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Anatomy and Cell Biology

Chair: Linda Hazlett, PhD
8374 Scott Hall
(313) 577-1061

Articles
Adler JE and Walker PD. Cyclic amp regulates substance p expression in developing and mature spinal sensory neurons. J Neurosci Res, 59:624‑631, 2000.

Basura GJ and Walker PD. Serotonin 2a and 2c receptor biosynthesis in the rodent striatum during postnatal development: mRNA expression and functional linkage to neuropeptide gene regulation. Synapse, 38:216‑225, 2000.

Basura GJ and Walker PD. Stimulated serotonin release from hyperinnervated terminals subsequent to neonatal dopamine depletion regulates striatal tachykinin, but not enkephalin gene expression. Mol Brain Res, 81:80‑91, 2000.

Berkowitz BA and Zhang W. Significant reduction of the panretinal oxygenation response after 28% supplemental oxygen recovery in experimental rop. Invest Ophthalmol Vis Sci, 41:1925-31, 2000.

Chen L and Hazlett LD. Heparan sulfate is required for p. aeruginosa adherence to the basement membrane of the wounded mouse cornea. Curr Eye Res, 20:260-267, 2000.

Danjo Y, Hazlett LD, and Gipson IK. Strain-dependent phenotype in muc 1 null mice. Invest Ophthalmol Vis Sci, 41:4080-4084, 2000.

Dore‑Duffy P, Owen C, Balabanov S, Murphy S and Rafols JA. Pericyte response to traumatic brain injury (tbi): elongation and migration from the microvascular wall. Microvascular Res, 60:55‑69, 2000

Frank RN, Puklin JE, Stock C, Canter LA. Race, iris color, and age-related macular degeneration. Trans Amer Ophthalmol Soc, 98:109-118, 2000.

Hannigan JH and Armant DR. Alcohol in pregnancy and neonatal outcome. Seminars in Neonatology, 5:243-254, 2000.

Hazlett LD, McClellan SA, Kwon B and Barrett R. Increased severity of p. aeruginosa corneal infection in strains of mice designated as th1 vs th2 responsive. Invest Ophthalmol Vis Sci, 41:805-810, 2000.

Henry DN, Frank RN, Hootman SR, Rood SE, Heilig CW, Busik JV. Glucose-specific regulation of aldose reductase in human retinal pigment epithelial cells in vitro. Invest Ophthalmol Vis Sci, 41:1554-1560, 2000.

Ikonomov O, Petrov T, Sogen K, Shisheva A, Manji, HK Lithium treatment in ovo: effects on embryonic heart rate, natural death of ciliary ganglion neurons, and brain expression of a highly evolutionary conserved chicken homologue of human mpg8/eto. Dev Brain Res, 123:13-24, 2000.

Ireland ME, Wallace P, Sandilands A, Poosch MS, Kasper M, Graw J, Liu A, Maisel H, Prescott A, Goebel D and Quinlin RA. Up-regulation of novel intermediate filament proteins in primary fiber cells: an indicator of all vertebrate lens fiber differentiation? Anatomical Rec, 258: 25-33, 2000.

Ireland ME and Mrock LK. Differentiation of chick lens epithelial cells: involvement of the epidermal growth factor receptor and endogenous ligand. Invest Ophthalmol Vis Sci, 41:183-190, 2000.

Jiang H, Duchala C, Awatramani R, Shumas S, Carlock L, Kamholz J, Garbern J, Scherer S, Shy M, Macklin W. Plp mrna stability is regulated by axonal contact in the rodent pns. J Neurobiol, 44:7-19, 2000.

Johnson RM, Buck S, Chiu C-H, Gage DA, Shen T-L, Hendricks AG, Gumucio DL, and Goodman M. Humans and old world monkeys have similar patterns of fetal globin expression. J Exp Zoology, 288:318-326, 2000.

Kernacki KA, Barrett RP, McClellan SM, and Hazlett LD. Aging and pmn response to p. aeruginosa infection. Invest Ophthalmol Vis Sci, 41:3019-3025, 2000.

Kernacki KA, Barrett R, Hobden J and Hazlett LD. Mip-2 is a mediator of pmn influx in ocular bacterial infection. J Immunol, 164:1037-1045, 2000.

