Seminar Series 2009 - 2010

DATE
SPEAKER AND TITLE
COMMENT
Oct 9










MINI-SYMPOSIUM: “Telomeres and Cancer”
Angelika Burger, Ph.D., Dept. of Pharmacology & Karmanos Cancer Institute, Wayne State University
“Telomerase as a Cancer Inhibitory Target”

Ramesh Babu Batchu, Ph.D., Dept. of Surgery & Karmanos Cancer Institute, Wayne State University
"Effect of a novel telomerase inhibitor, GRN163L, on growth of Barrett’s esophageal adenocarcinoma cells in vitro and in vivo"

 
Nov 13



Q. Ping Dou, Ph.D., Prevention Program, KCI & Dept. of Pathology, Wayne State University
"Targeting Tumor Proteasome with Small Molecule Drugs"
 
Dec 11





MINI-SYMPOSIUM:
Mark Greenwald, Ph.D. and Shane Perrine, Ph.D., Dept. of Psychiatry, Substance Abuse Research Division, Wayne State University
"Stress-induced molecular pharmacology and addiction-related phenotypes in animal and human subjects"
 
Dec 21


Lan Jiang, Ph.D., Department of Biological Sciences, Oakland University
"Regulation of Biological Tube Formation"
at 12:00 pm
Jan 22



James Whisstock, Ph.D., Dept. of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia
"Structural and functional studies on perforin-like proteins"
at 2:00 pm
Feb 12








Melody Neely, Ph.D., Dept. of Immunology and Microbiology, Wayne State University
"Zebrafish model of infectious diseases"

 
Feb 26


David Kessel, Ph.D., Dept. of Pharmacology, Wayne State University
"Evidence for impairment of the endocytic pathway by photodynamic therapy"
 
Mar 12



Russell Finley, Ph.D., Center for Molecular Medicine & Genetics, Wayne State University
"Using genetic networks to study cell cycle systems in Drosophila"
 
Mar 19


Sokol Todi, Ph.D., Dept. of Neurology, Univ. of Michigan
"Deubiquitinating enzymes in neurodegeneration: Understanding the functions and regulation of ataxin-3"
 
Mar 26


Jenifer Fenton, Ph.D., Dept. of Food Science & Human Nutrition, College of Nursing, Michigan State University
"Molecular mechanisms of obesity-related cancer risk"
 
April 9


David Rosenberg, M.D., Dept. of Psychiatry, Wayne State Univ. School of Medicine
"New advances in obsessive compulsive disorder"
 
April 19





Joint Seminar of the Depts. of Chemistry and Pharmacology

Thomas Meade, Ph.D., Depts. of Chemistry, Biochemistry, Molecular Biology and Cell Biology, Neurobiology, Physiology, and Radiology, Northwestern University, Chicago, IL
"Modulating transcription in development and cancer: Targeted Cobalt-DNA conjugates for the inhibition of zinc-finger transcription factors”"
Margherial Family Conference Center at
3:00 pm
April 23


Paul Stemmer, Ph.D., Proteomics Core, Wayne State Univ. School of Medicine and Karmanos Cancer Institute
"Proteomic Analysis for Identification, Quantitation and Characterization"
 
April 30



Jeff Loeb, Ph.D., Associate Director of CMMG and Associate Professor of Neurology, Wayne State University
"A systems approach to develop novel treatments for human neuropsychiatric disorders"
 
May 7


Stanley Terlecky, Ph.D., Dept. of Pharmacology, Wayne State University
Peroxisomes, Oxidative Stress, and Cellular Aging”
 
May 14





Akio Yamazaki, Ph.D., Dept. of Ophthamalogy,Wayne State University, Kresge Eye Institute
"Rhodopsin, a receptor of G-protein-mediated signal transduction, is essential for the activation of retinal guanylate cyclase (retGC): A new model for retGC activation and its link to retinal diseases"
 
May 21





Joint Seminar of the Dept. of Pharmacology and Karmanos Cancer Institute

Tayyaba Hasan, Ph.D., Dept. of Dermatology, Harvard-MIT Health Sciences and Technology
" Photodynamic Therapy:  A Translational Bridge between Chemistry and Medicine"
Held in the Wertz Auditorium
May 28



Raymond Mattingly, Ph.D., Dept. of Pharmacology, Wayne State Univ. School of Medicine
"Prenylation inhibitors induce cell death through apoptosis or aborted autophagy"
 
