Annual Report

2000-2001

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Features:
Letter from the Dean

Academia and Industry Working Together for Biomedical Advances

WSU Considered Model Program in Prenatal Genetic Analysis

WSU Gets Early Access to Corning Technologies

Dr. Joan Dunbar:  Research Matchmaker

Best Oncology Practices Standardized by Innovative Solutions

Freezing the Deadly Spread of Cancer

Combining Technology and Expertise to Discover New Genes in Epilepsy

General Motors Supports Prevention Program

Cell Therapy Center Advances Immunotherapies for Clinical Application

Robust Partnerships Aid Development of Cancer Vaccines

The Year in Review

WSU Gets Early Access To Corning Technologies


Environmental toxins combined with particular genetic factors may predispose individuals to specific diseases.  Wayne State has partnered with Corning to develop biosensors and investigate the relationship between gene expression and the environment.

When Corning Inc. released its CMT Yeast Gene Array in 2001, it was the first product in a brand new market line and it was the public’s first look at Corning’s Microarray Technologies. Wayne State University’s Dr. Craig Giroux, however, had already been testing the product for many months.

Dr. Giroux’s Early Access Partnership with Corning’s Microarray Technology division allows him advance previews of new products. “Currently, we are working with Corning to validate the products, to provide some practical data on its use and to develop new applications of the product in toxicogenomics, my area of expertise,” said Dr. Giroux, assistant professor in the Center for Molecular Medicine and Genetics.

Dr. Giroux’s work focuses on gene-environment interactions and the genetic factors that predispose an individual to environmentally responsive disease. He is developing biosensors that will identify hazardous chemicals in the environment and predict which genes make an individual susceptible to these specific hazards. This prediction is made possible by construction of a yeast genomics model for the human cellular stress response to environmental toxicants. By studying the target pathways that confer sensitivity to chemical agents in the yeast cell model, broader conclusions may be deduced about oxidative stress and molecular damage in the tissue and organ systems of exposed individuals.

The CMT Yeast-S288c Gene Array from Corning was produced to enable accurate genome-wide expression analysis. The array is a representation of the entire S. cerevisiae genome, one of the most wellstudied model systems for genetic analysis. The new product allows researchers to study yeast gene expression under various experimental conditions.

“The great thing about this partnership is: Wayne State develops the research protocols, and Corning develops the products. We provide constant feedback to one another. It helps my research run more efficiently and it helps them produce better materials,” Dr. Giroux said.  

2000 Report to Investors:
Creating Personal Partnerships

Partnerships for Life

The Quest to Improve Women's Health

Gifts from Alumni

Gifts from Faculty, Staff, Friends and Corporations

2000/2001 Alumni Annual Telefund Volunteers

2000 New Endowed Funds at the School of Medicine

Alumni Contact Information

Bibliographies:
Anatomy and Cell Biology

Barbara Ann Karmanos Cancer Institute

Biochemistry and Molecular Biology

Center for Healthcare Effectiveness Research

Center for Molecular Medicine and Genetics

Community Medicine

Dermatology and Syphilology

Emergency Medicine

Family Medicine

Immunology and Microbiology

Internal Medicine

Neurological Surgery

Neurology

Obstetrics and Gynecology

Ophthalmology

Orthopaedic Surgery

Otolaryngology

Pathology

Pediatrics

Pharmacology

Physical Medicine and Rehabilitation

Physiology

Psychiatry and Behavioral Neurosciences

Radiation Oncology

Radiology

Surgery

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