Features

Urology

Chair: J. Edson Pontes
1017 Harper Professional Building
(313) 745-7381

Aranha O., Grignon, R., Fernandes, N., Wood, Jr., D.P., and Sarkar, F.H.: Role of Ciprofloxacin as a Potential Chemotherapeutic Agent in Prostate Cancer. Oncogene, 2000 (in press).

Aranha, O., Wood, Jr., D.P., Sarkar, F.H.: Ciprofloxacin Mediated Cell Growth Inhibition, S/G2M Cell Cycle Arrest and Apoptosis in a Human Transitional Cell Carcinoma of the Bladder Cell Line. Clin Cancer Res (6):891-900, 2000.

Banerjee, M., Biswas, D., Sakr, W., Wood, Jr., D.P.: Recursive Partitioning for Prognostic Grouping of Patients with Clinically Localized Prostate Cancer. American Cancer Society, 404-411, 2000.

Bentley, G., Dey, J., Sakr, W.A., Wood, D.P., Pontes, J.E., Grignon, D.J.: Significance of the Gleason Scoring System after Neoadjuvant Hormonal Therapy. Molecular Urology (4) 125-129, 2000.

Feng, J., deGuia, K., Ward, C., Dey, J., Grignon, D., Powell, I., Wood, D., Pontes, J., and Sakr, W.: Changes in the Frequency and Volume of Index Tumors and High Grade Intraepithelial Neoplasia in Radical Prostatectomy Specimens in the 1990s. Jrnl Urol, 2000 (in press).

George VK, Bianco FJ, Dornelles EJ, Cher ML, Wood DP, Sakr W, Pontes JE, Powell IJ: Predictions of biological aggressiveness of early prostate cancer. Journal of Urology.

Hussain, M., Fisher, E.I., Petrylak, D.P., O’Connor, J., Wood, D.P., Small, E.J., Eisenberger, M.A., Crawford, E.D.: Androgen Deprivation and Four-Courses Fixed- Schedule Suramin in Patients with Newly Diagnosed Metastatic Prostate Cancer: A Southwest Oncology Group Study. J Clin Onc 18(5)1043-1049, 2000.

Jimenez, R.E., Gheiler, E., Oskanian, P., Tiguert, R., Sakr, W., Wood, Jr., D.P., Pontes, J.E., Grignon, D.J.: Grading the Invasive Component of Urothelial Cancer. Mod Path (in press).

Jimenez, R., Hussain, M., Vaishampayan, U., Tabazcka, P., Sakr, W.A., Pontes, J.E., Wood, Jr., D.P., and Grignon, D.J.: Her-2/neu in Overexpression in Muscle-Invasive Urothelial Carcinoma of the Bladder: Prognostic Significance and Comparative Analysis in Primary and Metastatic Tumors. Submitted to Jrnl Clin Onc, 2000 (in Press).

Littrup, P.J., Hinman, J., Raasch, J., Upadhyay, J, Wood, D.P., Sakr, W., and D. Grignon.: Transrectal US Grayscale and Color Doppler Evaluation of the Prostatic Fossa: PSA and Individual Biopsy Site Correlation. Urology (in press).

Narain V, Tiguert R, Banerjee J, Sakr W, Grignon D, Wood DP, Pontes JE, Powell IJ: Biochemical recurrence in African American and Caucasian men with a positive and negative family history of prostate cancer following radical prostatectomy. Journal of Urology, 165, 474-477, 2000.

Narain, V., and Wood, Jr., D.P.: Malignant Tumors of the Urogenital Tract. Handbook of Oncology, 2000.

Powell IJ, Sakr W, Weiss L, Haas G, Severson R: Prostate cancer is biologically more aggressive among younger African Americans than Caucasian men. Journal of Urology.

Powell IJ, Dey J, Pontes EJ, Cher ML, Sakr W, Wood DP: Disease free survival of local prostate cancer among African Americans and Caucasians: A multivariable analysis of race/ethnicity as an independent variable. Journal of Urology.

Powell IJ, Carpten J, Dunston G, Kittles R, Bennett J, Hoke G, Pettaway C, Weinrich S, Vijayakumar S, Ahaghotu CA, Boykin W, Mason T, Royal C, Baffoe-Bonnie A, Bailey-Wilson J, Berg K, Trent J, Collias F: African American hereditary prostate cancer study: a model for genetic research. Journal National Medical Society (in press).

