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Professor and Chair John Anagli, PhD Adjunct Assoc. Prof Rodrigo Andrade, Ph.D. Professor Jacob Aranda, MD, PhD Prof. Pediatrics, Pharm Cristina Artalejo, MD, PhD Assoc. Professor Michael Bannon, PhD Professor Julie Boerner, PhD Asst Prof. KCI, Pharm Chaya Brodie, PhD Adjunct Professor Dharam Chopra, PhD Prof. IEHS, Pharm Nicholas Davis, PhD Assoc. Prof. Gregory Kapatos Professor David Kessel, PhD Professor Thomas Kocarek, PhD Assoc. Prof. IEHS, Pharm Lawrence Lash, PhD Professor Karin List, PhD Asst. Prof Larry Matherly, PhD Professor Raymond Mattingly, PhD Assoc. Prof. Roy B. (Mac) McCauley, PhD Professor Kamiar Moin, PhD Subsidy Assoc.Prof. Raymond Novak, PhD Director IEHS, Pharm John Reiners, Jr., PhD Prof., IEHS, Pharm Sandra Rempel, PhD Adjunct Assoc Prof Tiziano Scarabelli, MD.PhD Adjunct Assoc Prof. David Schneider, PhD Assoc. Prof. Eugene Schoener, PhD Professor Robert B. Silver, PhD Prof. Pharm, Physiol, Radiol. Manuel Tancer, MD Prof. Psychiatry, Pharm Stanley Terlecky, PhD Assoc. Prof. Ellen Tisdale, PhD Assoc. Prof. Arun Wakade, PhD Professor Hai-Young Wu, PhD Assoc. Prof. Akio Yamazaki, PhD Prof. Ophthal., Pharm Russell Yamazaki, PhD Assoc. Prof, Assoc. Chair
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 David R. Schneider, Ph.D. Associate Professor Department of Pharmacology, Wayne State University, School of Medicine, Scott Hall Rm 6111, 540 E. Canfield, Detroit MI 48201 Tel: (313) 577-1579 FAX (313) 577-6739 E-mail: dschneid@med.wayne.edu Research Interests. The secretion of bioactive molecules into saliva, together with the measurement of such substances and other analytes present in blood constitutes a growing field for investigation, research and clinical use. The collection of saliva, its preservation if required, and subsequent methods to qualitatively or quantitatively measure various analytes and bioactive molecules can now be achieved by several means. Patents have been obtained in the US, as well as the PTO, Europe, and selected countries in the Pacific Rim for saliva preservation. Measurement of biomolecules and substrates if properly obtained and preserved, can be performed by colormetric, flurorometric, radioisotope or luninescence methods. Studies on ways to improve the gathering of samples, to eliminate problems with mucus and/or interference, and to analyze such substances are ongoing. Research using a combination of technologies described shows substance abuse agents can be collected and quantitatively measured. By extension, research to monitor ethical agents, including antibiotics, anticoagulants, antiepileptics, and cancer agents among others is possible. Because of heightened interest, methods correlating blood glucose, circulating insulin, c-protein, and the presence of various viruses (AIDS, hepatitis A, B, & C) in a saliva sample are under consideration. Finally, preliminary studies suggest such methods and protocols would be useful for selected diagnostic testing (PAS, lead) through a saliva medium. Recent Patents 1. Schneider,
D.R. PCT Published.
“Method and apparatus for preserving human saliva for testing”. 06/99.
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