Department of Anatomy and Cell Biology

Chair: Linda Hazlett, PhD
8374 Scott Hall
(313) 577-1061

Articles Published

Angeles R, Devine J, Barrett R, Goebel D, Blachly-Dyson E, Forte M and McCauley R.  Mutations in the voltage dependent anion channel of the mitochondrial outer membrane causes a dominant nonlethal growth impairment. J Bioenergetics and Biomembranes, 31:143-121, 1999.

Azzi G, Canady A, Ham S and Mitchell J.  Kaolin induced hydrocephalus in the hamster temporal sequence of changes intracranial pressure, ventriculomegaly and whole brain specific gravity. Acta Neuropathologica, 98:245-250, 1999.

Bagchi M, Ansari S, Lindemuth DM, VanWijnen A, Lian J, Stein J, and Stein G.  Nuclear matrix associated dna binding proteins of ocular lens epithelial cells.  Mol Bio Reports, 25:13-19, 1999.

Basura GJ and Walker PD.  Suppression of serotonin hyperinnervation does not alter the dysregulatory influences of dopamine depletion on striatal neuropeptide gene expression in rodent neonates.  Neurosci Let, 274:9-12, 1999.

Basura GJ and Walker PD.  Striatal serotonin 2a receptor mrna levels in the neonatal dopamine depleted rat remain upregulated following suppression of serotonin hyperinnervation. Dev Brain Res, 116:111-117, 1999.

Basura GJ and Walker PD.  Differential sensitivity of tachykinin vs enkephalin gene expression in the posterior striatum in response to acute p-chloroamphetamine treatment during postnatal development.  Dev Brain Res, 112:155-157, 1999.

Berkowitz BA, Kowluru RA, Frank RN, Kern TS, Hohman TC, and Prakash M.  Subnormal retinal oxygenation response precedes diabetic like retinopathy.  Invest Ophthalmol Vis Sci, 40:2100-5, 1999.

Bessert D and Skoff RP.  High resolution in situ hybridization and tunel staining with free floating brain sections.  J Histochem Cytochem, 47:693-701, 1999.

Cai W, Pourcho RG.  Localization of metabotropic glutamate receptor mglur1 and mglur2/3 in the cat retina.  J Comp Neurol 407:427-437, 1999.

Chaves R, Sampaio I, Schneider MP, Schneider H, Page SL, and Goodman M.  The place of callimico goeldii in the callitrichine phylogenetic tree evidence from von willebrand factor gene (vwf) intron II sequences.  Mol Phylogenet and Evol, 13:392-404, 1999.

Chiu CH, Gregoire L, Gumucio DL, Muniz JA, Lancaster WD, and Goodman M.  A model for the fetal recruitment of simian gamma globin genes based on findings from two new world monkeys cebus apella and callithrix jacchus (platyrrhini, primates).  J Exp Zool (Mol Dev Evol) 285:27-40, 1999.

Corriveau RA, Shatz CJ and Nedivi E.  Dynamic regulation of cpg15 during activity dependent synaptic development in the mammalian visual system.  Journal of Neuroscience, 19(18):7999-8008, 1999.

Dutcher SA, Underwood BD, Walker PD, Diaz FG, and Michael DB.  Patterns of immediate early gene expression following human traumatic brain injury.  Neurol Res, 21:234242, 1999.

Fusco F, Chen Q, Lamoreaux W, Figueredo Cardenas G, Jiao Y, Coffman J, Surmeier D, Honig M, Carlock L, and Reiner A.  Cellular localization of huntington in striatal and cortical neurons in rats lack of correlation with neuronal vulnerability in huntingtonÕs disease.  J Neurosci, 19:1189-1202, 1999.

Goebel DJ and Poosch MS.  NMDA receptor subunit gene expression in select regions of the rat brain: a quantitative analysis of endogenous mrna levels of nr1com, nr2a, nr2b, nr2c, nr2d and nr3a.  Mol Brain Res, 69:164-170, 1999.

Goldstein EN, Owen CR, White BC and Rafols JA.  Ultrastructural localization of phosphorylated eif2±# (eif2±#p) during brain reperfusion.  Acata Neuropathol, 98:493-505, 1999.

Goodman M.  The genomic record of humankindÕs evolutionary roots.  Am J Hum Genetics 64:31-39, 1999.

Goshgarian HG, Nacimiento W and Noth J.  International symposium on spinal cord injury: neurobiology and new therapeutic approaches.  J Spinal Cord Med, 22(Suppl.):2-3, 1999.

Gould DJ and Goshgarian H.G.  The effects of mitotic inhibition on the spinal cord response to the superimposed injuries of spinal cord hemisection and peripheral axotomy.  Exp Neurol, 158(2):394-402, 1999.

Gresch PJ and Walker PD.  Serotonin2 receptor stimulation normalizes striatal preprotachykinin mrna in an animal model of parkinsonÕs disease.  Neurosci, 93:831841, 1999.

Gresch PJ and Walker PD.   Synergistic interaction between serotonin2 receptor and dopamine d1 receptor stimulation on striatal preprotachykinin mrna expression in the 6hydroxydopamine lesioned rat.  Mol Brain Res, 70:125134, 1999.

Gresch PJ and Walker PD.  Acute pchloroamphetamine increases striatal preprotachykinin mrna: role of the serotonin 2a/c receptor and dependence on dopamine.  Mol Brain Res, 67: 190193, 1999.

