Curriculum Vitae Home Jena Lab Picture Gallery Research Program Selected Reviews  

Selected Publication (Secretion & Membrane Fusion)

  1. Jena, B.P. Secretory vesicles transiently dock and fuse at the porosome to discharge contents during cell secretion.  Cell Biol. Int. (in press).
  2. Cho, W-J., Shin, L.., Ren, G., Jena, B. P. (2009) Structure of membrane-associated neuronal SNARE complex: Implication in neurotransmitter release. [cover] J. Cell Mol. Med. (Published on-line ahead of print, September 8, 2009).
  3. Jena, B.P. (2009) Functional organization of the porosome complex and associated structures facilitating cellular secretion. [cover] Physiology (in press)
  4. Shin, L., Basi, N., Lee, J-S., Cho, W-J., Chen, Z., Abu-Hamdah, R., Oupicky, D., Jena, B. P. (2009).  Involvement of vH+-ATPase in synaptic vesicle swelling. J. Neurosci. Res. (Published Online: Jul 16 2009 2:42PM DOI: 10.1002/jnr.22180).
  5. Jena, B.P. (2009). Porosome: the secretory portal in cells. Biochemistry 48(19):4009-4018. (Published on-line ahead of print: 10.1021/bi9002698)
  6. Jena, B.P. (2009). Atomic force microscopy: contribution to the birth of NanoCellBiology. Encyclo. Analy. Chem.  [Ed. R. A. Meyers, John Wiley: Chichester. DOI: 10.1002/9780470027318.a9006. Published 15th September 2009]
  7. Jena, B. P. (2009). Atomic Force Microscopy: unraveling the fundamental principles governing secretion and membrane fusion in cells. Ultramicroscopy 109:1094-1104.
  8. Jena, B. P. (2009) Membrane Fusion: Role of SNAREs and Calcium. Prot. Pept. Res. 16:712-717.
  9. Lee, J-S., Cho, W-J., Jeftinija, K., Jeftinija, S., Jena, B. P. (2009) Porosome in astrocytes. J. Cell Mol. Med. 13:365-372.
  10. Cho, W-J, Ren, G., Lee, J-S, Jeftinija, K., Jeftinija, S., Jena, B.P. (2009) Nanoscale three-dimensional contour map of protein assembly within the astrocyte porosome complex. Cell Biol. Int. 33: 224-229.
  11. Jena, B.P. (2008) Porosome: the universal molecular machinery for cell secretion. Mol. Cells. 26:517-529..
  12. Jena, B.P. (2008). Extracellular dynamics at nm resolution in live cells. Methods in Nano Cell Biology. Methods in Cell Biology. 90:1-19. (cover illustration).
  13. Jena, B.P.  (2008). Intracellular organelle dynamics at nm resolution. Methods in Nano Cell Biology. Methods in Cell Biology. 90:20-37.
  14. Jena, B. P. (2008). Assembly and disassembly of SNAREs in membrane fusion. Methods in Nano Cell Biology. Methods in Cell Biology. 90:154-179.
  15. Jena, B.P. (2008). Understanding membrane fusion: combining experimental and simulation studies. Methods in Nano Cell Biology. Methods in Cell Biology. 90:180-195.
  16. Jena, B.P.  (2008). Nanoscale imaging and dynamics of amylin-membrane interaction and its implication in type II diabetes mellitus. Methods in Nano Cell Biology. Methods in Cell Biology. 90:264-283.
  17. Jena, B.P.  (2008) Methods in Nano Cell Biology. Methods in Cell Biology, Academic Press 90(Dec):1-505.
  18. Cook, J.D., Cho, W.J., Stemmler, T.L., Jena, B.P. (2008) Circular dichroism (CD) spectroscopy of the assembly and disassembly of SNAREs: the proteins involved in membrane fusion in cells. Chem. Phys. Lett. 462:6-9.
  19. Cho, W-J., Ren, G., Jena, B.P. (2008) EM 3D contour maps provide protein assembly at the nanoscale within the neuronal porosome complex.  J. Microscopy. 232:106-111.
  20. Potoff, J.F., Issa, Z., Manke Jr, C.W., Jena, B.P. (2008).  Ca2+-Dimethylphosphate complex formation: providing insight into Ca2+ mediated local dehydration and membrane fusion in cells. Cell Biol. Int. 32:361-366. doi:10.1016/j.cellbi.2008.03.002 (published on-line: March 20, 2008)

  21. Jena, B.P. (2007). Secretion machinery at the cell plasma membrane.  Cur. Opin. Struct. Biol.. 17:437-443

  22. Cho, W-J, Jeremic, A., Jin, H., Ren, G., Jena, B.P. (2007).  Neuronal fusion pore assembly requires membrane cholesterol.  Cell Biol. Int. 31:1301-1308.

