WSU Department of Pharmacology Student Journal Club W2005

PHC 7700 STUDENT JOURNAL CLUB WINTER 2006
Room 6364 Scott, Wednesday at noon Course Director: Russell Yamazaki, 6349 Scott Hall, 577-1173, ryamazak@med.wayne.edu Description: Graduate student presentations of journal articles relating to a topic Link to PDF file for Journal Club guidelines: JClubguide.pdf Click on the authors for the PubMed abstract. If your location has full-text access, you will see a button with the journal name (Example: PNAS Online). Click on the button to get to the text. You can usually also get a PDF file for printing or saving by clicking on the line that says "Reprint (PDF) version of this article". If you are accessing from off campus, you will need to use your WSU AccessID and password to authenticate your WSU affiliation to access full-text articles and proprietary databases that are licensed to the WSU Library.

PHC 7700 STUDENT JOURNAL CLUB
WINTER 2006

Room 6364 Scott, Wednesday at noon

Course Director: Russell Yamazaki, 6349 Scott Hall, 577-1173, ryamazak@med.wayne.edu

Description: Graduate student presentations of journal articles relating to a topic

Link to PDF file for Journal Club guidelines: JClubguide.pdf
Click on the authors for the PubMed abstract. If your location has full-text access, you will see a button with the journal name (Example: PNAS Online). Click on the button to get to the text. You can usually also get a PDF file for printing or saving by clicking on the line that says "Reprint (PDF) version of this article".
If you are accessing from off campus, you will need to use your WSU AccessID and password to authenticate your WSU affiliation to access full-text articles and proprietary databases that are licensed to the WSU Library.