Hadley SD, Walker PD, and Goshgarian HG.   Effects of serotonin inhibition on neuronal and astrocyte plasticity in the phrenic nucleus four hours following c2 spinal cord hemisection.  Exp Neurol, 160:433445, 1999 .

Hadley SD, Walker PD and Goshgarian HG.  Effects of the serotonin synthesis inhibitor p-cpa on the expression of the crossed phrenic phenomenon four hours following c2 spinal cord hemisection.  Exp Neurol, 160:479-488, 1999.

Hazlett LD, Masinick-McClellan SA, and Barrett RP.  Complement defects in aged mice compromise phagocytosis of pseudomonas aeruginosa.  Curr Eye Res, 19:26-32, 1999.

Hazlett LD, McClellan SM, Dajc JJ, Hume EBH, OÕCallagan RJ, and Willcox MDP.  Extended wear contact lens usage induces langerhans cell migration into cornea.  Exp Eye Res, 69:575-577, 1999.

Hobden JA, Masinick SA, Barrett RP, Bark KS, and Hazlett LD.  Pseudomonas aeruginosa keratitis in knockout mice deficient in intercellular adhesion molecule-1 (icam-1).  Infect Immun, 67:972-975, 1999.

Hogan BM and Lande MA.  D periodic collagen fibrils diversity in interstitial collagens: II.  Cartilage.  Eur J Molec Str, 4:16-21, 1999.

Johnson MJ, Ayzman I, Wood AS, Tkach JA, Klauschie J, Skarupa DJ, McAllister JPII, Luciano MG.  Development and characterization of an adult model of obstructive hydrocephalus.  Journal of Neuroscience Methods, 91:55-65, 1999.

Kernacki KA, Barrett P and Hazlett LD.  Evidence for timp-1 protection against p aeruginosa-induced corneal ulceration and perforation.  Invest Ophthalmol Vis Sci, 40:3168-3176, 1999.

Kiner DW, Mrock LK and Ireland ME.  Kinetics of cyclic amp-dependent accumulation of novel intermediate filament proteins in cultured chick lens cells.  Curr Eye Res, 18:214-223, 1999.

Knapp P, Bartlett W, Williams L, Yamada M, Ikenaka K, and Skoff R.  Programmed cell death in the jimpy mouse can occur without dna fragmentation: survival is enhanced by cell lines transfected with proteolipid protein cdnas.  Cell Death and Differentiation, 6:136-145, 1999.

Kurpakus MA, Daneshvar C, Davenport J, Kim A. Human corneal epithelial cell adhesion to laminins. Curr Eye Res, 19:106-116, 1999.

Kurpakus MA and Lin L. The lack of extracellular laminin b2 chain deposition correlates to the loss of conjunctival epithelial keratin k4 localization in culture. Curr Eye Res, 18:28-38, 1999.

Kurpakus-Wheater M, Kernacki KA, Hazlett LD.  Corneal cell proteins and ocular surface pathology: a review.  Biotech & Histochem, 74:146-159, 1999.

Lasker GW.  The hierarchial structure of an urban town, kidlington, oxfordshire, examined by the coefficient of relationship by isonymy.  Journal of Biosocial Science, 31:279-284, 1999.

Lin L, Kurpakus-Wheater M. Differential rapid adhesion of bovine ocular surface epithelial cells to laminin isoforms.  Curr Eye Res, 19:293-299, 1999.

Maiese K and Vincent AM.  Group I metabotropic receptors down-regulate nitric oxide induced caspase-3 activity in rat hippocampal neurons.  Neurosci Lett, 264(1-3):17-20, 1999.

Maiese K, Ahmad I, TenBroeke M, and Gallant J.  Metabotropic glutamate receptors independently modulate neuronal intracellular calcium.  J Neurosci Res, 55:472-485, 1999.

McAllister JPII, Wood AS, Johnson MJ, Connelly RW, Skarupa DJ, Secic M, Luciano MG, Harris NG, Jones HC.  Neuronal activation during the progression of experimental neonatal hydrocephalus.  Neurosurgical Focus 7:online, 1999.

McKeown TR, Goldstein EN, Sullivan JM, Rafols JA, White BC, and Krause GS.  Nuclear localization and dna binding properties of phosphorylated eif2±#(p) in vulnerable hippocampal neurons during reperfusion.  J Cereb Blood Flow Metab, 19(Suppl 1):S510, 1999.

Meireles CM, Czelusniak J, Ferrari SF, Schneider MP, and Goodman, M.  Phylogenetic relationships among brazilian howler monkeys, genus alouatta (platyrrhini, atelinae) based on gamma1 globin pseudogene sequences.  Genet & Mol Biol, 22:337-344, 1999.

Meireles CM, Czelusniak J, Schneider MP, Muniz JA, Brigido MC, Ferreira HS, and Goodman M.  Molecular phylogeny of ateline new world monkeys (platyrrhini, atelinae) based on gamma-globin gene sequences: evidence that brachyteles is the sister group of lagothrix.  Mol Phylogenet & Evol, 12:10-30, 1999.

Meireles C.M, Czelusniak J, and Goodman M.  The tarsius gamma-globin gene: pseudogene or active gene?  Mol Phylogenet & Evol, 13:434-439, 1999. 

