| Annual Report |
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| 2000-2001 | |
| Annual Report |
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| 2000-2001 | |
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Features: Academia and Industry Working Together for Biomedical Advances WSU Considered Model Program in Prenatal Genetic Analysis WSU Gets Early Access to Corning Technologies Dr. Joan Dunbar: Research Matchmaker Best Oncology Practices Standardized by Innovative Solutions Freezing the Deadly Spread of Cancer Combining Technology and Expertise to Discover New Genes in Epilepsy General Motors Supports Prevention Program Cell Therapy Center Advances Immunotherapies for Clinical Application |
Pharmacology Chair: Bonnie Sloane, PhD Articles Jena, BP. Insights on membrane fusion. Cell Biol Int 24(11):769-771, 2000. Kessel D, Poretz RD. Sites of photodamage induced by photodynamic therapy with a chlorin e6 triacetoxymethyl ester (CAME). Photochem Photobiol 71:94-96, 2000. Kessel D, Luo Y, Mathieu P, Reiners Jr J. Determinants of the apoptotic response to lysosomal photodamage. Photochem Photobiol 71:196-200, 2000. Blumenkranz MS, Woodburn KW, Qing F, Verdooner S, Kessel D and Miller R. Luteitum texaphyrin (Lu-Tex): a potential new agent for ocular fundus angiography and photodynamic therapy. Am J Ophthalmol 129:353-362, 2000. Kessel D, Luo Y. Cells in cryptophycin-induced cell-cycle arrest are susceptible to apoptosis. Cancer Lett 151:25-29, 2000. Webber J, Herman M, Kessel D, Fromm D. Photodynamic treatment of neoplastic lesions of the gastrointestinal tract. Langebecks Arch Surg 385:299-304, 2000. Kessel D, Caruso JA, Reines JR Jr. Portentiation of photodynamic therapy by ursodeoxycholic acid. Cancer Res 60:6985-6988, 2000. Kessel D and Luo Y. Intracellular sites of photodamage as a factor in apoptotic cell death. J Porphyrin Phthalo. Webber J, Kessel D and Fromm D. Surgical sisde effects of 5-aminolevulinic acid. Arch Surg Woodburn KW, Rodriquez S, Robbins RC, Kessel D, and Yamaguchi A. Photodynamic therapy using motexafrin in graft coronary artery disease. J Porph Phthalo Chen Z, Putt DA, Lash LH. Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: Further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport. Arch Biochem Biophys 373:193-202, 2000. Cummings BS, Parker, JC, Lash LH. Role of cytochrome P450 and glutathione S-transferase ? in metabolism and cytotoxicity of trichloroethylene in rat kidney. Biochem Pharmacol 59:531-543, 2000. Cummings BS, Lash LH. Metabolism and toxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in freshly isolated human proximal tubular cells. Toxicol Sci 53:458-466, 2000. Stokes AH, Lewis DY, Lash LH, Jerome III WG, Grant KW, Aschner M, Vrana KE. Dopamine toxicity in neuroblastoma cells: Role of glutathione depletion by L-BSO and apoptosis. Brain Res 858:1-8, 2000. Cummings BS, Lasker JM, Lash LH. Expression of glutathione-dependent enzymes and cytochrome P450s in freshly isolated and primary cultures of proximal tubular cells from human kidney. J Pharmacol Exp Ther 293:677-685, 2000. Reiners Jr JJ, Mathieu P, Okaford C, Putt DA, Lash LH. Depletion of cellular glutathione by conditions used for the passaging of adherent cultured cells. Toxicol Lett 115:153-163, 2000. Reilly TP, Lash LH, Doll MA, Hein DW, Woster PM, Svensson CK. A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions. J Invest Dermatol 114:1164-1173, 2000. Cummings BS, Zangar RC, Novak