  23. Cho, W-J, Jena, B.P. (2007).  N-ethylmaleimide-Sensitive Factor is a Right-Handed Molecular Motor. J. Biomed. Nanotechnol. 3(2):209-211.

  24. Jena, B.P. (2006) Cell Secretion Machinery:  Studies Using the AFM. Ultramicroscopy 106:663-669. (published online 4/2/06) (Cover Illustration).

  25. Jeremic, A., Cho, W-J, Jena, B.P. (2006). Cholesterol is critical to the integrity of neuronal porosome/fusion pore. Ultramicroscopy 106:674-677 (published online 4/2/06) (Cover Illustration).

  26. Abu-Hamdah, A., Cho, W.J, Hoerber, J.K.H.,, Jena, B.P. (2006) Secretory vesicles in live cells are not free-floating but tethered to filamentous structures: A study using photonic force microscopy. Ultramicroscopy 106:670-673 (published online 4/2/06)

  27. Jeremic, A., Quinn, A.S., Cho, W-J., Taatjes, D.J., Jena, B.P. (2006) Energy-Dependent Disassembly of Self-Assembled SNARE Complex: Observation at Nanometer Resolution Using Atomic Force Microscopy. J. American Chem. Soc. 128(1)L26-27, (published electronically 12/8/05).

  28. Cho, W-J., Jeremic, A., Jena, B.P. (2005). Size of Supramolecular SNARE Complex: Membrane-Directed Self-Assembly. J. American Chem. Soc. 127:10156-10157.

  29. Cho, W-J., Jeremic, A., Jena, B.P. (2005). Direct interaction between SNAP-23 and L-type calcium channel.  J. Cellular & Mol. Med. 9(2):380-386.

  30. Jeremic, A., Cho, W-J., Jena, B.P  (2005).  Involvement of water channels in synaptic vesicle swelling. Exp. Bio., Med., 230:674-680.

  31. Jena, B.P.  (2005). Molecular Machinery and Mechanisms of Cell Secretion.  Exp. Biol. Med. 230:307-319.

  32. Kelly, M.L., Abu-Hamdah, R., Cho, S.J., Ilie, A.L., Jena, B.P. (2005). Patch clamped single pancreatic zymogen granules; direct measurements of ion channel activities at the granule membrane.  Pancreatology. 5(4-5):443-449.

  33. Jena, B.P. ( 2005).  Cell Secretion and Membrane Fusion. Domest. Anim. Endocrinol. 29:145-165.

  34. Jeremic, A., Cho, W.-J., Jena, B.P. (2004). Membrane fusion: what may transpire at the atomic level. J. Biol. Phys. & Chem. 23JE04N:139-142.

  35. Won Jin Cho, Aleksandar Jeremic, Kathy T. Rognlien, Mzia G. Zhvania, Ilia Lazrishvili, Bikashvili Tamar and Bhanu P. Jena. (2004) Structure, isolation, composition and reconstitution of the neuronal fusion pore. Cell Biol. Int. 28:699-708. (Published online 25 August 2004).

  36.   Marie L. Kelly, Won Jin Cho, Aleksandar Jeremic, Rania Abu-Hamdah and Bhanu P. Jena. (2004).  Vesicle swelling regulates content expulsion during secretion. Cell Biol. Int. 28:709-716. (Published online 25 August 2004).
  37. Jena, B.P. (2004) Discovery of the Porosome: revealing the molecular mechanism of secretion and membrane fusion in cell.  J. Cell. Molec. Med. 8:1-21 (Cover Illustration).

  38. Jeremic, A., Kelly, M., Cho., J-H., Cho, S-J., Horber, J.K.H., Jena, B.P. (2004). Calcium drives fusion of SNARE-apposed bilayers. Cell Biol. Int. (published online Dec. '03). 28:19-31 (Cover Illustration).

  39. Abu-Hamdah, R., Cho, W-J., Cho, S-J., Jeremic, A., Kelly, M., Ilie, A.E., Jena, B.P. (2004). Regulation of the water channel aquaporin-1: isolation and reconstruction of the regulatory complex. Cell Biol. Int. (published online Dec. '03). 28:7-17. (Addendum)

  40. Jeremic, A., Kelly, M., Cho,  S-J., Stromer, M.H., Jena, B.P. (2003). Reconstituted Fusion Pore. Biophys. J., 85(3):2035-2043.

  41. Jena , B. P., Cho, S.-J., Jeremic, A., Stromer, M. H., Abu-Hamdah, R. (2003).  Structure and Composition of the Fusion Pore. Biophys. J. 84:1337-1343.

  42. Cho, S.-J., Kelly, M., Rognlien, K. T., Cho, J. A., Jena, B. P. (2002). Neuronal t- and v-SNAREs in opposing bilayers interact in a circular array to form conducting pores. Biophys. J. 83:2522-2527.