June 4




Thomas Bugge, Ph.D., Chief, Proteases and Tissue Remodeling Unit, OPCB, NIH/NIDCR
"Transmembrane serine proteases and their transmembrane serine protease inhibitors: Guardians of epithelial integrity"
 
June 18


Douglas Ruden, Ph.D., Environmental Health Sciences, Wayne State University
"Epigenetic directed errors in cancer and evolution"
 
     

 

Seminar Series 2008 -2009

DATE
SPEAKER AND TITLE
COMMENT
Sept 19




Katarina Wolf, Ph.D.
Dept. of Cell Biology, Radboud Univ. Nijmegen Medical
Centre, The Netherlands
"Functional imaging of pericellular proteoysis in cancer cell invasion through 3D extracellular matrices"

 
Sept 26


David Kessel, Ph.D
Dept. of Pharmacology, Wayne State University
"Recent progress in photodynamic therapy"
 
Oct 10


Eric Fearon, M.D., Ph.D.
Dept. of Human Genetics, University of Michigan
"The Molecular Pathogenesis of Colorectal Cancer"
 
Oct 17




John Basile, D.D.S., D.M.Sc.
Dept. of Diagnostic Sciences & Pathology, Univ. of Maryland
Dental School
"The Role of Semaphorin 4D in Tumor-Induced Angiogenesis"
 
Oct 24



G. Angus McQuibban, Ph.D.
Dept. of Biochemistry, University of Toronto
"The mitochondrial rhomboid protease: cutting up the membrane in Parkinson's disease"
 
Nov 7




Jim W. Xuan Ph. D.
London Health Sciences Centre, London, Ontario, Canada
" Molecular diagnosis and prognosis of prostate cancer by Flk1-UTMD imaging technology in PSP94 gene-directed genetically engineered mouse prostate cancer models"
 
Nov 14




Masood A. Shammas, Ph.D.
Surgical Oncology And Developmental Therapeutics Laboratory, Karmanos Cancer Institute
"Exploring The Mechanisms Of Genomic Instability, Telomere Maintenance, And Oncogenesis"
 
Nov 21




Dudley K. Strickland, Ph.D.
Dept. of Surgery, University of Maryland School of Medicine, Baltimore
“The LDL receptor-related protein: Role in protecting the vasculature”
 
Dec 5




Qingyu Wu, M.D., Ph.D.
Molecular Cardiology/Nephrology & Hypertension, Learner
Research Institute, The Cleveland Clinic Foundation
"The cardiac transmembrane protease corin: discovery, function, and disease"
 
Jan 16



Barbara Fingleton, Ph.D.
Vanderbilt-Ingram Cancer Center, Nashville, TN
“MMP-9, a context-dependent regulator of breast cancer metastasis”
 
Jan 23


Nicholas G. Davis, Ph.D.
Department of Pharmacology, Wayne State University
"Protein Palmitoylation in Yeast and Brain"
 
Feb 13


Alfredo  Kirkwood, Ph.D
Mind/Brain Institute, Johns Hopkins University, Baltimore, MD
"Neuromodulation of synaptic plasticity"
 
Feb 20







Nancy Oleinick, Ph.D.
Radiation Oncology, Biochemistry, Environmental Health Sciences, Case Comprehensive Cancer Center
"Mitochondrial Damage and Consequences in Photodynamic Therapy: From Molecules to Cells to Tumors"

Host: D. Kessel

 
Feb 27






Mark McNiven, Ph.D.
Dept. Biochemistry and Molecular Biology, Mayo Clinic College of Medicine
"Cytoskeletal Membrane Dynamics in the Metastatic Process"

Host: J. Boerner
 
Mar 6





Maik Hüttemann, Ph.D.
Center for Molecular Medicien & Genetics, Wayne State Univ. School of Medicine
"Regulation of mitochondrial energy and free radical production, inflammation and lung cancer"

 
Mar 20






Vincent Njar, Ph.D.
Dept of Pharmacology & Experimental Therapeutics
University of Maryland School of Medicine
"Development of an Atypical CYP17 Inhibitor VN/124-1 (TOK-001 as a Prostate Cancer Therapeutic"

Host: A. Burger

 
Apr 3




Rafael Fridman, Ph.D.
Dept. of Pathology, Wayne State Univ. School of Medicine
"Membrane type-matrix metalloproteinases:  Proteolysis at the cell surface and beyond"