Newland TJ, McDermott ML, Hazlett LD, Apple DJ, Lambert RJ.  Experimental neodymium: yag laser damage to acrylic, pmma and silicone intraocular lens materials.  J Cataract and Refractive Surgery, 25:72-76, 1999.

ONeil BJ, McKeown TR, DeGracia DJ, Alousi SS, Rafols JA, and White BC. Cell death, calcium mobilization and immunostaining for phosphorylated eukaryotic initiation factor 2±# in neuronally-differentiated nb-104 cells: arachidonate and radical-mediated injury mechanisms.  Resuscitation, 41:71-83, 1999.

Owczarzak MT, and Pourcho RG.  Transmitterspecific input to offalpha ganglion cells in the cat retina.  Anat Record, 255:363373, 1999.

Page SL, Chiu C-H, and Goodman M.  Molecular phylogeny of old world monkeys (cercopithecidae) as inferred from gamma-globin dna sequences.  Mol Phylogenet & Evol  13:348-359, 1999.

Paoli G, Franceschi AG, and Lasker GW.  Changes over 100 years in degree of isolation of 21 parishes of lima valley, italy, as assessed by surname isonymy.  Human Biology, 71:123-133, 1999.

Porter CA, Czelusniak J, Schneider H, Schneider MP, Sampaio I, and Goodman M.  Sequences from the 5Õ flanking region of the epsilon-globin gene support the relationship of callicebus with the pitheciins.  Am J Primatology,  48:669-75, 1999.

Qin P and Pourcho RG.  AMPAselective glutamate receptor subunits glur2 and glur4 in the cat retina: an immunocytochemical study.  Visual Neurosci, 16:11051114, 1999.

Qin P and Pourcho RG.  Localization of AMPAselective glutamate receptor subunits in the cat retina: a light and electron microscopic study.  Visual Neurosci, 16:169177, 1999.

Rafols JA, Alousi SS, Owen CR, White BC and Sullivan JM.  High doses of insulin do not prevent dephosphorylation of eif2±#(p), recovery of protein synthesis, and atrophy of hippocampal ca3 neurons during reperfusion.  J Cereb Blood Flow Metab, 19(Suppl 1):S510, 1999.

Richiert DM and Ireland ME.  TGF-ß elicits fibronectin secretion and proliferation in cultured chick lens epithelial cells.  Curr Eye Res, 18:62-71, 1999.

Richiert DM and Ireland ME.  Matrix metalloproteinase secretion is stimulated by tgf-ß in cultured lens epithelial cells.  Curr Eye Res, 19:269-275, 1999.

Schmidt TR, Goodman M, and Grossman LI.  Molecular evolution of the Cox7a gene family in primates.  J Mol Biol & Evol 16:619-626, 1999.

Stojanovic N, Florea L, Riemer C, Gumucio D, Slightom J, Goodman M, Miller W and Hardison R.  Comparison of five methods for finding conserved sequences in multiple alignments of gene regulatory regions.  Nucleic Acids Research, 27:3899-3910, 1999.

Sullivan JM, Alousi SS, Hikade KR, Rafols JA, Krause GS, and White BC.  Insulin induces dephosphorylation of eif2±#(p) and restores protein synthesis in vulnerable hippocampal neurons following transient brain ischemia.  J Cereb Blood Flow Metab, 19:1010-1019, 1999.

Vincent AM, TenBroeke M, and Maiese K.  Metabotropic glutamate receptors prevent programmed cell death through the modulation of neuronal endonuclease activity and intracellular ph.  Exp Neurol, 155:79-94, 1999.

Vincent AM and Maiese K.  Nitric oxide induction of neuronal endonuclease activity in programmed cell death.  Exp Cell Res, 246:290-300, 1999.

Vincent AM and Maiese K.  Temporal analysis of apoptosis in living neurons.  J Histochem Cytochem, 47(5):661-672, 1999.

Vincent AM, TenBroeke M, and Maiese K.  Neuronal intracellular ph directly mediates nitric oxide-induced programmed cell death.  J Neurobiol, 40:171-184, 1999.

Zhao Z, Kulkarni JS, Wakade TD, Wakade AR, and Crossland WJ.  2deoxyadenosine causes cell death in chick sympathetic ganglia and brain.  Cell Tissue Res, 296:281291, 1999.

Zhou S-Y and Goshgarian H.G.  Effects of serotonin on crossed phrenic nerve activity in cervical spinal cord hemisected rats.  Exp Neurol, 160:446-453, 1999.

Zhu W, TomHon C, Sheldon E, Mason M, Campbell T, Richards N, Goodman M and Gumucio DL.  Analysis of linked human epsilon and gamma transgenes: effect of locus control region hypersensitive sites 2 and 3 or a distal yy1 mutation of stage-specific expression patterns.  Blood,  93:3540-3549, 1999.

Articles In Press

Abdolvahabi RM, McAllister JPII.  Effects of chronic hydrocephalus on the gonadotropin releasing hormone system: implications for amenorrhea and precocious puberty.  Neurological Research (in press).

Adler JE and Walker PD.  Cyclic amp regulates substance p expression in developing and mature spinal sensory neurons.  J Neurosci Res (in press).

Basura GJ and Walker PD.  Serotonin 2a and 2c receptor biosynthesis in the rodent striatum during postnatal development: mrna expression and functional linkage to neuropeptide gene regulation. Synapse (in press).