  43. Jena, B. P. (2003). Fusion Pore or Porosome: Structure and Dynamics.  J. Endocrinology 176:169-174.

  44. Jena, B. P. (2002).Fusion Pores in Live Cells. NIPS  17:219-222. (Cover illustration).

  45. Cho, S.-J., Satter, A.K., Jeong, E.-H., Satchi, M., Cho, J. A., Dash, S., Mayes, M. S., Stromer, M. H., Jena, B. P. (2002). Aquaporin 1 Regulates GTP-Induced Rapid Gating of Water in Secretory Vesicles. Proc. Natl. Acad. Sci. USA. 99(7):4720-4724. 

  46. Sattar, AKM, Boinpally, R., Stromer, MH., Jena, BP, (2002). Gai3 in pancreatic zymogen granule participates in vesicular fusion. J. Biochemistry. 131:815-820.

  47.  Cho, S.-J., Jeftinija, K., Glavaski, A., Jeftinija, S., Jena, B.P, Anderson, L. L., (2002). Structure and Dynamics of the Fusion Pores in Live GH-secreting Cells Revealed Using Atomic Force Microscopy. Endocrinology 143(3):1144-1148  (Cover illustration)

  48. Cho, S.-J., Quinn, A. S., Stromer, M. H., Dash S., Cho, J. A., Taatjes, D. J., Jena, B. P., (2002). Structure and dynamics of the fusion pore in live cells. Cell Biol. Int. 26(1):35-42 (Cover illustration)

  49. Cho, S.-J., Cho J. A., Jena, B. P., (2002). Number of Secretory Vesicles Remains Unchanged Following Exocytosis. Cell Biol. Int. 26(1):29-33 (Cover illustration)

  50. Schneider SW, Sritharan KC, Geibel JP, Oberleithner H, Jena BP. (1997). Surface dynamics in living acinar cells imaged by atomic force microscopy: identification of plasma membrane structures involved in exocytosis.  Proc.Natl. Acad. Sci. USA. 94(1):316-21.
  51. Jena BP. (2002). Book entitled "Atomic Force Microscopy in Cell Biology", for Methods in Cell Biology, Academic Press, 68:1-409.
  52. Jena BP, Cho S-J. (2002). AFM in the study of membrane fusion and exocytosis. Methods in Cell Biology, Academic Press 68:33-48. (Cover illustration)  
  53. Jeong E-H, Webster P, Khuong CQ, Sattar AKMA, Satchi M, Jena BP. (1998). The native membrane fusion machinary in cells Cell Biology International 22(9/10):657-70.   Animation of Membrane Fusion
  54. Sritharan KC, Quinn AS, Taatjes DJ, Jena BP. (1998). Binding contribution between synaptic vesicle membrane and plasma membrane proteins in neurons: An AFM Study.Cell Biol. Intl. 22(9/10):650-56.
  55. Schneider SW, Yano Y, Sumpio BE, Jena BP, Geibel JP, Gekle M, Oberleithner H. (1997). Rapid aldosterone-induced cell volume increase of enthothelial cells measured by the atomic force microscope. Cell Biol. Intl. 21(11):759-68.
  56. Schneider SW, Egan ME, Jena BP, Guggino WB, Oberleithner H, Geibel JP. (1999). Continuous Detection of Extracellular ATP on Living Cells Using Atomic Force Microscopy. Proc. Natl. Acad. Sci. USA. 96(21):12180-12185 .
  57. Jena BP, Geibel JP, Schneider SW. Introduction to Use of Atomic Force Microscopy and Optical Tweezers in Biology. Microscopy Research and Techniques 44(5):311, 1999.
  58. Jena BP. (1997). Atomic Force Microscope: Providing New Insights on the Structure and Function of Living Cells. Cell Biol. Intl. 21(11):683-4.
  59. Jena BP, Webster P, Geibel JP, Van den Pol AN, Sritharan KC. (1997). Localization of SH-PTP1 to synaptic vesicles: a possible role in neurotransmission. Cell Biol. Intl. 21(8):469-76.
  60. Jena BP, Schneider SW, Geibel JP, Webster P, Oberleithner H, Sritharan KC. (1997). Gi regulation of secretory vesicle swelling examined by atomic force microscopy. Proc. Natl. Acad. Sci. USA. 94(24):13317-22.
  61. Jena BP. (1997). Exocytotic fusion: total or transient? Cell Biol. Intl. 21(5):257-9.

Books:    

  1. 2001    "Atomic Force Microscopy in Cell Biology", Academic Press 68:1-409.

                          

  1. 2006   "Force Microscopy in Biology and Medicine", Wiley Press, 1-298.   

                        

  1. 2008 "Methods in Nano Cell Biology", [Dedicated in memory of George E. Palade (1912-2008), the father of modern cell biology] Academic Press/Elsevier 90:1-505.

    

Copyright (C), Bhanu P. Jena, PhD., All right reserved. 2008
Updated: 10/29/2009 by Christine Cupps (web manager for Jena-site)