DATE	SPEAKER, TITLE AND REFERENCES
Jan 11	Rotation reports
Jan 18	Organizational meeting
Jan 25	Kadija Abounit - Calpains and cancer Paper: Libertini SJ, Robinson BS, Dhillon NK, Glick D, George M, Dandekar S, Gregg JP, Sawai E, Mudryj M. Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype. Cancer Res. 2005 Dec 1;65(23):10700-8. Review: Franco SJ, Huttenlocher A. Regulating cell migration: calpains make the cut. J Cell Sci. 2005 Sep 1;118(Pt 17):3829-38.
Feb 1	Jonathan Wojtkowiak - Kinases and angiogenesis Paper: ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis. Mavria G, Vercoulen Y, Yeo M, Paterson H, Karasarides M, Marais R, Bird D, Marshall CJ. Cancer Cell. 2006 Jan;9(1):33-44. [Click here to go to Cancer Cell to search for the paper.] Review: Angiogenesis as a therapeutic target. Ferrara N, Kerbel RS. Nature. 2005 Dec 15;438(7070):967-74.
Feb 8	Heather McClung - Gliomal invasion mechanisms Ram R, Lorente G, Nikolich K, Urfer R, Foehr E, Nagavarapu U. Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2. J Neurooncol. 2005 DOI 10.1007/s11060-005-6874-1 Review: Demuth T, Berens ME. Molecular mechanisms of glioma cell migration and invasion. J Neurooncol. 2004 Nov;70(2):217-28
Feb 15	Qing Zhong - Cyclooxygenase, presenilins and Alzheimer's disease Paper: Qin W, Peng Y, Ksiezak-Reding H, Ho L, Stetka B, Lovati E, Pasinetti GM. Inhibition of cyclooxygenase as potential novel therapeutic strategy in N141I presenilin-2 familial Alzheimer's disease. Mol Psychiatry. 2006 Feb;11(2):172-81. Reviews: McCarthy JV. Involvement of presenilins in cell-survival signalling pathways. Biochem Soc Trans. 2005 Aug;33(Pt 4):568-72. Prasad KN, Cole WC, Prasad KC. Risk factors for Alzheimer's disease: role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment. J Am Coll Nutr. 2002 Dec;21(6):506-22.
Feb 22	Nicole Najor - Neurofibromin and cell motility Paper: Ozawa T, Araki N, Yunoue S, Tokuo H, Feng L, Patrakitkomjorn S, Hara T, Ichikawa Y, Matsumoto K, Fujii K, Saya H. The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway. J Biol Chem. 2005 Nov 25;280(47):39524-33. Review: Yamazaki D, Kurisu S, Takenawa T. Regulation of cancer cell motility through actin reorganization. Cancer Sci. 2005 Jul;96(7):379-86.
Mar 1	Eric Hales - Chromatin insulators Paper: Maya Capelson and Corces, V.G. (2005) The ubiquitin ligase dTopors directs the nuclear organization of a chromatin insulator. Mol. Cell 20, 105-116. Review: Adam G. West, et al. (2002). Insulators: many mechanisms, many functions. Genes and Development 16, 271-288.
Mar 8	Tony Cimini - Shaping the ER Paper: Voeltz GK, Prinz WA, Shibata Y, Rist JM, Rapoport TA. A Class of Membrane Proteins Shaping the Tubular Endoplasmic Reticulum. Cell 124, 573-586, February 10, 2006. Review: Ruth N. Collins. How the ER Stays in Shape. Cell. 2006 Feb 10;124(3):464-6.
Mar 15	Spring Break - no meeting
Mar 22	Chris Jedeszko - Cadherin-catenin-actin complex Papers: Yamada S, Pokutta S, Drees F, Weis WI, Nelson WJ. Deconstructing the cadherin-catenin-actin complex. Cell. 2005 Dec 2;123(5):889-901. Drees F, Pokutta S, Yamada S, Nelson WJ, Weis WI. Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell. 2005 Dec 2;123(5):903-15. Review : Gates J, Peifer M. Can 1000 reviews be wrong? Actin, alpha-Catenin, and adherens junctions. Cell. 2005 Dec 2;123(5):769-72.
Mar 29	Komal Sane - Pharmacotherapy for a sick enzyme Paper: Qiao Y, Molina H, Pandey A, Zhang J, Cole PA. Chemical rescue of a mutant enzyme in living cells. Science. 2006 Mar 3;311(5765):1293-7. Review: Cole PA, Courtney AD, Shen K, Zhang Z, Qiao Y, Lu W, Williams DM. Chemical approaches to reversible protein phosphorylation. Acc Chem Res. 2003 Jun;36(6):444-52.
Apr 5	Maggie Kilar - How to make a dopamine neuron Paper: Martinat C, Bacci JJ, Leete T, Kim J, Vanti WB, Newman AH, Cha JH, Gether U, Wang H, Abeliovich A. Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8): 2874-2879. Review: Wallen, A. & Perlmann, T. Transcriptional control of dopamine neuron development. Ann N Y Acad Sci. 2003 Jun;991:48-60.
Apr 12	Jessica Zhu - 14-3-3 and the AKT pathway Paper: Yang H, Wen YY, Zhao R, Lin YL, Fournier K, Yang HY, Qiu Y, Diaz J, Laronga C, Lee MH. DNA damage-induced protein 14-3-3 sigma inhibits protein kinase B/Akt activation and suppresses Akt-activated cancer. Cancer Res. 2006 Mar 15;66(6):3096-105. Review: Altomare DA, Testa JR. Perturbations of the AKT signaling pathway in human cancer. Oncogene. 2005 Nov 14;24(50):7455-64.
Apr 19	Irene Papanayotou - Protein quality control Paper: McClellan AJ, Scott MD, Frydman J. "Folding and Quality Control of the VHL Tumor Suppressor Proceed through Distinct Chaperone Pathways" Cell, Vol. 121 739-748 Review: McClellan AJ, Tam S, Kaganovich D, Frydman J. "Protein quality control: chaperones culling corrupt conformations" Nature Cell Biology Vol.7 August 2005
May 3	Chris Wood - Research report
May 10	Rotation reports
May 17	Jay Koepke - Research report

DATE

SPEAKER, TITLE AND REFERENCES

Jan 11

Rotation reports

Jan 18

Organizational meeting

Jan 25

Kadija Abounit - Calpains and cancer
Paper: Libertini SJ, Robinson BS, Dhillon NK, Glick D, George M, Dandekar S, Gregg JP, Sawai E, Mudryj M. Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype. Cancer Res. 2005 Dec 1;65(23):10700-8.
Review: Franco SJ, Huttenlocher A. Regulating cell migration: calpains make the cut. J Cell Sci. 2005 Sep 1;118(Pt 17):3829-38.

Feb 1

Jonathan Wojtkowiak - Kinases and angiogenesis
Paper: ERK-MAPK signaling opposes Rho-kinase to promote endothelial cell survival and sprouting during angiogenesis. Mavria G, Vercoulen Y, Yeo M, Paterson H, Karasarides M, Marais R, Bird D, Marshall CJ. Cancer Cell. 2006 Jan;9(1):33-44. [Click here to go to Cancer Cell to search for the paper.]
Review: Angiogenesis as a therapeutic target. Ferrara N, Kerbel RS. Nature. 2005 Dec 15;438(7070):967-74.