Kilburn B, Wang J, Duniec-Dmuchkowski ZM, Leach RE, Romero R and Armant DR. Extracellular matrix composition and hypoxia regulate the expression of hla-g and integrins in a human trophoblast cell line. Biology of Reproduction, 62:739-747, 2000.

Lin L, Daneshvar C, and Kurpakus-Wheater M. Evidence for differential signaling in human conjunctival epithelium adherent to laminin isoforms. Exp Eye Res, 70:537-546, 2000.

Lin S-H, Vincent A, Shaw T, Maynard K I and Maiese K. Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death. J Cereb Blood Flow Metab, 20(9):1380-1391, 2000.

Maiese K and Vincent AM. Critical temporal modulation of neuronal programmed cell injury. Cell Mol Neurobiol, 20:383-400, 2000.

Maiese K and Vincent AM. Membrane asymmetry and dna degradation: functionally distinct determinants of neuronal programmed cell death. J Neurosci Res (Rapid Publication), 55(4):472-485, 2000.

Maiese K, Vincent AM, Lin S-H, and Shaw T. Group i and group iii metabotropic glutamate receptor subtypes provide enhanced neuroprotection. J Neurosci Res, 62(2):257-272, 2000.

Miyamoto MM, Porter CA, and Goodman M. cMyc gene sequence and the phylogeny of bats and other eutherian mammals. Syst Biol, 49:501-514, 2000.

Pan Z-H. Differential expression of high- and two types of low-voltage-activated calcium currents in rod and cone bipolar cells of the rat retina. J Neurophysiol, 83:513-527, 2000.

Pan Z-H, Zhang X, and Lipton SA. Redox modulation of recombinant human gaba_A receptors. Neuroscience, 98:333-338, 2000.

Pan Z-H, Zhang D, Zhang X, and Lipton SA. Evidence for co-assembly of mutant gaba_C D1 with gaba_A (2S, glycine "1 and glycine "2 receptor subunits in vitro. Euro J Neurosci, 12:3137-3145, 2000.

Pan Z-H. and Hu H-J. Voltage-dependent na⁺ currents in mammalian retinal cone bipolar cells. J Neurophysiol, 84:2564-2571, 2000.

Petrov T, Page AB, Owen S, Rafols JA. Expression of the inducible nitric oxide synthase in distinct cellular types after traumatic brain injury: an in situ hybridization and immunocytochemical study. Acta Neuropathol, 100:196-204, 2000.

Pillar CM, Hazlett LD and Hobden JA. The role of pseudomonas aeruginosa alkaline protease in corneal infections. Curr Eye Res, 21:730-739, 2000.

Rudner XL, Kernacki KA, Barrett RP, and Hazlett LD. Prolonged elevation of Il-1 in pseudomonas aeruginosa ocular infection regulates mip-2 production, pmn persistence and corneal perforation. J Immunol, 164:6576-6582, 2000.

Saluja I, Granneman J, Skoff RP. PPAR delta agonists stimulate oligodendrocyte differentiation. Glia, 33, 2001.

Sun H, Crossland WJ. Quantitative assessment of localization and colocalization of glutamate, aspartate, glycine, and GABA immunoreactivity in the chick retina. Anatomical Record, 260:158-179, 2000.

Vijesurier R, Carlock L, Blumenthal RM, and Dunbar JC. Role and mechanism of action of c. pvull, a regulatory protin conserved among restriction-modification systems. J Bacteriology, 182:477-487, 2000.

Vincent AM and Maiese K. The metabotropic glutamate system promotes neuronal survival through distinct pathways of programmed cell death. Exp Neurol, 166(1):65-82, 2000.

Waldorf RL, Lande MA and Schneider AK. Stability of labelled rat elastic aortic tissue with age and pregnancy. Arch Path, 82:46-49, 2000.

Walker PD, Andrade R, Quinn JP, and Bannon MJ. Real time analysis of preprotachykinin promoter activity in single cortical neurons. J Neurochem, 75:882‑885, 2000.

Wang J, Mayernik L, Schultz JF and Armant DR. Acceleration of trophoblast differentiation by heparin-binding egf-like growth factor is dependent on the stage-specific activation of calcium influx by erbb receptors in developing mouse blastocysts. Development, 127:33-44, 2000.