Chen L and Hazlett LD.  Heparan sulfate is required for p aeruginosa adherence to the basement membrane of the wounded mouse cornea.  Curr Eye Res (in press).

Danjo Y, Hazlett LD and Gipson IK.  Strain dependent phenotype in muc 1 null mice.  Invest Ophthalmol Vis Sci (in press).

Dore-Duffy P, Owen C, Balabanov R, Murphy S, and Rafols JA.  Pericyte response to traumatic brain injury (tbi): elongation and migration from the microvascular wall.  J Vascular Res (in press).

Ferguson GT, Khanchandani N, Lattin CD and Goshgarian HG.  Clinical effects of theophylline on inspiratory muscle drive in tetraplegia.  Neurorehab and Neural Repair (in press).

Goodman M.  Molecular Anthropology.  McGraw Hill Encyclopedia of Science & Technology (in press).

Hannigan, JH and Armant, DR.  Alcohol in pregnancy and neonatal outcome. Seminars in Neonatology (in press).

Hazlett LD, McClellan SA, Kwon B and Barrett R.  Increased severity of p aeruginosa corneal infection in strains of mice designated as th1 vs th2 responsive.  Invest Ophthalmol Vis Sci (in press).

Ireland ME, Wallace P, Sandilands A, Poosch MS, Kasper M, Graw J, Liu A, Maisel H, Prescott A, Goebel D and Quinlin RA.  Up-regulation of novel intermediate filament proteins in primary fiber cells: an indicator of all vertebrate lens fiber differentiation?  Anatomical Rec, 258:25-33 (in press).

Kernacki KA, Barrett RP, and Hazlett LD.  Dysregulation of mip-2 in aged mice leads to a susceptibility response to pseudomonas aeruginosa corneal infection.  Invest Ophthalmol Vis Sci (in press).

Kilburn B, Wang J, Duniec-Dmuchkowski ZM, Leach RE, Romero R and Armant DR.  Extracellular matrix composition and hypoxia regulate the expression of hla-g and integrins in a human trophoblast cell line.  Biology of Reproduction (in press).

Kriebel RM, McAllister JPII.  The pathology of the hippocampus and basal forebrain nuclei in experimental hydrocephalus.  Neurological Research (in press).

Lin L, Daneshvar C, Kurpakus-Wheater M. Evidence for differential signaling in human conjunctival epithelium adherent to laminin isoforms. Exp Eye Res (in press).

Maiese K and Vincent AM.  Membrane asymmetry and dna degradation: functionally distinct determinants of neuronal programmed cell death.  J Neurosci Res (Rapid Publication) (in press).

Maiese K, Lin S-H, and Vincent AM.  Dual pathways of free radical injury in vascular  endothelial cells: loss of nuclear dna integrity and membrane asymmetry during enhanced cysteine protease activity.  Proceedings of the 6th Keio International Symposium for Life Sciences and Medicine (in press).

Maiese K and Vincent AM.  Critical temporal modulation of neuronal programmed cell injury. Cell Mol Neurobiol (in press).

McAllister JPII.  Hydrocephalus enters the new millennium.  Neurological Research (in press).

Nantwi KD, El-Bohy A, Schrimsher GW, Reier PJ and Goshgarian HG.  Spontaneous functional recovery in a paralyzed hemidiaphragm following upper cervical spinal cord injury in adult rats.  Neurohab and Neural Repair (in press).

Petrov T, Page AB, Owen CR, and Rafols JA.  Expression of the inducible nitric oxide synthase in distinct cellular types after traumatic brain injury: an in situ hybridization and immunocytochemical study.  Acta Neuropathol (in press).

Wang J, Mayernik L, Schultz JF and Armant DR.  Acceleration of trophoblast differentiation by heparin-binding egf-like growth factor is dependent on the stage-specific activation of calcium influx by erbb receptors in developing mouse blastocysts.  Development (in press).

Books, Chapters and Reviews

Corriveau RA.  Electrical activity and gene expression in the development of neural circuits.  Journal of Neurobiology, 41:148-157, 1999.

Del Bigio MR, McAllister JPII.  Hydrocephalus Ð pathophysiology.  In: Pediatric neurosurgery (M Choux, CE DiRocco, AD Hockley, ML Walker, eds.), Churchill Livingstone, London, 217-236, 1999.

Goodman M, Page SL, Meireles CM, and Czelusniak J.  Primate phylogeny and classification elucidated at the molecular level.  In: evolutionary theory and processes: modern perspectives, (SP Wasser, ed.), Kluwer Academic Publishers b.v., Dordrecht, The Netherlands, pp. 193-212, 1999.

Kernacki KA, Hobden JA, and Hazlett LD.  Murine model of bacterial keratitis.  In: Handbook of animal models of infection, (O Zak and M Sande, eds.), Academic Press, London, UK, 1999.

Maiese K.  Persistent vegetative state.  In:  Neurobase, 5th ed, (S Gilman, GW Goldstein, and SG Waxman, eds.), Arbor Publishing Corp, La Jolla, CA, 1999.

Maiese K.  Nitric oxide: Cellular and molecular pathways of protection in stroke.  In:  Stroke therapy: Basic, preclinical, and clinical directions, (LP Miller, ed.), Wiley - Liss, Inc., 219-244, 1999.

