation of immediate early gene responses.  JPNS, 4:200, 1999.

Shy ME, Krajewski K, Turansky C, Garbern J, Kamholz JA, Lewis R. CMT1A phenotype correlates with secondary axonal degeneration but not demyelination. Neurology, 52(suppl 2):A217, 1999.

Sima AAF, Jiang H, Xu G, Shy ME. Immediate early gene responses are attenuated in diabetic nerve following crush injury.  Diabetes, 48(Suppl 1):A152, 1999.

Sima AAF, Xu G, Jiang HY, Shy ME. Automated immediate early gene responses in the diabetic BB/W-rat precede impaired nerve regeneration. Diabetologia, 42(Suppl 1):A291, 1999.

Sima AAF, Zhang W, Xu G, Wahren J, Sugimoto K.  C-peptide treatment has a long-term ameliorating effect on type-1 diabetic neuropathy. JPNS, 4:200, 1999.

Sima AAF, Zhang W, Xu G, Wahren J, Sugimoto K.  Long-term effect of C-peptide treatment on type-1 diabetic neuropathy. Diabetes, 48(Suppl 1):A149, 1999.

Sima AAF. C-peptide protects against hippocampal apoptosis in type 1 diabetes.  Karolinska-Wayne-Mayo Symp. Stockholm, 1999.

Sima AAF. The long term effect of C-peptide on diabetic neuropathy in the BB/W-rat.  Karolinska ÐWayne-Mayo Symp. Stockholm, 1999.

Sima AAF: In Memoriam Julio H. Garcia 1933-1998: J. Neurol Sci., 1999

Skundric DS, Lisak RP, Rouhi M, Hartung H-P. Schwann cell specific mechanisms of IL-1 autoregulation in vivo. J Neurochem, 73(Suppl):S76C, 1999.

Somerville AL, Murry KR, Coplin WM, Rhoney DH. Evaluation of prescribing variability for status epilepticus. Crit Care Med, 27:A74, 1999.

Srinivas PR, Cintron V, Sima AAF, Grunberger G. Primary cultures of vascular smooth muscle cells from the BB/W type 1 diabetic rat retain their hyperglycemic memory.  Diabetes, 48(Suppl 1):A132, 1999.

States J C, Vincent A, Wright J, Shaw T. Maiese K. Rapid neuronal intracellular acidification triggers nitirc oxide induced programmed cell death. Soc Neurosci Abstr, 25:792, 1999.

Sugimoto K, Zhang W, Xu G, Sima AAF.  Localization of insulin receptor isoforms in rat peripheral nerve.  JPNS, 4:200, 1999.

Sugimoto K, Zhang W-X, Xu G, Wahren J, Sima AAF:  Expression of insulin and IGF-1 receptors mRNA in peripheral nerve of type 1 diabetic BB/W-rat: effects of C-peptide.  Diabetologia, 42(Suppl, 1):A291, 1999.

Sundkvist G, Dahlin L-B, Nilsson H, Eriksson K-F, Lindgärde F, RosŽn I, Lattimer SA, Sima AAF, Sullivan K, Greene DA.  Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired and normal glucose tolerance.  JPNS, 4:195, 1999.

Sundquist G, Dahlin L-B, Eriksson K-F, RosŽn I, Lattimer SA, Sima AAF, Sullivan K, Greene DA.  Polyol levels and morphology of sural nerve in relation to nerve functional and neuropathy.  Diabetologia, 42(Suppl 1):A43, 1999.

Tanne D, Demchuk A, Kasner S, Grond M, Hanson S, Hamilton S, Buchan AM, Wang DZ, Wechsler LR, Zweifler R, Levine SR, and the t-PA in Acute Stroke Collaborators. A large multinational investigation to predict t-PA related symptomatic ICH in patients with acute ischemic stroke. Stroke, 30:248, 1999.

Tanne D, Gorman M, Bates VE, Verro P, Kasner SE, Book D, Dayno JM, Scott P, Schultz LR, Levine SR.. Intravenous t-PA for acute ischemic stroke in patients age 80 or over. Stroke, 30:242, 1999.

Vincent A, Maiese K. Membrane stabilization during neuronal programmed cell death by metabotropic glutamate receptor activation. Soc Neurosci Abstr, 25:792, 1999.

Vincent A., TenBroeke M, Maiese K. Rapid reversal of neuronal programmed cell death during metabotropic glutamate receptor activation. Stroke, 30:247, 1999.

Watson C, Chen W, Kupsky W, Shah J, Fuerst D, Shah A, Chugani HT. The characteristics of microscopic dual pathology: A volumetric MRI and histopathologic study. Epilepsia, 40(suppl 7):200, 1999.

Whitaker, JN, McIntyr, BM, Bartolucci, AA, Wolinsky, JS, Goodwin, KJ and the North American Linomide Trialists (Lisak, RP, Tselis AC, Garbern J, Kamholz J, Lewis R, members of trialist group). Correlation of black hole volume on cranial MRI and urinary myelin basic protein-like material in advanced multiple sclerosis patients. Neurology, 52 (Suppl 2): A380, 1999.

