PHC 7700 STUDENT JOURNAL CLUB
WINTER 2001
Room 6364 Scott, 12-1 pm Wednesdays

Course Director: Dr. Stanley Terlecky   Phone: 577-3557 FAX: 577-6739
                           Email: s.r.terlecky@wayne.edu

Description: Graduate student presentations of journal articles relating to a topic

Click on the title for the PubMed abstract. If your location has full-text access, you will see a button with the journal name (Example: PNAS Online). Click on the button to get to the text. You can usually also get a PDF file for printing or saving by clicking on the line that says "Reprint (PDF) version of this article".
DATE
SPEAKER AND REFERENCES
 Feb 14  Ray Menard - Cadmium toxicity at the molecular level
Primary paper: Chrestensen CA, Starke DW, Mieyal JJ., "Acute cadmium exposure inactivates thioltransferase (Glutaredoxin), inhibits intracellular reduction of protein-glutathionyl-mixed disulfides, and initiates apoptosis." J Biol Chem. 2000 Aug 25;275(34):26556-65
Secondary papers:
Biaglow JE, Donahue J, Tuttle S, Held K, Chrestensen C, Mieyal J. "A method for measuring disulfide reduction by cultured mammalian cells: relative contributions of glutathione-dependent and glutathione-independent mechanisms." Anal Biochem. 2000 May 15;281(1):77-86.
Waalkes MP, Fox DA, States JC, Patierno SR, McCabe MJ Jr "Metals and disorders of cell accumulation: modulation of apoptosis and cell proliferation."
Toxicol Sci. 2000 Aug;56(2):255-61
 Feb 21 No session
 Feb 28 Chien-Chung Chen - Molecular basis of Niemann-Pick C disease
Primary papers: Davies JP, Chen FW, Ioannou YA "Transmembrane molecular pump activity of niemann-pick C1 protein", Science. 2000 Dec 22;290(5500):2295-8.
Naureckiene S, Sleat DE, Lackland H, Fensom A, Vanier MT, Wattiaux R, Jadot M, Lobel P.
"Identification of HE1 as the second gene of niemann-pick C disease", Science. 2000 Dec 22;290(5500):2298-301.
Mar 7
 Sreenivasa Chandana - Processing of amyloid precursor protein
Primary papers:Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC "BACE1 is the major beta-secretase for generation of Abeta peptides by neurons" Nat Neurosci 2001 Mar;4(3):233-234
Luo Y, Bolon B, Kahn S, Bennett BD, Babu-Khan S, Denis P, Fan W, Kha H, Zhang J, Gong Y, Martin L, Louis JC, Yan Q, Richards WG, Citron M, Vassar R. "Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation" Nat Neurosci. 2001 Mar;4(3):231-232.
Review paper: Kienlen-Campard P, Tasiaux B, Octave JN. "The processing and biological function of the human amyloid precursor protein (APP): lessons from different cellular models" Exp Gerontol. 2000 Sep;35(6-7):843-50
Mar 14
 Wei Cao - Regulation of cholesterol homeostasis
Primary paper: Repa JJ, Turley SD, Lobaccaro JA, Medina J, Li L, Lustig K, Shan B, Heyman RA,  Dietschy JM, Mangelsdorf DJ. "Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers." Science. 2000 Sep 1;289(5484):1524-9.
Secondary paper: Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, Hull MV, Lustig KD, Mangelsdorf DJ, Shan B. "Identification of a nuclear receptor for bile acids." Science. 1999 May 21;284(5418):1362-5.
Review paper: Kliewer SA, Lehmann JM, Willson TM. "Orphan nuclear receptors: shifting endocrinology into reverse." Science. 1999 Apr 30;284(5415):757-60. Review.
 Mar 21
 Michelle Milstein - Retroviral budding and ubiquitin
Primary paper: Schubert U, Ott DE, Chertova EN, Welker R, Tessmer U, Princiotta MF, Bennink JR,
Krausslich HG, Yewdell JW. "Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2." Proc Natl Acad Sci U S A. 2000 Nov 1;97(24):13057-62.
Secondary paper: Patnaik A, Chau V, Wills JW. "Ubiquitin is part of the retrovirus budding machinery." Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13069-74.
Mar 28
 Grant Blouse - Angiogenesis- Where does PAI-1 and the Plasminogen Activation System Fit in?
Primary papers: Stefansson S, Petitclerc E, Wong MK, McMahon GA, Brooks PC, Lawrence DA. "Stefansson S, Petitclerc E, Wong MK, McMahon GA, Brooks PC, Lawrence DA."Inhibition of Angiogenesis in vivo by Plasminogen Activator Inhibitor-1." J Biol Chem. 276, 8135-8141 (2001)
Bajou K, Noel A, Gerard RD, Masson V, Brunner N, Holst-Hansen C, Skobe M, Fusenig NE, Carmeliet P, Collen D, Foidart JM. "Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization." Nat Med. 1998 Aug;4(8):923-8.
Review: Carmeliet P, Jain RK. "Angiogenesis in cancer and other diseases." Nature. 2000 Sep 14;407(6801):249-57. 
Apr 4
 Johnathan Whetstine - Research Presentation
"The Molecular Characterization of the Human Reduced Folate Carrier in Normal Human Tissues."
Apr 11
 Ravi Shridhar - Research Presentation
"The role of Cystatin M in tumor proliferation, invasion and metastasis"
 Apr 18
 Julie Legakis - Targeting of Membrane Proteins to the Peroxisome
Papers: Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ. "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis" J Cell Biol 2000 Mar 6;148(5):931-44
Snyder WB, Koller A, Choy AJ, Subramani S, "The peroxin Pex19p interacts with multiple, integral membrane proteins at the peroxisomal membrane" J Cell Biol 2000 Jun 12;149(6):1171-8
Review: Terlecky SR, Fransen M, "How peroxisomes arise" Traffic 2000 Jun;1(6):465-73
   
   

Last update 04/03/01

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