Maiese K.  Metabolic coma.  In:  Neurobase, 5th ed, (S Gilman, GW Goldstein, and SG Waxman, eds.),  Arbor Publishing Corp, La Jolla, CA, 1999.

Maiese K.  Sequelae of cardiac arrest.  In: Neurobase, 5th ed, (S Gilman, GW Goldstein, and SG Waxman, eds.), Arbor Publishing Corp, La Jolla, CA, 1999.

Maiese K.  Brain herniation.  In:  Neurobase, 5th ed, (S Gilman, GW Goldstein, and SG Waxman, eds.), Arbor Publishing Corp, La Jolla, CA, 1999.

Maiese K.  Hypoxic-ischemic encephalopathy.  In:  Neurobase, 5th ed, (S Gilman, GW Goldstein, and SG Waxman, eds.),  Arbor Publishing Corp, La Jolla, CA, 1999.

Maiese K.  Neurodegeneration:  A view from within the neuron.  In:  Recent research developments in neurochemistry, (SG Pandalai, ed.), Trivandrum, India:  Research Signpost, Recent Re. Devel. Neurochem., 2:403-422, 1999.

Books and Chapters In Press

Armant DR  Genes and development.  In: Prenatal diagnosis: Genetics, reproductive risks, testing and management (MI Evans, ed.), McGraw-Hill (in press).

Lasker GW.  Happenings and hearsay: Experiences of a biological anthropologist.  Savoyard Books, Detroit (in press).

Maiese K and Caronna JJ.  Evaluating the outcome of ischemic cerebral injury.  In:  Principles and practice of neurocritical care, (DF Hanley, ed), Williams and Wilkins, Baltimore (in press).

Maiese K.  The quarterly review of biology, suny.  ÒCerebral ischemia:  Molecular and cellular pathophysiologyÓ, (Wolfgang, ed.), Walz (in press).

Maiese K.  The quarterly review of biology, suny.  ÒNeuronal degeneration and regeneration: From basic mechanisms to prospects for therapy,Ó (FW Van Leeuwen, A Salehi, RJ Giger, AJG D Holtmaat, and J Verhaagen, eds.) (in press).

Maiese K.  Dynamic modulation of molecular neurodegeneration:  Transformation into neuroprotection.  Histology and Histopathology (in press).

Maiese K and Caronna JJ.  Coma.  In:  The high risk patient: Management of the critically ill, (ED Sivak, T Higgins and A Seiver, eds.), Lea and Febiger, Philadelphia (in press).

Meireles CM, Czelusniak J, Schneider MP, and Goodman M.  Evolutionary history of the duplicated gamma hemoglobin genes in new world monkeys (primates, atelinae).  In: A primatologia no brasil, vol. 7 (C. Alonso and A. Langguth, eds.), Brazilian Society of Primatology, Jaao Pessoa, Paraiba, Brazil (in press).

McAllister JPII, Ding Y, Canady AI.  Pathophysiology of hydrocephalus: A critical review of advances and future directions.  In: Neurosurgery of the Child, (C Sainte-Rose, G Cinalli, eds.), Churchill Linvingstone, London (in press).

Owen C, Lipinski C, Page A, White BC, Sullivan J, DeGracia D, Rafols JA and Krause G.  Characterization of the eif2-associated protein p67 during brain ischemia and reperfusion.  Maturation phenomenon in cerebral ischemia iv, Berlin, Heidelberg, SpringerVerlag (in press)

Abstracts Published

Abdolvahabi RM, Cortese JJ, Mitchell JA, Rafols JA, White BC, Diaz FG, McAllister JP II.  Effects of shunt treatment on the gnrh system in congenital hydrocephalus.  Journal of Neurotrauma, 16:988, 1999.

Abdolvahabi RM, Cortese JJ, Mitchell JA, Rafols JA, White BC, Diaz FG, McAllister JP II.  Intraventricular shunts attenuate hydrocephalus-related alterations in the gnrh system in the h-tx rat.  Society for Neuroscience, Abstracts 25:1449, 1999.

Armant DR, Wang J, Schultz JF and Mayernik L.  Integrin signaling and trophoblast phenotype conversion during mouse blastocyst implantation. Eur J Cell Biol, 78(Supp 49):9, 1999.

Basura GJ and Walker PD.  Striatal neuropeptide and serotonin 2a receptor mrna levels remain dysregulated following suppression of serotonin hyperinnervation in rodents depleted of dopamine as neonates.  Soc Neurosci (abstract), 25:1159, 1999.

Basura GJ and Walker PD.  Serotonin 2a receptor mrna levels in the neonatally dopamine depleted rat striatum remain upregulated following inhibition of serotonin hyperinnervation, FASEB J. 13:A343, 1999.

Boucher SEM, Skoff RP.  In vitro myelination in co-cultures of postnatal rat drg neurons and oligodendrocytes.  J Neurochem 72 (Suppl), S80D, 1999.

Boucher S, Carlock L, and Skoff R.  PLP regulates survival and death of neurons.  1999 Great Lakes Glia meeting, Thompsonville, MI 1999.

Campbell BM and Walker PD.  Striatal preprotachykinin mrna regulation in organotypic slice culture: effects of stimulatory agents and serotonin 2 receptor agonism.  Soc Neurosci (abstract) 25:1159, 1999.