Wu W, Schmidt TR, Goodman M, and Grossman LI. Molecular evolution of cytochrome c oxidase subunit I in primates: is there a co-evolution between mitochondrial and nuclear genomes? J Mol Evol, 17:294-304, 2000.

Zhou S-Y and Goshgarian HG. 5-Hydroxytrypophan-induced respiratory recovery following cervical spinal cord hemisection in rats. J Appl Physiol, 89:1528-1536, 2000.

Armant DR, Wang J and Liu Z. Intracellular signaling in the developing blastocyst as a consequence of the maternal-embryonic dialogue. Seminars in Reproductive Medicine (in press).

Bagchi M, Katar M, and Maisel H. A heat shock transcription factor like protein in the nuclear matrix compartment of the tissue cultured mammalian lens epithelial cell. J Cell Biochem (in press).

Campbell BM and Walker PD. Striatal preprotachykin in mrna levels are regulated by stimulatory agents and dopamine d1 receptor manipulation in rodent organotypic slice cultures. Brain Res (in press).

Campbell BM and Walker PD. MK‑801 prevents dopamine d1 but not serotonin 2a stimulation of striatal preprotachykin in mrna expression. NeuroReport (in press).

Chen L and Hazlett LD. Human corneal epithelial extracellular matrix perlecan serves as a site for p. aeruginosa binding. Curr Eye Res (in press).

Esco MA, Wang Z, and Kurpakus-Wheater M. Potential role for laminin-5 in hypoxia-mediated apoptosis of human corneal epithelial cells. J Cell Sci (in press).

Goebel DJ and Poosch MS. Transient down regulation of nmda receptor gene expression in the rat retina following nmda-induced neurotoxicity is attenuated in the presence of the non-competitive nmda receptor antagonist mk-801. Experimental Eye Res (in press).

Goodman M. Molecular anthropology. McGraw Hill Encyclopedia of Science and Technology (in press).

Grossman LI, Schmidt TR, Wildman DE, and Goodman M. Molecular evolution of aerobic energy metabolism in primates. Mol Phylogenet and Evol (in press).

Ito Y, and Berkowitz BA. MR studies of retinal oxygenation. Vision Res (in press).

Lin S-H and Maiese K. The metabotropic glutamate system protects against ischemic free radical programmed cell death in rat brain endothelial cells. J Cereb Blood Flow Metab (in press).

Lin S-H and Maiese K. Group i metabotropic receptors prevent endothelial programmed cell death independent from map kinase p38 activation in rat. Neurosci Lett (in press).

Lin S-H, Walraven T, Chong ZZ and Maiese K. Nicotinamide: a nutritional supplement that provides protection against neuronal and vascular injury. J Med Food (in press).

Maiese K. The dynamics of cellular injury: transformation into neuronal and vascular protection. Histology and Histopathology (in press).

Nantwi KD and Goshgarian HG. Alkylxanthine-induced recovery of respiratory function following cervical spinal cord injury in adult rats. Exp Neurol (in press).

Page SL and Goodman M. Catarrhine phylogeny: noncoding dna evidence for a diphyletic origin of the mangabeys and for a human-chimpanzee clade. Mol Phylogenet and Evol (in press).

Pan, Z.-H. Voltage-gated ca²⁺ channels and gaba receptors revealed at presynaptic terminals of mammalian retinal bipolar cells. Visual Neurosci (in press).

Petrov T, Rafols JA. Coordinated expression of endothelin and nitric oxide in cortical blood vessels following traumatic brain injury. Neurol Res (in press).

Petrov T and Rafols JA. Acute alterations of endothelin‑1 and inos expression and control of the brain microcirculation after head trauma. Neurological Research, 23 (in press).

Phillis JW and Goshgarian HG. Adenosine and neurotrauma: therapeutic perspectives. Neurol Res (in press).

Pourcho RG. Quin P, Tai Q and Goebel DJ. Cellular and subcellular distribution of nmda receptor subunit NR2B in the retina. J Comp Neurology (in press).

Qin P and Pourcho RG. Immunocytochemical localization of kainate-selective glutamate receptor subunits glur5, glur6, and glur7 in the cat retina. Brain Research (in press).

Schmidt TR, Wu W, Goodman M, and Grossman LI. Evolution of nuclear and mitochondrial encoded subunit interaction in cytochrome c oxidase. Mol Biol Evol (in press).