RF, Lash LH. Cytotoxicity of trichloroethylene and S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of rat renal proximal tubular and distal tubular cells. Toxicology 150:83-98, 2000. Cummings BS, Angeles R, McCauley RB, Lash LH. Role of voltage-dependent anion channels in glutathione transport into yeast mitochondria. Biochem Biophys Res Commun 276:940-944, 2000. Lash LH, Putt DA, Zalups RK. Biochemical and functional characteristics of cultured renal epithelial cells from uninephrectomized rats: Factors influencing nephrotoxicity. J Pharmacol Exp Ther (in press). Lash LH, Putt DA, Hork III SJ, Zalups RK. Functional and toxicological characteristics of isolated renal mitochondria: Impact of compensatory renal growth. Biochem Pharmacol (in press). Cummings BS, Parker JC, Lash LH. Cytochrome P450-dependent metabolism of trichloroethylene in rat kidney. Toxicol Sci (in press). Lash LH, Qian W, Putt DA, Hueni SE, Elfarra AA, Krause RJ, Parker JC. Renal and hepatic toxicity of trichloroethylene and its glutathione-derived metabolites in rats and mice: Sex-, species-, and tissue-dependent differences. J Pharmacol Exp Ther (in press). Taub JW, Huang X, Ge Y, Dutcher JA, Stout ML, Mohammad RM, Ravindranath Y and Matherly LH. Cystathionine-$-Synthase cDNA Transfection Alters the Sensitivity and Metabolism of Cytosine Arabinoside in CCRF-CEM Leukemia Cells In Vitro and In Vivo: A Model of Down Syndrome and Leukemia, Cancer Res, 60: 6421-6426, 2000. Said HM, Chatterjee N, Haq RU, Subramanian VS, Ortiz A, Matherly LH, Sirotnak FM, Halsted C, and Rubin SA. Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency. Am J Physiol Cell Physiol 279: C1889-1895, 2000. Ding BC, Witt TL, Hukku B, Heng H, Zhang L and Matherly LH. Deletions and translocations of the reduced folate carrier gene are associate with profound loss of gene expression in methotrexate resistant K562 human erythroleukemia cells. Biochem Pharmacol, in press. Shah SJ, Taub JW, Witt TL, Pollock BH, Ding BC, Moore D.S, Amylon M, Pullen J, Ravindranath Y, and Matherly LH. Relationship of p15 and p16 Gene Alterations to Elevated Dihydrofolate Reductase in Childhood Acute Lymphoblastic Leukemia. Br J Hematol., in press. Whetstine JR and Matherly LH. The Basal Promoters for the Human Reduced Folate Carrier Gene Are Regulated by a GC-Box and a CRE/AP1-Like Element: Basis for Tissue Specific Gene Expression. J Biol Chem, in press. Ding BC, Whetstine JR, Witt TL, Schuetz JD and Matherly LH. Repression of Human Reduced Folate Carrier Gene Expression by Wild Type p53. J Biol Chem, in press. Gey Y, Konrad M, Matherly LH and Taub JW. Transcriptional regulation of the human cystathionine ?-synthase-1B Basal Promoter: Synergistic transactivation by NF-Y and SP1/SP3. Biochem J, in press. Kessel D, Luo Y, Mathieu P and Reiners Jr JJ. Determinants of the apoptotic response to lysosomal photodamage. Photochem. Photobiol 71:196-200, 2000. Reiners Jr JJ, Mathieu P, Okafor, C, Putt DA and Lash LH. Depletion of cellular glutathione by conditions used for the passaging of adherent cultured cells. Toxicol Lett 115:153-163, 2000. Guo M and Reiners Jr JJ. Phorbol ester-induced production of cytostatic factors by normal and Ha-ras transformed human breast cell lines. Carcinogenesis 21:1303-1312, 2000. Guo M, Joiakim A and Reiners Jr JJ. Phosphatidylinositol 3-kinase inhibitor LY294002 is an antagonist of the aryl hydrocarbon receptor. Biochem Pharmacol 60:635-642, 2000. McCabe Jr