Chen LL, Garrett M, McClellan S and Hazlett LD.  Heparan sulfate may be required for p aeruginosa adherence to mouse and human corneal epithelium.  Invest Ophthalmol Vis Sci, 40:1367, 1999.

Cypher MA, Perry C, Nguyen M, Skoff R, Carlock L.  Protein processing and cell death in transfected and stable cell lines expressing normal or mutant plp/dm20 proteins.  J Neurochem 72 (Suppl), S8C, 1999.

Cypher MA, Perry C, Nguyen M, Skoff R, Carlock L.  Comparison of normal and mutant plp/dm20 protein transport with cell death in transfected and stable cell lines expressing normal or mutant plp/dm20-egfp fusion proteins.  European Soc for Dysmyelinating Diseases, (Padua, Itlay), 1999.

Cypher MA, Kerwin S, Perry C, Skoff R, and Carlock L.  Examining transport and processing of normal and mutant plp/dm20 proteins in stable cell lines. 1999 Great Lakes Glia meeting, Thompsonville, MI, 1999.

Danjo Y, Hazlett LD and Gipson IK.  Lack of ocular surface phenotype in muc-1 null mice.  Invest Ophthalmol Vis Sci, 40:2826, 1999.

Ding Y-C, McAllister JP II, Canady AI.  Axonal damage and neuron tolerance in hydrocephalus.  Journal of Neurotrauma, 16:1004, 1999.

Ding Y-C, McAllister JP II, Canady AI, Zhang M-Z.  Neuronal damage and tolerance in hydrocephalus.  Society for Neuroscience, Abstracts 25:1589, 1999.

Dinsay R, Wang J and Armant DR.  Supplementation with calcitonin during mouse preimplantation development accelerates trophoblast differentiation. ACOG, Michigan Section, Annual Resident/Fellow Day, May 26, 1999.

Dinsay R, Wang J, Kilburn BA, Romero R and Armant DR.  Calcitonin promotes invasiveness of human trophoblast cells through intracellular calcium signaling.  Fert Steril, 72:S224, 1999.

Dinsay R, Wang J and Armant DR.  Supplementation with calcitonin during mouse preimplantation development accelerates trophoblast differentiation.  Fert Steril, 72:S48, 1999.

Esco MA, McDermott ML, Kurpakus MA.  Effects of hypoxia on human corneal epithelial cell-cell and cell-matrix adhesion.  Invest Ophthalmol Vis Sci, 40:S325, 1999.

Goebel DJ and Poosch MS.  NMDA-induced excitotoxicity transiently reduces nr2a, nr2b, nr2c and nr1 receptor subunit gene expression in the rat retina.  ARVO Abstracts,  Invest  Ophthalmol.Vis Sci, 40(4, Suppl):S716, 1999.

Hadas B, OSullivan N L, and Montgomery PC.  An in vitro model for autoimmune dacryoadenitis: Co-culture of lacrimal gland acinar cells with lymphocytes. International Congress of Dacryology, Jerusalem, Israel, 1999.

Ham S, Schermerhorn T, Vandenbelt S, Riutta J, Canady A, and Mitchell J.  BBÕ iminodipropionitrile induces hydrocephalus in the hamster.  American Association of Neurological Surgeons, 1999.

Hazlett LD and Kernacki KA.  MIP-2 is a major mediator of pmn influx in ocular bacterial infection.  First International Congress on Cytokines/Chemokines in Infectious Disease. Bethesda, MD, September 1999.

Hazlett LD and McClellan SA.  Th1 responsiveness may dictate susceptibility to ocular challenge with pseudomonas aeruginosa.  Invest Ophthalmol Vis Sci, 40:4178, 1999.

Hogan BM and Lande MA.  Extracellular degradation of newly synthesized cartilage collagens.  Ann XVII Eur Congr Biochem, Modena, Italy, 372A, 1999.

Ireland ME, Chen F and Mrock L.  Transforming growth factor-±# (tgf-±#) stimulates lens fiber differentiation.  Invest Ophthalmol Vis Sci, 40: S561, 1999.

Jacobs DB, Tampa DG and Ireland M.  Insulin mediated irs-1 signal-transduction in bovine and porcine lens.  Invest Ophthalmol Vis Sci, 40: S885, 1999.

Kernacki KA, Barrett RP, and Hazlett LD. Evidence that timp-1 is protective against p aeruginosa induced corneal ulceration and perforation.  International Proteolysis Society, Mackinac Island, MI, September 1999.

Kernacki KA, Hobden JA, and Hazlett LD.  MIP-2 expression correlates with pmn influx  and tissue injury during p aeruginosa corneal infection. Supplement Invest Ophthalmol Vis Sci, 40:4177, 1999.

Lai Q, Ding Y-C, McAllister JP II, Canady AI.  Motor skill learning and memory impairment in hydrocephalus.  Journal of Neurotrauma, 16:988, 1999.

Lai Q, Ding Y-C, McAllister JP II, Koo BKK, Canady AI, Ham SD, Sood SS.  Memory impairment of motor skill learning in hydrocephalus.  Society for Neuroscience, Abstracts 25:1898, 1999.

Li ZG, Zhang H, Diaz FG, McAllister JP II.  Apoptosis and dark neurons in hydrocephalic brains.  Journal of Neurotrauma, 16:1003, 1999.