Shuichen Z, Leske DA, Lanier WL, Berkowitz BA, Holmes JM. Preretinal neovascularization in the neonatal rat associated with acetazolamide-induced systemic acidosis. Invest Ophthalmol Vis Sci (in press).

Skoff RP, Bessert DA, Barks JDE, Song D, Cerghet M, Silverstein FS. Hypoxic-ischemic injury results in acute disruption of myelin gene expression and death of oligodendroglial precursors in neonatal mice. Intl J Devel Neurosci (in press).

Skoff RP TUNEL. Encyclopedia of Molecular Medicine (in press).

Sugiura N, Patel RG, Corriveau RA. N-methyl-d-aspartate receptors regulate a group of transiently expressed genes in the developing brain. Journal of Biological Chemistry (in press).

Wheeler D, Hope R, Cooper SJB, Dolman G, Webb G, Gooley AA, Goodman M, and Holland RAB. An orphaned mammalian $-globin gene of ancient evolutionary origin. Proc Natl Acad Sci (in press).

Zhang D, Pan Z-H., Awobuluyi M, and Lipton SA. Structure and function of gaba_C receptors: a comparison of native versus recombinant receptors. Trends Pharmacol Sci (in press).

Books, Chapters and Reviews
Frank RN. Etiologic mechanisms in diabetic retinopathy. In: "Retina" 3d Edition (SJ Ryan, TE Ogden, AP Schachat, CP Wilkinson, D Hinton, eds.), Harcourt-Mosby, St. Louis, pp. 1259-1294, 2000.

Maiese K. Brain herniation. In: Neurobase, 6th ed, (S Gilman, GW Goldstein, and SG Waxman, eds.), Arbor Publishing Corp, La Jolla, CA, 2000.

Maiese K, Lin S-H, and Vincent AM. Dual pathways of free radical injury in vascular endothelial cells: Loss of nuclear dna integrity and membrane asymmetry during enhanced cysteine protease activity. In: Ischemic Blood Flow in the Brain, Keio University Symposia for Life Science and Medicine, Vol 6, (Y Fukuuchi, M Tomita and A Koto, eds.), 108-199, 2000.

Maiese K. Persistent vegetative state. In: Neurobase, 6th ed, (S Gilman, GW Goldstein and SG Waxman, eds.), Arbor Publishing Corp., La Jolla, CA, 2000.

Maiese K. Metabolic coma. In: Neurobase, 6th ed, (S Gilman, G Goldstein, and SG Waxman, eds.), Arbor Publishing Corp., La Jolla, CA, 2000.

Maiese K. Sequelae of cardiac arrest. In: Neurobase, 6th ed, (S Gilman, GW Goldstein and SG Waxman, eds.), Arbor Publishing Corp., La Jolla, CA, 2000.

Maiese K. Hypoxic-ischemic encephalopathy. In: Neurobase, 6th ed, (S Gilman, GW Goldstein and SG Waxman, eds.), Arbor Publishing Corp., La Jolla, CA, 2000.

Maiese K. The quarterly review of biology, SUNY. Cerebral ischemia: molecular and cellular pathophysiology, (W Walz, ed.), 75(3): 364-365, 2000.

Maiese K. The quarterly review of biology, SUNY. Neuronal degeneration and regeneration: from basic mechanisms to prospects for therapy, (FW Van Leeuwen, A Salehi, R J Giger, AJG D Holtmaat, and J Verhaagen, eds.), 75(3): 350-351, 2000.

White BC, Sullivan JM, DeGracia DJ, O'Neil BJ, Neumar RW, Grossman LI, Rafols JA, Krause GS. Brain ischemia and reperfusion: molecular mechanisms of neuronal injury. J Neurol Sci, 179:1‑33, 2000.

Armant DR. Genes and development. In: prenatal diagnosis: genetics, reproductive risks, testing and management, (MI Evans, ed.), McGraw-Hill (in press).

Frank RN. Role of vegf and other mediators in the pathogenesis of diabetic retinopathy. Canad J Diabetes Care (in press).

Goshgarian HG. The anatomy and function of the spinal cord. In: Spinal Cord Medicine, (V Lin, ed.), Demos Publishing Company, New York (in press).

