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Each session will consist of 3 hours of lecture per week for 4 weeks and will be allotted 1 credit. Class meeting times will be arranged with the instructors. An organizational meeting for all courses will be held on Thursday, September 7th at 1:00 PM in the Pharmacology Library (6364 Scott Hall). Contact the listed instructors for course details or R. Yamazaki (ryamazak@med.wayne.edu) for general information. |
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September 11 - October 6 |
October 9 - November 3 |
November 6 - December 8 |
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Julie Boerner This course will focus on the importance of the design of effective targets to tyrosine kinase receptors. An emphasis will be placed on the role of receptor tyrosine kinases in cancer, but other diseases will all be discussed. The format of the course will involve a combination of lectures and primary literature discussions. |
“Pharmacology and Molecular Biology of Membrane Transporters”Lawrence H. Lash, Ph.D., Professor, Dept. Pharmacology, T: 313-577-0475; E-mail: l.h.lash@wayne.edu Larry H. Matherly, Ph.D., Professor, Karmanos Cancer Institute and Dept. Pharmacology, T: 313-833-0715 x2407; E-mail: matherly@karmanos.org
This minicourse will focus on the process of membrane
transport, and will emphasize biochemical mechanisms involved in the regulation
and toxicological, nutritional, and pathological significance of selected
transport pathways. The course will be a combination of lectures, which will
provide background material, and study and discussion of original literature
focused on specific transporters. |
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| "R7 family of
RGSs (regulators of G protein signaling): GTPases that really matter"
Rodrigo Andrade, Mike Bannon, Mohamad Bouhamdan We will review gene structure and alternate RNA splicing, modulation of metabotropic and ionotropic receptor signaling, binding partners and subcellular targeting, and behavioral and clinical functions of this important family of RGS proteins.
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"Basic
Introduction to LC/MS/MS"
Dr. David R. Schneider and Dr. Robert B. Silver The Basic Introduction to LC/MS/MS Mini-Course is oriented to the practical use of Liquid Chromatography (LC), Mass Spectrometry (MS) and associated analytical methods in basic and applied research and clinical/diagnostics applications. This mini-course will introduce the mass spectrometer, and will include a substantial amount of practical information about liquid chromatography and the means of separating bio-molecules of interest prior to introducing them into the MS. The course will begin with a review of the relevant chemical and physical principles, and proceed to review some of the new vistas in pharmacology, neutraceuticals, genomics, proteomics, et cetera. Students will the approach to be a marriage of basic principles and real-world applications. Additional considerations:
Planned Class Schedule: Week 1 Basic Chromatography Theory Week 2 Chromatographic Theory & Sample Preparation Week 3 MS Fundamentals – How Does It Work? Week 4 Real-world applications of LC/MS. Future Plans: It is envisioned that there will be 3 mini-courses in the entire sequence: These courses will be taught in order, 1 course each semester or period, with 4 students maximum per course, and the mini-courses must be taken in seriatim. The second mini-course is planned to include in depth treatment of chromatographic methods used to separate biomolecules via gradients, charged buffers and ionization techniques. Each student will have an opportunity to demonstrate their knowledge of practical chromatography by separating peptides of a few amino acids each. In a final session, student will bring their own sample (from their research) and carry out a separation with MS following. The third course is planned to demonstrate the ability of the LC/MS/MS to separate a mixture of biomolecules (drugs) in a mixture, using principles provided in the 1st and 2nd parts of this course sequence.
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"Proteases, Inflammation and Cancer" Bonnie Sloane (bsloane@med.wayne.edu), Dora Cavallo-Medved and Izabela Podgorski
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