Li ZG, Zhang H, Diaz FG, Krause GS, McAllister JP II.  Dark cells and apoptosis in hydrocephalic brains.  Society for Neuroscience, Abstracts 25:1610, 1999.

Lin L and Kurpakus MA.  Differential adhesion of ocular surface epithelial cells to laminin. Invest Ophthalmol Vis Sci, 40:S325, 1999.

Lin S-H, Vincent A, Shaw T, Wright J, and Maiese K.  Group I metabotropic receptors selectively down-regulate nitric oxide induced cpp32 activity.  Soc Neurosci (abstract), 25 (part 1):1060, 1999.

McClellan SA, Barrett RP and Hazlett LD.  Mechanisms of resistance vs susceptibility to p aeruginosa infection: The role of langerhans cells.  Invest Ophthalmol Vis Sci, 40:1372, 1999.

Montgomery PC, Skandera CA and OÕSullivan N L.  Mononuclear cell populations in rat lacrimal glands.  Invest Ophthalmol Vis Sci, 40:S554, 1999.

OSullivan N L, Skandera C A and Montgomery PC. Rat glandular mononuclear cell populations.  Immunol Letters, 69:146, 1999.

Pan ZH.  Differential expression of high and two low voltageactivated calcium currents, and sodium currents in rod and cone bipolar cells of the rat retina.  Invest Ophthalmol Vis Sci (Suppl.) 40:791,1999.

Petrov T, Owen C and Rafols JA.  Differential synthesis of endothelin (ed-1) and nitric oxide (no) in rat cerebral microvessels following traumatic brain injury (tbi).  Soc Neurosci (abstract) 25 (part 1):822, 1999.

Pillar CM, Hazlett LD and Hobden JA.  The effect of pseudomonas aeruginosa alkaline protease on bacterial adherence in vitro.  Amer Soc Microbiol, 1999.

Proctor J, Ireland M, Quinlan R, Mogensen M and Prescott A.  The disappearance and reappearance of the centrosome during lens fiber cell differentiation.  14th European Cytoskeleton Forum, Oeiras, Portugal, August 28-September 2, 1999.

Qin P and Pourcho RG.  AMPAselective glutamate receptor subunits glur2 and glur4: Localization in the cat retina.  Invest Ophthalmol Vis Sci, 40:S236, 1999.

Rafols JA, White BC, Owen C and Sullivan JM.  Insulin does not prevent injury to the cytoskeleton and endoplasmic reticulum of rat hippocampus ca3 neurons following ischemia/reperfusion.  Soc Neurosci (abstract) 25 (part 1):1850, 1999.

Reddan JR, Lindeman CB, Hitt AL, Bagchi M, Raphtis EM, Pena JT, and Dziedzic DC.  Generation of two non-transfected lens epithelial cell lines.  Invest Ophthal Vis Sci, 40:S970, 1999.

Rudner XL, Kernacki KA and Hazlett LD. Early cytokine response to p aeruginosa corneal infection differs in susceptible vs resistant mice. First International Congress on Cytokines/Chemokines in Infectious Disease.  Bethesda, MD, September 1999.

Rudner XL, Kernacki KA, Hazlett LD.  Early cytokine response to p aeruginosa infection differs in susceptible and resistant mice.  Supplement Invest Ophthalmol Vis Sci, 40:1374, 1999.

Shaw T, Moon B-K, Wright J, and Maiese K.  The transcription factor e2f directs attempted cell cycle induction during neuronal programmed cell death.  Soc Neurosci (abstract), 25 (part 1): 793, 1999.

States JC, Vincent A, Wright J, Shaw T, and Maiese K.  Rapid neuronal intracellular acidification triggers nitric oxide induced programmed cell death.  Soc Neurosci (abstract), 25 (part 1):792, 1999.

Underwood BD, Lipinski CA, Rafols JA, Crossland WJ, McAllister JP, Diaz FG, and White, BC.  Effect of traumatic brain injury on phosphorylated eukaryotic initiation factor 2a in the rat. Soc Neurosci Abstr, 23:820, 1999.

Vincent A, TenBroeke M, and Maiese K.  Rapid reversal of neuronal programmed cell death during metabotropic glutamate receptor activation.  Stroke, 30(1):247, 1999.

Vincent A and Maiese K.  Membrane stabilization during neuronal programmed cell death by metabotropic glutamate receptor activation.  Soc Neurosci (abstract), 25 (part 1):792, 1999.

Wang J, Mayernik L, Schultz JF, Armant DR.  Integrin signaling up regulates fibronectin binding activity in mouse periimplantation blastocysts. Dev Biol, 210:191, Abstract #66, 1999.

Wang J and Armant DR.  Heparin-binding egf-like growth factor and erbb4-mediated signaling regulate peri-implantation development of mouse trophoblast cells.  Fert Steril, 72:S47, 1999.

Wang J, and Armant DR.  Expression of erbb4 on the surface of mouse blastocysts is required for the regulation of peri-implantation development by heparin-binding egf-like growth factor. 19th Annual Great Lakes Mammalian Development Meeting, Toronto, ON, Canada, April 9-11, 1999.

Wright J, Shaw T, and Maiese K.  Peptide growth factors actively prevent induction of the cell cycle during programmed cell death.  Soc Neurosci (abstract), 25 (part 1):299, 1999.