MJ, Singh KP, Reddy SA, Chelladurai B, Pounds JG, Reiners Jr JJ and States JC. Sensitivity of myelomonocytic leukemia cells to arsenite-induced cell cycle disruption, apoptosis and enhanced differentiation is depednent on the inter-relationship between arsenic concentration, duration of treatment and cell cycle phase. J Pharmacol Exp Therapeut 295:724-733, 2000. Kessel D, Caruso J and Reiners Jr JJ. Interactions between ursodeoxycholic acid and photodynamic therapy. Cancer Res 60: 6985-6988, 2001. Caruso JA, Reiners Jr JJ, Emond J, Shultz T, Tainsky MA and Batist G. Genetic alteration of chromosome 8 is a common feature of human mammary epithelial cell lines transformed in vitro with benzo[a]pyrene. Mutation Res 473:85-99, 2001. Guo M, Joiakim A, Dudley DT and Reiners Jr JJ. Suppression of TCDD-mediated CYP1A1 and CYP1B1 Induction by 12-0-tetradecanoylphorbol-13-acetate: Role of transforming growth factor beta and mitogen-activated protein kinases. Biochem Pharmacol tentitively accepted 2/6/01 pending editorial revision. States JC, Reiners Jr JJ, Pounds JG, Kaplan DJ, Mathieu P, Sowder HG, Lumetta VJ, McNeely SC, McCabe MJ. P53 expression prevents arsenite induced mitotic arrest associated apoptosis. submitted to Cancer Research on 12/24/2000. Schubiner H, Tzelepis A, Millberger F, Lockhart N, Kruger M, Kelley B and Schoener EP. Prevalence of attention deficit hyperactivity and conduct disorder among substance abusers. J Clin Psychiatry, 61:244-251, 2000. Niedbala RS, Kardos K, Waga J, Fritsch D, Yeager L, Wiscarson D, Davis AE, Doddammane S and Schoener, EP. Analytical Toxicol, in press. Moin K, Demchick L, Mai J, Duessing J, Peters J, Sloane BF. Observing proteases in living cells. In, Cellular peptidases in immune functions and diseases (2): 391-401. 2000 Sameni M, Moin K and Sloane BF. Imaging proteolysis by living human breast cancer cells. Neoplasia, 2: 406-504. 2000 Yan S-Q, Berquin IM, Troen BR and Sloane BF. Transcription of human cathepsin B is mediated by Sp1 and Ets family factors in glioma. DNA Cell Biol 19: 79-91, 2000. Mai J, Finley R, Waisman DM and Sloane BF. Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cells. J Biol Chem 275: 12806-12812, 2000. Hulkower KI, Butler CC, Linebaugh BE, Klaus JL, Keppler D, Giranda VL and Sloane BF. Fluorescent microplate assay for cancer cell-associated cathepsin B. Eur. J Biochem 267: 1-7, 2000. Ahram M, Sameni M, Qiu R-G, Linebaugh B, Kirn D and Sloane BF. Rac1-induced endocytosis is associated with intracellular proteolysis during migration through a 3-dimensional matrix. Exptl. Cell Res. 260: 292-303, 2000. Sameni M, Moin K and Sloane BF. Imaging proteolysis by living human breast cancer cells. Neoplasia 2: in press, 2000. Fernandez PL, Farre X, Nadal A, Fernandez E, Peiro N, Sloane BF, Shi G-P, Chapman HA, Campo E and Cardesa A. Expression of cathepsins B and S in the progression of prostate carcinoma. Int J Cancer, in press. Sameni M, Dosescu J and Sloane BF. Imaging proteolysis by living human glioma cells. Biol. Chem., in press. Premzl A, Puizdar V, Bergant VZ, Lah T, Katunuma N, Sloane BF, Turk V and Kos J. Invasion of ras-transformed breast epithelial cells depends on proteolytic activity of cysteine and aspartic proteinases. Biol Chem, in press. Terlecky SR and Fransen M. How peroxisomes arise. Traffic, 1:465-473, 2000. Terlecky SR, Legakis JE, Hueni SE, and Subramani S. (2001) Quantitative analysis of peroxisomal protein import in vitro. Experimental