Kurpakus-Wheater M, Kernacki KA and Hazlett LD. How the window stays clear. In: Histochemistry and Cytochemistry (in press).

Maiese K. Brain herniation. In: Neurobase, 7th ed. (S Gilman, GW Goldstein and SG Waxman, eds.), Arbor Publishing Corp (in press).

Maiese K. Persistent vegetative state. In: Neurobase, 7th ed, (S Gilman, GW Goldstein and SG Waxman, eds.), Arbor Publishing Corp (in press).

Maiese K. Metabolic coma. In: Neurobase, 7th ed., (S Gilman, GW Goldstein and SG Waxman, eds.), Arbor Publishing Corp (in press).

Maiese K. Sequelae of cardiac arrest. In: Neurobase, 7th ed, (S Gilman, GW Goldstein and SG Waxman, eds.), Arbor Publishing Corp (in press).

Maiese K. Hypoxic-ischemic encephalopathy. In: Neurobase, 7th ed, (S Gilman, GW Goldstein and SG Waxman, eds.), Arbor Publishing Corp (in press).

Maiese K and Caronna JJ. Coma. In: The high risk patient: management of the critically ill, (ED Sivak, T Higgins and A Seiver, eds.), Philadelphia: Lea and Febiger (in press).

Maiese K and Caronna JJ. Evaluating the outcome of ischemic cerebral injury. In: Principles and practice of neurocritical care, (DF Hanley, ed.), Baltimore: Williams and Wilkins (in press).

Maiese K. Molecular mechanisms of no induced vascular injury. Thrombosis and Vascular Biology Newsletter, Health Science Communications (in press).

Maiese K and Ahmad I. Cerebral vascular disease. In: Pearls of wisdom neurology review series, 2nd edition, (M Labanowski MD, ed.), Boston Medical Publishing, Inc (in press).

Maiese K. Organic brain disease. In: Encyclopedia of the human brain, 1st edition, (VS Ramachandran, ed.), Academic Press (in press).

Miereles CM, Czelusniak J, Schneider MP, and Goodman M. Evolutionary history of the duplicated gamma hemoglobin genes in new world monkeys (primates, atelinae). In: a primatologia no brasil, vol. 7 (C Alonso and A Langguth, eds.), Brazilian Society of Primatology, Jaao Pessoa, Paraiba, Brazil (in press).

Abstracts, Letters to the Editor and Articles in Non-Refereed Journals
Bagchi M, Katar M, and Maisel H. Constitutive and inducible heat shock protein-70 in adult and fetal lenses. Invest Ophth Visual Sci, 41:S584, 2000.

Barrow D, McDermott M, Eliott D, Frank R. Corneal epithelial defects after pars plan a vitrectomy. Invest Ophthalmol Vis Sci, 41:S912, 2000.

Berkowitz BA, Zhang W. 28% supplemental oxygen recovery (SOR) and acetazolamide treatment in the newborn rat rop model. Invest Ophth Vis Sci, 41:(4) S640-S640 Suppl, 2000.

Boucher SEM, Carlock LR, Skoff RP. PLP gene modulates neuron viability and morphology. J Neurochem 74 Suppl, S31A, 2000.

Campbell BM and Walker PD. Dopamine d1‑ and serotonin 2‑receptors synergistically regulate preprotachykinin mrna expression in the intact and dopamine‑depleted rat striatum. Soc Neurosci Abstr, 27, 2000.

Castro-Moure F, El-Bohy A, Chappell T and Goshgarian HG. Diaphragmatic motor recovery in hemisected rats following spinal cord repair using peripheral nerve transplants and an acidic fibroblastic growth factor ("fgf) suspension. In Eighth International Symposium on Neural Regeneration. Exp Neurol, 163(1):298, 2000.

Chen L and Hazlett LD. Heparan sulfate in the basement membrane of corneal epithelium serves as a receptor for p. aeruginosa binding. IOVS, 41:153, 2000.

Chong Z, Lin S-H, Zhang Y, Lisak R P, Maynard K I, and Maiese K. Nicotinamide confers ischemic neuroprotection through the modulation of a cascade of cysteine protease activity. Soc Neurosci Abstr, 26 (Part 1):773, 2000.

