Current Courses
Winter 2009
PHC7650 Minicourses
Each session will consist of 3 hours of lecture per week for 4 weeks and will be allotted 1 credit. Class meeting times will be arranged with the instructors. An organizational meeting for all courses will be held on Thursday, January 15 at 1:00 PM in the Pharmacology Library (6364 Scott Hall). Contact the listed instructors for course details or R. Yamazaki (ryamazak@med.wayne.edu) for general information.
Session 1 January 19 – February 13
Xenobiotic Receptors - Instructor: Thomas Kocarek
This minicourse will explore current topics on the biology of the xenobiotic-sensing nuclear receptors, CAR and PXR, as well as of the aryl hydrocarbon receptor. The format of the course will include a combination of didactic lecture and discussion of the current primary literature.Session 2 February 16 – March 13
Proteomic analysis - Instructor: Paul Stemmer
This minicourse will cover selected methods used in protein fractionation and the analysis of proteomes. Material providing a theoretical basis for the analysis will be presented. Students will participate in discussions and in mass spectroscopic-based identification of proteins. This includes “hands on” work to generate spectra and to complete the analysis using internet-based software.Session 3 March 16 – April10
DNA Damage Responses - Instructor: Gan Wang
This minicourse will explore recent research progress in DNA repair and the role of DNA repair deficiency in human disease development. Individual DNA repair pathways, DNA damage-mediated cell cycle checkpoint regulation, and the consequences of DNA repair defects will be discussed. The minicourse will consist of eight sessions, with each session consisting of an introductory lecture followed by the discussion of a specific assigned paper.DNA topoisomerases as the therapeutic targets for chemotherapeutic agents - Instructor: Hai-Young Wu
A group of chemotherapeutic agents are capable of converting the functionally important DNA topoisomerases into protein-conjugated DNA lesions (poisons) that lead to the cell death. Based on this drug mechanism, many anti-microbial and anti-tumor agents have been developed and used clinically. This course will discuss about the biochemistry and molecular biology underlying this drug mechanism. The molecular details responsible for the drug resistance developed during the clinical uses of these agents will also be discussed.
Course format: 4 lecture sessions followed by journal article discussions, and a final written essay.
Evaluation will be based on the student participations in the journal article discussions, and the essay.