Woo D, Broderick J, Kothari R, Lu M, Brott T, Lyden P, Marler J, Grotta J, and the NINDS t-PA Stroke Study Investigators: Does the National Institutes of Health Stroke Scale favor left hemisphere strokes? Ann Neurol, 46:450, 1999.

Wrensch M., Davis R, Barger G, Miike R. Diagnostic discrepancies in a neuropathology review of 492 population based cases, San Francisco Bay area adult glioma study. Neuro Oncology, 1:S64, 1999.

Wright J, Shaw T, Maiese K. Peptide growth factors actively prevent induction of the cell cycle during programmed cell death.  Soc Neurosci Abstr, 25:299, 1999.

Zakarian VL, Loeb JA. Regulation of neuregulin expression in embryonic motor neurons by target interactions.  Soc Neurosci Abs, 25:770, 1999.

Abstracts In Press

Brey RL, Levine SR, Thompson JLT, Sacco RL, Tilley BC, Costigan TM, Rhine CB, Zidel A, Ruzicka J, Xu D, Mohr JP, APASS/WARSS Collaborative Study Investigators. Baseline frequencies, isotypes, and titers of antiphospholipid antibodies in the Warfarin Aspirin Recurrent Stroke Study/Antiphospholipid Antibody in Stroke Study (WARSS/APASS) Collaboration; Preliminary results. Stroke, (in press).

Chabut J, Hurst R, Brey P, Jacobs BS, Oshi K, Hickenbottom S, Lewis G, Hogan J, Daley S, Crafton M, Shearer C, Levine SR, and the Michigan Stroke Initiative Members. A model for a state-based multidisciplinary approach to improve stroke awareness and care: The Michigan Stroke Initiative (MSI). Stroke, (in press).

Chaturvedi S, Joshi N, Murugappan A. Homocysteine levels and carotid stenosis in Indian males. Thromb Haemost, (in press).

Chaturvedi S, Joshi N, Coplin WM. Poor prognosis of acute stroke patients denied thrombolysis due to early CT changes. J Neuroimaging, (in press).

Chaturvedi S, Kulkarni V, Shah AK. Interspecialty measurement of carotid stenosis: Are we speaking the same language? Stroke, (in press).

Chaturvedi S, Lavine S. Utility of venous ultrasound in patients with patent foramen ovale and cryptogenic stroke. J Neuroimaging, (in press).

Frankel MR, Morgenstern LB, Kwiatkowski T, Lu M, Tilley BC, Broderick JP, Libman R, Levine SR, Brott T and the NINDS rt-PA Stroke Trial Investigators. Predicting poor prognosis after acute ischemic stroke: An analysis of the placebo group from the NINDS rt-PA Stroke Trial. Neurology, (in press).

Grunberger G, Qiang X, Mathews ST, Li Z-G, Sima AAF, Sbrissa D, Shisheva A. C-peptide stimulates glycogen synthesis via a Wortmannin-sensitive and Akt-independent pathway.  Amer Diab Assoc (in press).

Jacobs BS, Ottney-Schweiss C, Choate LM, Hall LH, Hubbert K, Jones K, Parliament C, Pfalzgraf B, Schuster A, Lewandowski CA, Levine SR, and members of the Detroit ÒOperation Stroke ÒTask Force. Operation Stroke: A tri-county surveillance of pre-hospital and hospital stroke treatment capabilities. Stroke, (in press).

Kapen S, Anderson SLP, Mozahem K. Sleep onset REM periods in obstructive sleep apnea patients: results of treatment.  Neurology, (in press).

Li Z-G, Zhang W-X, Grunberger G, Sima AAF. C-peptide corrects IFGÕs and prevents apoptosis in type 1 BB/-rat hippocampus.  Amer Diab Assoc, (in press).

Li Z-G, Zhang W-X, Sima AAF. Hippocampal apoptosis in type 1 diabetes is prevented by C-peptide.  Amer Assoc NeuroPath, (in press).

Lin S-H, Vincent A, Shaw T, Wright J, Maiese K. Group I metabotropic glutamate receptors selectively and specifically inhibit cysteine protease activity during ischemic nitric oxide exposure. Stroke, (in press).

Lisak, RP, Bealmear, B, Benjamins, JA, Skoff, AM. IFN-g, TNF-a and TGF-b inhibition of cyclic AMP (cAMP) induction of Schwann cell (SC) differentiation in vitro. J Neurochem, (in press).

Lyden P, Lu M, Jackson C, Marler J, Kothari R, Brott T, Zivin J, and the NINDS rt-PA Stroke Trial Investigators (Levine SR, investigator). Underlying structure of the NIH Stroke Scale: Results of a factor analysis. Stroke, (in press).

Murugappan A, McAllen KJ, Coplin WM, King JJ, Redman ME, Schwamm LH, Wechsler L, Saver JL, Broderick JP, Smoot K, Rordorf G, Starkman S, Duckwiler G, Tietjen GE, Levine SR: Thrombolytic therapy for acute ischemic stroke during pregnancy. Neurology, (in press).