Corriveau RA, Sugiura N. NMDA receptor-dependent gene expression during neuronal development. Society For Neuroscience Abstracts, V26:837, 2000.

Cypher M, Latham A, Skoff R, Carlock L. Regulation of plp protein concentration by the proteasome prevents programmed cell death. J Neurochem, 74 Suppl, 2000.

Esco, M.A., McDermott, M.L., Kurpakus-Wheater, M., and Hazlett, L.D. Extracellular matrix deposited by chronically hypoxic corneal epithelium is a preferred substrate for bacterial binding. Invest. Ophthalmol. Vis. Sci., 41:S153, 2000.

Ferguson GT, Lattin CD and Goshgarian HG. Neural activation of inspiratory muscles in tetraplegics after acute and chronic theophylline. J Spinal Cord Med, 23(3):172-173, 2000.

Goebel DJ, Poosch MS, Wojtkowicz JL, Slocum NK and Winkler BS. GABA mediates neuronal cell death in the rat retina. Society for Neuroscience, 26(1):446.16, 2000.

Goshgarian HG and Nantwi KD. Theophylline-induced respiratory muscle recovery following cervical spinal cord injury. J Spinal Cord Med, 23(3):193, 2000.

Hazlett LD, Kernacki KA and Szliter EA. In vitro detection of cytokine and chemokine mrna in wounded and unwounded cornea after pseudomonas aeruginosa challenge. IOVS, 41:151, 2000.

Hu H-J and Pan Z-H. Comparison of voltage- and calcium-activated potassium currents and inward rectifier currents in rod and cone bipolar cells of rat retina. Invest Opthalmol Vis Sci, Suppl, 41:621, 2000.

Ireland ME, Shaw M and Quinlan R. Transfection of lens cells with beaded filament-gfp fusion protein constructs. Invest Ophthalmol Vis Sci, 41:S955, 2000.

Ito Y, Berkowitz B. Measuring the human retinal oxygenation response: motion-artifact free mrl. Invest Ophth Vis Sci, 41:(4) S172-S172 Suppl, 2000.

Jacobs DB, Kantor SS, Mantis S and Ireland M. Culturing lenses in hypo- and hyper glycemic glucose conditions or exposing them to oxidative insult induces a loss of lens transparency associated with decreased Glut1 gene expression. Invest Ophthalmol Vis Sci, 41:S628, 2000.

Kernacki KA and Hazlett LD. Discordant expression of mmp-9 and mmp-13 in cornea following p. aeruginosa infection. IOVS, 41:153, 2000.

Kerwin S, Cypher M, and Carlock L. Using protein engineering to examine the synthesis, processing and transport of the proteolipid proteins plp and dm20. Am Soc Neurochem, 2000.

Kilburn BA, Wang J, Leach RE, Romero R, Armant DR. The epidermal growth factor (egf) family regulates adhesive differentiation of human trophoblast cells. Journal of the Society of Gynecologic Investigation, 7 Suppl:161A, 2000.

Kurpakus-Wheater M and Chen F. Laminin-5 is a component of preserved human amniotic membrane. Invest Ophthalmol Vis Sci, 41:S456, 2000.

Li Q, Wang J, Armant DR, Bagchi MK and Bagchi IC. Calcitonin down‑regulates e‑cadherin expression in uterine epithelium during implantation. Biology of Reproduction, 62 Suppl:283, 2000.

Lin L and Kurpakus-Wheater M. Evidence for differential signaling in human conjunctival epithelium adherent to laminin isoforms. Invest Ophthalmol Vis Sci, 41:S262, 2000.

Lin S-H, Vincent A, Shaw T, Wright J, and Maiese K. Group i metabotropic glutamate receptors selectively and specifically inhibit cysteine protease activity during ischemic nitric oxide exposure. Stroke, 30 (1):281, 2000.

Lin S-H, Daffu G, Vincent A M, Miller J, Zhang Y, Benjamins J A, Maynard K I, and Maiese K. Prevention of nitric oxide-induced neuronal injury through the modulation of discrete pathways of programmed cell death. Soc Neurosci Abstr, 26 (Part 1):773, 2000.

Maiese K, Vincent A, Shaw T, and Wright J. Selective ischemic nuclear dna cleavage is dependent upon the free radical generation of caspase-3 and the specific induction of neuronal endonuclease genes. Keio University Symposia for Life Science and Medicine, 6:108, 2000.