Cell Research, 263:98-106. [Cover illustration] Legakis JE. and Terlecky SR. Peroxisome targeting signal 2 protein import in mammalian cells. Traffic, in press. Legakis JE, Koepke JI, and Terlecky SR. Peroxisome biogenesis in aging human fibroblasts. Manuscript in preparation. Tisdale EJ. Rab2 requires PKCi/l to recruit b-COP for vesicle formation. Traffic, 1:702-712,2000. Tisdale EJ. Glyceraldehyde-3-Phosphate Dehydrogenase is required for vesicular transport in the early secretory pathway.J Biol Chem 276:2480-2486,2001. Mahata SK, Mahata M, Wakade AR and O’Conner DT. Primary structure and function of the catecholamine release inhibitory peptide catestatin (Chromogranin A34-364): Identification of amino acidresidues crucial for activity. Molecular Endocrinology, 14: 1525-1535, 2000. Ohta T, Wakade AR, Nakazato Y. Ito, S. Ca2+ -dependent K+ current and exocytosis in response to caffeine and muscranie in voltage – clamped adrenal chromaffin cells. Journal of Neurochemistry, in press. Wakade AR, Wakade T and Przywara D. Intracellular, nonreceptor mediated signaling by adenosine: Induction and prevention of neuronal apoptosis. Progress in Neurobiology, in press. Fang M, Majumder A, Tsai, K-J and Wu, H-Y. ppGpp dependent leuO expression in bacteria under stress. Biochem. Biophy. Res. Commun. 276, 64-70, 2000. Chen C-C, Fang M, Majumder A and Wu H-Y. A 72 base pair AT-rich DNA sequence element functions as a bacterial gene silencer. J. Biol. Chem. 276, 2001. in press. Books, Chapters and Reviews Jena, BP. AFM in the study of membrane fusion and exocytosis. In: Methods in Cell Biology, Academic Press, in press. Lash, LH. Role of glutathione in the metabolism, transport and toxicity of metals. In: The Molecular Biology and Toxicology of Metals, (RK Zalups and DJ Koropatnick, eds.), Taylor & Francis, London, pp 382-413, 2000. Matherly LH. Molecular correlates of folate and antifolate membrane transport. In: Progress in nucleic acid research and molecular biology. K. Moldave, ed., Harcourt/Academic Press, San Diego, in press. Mai J, Waisman DM and Sloane BF. Cell surface complex of cathepsin B/annexin II tetramer in malignant progression. Biophys Biochim Acta 1477: 215-230, 2000. Shridhar R, Sloane BF and Keppler D. Inhibitors of papain-like cysteine peptidases in cancer. Handbook Exptl Pharmacol 140: 301-328, 2000. Koblinski JE, Ahram M. and Sloane BF. Unraveling the roles of proteases in cancer. Clin Chim Acta 291: 113-135, 2000. Moin K, Demchik LL, Mai J, Deussing J, Peters C. and Sloane BF. Observing proteases in living cells. Adv Exp Med Biol 477: 391-401, 2000.
Abstracts Artalejo CR, Elhamdani A and Palfrey HC. Rapid and slow endocytosis in calf chromaffin cells are mechanistically distinct and occur in response to different stimulant patterns. 44th Biophysical Society Annual Meeting. New Orleans, Louisiana, February 12-16, 2000. Elhamdani A Brown ME, Palfrey HC and Artalejo CR. Enhancement of the secretory cycle by glucocorticoid differentiation of PC12 cells: characteristics of rapid exocytosis and endocytosis. 44th Biophysical Society Annual Meeting. New Orleans, Louisiana, February 12-16, 2000. Lash LH, Putt DA, Matherly LH. Cloning and expression of rat kidney mitochondrial dicarboxylate carrier exhibiting glutathione transport activity. Toxicol Sci 54 (1-S):26, 2000. Zalups RK, Putt DA, Horky III SJ, Lash LH. Mitochondrial function in rat kidney after compensatory hypertrophy. Toxicol Sci 54 (1-S):407, 2000.