Parker R, Kyshtoobayeva A, Mehta R, Brem H, Brem S, Vanier V, Barger J, Fruehauf JP.  In vitro drug response (IVDR) and prognostic marker (M) profiles in primary brain tumors (BT). American Association of Cancer Research Annual Meeting (in press).

Pratt CA, Tilley B, Levine S, Chopp M, Chase G: Stroke knowledge, prevention practices, and preferred approaches to stroke education: Towards developing a new ethnically specific, culturally sensitive survey tool. Stroke, (in press).

Qiang X, Srinivas PR, Mathews ST, Riedel H, Sima AAF, Grunberger G. C-peptide stimulates glycogen synthesis in L6 myoblasts.  J Diab Comp, (in press).

Shaw T, Vincent A, Lin S-H, Maiese K. The transcription factor E2F represents a novel molecular checkpoint in post-mitotic neurons against ischemic cell cycle induction and neuronal programmed cell death. Stroke, (in press).

Sima AAF. C-peptide deficiency plays a prominent pathogenetic role in type 1 diabetic neuropathy.  Leipzig 2000, International Symp., Leipzig, Germany, (in press).

Sima AAF, Sugimoto K, Zhang W-X, Pierson C, Murakawa Y. C-peptide prevents nodal and paranodal structural and molecular changes in type 1 diabetic neuropathy. Amer Diab Assoc, (in press).

Sima AAF. The pathogenetic role of C-peptide deficiency in type 1 diabetic neuropathy. JNeurochem., (in press).

Skundric, DS, Rouhi, M, Madala, SR, Lisak, RP.  Regulation of IL-1 and IL-1RA expression  by Schwann cells (SC) during their differentiation in vivo. J Neurochem, (in press).

Sloan AE, Kabrossi B, Barger G, Zamorano L, Diaz F, Baynes R, Wood G. Vaccination of patients with recurrent malignant astrocytoma with autologous tumor and granulocyte macrophage colony stimulating factor (GM-CSF). 2000 AANS/CNS Section on Tumors: Fourth Biennial Brain Tumor Satellite Symposium (in press).

Sugimoto K, Zhang W-X, Xu G, Sima AAF. Localization of insulin receptor isoforms in rat peripheral nerve.  J Diab Comp, (in press).

Vincent A, Wright J, Lin S-H, Maiese K. Free radical induction of acidic endonuclease activity is a potential regulatory therapeutic target against neuronal apoptosis. Stroke, (in press).

Wright J, Shaw T, Vincent A, Maiese K  Trophic factor protection against ischemic neurodegeneration is mediated by the regulation of genomic DNA transcription. Stroke, (in press).

Xu G, Jiang HY, Shy ME, Sima AAF. Delayed initiation of regeneration in diabetic nerve is preceded by attenuation of immediate early gene responses. J Diab Comp, (in press).

Zhang W-X, Sima AAF. The effect of C-peptide on cell growth in human neuroblastoma cells with and without insulin and IGF-1.  J Diab Comp, (in press).

Zvartau-Hind M, DÕOlhaberriague L, Chaturvedi S. Mechanisms of ischemic stroke in young African American and Caucasian patients. Stroke, (in press).

Patents and Intellectual Property

HYPERLINK Òhttp://www.telestroke.net/Ó http://www.telestroke.net (website under construction), Levine SR.

HYPERLINK Òhttp://www.telestroke.com/Ó http://www.telestroke.com (website under construction), Levine SR.

Kenneth Maiese and Andrea Vincent.  Assessment of the induction and course of cellular programmed cell death over time.  (U.S. Serial Number 09/144,045, February 15, 1999).

Kenneth Maiese and Andrea Vincent.  Temporal assessment of the progression of programmed cell death in tissue and in vivo preparations.  (Patent Pending).

Letters to the Editor

Chaturvedi S. National Stroke Association guidelines to prevent stroke. JAMA, 282: 1999-2000, 1999.

Coplin WM, Rhoney DH, Lyons EA, Murry KR. Incidence and clinical consequences of the purple glove syndrome in patients receiving intravenous phenytoin. [letter] Neurology, 53:1611-1612, 1999.

Gorman MJ, Levine SR, Dafer R. Ataxic hemiparesis: An old debate for lacune aficionados (invited reply to a letter to the editor). Stroke, 30:1492-1493, 1999.

Tietjen GE, Schultz LR, Levine SR: Role of anticardiolipin antibodies in young persons with migraine and transient focal neurologic events. (invited reply to a letter to the editor). Neurology, 52:1107, 1999.

Letters to the Editor In Press

Levine SR. Presence or absence of aPL antibodies may predict Sneddon Syndrome features. Journal Watch Neurology (in press).

Lewis RA. Multifocal motor neuroapthy and Lewis Sumner Syndrome. Muscle & Nerve, in press.

Lewis RA. The challenge of CMTX and connexin32 mutations. Muscle & Nerve, in press

Shah AK, Freij W. Response to a letter to the editor regarding Dramatic headache relief after sumatriptan in a patient with pituitary macroadenoma. Headache, (in press).