Maisel H., Lo WK, and Bagchi M. Ezrin in the lens. Invest Ophth Vis Sci, 41:S864, 2000.

McClellan SA, Kernacki KA and Hazlett LD. Mip-2 contributes to the dysregulated pmn response in aged mice infected with p. aeruginosa. IOVS, 41:151, 2000.

Miller J, Lin S-H, Zhang Y, Chong Z, Reeves SA, and Maiese K. The tyrosine phosphatase shp2 is a primary determinant of neuronal programmed cell death. Soc Neurosci Abstr, 26 (Part 1):807, 2000.

Nantwi KD and Goshgarian HG. Correlation of serum theophylline levels and functional recovery of a hemidiaphragm paralyzed by upper cervical spinal cord hemisection in rats. J Spinal Cord Med, 23(3):204-205, 2000.

Nantwi KD and Goshgarian HG. The actions of specific adenosine receptors in recovery of respiratory function following cervical spinal cord injury in adult rats. Soc for Neurosci, 26:(2):2299, 2000.

Obrosova IG, Fathallah L, Stockert CM, Kennedy A, Frank RN, Stevens MJ. Early upregulation of vascular endothelial growth factor in diabetic rat retina: attenuation by taurine. Diabetes, 49 Suppl 1: A172, 2000.

Obrosova IG, Fathallah L, Stockert CM, Kennedy A, Stevens MJ, Frank RN. Early upregulation of vascular endothelial growth factor in the diabetic rat retina: attenuation by taurine. Diabetologia, 43 Suppl 1: A66, 2000.

Obrosova IG, Fathallah L, Kennedy A, Frank RN, Stevens MJ. Antioxidants attenuate early upregulation of vascular endothelial growth factor (VEGF) in the diabetic rat retina. Diabetes Research and Clinical Practice, 50 Suppl 1: S360, 2000.

Pan, Z.-H. Voltage-activated calcium channels and ionotropic gaba receptors at presynaptic terminals of mammalian retinal rod bipolar cells. Invest Opthalmol Vis Sci Suppl, 41:622, 2000.

Petrov T, Underwood BD, Alousi SS, Owen CR, Rafols JA. Increased synthesis of inos and eif-2a(P) parallels suppressed hypothalamic protein synthesis after traumatic brain injury (tbi). Soc Neurosi, 26:514, 2000.

Qin P and Pourcho RG. Immunocytochemical localization of kainate-selective glutamate receptor subunits in cat retina. Investigative Ophthalmology and Visual Science, 41:S1292, 2000.

Rout U, Bessert DA, Carlock L, Ghandour MS, Armant R, Skoff RP. CNS myelin protein genes are robustly expressed in many tissues including preimplantation embryos. J Neurochem, 74 Suppl, S31B, 2000.

Rudner XL, Kernacki KA, Barrett RP and Hazlett LD. Role of il-1 in mediating corneal stromal destruction after pseudomonas infection. IOVS, 41:151, 2000.

Saluja I, Granneman J, Skoff RP. Agonists for the transcription factor ppard stimulate the differentiation of oligodendrocytes in tissue culture. J Neurochem, 73 Suppl, S45D, 2000.

Shaw T, Vincent A, Lin S-H, and Maiese K. The transcription factor e2f represents a novel molecular checkpoint in post-mitotic neurons against ischemic cell cycle induction and neuronal programmed cell death. Stroke, 30 (1):344, 2000.

Shoelson B, Clermont A, Abiko T, et al. Comparison of retinal physiological responses to carbogen breathing in normal and diabetic rats. Invest Ophth Vis Sci, 41:(4) S771-S771 Suppl., 2000.

Silverstein, FS, Song D, Xu H, Barks J, Schielke G, Skoff R. Resistance to hypoxic-ischemic oligodendroglial injury in neonatal interleukin-1 converting enzyme deficient mice. Soc for Neuroscience, 26:2065, 2000.

Sosne G, Kernacki KA, Barrett R, Szliter B, Kleinman I, and Hazlett LD. Thymosin beta 4 promotes wound healing and decreases inflammation after corneal alkali burn. 5^th International Symposium on Ocular Trauma, Montreal, Quebec, Canada, July 6-9, 2000.