Powell IJ, Forman J, Chuba P, Cher ML, Wood DP, Dey J, Pontes JE. An Explanation for Differences in Survival Between African Americans and Caucasians Treated by Radical Prostatectomy and Radiotherapy. J Urol 163: #1439, 2000.

Powell IJ, Banerjee M, Novallo M, Sakr W, Grignon D, Wood DP, Pontes JE: Should the age specific PSA cut-point for prostate biopsy be higher among African American vs. Caucasian men above 50 years. J of Urol, Vol 163, 146-149, January 2000.

Powell I J, Meykens FL: African American males and hereditary/familial prostate cancer: intermediate risk population for chemoprevention trials (in press).

Powell IJ, Banerjee M, Novallo M, Sakr W, Grignon D, Wood DP, Pontes JE: Prostate cancer biochemical recurrence stage for stage is more frequent among African American versus caucasian men with locally advanced but not organ confined disease. Urology, Vol 55, 246-251, February 2000.

Powell, I.J., Banerjee, M., Novallo, M., Sakr, W., Grignon, D., Wood, D.P., Pontes, J.E.: Should The Age Specific PSA Cut-Point For Prostate Biopsy Be Higher Among African American vs. American Caucasian Men Above 50 Years: J Urol 163(1):146-9, 2000.

Rakozy, C., Gheiler, E., Tiguert, R., Sarkar, F.H., Sakr, W., Pontes, J.E., Wood, Jr. D.P. Forman, J., Grignon, D.: Cell-Cycle- and Apoptosis-Related Markers May Predict Time to Recurrence and Clinical Outcome in Patients with Recurrent Prostate Carcinoma after Radiation Failure. Human Pathology (in press).

Royal C, Baffoe-Bonnie H, Kittles R, Powell I, Bennett J, Hoke G, Pettaway C, Dunston G, Collins F, et al: Recruitment experience in the first phase of the African American hereditary prostate Cancer (AAHPC) nstudy. J. of Epidemology (in press).

Sakr WA, Grignon DJ, Powell IJ, Banerjee M, Littrup PJ, Wood DP, Crissman JD, Pontes JE: Clinical and pathologic characteristics of T1C prostate cancer in African American and Caucasian patients treated by radical prostatectomy (in press).

Sakr W, Grignon D, Dey J, Powell I, Wood D, Pontes J: Predictors of Biochemical Recurrence in Pathologically Organ –Confined Prostate Cancer.

Sakr, W.A., Tefilli, M.V., Gheiler, E.L., Tiguert, R., Grignon, D.J., Banerjee, M., Powell, I.J., Pontes, J.E., Crissman, J.D., Wood, Jr., D.P.: Gleason Score 7 Prostate Cancer: A Heterogeneous Entity? Correlation with Pathologic Parameters and Disease Free Survival. Journal Urology (in press).

Shekarriz B, Tiguert R, Gheiler E, Upadhyay J, Powell J, Pontes J, Grignon D, Wood D: Impact of location and multifocality of positive surgical margins on disease free survival following radical prostatectomy: A comparison between African American and Caucasian men. Urology, Vol 55, 899-903, June 2000.

Tiguert R, Harb JF, Hurley PM, Gomes De Oliveira J, Castillo-Frontera RJ, Triest JA and Gheiler EL: Management of shotgun injuries to the pelvis and lower genitourinary system. Urology 55(2): 193-7, 2000.

Tiguert, Rabi, Oskanian, P., Li Yiwei, Grignon, D.J., Wood, Jr., D.P., Pontes, J.P., and Sarkar, F.: Correlation of Alteration of p53 Protein with Survival Following Radical Cystectomy for Muscle Invasive Bladder Cancer. Submitted 2000 (in press).

Washburn JE, Wojno KJ, Dey J, Powell IJ, Macoska JA: 8pter-p23. Deletion is associated with racial differences in prostate cancer outcomes. Clinical Cancer Research, Vol 6, 4647-4652, 2000.

Wei, J.T., Park, J., Vallorosi, C., David Wood, and Montie, J.E.: Examining the Gender Differences in Urinary Function Following Orthotopic Neobladder Surgery. Submitted Contemporary Urology, 2000 (in press).