Lash LH, Putt DA, Matherly LH. Function of cloned and expressed rat kidney mitochondrial dicarboxylate carrier in glutathione transport. FASEB J 14:A1568, 2000. Lash LH, Putt DA, Matherly LH. Kinetics and specificity of cloned and expressed rat kidney mitochondrial dicarboxylate carrier exhibiting glutathione transport. J Am Soc Nephrol 11:44A-45A, 2000. Putt DA, Hueni SE, Cao W, Kulidjian S, Horwitz JP, Lash LH. Cellular energetics and glutathione transport and metabolism in NRK-52E cells. Toxicol Sci, in press. Lash LH, Hueni SE, Putt DA. Time and concentration dependence of S-(1,2-dichlorovinyl)-L-cysteine-induced apoptosis and necrosis in human proximal tubular cells. Toxicol Sci, in press. Putt DA, Hueni SE, Cao W, Kulidjian S, Horwitz JP, Lash LH. Mitochondrial function and glutathione transport and metabolism in NRK-52E cells. FASEB J, in press. Lash LH, Hueni SE, Putt DA. Patterns of S-(1,2-dichlorovinyl)-L-cysteine-induced apoptosis and necrosis in human proximal tubular cells. FASEB J, in press. Ding BC, Whetstine J, Matherly LH. Inhibition of human reduced folate carrier gene expression by wild type p53. Abstracts, American association for Cancer Research, 41: 5, 2000. Whetstine J, Matherly LH. Characterization of the basal transcriptional regions for the human reduced folate carrier promoters, Abstracts, American Association for Cancer Research, 41: 105, 2000. Ge Y, Huang X, Stout ML, Ravindranath Y, Matherly LH, Taub JW. Increased cytarabine phosphorylation and drug activity in cystathionine beta synthase transfected CCRF-CEM cells is associated with posttranscriptional activation of deoxycytidine kinase. Abstract, American Asssociation for Cancer Research 41: 803, 2000. Gifford AJ, Whetstine JR, Bark KS, Kulkarni JS, Taub JW, Haber M, Norris MD, Matherly LH. Mutations in the reduced folate carrier gene (RFC) in childhood acute lymphoblastic leukemia (ALL). Abstract, American Association for Cancer Research 41: 758, 2000. Lash LH, Putt DA, Matherly LH. Cloning and expression of rat kidney mitochondrial dicarboxylate carrier exhibiting glutathionine transport activity. Toxicol Sci, 54(1-S), 26, 2000. Lash LH, Putt DA, Matherly LH. Function of cloned and expressed rat kidney mitochondrial dicarboxylate carrier in glutathione transport. FASEB J 14: A1568, 2000. Lash LH, Putt DA, and Matherly LH. Kinetics and specificity of cloned and expressed rat kidney mitochondrial dicarboxylate carrier exhibiting glutathione transport. J Am Soc Neurol. 44A-45A (2000). Cummings B, Angeles R, McCauley R and Lash L. Role of the voltage-dependent anion channels in glutathione transport into yeast mitochondria. Biochem Biophys Res Comm 276: 940-944, 2000. Schoener EP, Dodammane S, Kardos S and Niedbala RS. Detection of abused drugs in oral fluid.. College on Problems of Drug Dependence. Puerto Rico, June, 2000. Tisdale, EJ.Glyceraldehyde-3-Phosphate dehydrogenase is required for transport in the early secretory pathway.Mol. Biol. Cell, S11:208a,2000. A 72 base pair AT-rich DNA sequence element functions as a bacterial gene silencer. Wu, H.-Y., Chen, C.-C., Fang, M., and Majumder A. The Keystone symposium, Bacterial Chromosome, New Mexico, February 7-13, 2001. |
2000
Report to Investors: The Quest to Improve Women's Health Gifts from Faculty, Staff, Friends and Corporations 2000/2001 Alumni Annual Telefund Volunteers 2000 New Endowed Funds at the School of Medicine Bibliographies: Barbara Ann Karmanos Cancer Institute Biochemistry and Molecular Biology Center for Healthcare Effectiveness Research Center for Molecular Medicine and Genetics Physical Medicine and Rehabilitation |