Feb 8

Heather McClung - Gliomal invasion mechanisms
Ram R, Lorente G, Nikolich K, Urfer R, Foehr E, Nagavarapu U. Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2. J Neurooncol. 2005 DOI 10.1007/s11060-005-6874-1
Review: Demuth T, Berens ME. Molecular mechanisms of glioma cell migration and invasion. J Neurooncol. 2004 Nov;70(2):217-28

Feb 15

Qing Zhong - Cyclooxygenase, presenilins and Alzheimer's disease
Paper: Qin W, Peng Y, Ksiezak-Reding H, Ho L, Stetka B, Lovati E, Pasinetti GM. Inhibition of cyclooxygenase as potential novel therapeutic strategy in N141I presenilin-2 familial Alzheimer's disease. Mol Psychiatry. 2006 Feb;11(2):172-81.
Reviews: McCarthy JV. Involvement of presenilins in cell-survival signalling pathways. Biochem Soc Trans. 2005 Aug;33(Pt 4):568-72.
Prasad KN, Cole WC, Prasad KC. Risk factors for Alzheimer's disease: role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment. J Am Coll Nutr. 2002 Dec;21(6):506-22.

Feb 22

Nicole Najor - Neurofibromin and cell motility
Paper: Ozawa T, Araki N, Yunoue S, Tokuo H, Feng L, Patrakitkomjorn S, Hara T, Ichikawa Y, Matsumoto K, Fujii K, Saya H. The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway. J Biol Chem. 2005 Nov 25;280(47):39524-33.
Review: Yamazaki D, Kurisu S, Takenawa T. Regulation of cancer cell motility through actin reorganization. Cancer Sci. 2005 Jul;96(7):379-86.

Mar 1

Eric Hales - Chromatin insulators
Paper: Maya Capelson and Corces, V.G. (2005) The ubiquitin ligase dTopors directs the nuclear organization of a chromatin insulator. Mol. Cell 20, 105-116.
Review: Adam G. West, et al. (2002). Insulators: many mechanisms, many functions. Genes and Development 16, 271-288.

Mar 8

Tony Cimini - Shaping the ER
Paper: Voeltz GK, Prinz WA, Shibata Y, Rist JM, Rapoport TA. A Class of Membrane Proteins Shaping the Tubular Endoplasmic Reticulum. Cell 124, 573-586, February 10, 2006.
Review: Ruth N. Collins. How the ER Stays in Shape. Cell. 2006 Feb 10;124(3):464-6.

Mar 15

Spring Break - no meeting

Mar 22

Chris Jedeszko - Cadherin-catenin-actin complex
Papers: Yamada S, Pokutta S, Drees F, Weis WI, Nelson WJ. Deconstructing the cadherin-catenin-actin complex. Cell. 2005 Dec 2;123(5):889-901.
Drees F, Pokutta S, Yamada S, Nelson WJ, Weis WI. Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell. 2005 Dec 2;123(5):903-15.
Review : Gates J, Peifer M. Can 1000 reviews be wrong? Actin, alpha-Catenin, and adherens junctions. Cell. 2005 Dec 2;123(5):769-72.

Mar 29

Komal Sane - Pharmacotherapy for a sick enzyme
Paper: Qiao Y, Molina H, Pandey A, Zhang J, Cole PA. Chemical rescue of a mutant enzyme in living cells. Science. 2006 Mar 3;311(5765):1293-7.
Review: Cole PA, Courtney AD, Shen K, Zhang Z, Qiao Y, Lu W, Williams DM. Chemical approaches to reversible protein phosphorylation. Acc Chem Res. 2003 Jun;36(6):444-52.

Apr 5

Maggie Kilar - How to make a dopamine neuron
Paper: Martinat C, Bacci JJ, Leete T, Kim J, Vanti WB, Newman AH, Cha JH, Gether U, Wang H, Abeliovich A. Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8): 2874-2879.
Review: Wallen, A. & Perlmann, T. Transcriptional control of dopamine neuron development. Ann N Y Acad Sci. 2003 Jun;991:48-60.

Apr 12

Jessica Zhu - 14-3-3 and the AKT pathway
Paper: Yang H, Wen YY, Zhao R, Lin YL, Fournier K, Yang HY, Qiu Y, Diaz J, Laronga C, Lee MH. DNA damage-induced protein 14-3-3 sigma inhibits protein kinase B/Akt activation and suppresses Akt-activated cancer. Cancer Res. 2006 Mar 15;66(6):3096-105.
Review: Altomare DA, Testa JR. Perturbations of the AKT signaling pathway in human cancer. Oncogene. 2005 Nov 14;24(50):7455-64.

Apr 19

Irene Papanayotou - Protein quality control

Paper: McClellan AJ, Scott MD, Frydman J. "Folding and Quality Control of the VHL Tumor Suppressor Proceed through Distinct Chaperone Pathways" Cell, Vol. 121 739-748
Review: McClellan AJ, Tam S, Kaganovich D, Frydman J. "Protein quality control: chaperones culling corrupt conformations" Nature Cell Biology Vol.7 August 2005