 
Apr 10



Lisa Coussens, Ph.D.
Dept. of Pathology and Cancer Research Institute, Univ. of California - San Francisco
"Inflammation and Cancer: Regulation of
Tissue-Specific Protumor Immunity"

 
May 15




Suneel Apte, Ph.D.
Dept. of Biomedical Engineering, Cleveland Clinic
"ADAMTS proteases: regulators of cell behavior in development and disease"

 
May 22



Dr. Robert J. Schneider
Assoc. Director, NYU Cancer Institute, Co-director, Breast
Cancer & Translational Cancer Research, New York

 
May 29


Dr. Fred Miller
Barbara Ann Karmanos Cancer Institute and Dept. of Pathology, Wayne State University
"MCF10DCIS.com and the plasticity of stem cells"

 
June 5


Thomas Reinheckel, Ph.D.
Institute of Molecular Medicine and Cell Research, Albert-
Ludwigs-University, Freiburg, Germany
"Effects and Regulation of Cysteine Cathepsins in the Tumor Microenvironment"
 
     

 

Seminar Series 2008

DATE
SPEAKER AND TITLE
COMMENT

Feb 01

Dr. Daniel Lawrence, Ph.D.
Dept. of Internal Medicine, University of Michigan
"Regulation of the Blood Brain Barrier During Ischemic Stroke: Implications for the use of thrombolytic therapy"
 
Feb 08
Open
 
Feb 15
Dr. Sarah Parsons, Ph.D.
Dept. of Microbiology, University of Virginia
"EGFR and c-Src in the mitochondria: New roles in cancer"
 
Feb 22
Dr. Grant Brown, Ph.D.
Dept. of Biochemistry University of Toronto
"The Cellular Response to DNA Replication Fork Stalling"

Feb 29
Dr. Sharon Michelhaugh, Ph.D.
Dept. of Pharmacology , Wayne State U.
"Isoforms of the transcription factor nurr1 differentially regulate dopaminergic genes"

Mar 7
Dr. Hey-Kyoung Lee, Ph.D. 
Dept. of Biology, University of Maryland
"Regulation of excitatory synapses in sensory cortices by visual experience"
Host:
Andrade
Mar 14
Dr. James Basilion, Ph.D.
Biomedical Engineering, Case Western Reserve University
"Intraoperative Molecular Imaging to guide tumor resection"
 
Mar 21
Open
 
Mar 28
Dr. Manohar Ratnam 
Medical University of Ohio, Toledo, Ohio
"New mechanisms of steroid receptor signaling in relation to
development and cancer"

Host:
Matherly

Apr 11
Dr. William Atchison
Professor of Pharmacology/Toxicology, Michigan State University, East Lansing, Michigan
"Cerebellar GABA-A Receptors as Targets of Environmental Mercurials"
 
Apr 18
Dr. Maria Diakonova, Ph.D
Assistant Professor, Dept. of Biological Sciences, University of Toledo
"JAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity  and functions"
Host:
Mattingly 
Apr 25
Open
 
May 2
Dr. Mohamad Bouhamden, Ph.D.
Dept. of Pharmacology, Wayne State U.

May 9
Dr. Amy Chang, Ph.D.
Dept. Molecular, Cellular & Developmental Biology, University of Michigan
"Protein quality control in the yeast secretory pathway"

May 16
Dr. Tayyaba Hasan, Ph.D.
Harvard Medical School

May 23
Dr. Ladislau Kovari, PhD
Dept of Biochemistry and Molecular Biology, Wayne State University School of Medicine
TBA

May 30
Dr. John Goudreau, D.O., Ph.D.
Dept. of Neurology and Dept of Pharmacology and Experimental Therapeutics, Michigan State University
"Molecular mechanisms of differential susceptibility of dopamine neuronal populations in Parkinson's disease"
 
Jun 6
Dr. Sanford Barsky M.D.
The Ohio State University Medical Center
TBA

Jun 13
Dr. Robert Campell Ph.D.
University of Alberta, Dept. of Chemistry
TBA

Jun 20
Dr. Daniel Lawrence Ph.D.
University of Michigan, Dept. of Internal Medicine
"Regulation of the Blood Brain Barrier During Ischemic Stroke: Implications for the use of thrombolytic therapy"