Santucci RA and McAninch J: Diagnosis and management of renal injuries: Past, present, and future. JACS, 191:443-451, 2000.

Santucci RA and McAninch J: Bladder injuries: Evaluation and management. Braz. J Urol . 26: 408-414, 2000.

Santucci RA and Krieger, JN. Gentamicin for the practicing urologist: Review of efficacy, once-daily dosing and “switch” therapy. J Urol, 163: 1076-84, 2000.

Bianco FJ, Wood DP, de Oliveira JG, Nemeth JA, Beaman A, Cher ML. Proliferation of Prostate Cancer Cells in the Bone Marrow Predicts Recurrence in Patients with Localized Prostate Cancer, submitted.

Buhler KR, Santucci RA, Royai RA, Whitney SC, Vessella RL, Lange PH and Ellis WJ. Intermittent androgen suppression in the LuCaP 23.12 prostate cancer xenograft. The Prostate, 43:63-70, 2000.

Erlich JH, Boyle EM, Labriola J, Kovacich JC, Santucci RA, Fearns C, Morgan EN, Yun W, Luther T, Kojikawa O, Martin TR, Pohlman TH, Verrrier ED and Mackman, N. Induction of tissue factor in myocardium after ischemia/reperfusion contributes to infarct size. Am J Pathol, 157:1849-62, 2000.

Hukku B, Mally M, Cher ML, Peehl DM and Rhim JS. Stepwise Genetic Changes Associated With Progression of Nontumorigenic HPV-18 Immortalized Human Prostate Cancer-Derived Cell Line to a Malignant Phenotype. Cancer Genet. Cytogenet. 120: 117-126, 2000.

Lin DW, Santucci RA, Mayo ME, Lange PH and Mitchell MM. Urodynamic evaluation and long-term results of the orthotopic gastric neobladder in men. J. Urol,164:356-9, 2000.

Nemeth JA, Roberts JW, Mullins CM, and Cher ML. Persistence of Human Vascular Endothelium in Experimental Human Prostate Cancer Bone Tumors. Clinical and Experimental Metastasis (in press).

Santucci RA, Erlich J, Labriola J, Wilson M, Kao KJ, Kickler TS, Spillert C and Mackman N: Establishment of a new assay to measure tissue factor levels in whole blood. Thrombosis and Haemostasis, 83:445-54, 2000.

Santucci RA, Mario LA and McAninch JW: Anastomotic urethroplasty for anterior stricture: Analysis of 135 consecutive patients. J Urol (submitted).

Santucci RA, Mario LA, and McAninch, JW: Urethral reconstruction of strictures resulting from treatment of benign prostatic hypertrophy and prostate cancer. J Urol (submitted).

Shekarriz B, Upadhyay J, Nemeth JA, Dong Z, Mullins C, Fridman R, Grignon DJ, Cher ML. The human bone microenvironment induces expression of MT1-MMP, MMP-2, and MMP-9 in prostate cancer cells in the SCID-human model, (submitted).

Toth M, Bernardo MM, Gervasi DC, Soloway PD, Wang Z, Bigg HF, Overall CM, DeClerck YA, Tschesche H, Cher ML, Brown S, Mobashery S, Fridman R. TIMP-2 Acts Synergistically with Synthetic MMP Inhibitors but not with TIMP-4 to Enhance the MT1-MMP-dependent Activation of Pro-MMP-2. J Biol Chem, 2000 (in press).

Book, Chapters and Reviews
Cher ML, Nemeth JA: The Bone Microenvironment. In: American Cancer Society Atlas of Clinical Oncology: Prostate Cancer. Ed: Carroll PR, 2000 (in press).

Powell IJ: Epidemiology in African Americans: “Advanced Therapy of Prostate Disease”

Powell IJ: Race and Risk: “Prostate Cancer” ( to be published by Lippincott Williams and Wilkins)

Shekarriz, B., and Wood, Jr., D.P.: Gleason Score 7 Adenocarcinoma of the Prostate: A Separate Entity. Contemporary Urology, 2000.

Wood, D.P.: Orthotopic Urinary Diversion In Women. In: Urol Clin North Am, W.B. Saunders Company, 27(2):367-378, 2000.