Abstracts In Press

Abdolvahabi RM, Cortese J, Mitchell JA, Rafols JA, White BC, Diaz FG, and McAllister JP.  Intraventricular shunts attenuate hydrocephalus-related alterations in gnrh system in the h-tx rat.  Soc Neurosci (Abstract) 25:1449 (in press).

Boucher SEM, Carlock LR, Skoff RP.  PLP gene modulates neuron viability and morphology.  J Neurochem 72, (Suppl.), (in press).

Castro-Moure F, El-Bohy A, Chappell T, and Goshgarian HG.  Diaphragmatic motor recovery in hemisected rats following spinal cord repair using peripheral nerve transplants and an acidic fibroblastic growth factor (±#fgf) suspension.  In  Eighth International Symposium on Neural Regeneration.   Exp Neurol (in press).

Cypher M, Latham A, Skoff R, and Carlock L.  Regulation of plp protein concentration by the proteasome prevents programmed cell death.  Am Soc Neurochem (in press).

Ding Y-C, Lai Q, McAllister JP II, Ham SD, Sood SS, Canady AI.  Impaired motor learning in children with hydrocephalus.  Oral presentation at the Pediatric Section of the AANS Meeting, Atlanta, GA (in press).

Goshgarian HG.  Theophylline-induced recovery of respiratory muscle function following cervical spinal cord injury.  J Spinal Cord Med (in press).

Kernacki KA, and Hazlett LD.  Discordant expression of mmp-9 and mmp-13 in cornea following p aeruginosa infection.  Invest Ophthalmol Vis Sci (in press).

Li ZG, Zhang H, McAllister JP II.  Apoptosis and dark neurons in hydrocephalic brains.  Poster presentation at the Pediatric Section of the AANS Meeting, Atlanta, GA (in press).

McClellan SA, Kernacki KA, Barrett RP and Hazlett LD.  MIP-2 contributes to the dysregulated pmn response in aged mice infected with p aeruginosa.  Invest Ophthalmol Vis Sci (in press).

Kerwin S, Cypher M, and Carlock L.  Using protein engineering to examine the synthesis, processing and transport of the proteolipid proteins plp and dm20.  Am Soc Neurochem (in press).

Lin S-H, Vincent A, Shaw T, Wright J, and Maiese K.  Group I metabotropic glutamate receptors selectively and specifically inhibit cysteine protease activity during ischemic nitric oxide exposure.  Stroke (in press).

Nantwi KD and Goshgarian HG.  Actions of a selective adenosine a1 receptor antagonist on respiratory recovery following cervical spinal cord injury.  J Spinal Cord Med (in press).

Nantwi K and Goshgarian HG.  Involvement of adenosine a1 receptors in respiratory recovery following cervical spinal cord injury in adult rats.  In ÒEighth International Symposium on Neural Regeneration.Ó  Exp Neurol (in press).

Owen C, Lipinski C, White BC, Sullivan J, DeGracia D, Rafols JA, Datta B and Krause GS.  Stability of the glycosylated eif2-binding terminal methionine aminopeptidase (p67) during brain ischemia and reperfusion.  Proc Fourth Interntl.  Workshop on Maturation Phenomenon in Cerebral Ischemia: Apoptosis and/or Necrosis, Neuronal Recovery vs Death, and Protection for Infarction (in press).

Rout U, Bessert DA, Carlock L, Ghandour MS, Armant R, Skoff RP.  CNS myelin protein genes are robustly expressed in many tissues including preimplantation embryos.  J Neurochem 73, (Suppl.) (in press).

Saluja I, Granneman J, Skoff RP.  Agonists for the transcription factor ppar´# stimulate the differentiation of oligodendrocytes in tissue culture.  J Neurochem 73, (Suppl.) (in press).

Shaw T, Vincent A, Lin S-H, and Maiese K.  The transcription factor e2f represents a novel molecular checkpoint in post-mitotic neurons against ischemic cell cycle induction and neuronal programmed cell death.  Stroke (in press).

Vincent A, Wright J, Lin S-H, and Maiese K.  Free radical induction of acidic endonuclease activity is a potential regulatory therapeutic target against neuronal apoptosis.  Stroke (in press).

Wright J, Shaw T, Vincent A, and Maiese K.  Trophic factor protection against ischemic neurodegeneration is mediated by the regulation of genomic dna transcription.  Stroke (in press).

Xu H, Liu YC, Skoff R, Barks JD, Silverstein FS.  Acute oligodendroglia injury in neonatal rodent brain.  Pediatric Academic Societies (in press).

Zhou S-Y, and Goshgarian HG.  Serotonin-induced respiratory recovery in the phrenic nerve after cervical spinal cord hemisection.  In ÒEighth International Symposium on Neural Regeneration.Ó  Exp Neurol (in press).

Zhou S-Y, Castro-Moure F and Goshgarian HG.  Activation of a latent respiratory motor pathway by medullary chemoreceptor stimulation after cervical spinal cord hemisection.  J Spinal Cord Med (in press).

Patents and Intellectual Property

Maiese K and Vincent A.  Assessment of the induction and course of cellular programmed cell death over time.  (U.S. Serial Number 09/144,045, February 15, 1999).

Maiese K and Vincent A. Temporal assessment of the progression of programmed cell death in tissue and in vivo preparations. (Patent Pending).