Sun H, Crossland WJ. Patterns of transient GABA immunoreactivity in the chick embryo retina. Society for Neuroscience Abstracts, 26:316.3, 2000.

Vincent A, Wright J, Lin S-H, and Maiese K. Free radical induction of acidic endonuclease activity is a potential regulatory therapeutic target against neuronal apoptosis. Stroke, 30 (1): 282, 2000.

Vincent AM, Lin S-H, Zhang Y, Miller J, and Maiese K. Free radical generated cysteine proteases determine independent pathways of neuronal programmed cell death. Soc Neurosci Abstr, 26 (Part 1):807, 2000.

Waldorf RL, Lande MA and Carter PK. Elastic aortic tissue turnover during pregnancy in the rat. Acta Physiol Scand, 132:77, 2000.

Wright J, Shaw T, Vincent A, and Maiese K. Trophic factor protection against ischemic neurodegeneration is mediated by the regulation of genomic dna transcription. Stroke, 30 (1): 344, 2000.

Xu H, Liu YC, Skoff R, Barks JD., Silverstein FS. Acute oligodendroglia injury in neonatal rodent brain. Pediatric Academic Societies, 57:203, 2000.

Yost R, Ahmad I, Lin S-H, Zhang Y, Miller J, and Maiese K. Metabotropic glutamate receptors: Molecular protection against endothelial cell programmed cell death. Soc Neurosci Abstr, 26 (Part 1):504, 2000.

Zhang S, Leske DA, Lanier WL, et al. Acetazolamide-induced acidosis in the neonatal rat: a new model for rop. Invest Ophth Vis Sci, 41:(4) S337-S337 Suppl, 2000.

Zhang Y, Lin S-H, Miller J, Wu R, Reeves SA. and Maiese K. Peptide growth factors invoke the activation of the tyrosine phosphatase shp2 during neuronal programmed cell death. Soc Neurosci Abstr, 26 (Part 1):781, 2000

Zhou S-Y, and Goshgarian HG. Serotonin-induced respiratory recovery in the phrenic nerve after cervical spinal cord hemisection. In Eighth International Symposium on Neural Regeneration. Exp Neurol, 163(1):296, 2000.

Zhou S-Y and Goshgarian HG. Involvement of 5ht2 receptors in respiratory recovery after cervical spinal cord hemisection. Soc for Neurosci, 26(1):510, 2000.

Goebel DJ, Poosch MS, Yu F and Kim H-R. NMDA induces caspase-3 activity in the rat retina. ARVO Abstracts, Invest Ophthalmol Vis Sci, 42(4, Suppl) (in press).

Maiese K, Lin S-H, and Vincent A. Membrane asymmetry and genomic dna cleavage employs nitric oxide induced cysteine protease activity and endonuclease gene induction. Proceedings of the First International Symposium on HO/CO (in press).

Maiese K, Lin S-H, Chong ZZ, and Walraven T. SHP2 tyrosine phosphatase is a molecular checkpoint for trophic factor protection against programmed cell death. J Cereb Blood Flow Metab (in press).

Pan Z-H, Hu H-J, Perring P, and Andrade R. Activation of t-type ca²⁺ channels triggers transmitter release in retinal bipolar cells. Invest Opthalmol Vis Sci, (42 Suppl) (in press).

Qin P, Goebel DJ and Pourcho RG. Functional labeling of kainate-selective glutamate receptors parallels the distribution of conventional kainate receptor subunits in cat retina. ARVO Abstracts, Invest Ophthalmol Vis Sci, 42(4, Suppl) (in press).

Frank RN, Grunberger G. Cancer in a patient receiving IGF-1 therapy. Diabetes Care, 23:435, 2000.

Sosne G, Chan CC, Thai K, K, Kennedy M, Szliter EA and Hazlett LD. Thymosin beta 4 promotes corneal wound healing and modulates inflammatory mediators in vivo. Exp Eye Res (in press).

2000 Report to Investors:
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The Quest to Improve Women's Health

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2000 New Endowed Funds at the School of Medicine

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Bibliographies:
Anatomy and Cell Biology

Barbara Ann Karmanos Cancer Institute

Biochemistry and Molecular Biology

Center for Healthcare Effectiveness Research