Abstracts
Bianco FJ, Cher ML, Beaman A, Nemeth JA, Powell I, Wood DP. Presence of Circulating Prostate Cancer Cells in African American Males Adversely Affects Disease Free Survival. J Urol 163: #823, 2000.

Cher ML, Bianco FJ, Nemeth JA, deOliveira JG, Beaman A, Wood DP. Proliferation of Bone Marrow Micrometastatic Cells Predicts Recurrence in Patients with Localized Prostate Cancer. J Urol 163: #434, 2000.

George VK, Bianco FJ, Dornalles EJ, Cher ML, Wood DP, Sakr W, Pontes JE, Powell I. Predictors of Biological Aggressiveness of Early Prostate Cancer. J Urol 163: #347, 2000.

Narain V, Tiguert R, Banerjee M, Sakr W, Grignon D, Wood DP, Pontes JE, Powell IJ. Detroit, MI. (Presented by Vivek Narain) Biochemical recurrence in African American and Caucasian men with a positive and negative family history of prostate cancer following radical prostatectomy. J of Urol, 163, April 2000, Abstract #240.

Nemeth JA, Roberts J, Mullins C, Cher ML. Persistence of Human Vascular Endothelium in the SCID-Human Model of Prostate Cancer Bone Metastasis. Proc Amer Assoc Cancer Res 41: #1937, 2000.

Pontes, J.E., Yousif, R., Tiguert, R., Bianco,Jr., F.J., Gheiler, E.L., Wood, D.P.: Value of Computed Tomography in Detecting Recurrence Following Radical Prostatectomy. Annual Meeting of the American Urological Association, Atlanta, GA, April 2000.

Powell IJ, Sakr W, Weiss L, Haas G, Severson R. Detroit MI; Syracuse NY (Presented by Isaac J. Powell). Prostate cancer is biologically more aggressive among African Americans than Caucasian men under age 70 years: Hypothesis supported by autopsy and seer data. J of Urol, 163, April 2000, Abstract #243.

Powell IJ, Forman J, Chuba P, Cher M, Wood D, Dey J, Pontes JE. Detroit, MI An explanation for differences in survival between African Americans and Caucasians treated by radical prostatectomy and radiotherapy. J of Urol, 163, April, Abstract #1439.

Reddy A, Yousif R, Shekarriz B, Upadhyay J, Nemeth JA, Cher ML. Progressive Migration of Human Prostate Cancer Cells to Endosteal Surfaces in the SCID-Human Bone Model. J Urol 163: #462, 2000.

Sakr WA, Angelakis K, deGuia K, Cher ML, Wood D, Grignon DJ, Powell I. The Prevalence and Evolution of Isolated High Grade Prostatic Intraepithelial Neoplasia (HGPIN) in African Americans and Caucasian Men—A Study of Needle Biopsies. J Urol 163: #245, 2000.

Sakr, W., Feng, J., deGuia, K., Grignon, D., Powell, I., Wood, D.: Volume of “Index” Tumor, Number of Tumor Foci and Distribution of High Grade PIN in Radical Prostatectomy Specimens (RPS) Between 1991-1999. Annual Meeting of the American Urological Association, Atlanta, GA, April 2000.

Shekarriz B, Tefilli M, Bianco FJ, Upadhyay J, Tiguert R, Cher ML, Grignon D, Wood DP. Impact of Sequential Increases in Preoperative Serum PSA Level up to 10 ng/ml on Pathological Findings and Disease Free Survival. J Urol 163: #835, 2000.

Yousif R, Reddy A, Nemeth JA, Cher ML. Inhibition of Matrix Metalloproteinase Activity Reduces Metastatic Prostate Tumor Cell Proliferation and Osteoclast Recruitment in Human Bone, J Urol: 163: #427, 2000.

2000 Report to Investors:
Creating Personal Partnerships

Partnerships for Life

The Quest to Improve Women's Health

Gifts from Alumni

Gifts from Faculty, Staff, Friends and Corporations

2000/2001 Alumni Annual Telefund Volunteers

2000 New Endowed Funds at the School of Medicine

Alumni Contact Information

Bibliographies:
Anatomy and Cell Biology

Barbara Ann Karmanos Cancer Institute

Biochemistry and Molecular Biology

Center for Healthcare Effectiveness Research