Rodrigo Andrade, Ph.D.
Research in the Andrade lab focuses on on the mechanisms underlying neuronal communication/synaptic transmission in the brain. Specifically our work seeks to elucidate the molecular mechanisms whereby neurotransmitters acting via G protein coupled receptors signal their responses in central neurons. Specifically we focus on serotonin and acetylcholine muscarinic receptors in hippocampus and cortex and uses the experimental benefits afforded by brain slices to delineate what and how these receptors signal in the brain.
Our approach to this broad research area is to use electrophysiological techniques in combination with pharmacological, molecular biological, and cell imaging approaches to understand the molecular and cellular mechanisms underlying the function of these receptors in central neurons. While this work falls squarely in the area of basic molecular neuroscience, the broader significance of this work lies in its ability to identify molecular targets for therapeutics, while providing a conceptual platform upon which to build an integrated view of the function of acetylcholine and serotonin in the brain. The hope is that this work can bridge advances at the basic science level with preclinical and clinical efforts effort at developing therapeutic approaches to mental disorders.
Kelly McGregor, B.S., Pharmacology Graduate Student
Joseph Lyons, B.S. Research Assistant
Elaine T. Andrade, M.S., Lab Manager
Ricardo C. Araneda, PhD. 1988-1991. Currently Assistant Professor, Dept. of Biology, University of Maryland.
Gonzalo E. Torres, PhD. 1993-1996. Currently Associate Professor, Dept of Neurobiology, Univ of Pittsburg.
James E. Cooper, M.D. 1997- 1999. Currently Assistant Professor, University of Colorado School of Medicine.
Paul D. Perring, M.D. 2000-2002. Currently in clinical practice at ProMedica Anesthesiology Consultants, Ohio.
Mary Elliott, B.S. 2009-2010. Currently medical student at Michigan State University
Daniel Wyskiel, B.S. 2010-2011. Currently Neuroscience PhD student at the University of Virginia.
Peter Tanaka, B.S. 2010-2012. Currently studying life in Dublin, Ireland
Alicia Aleardi, B.S. 2012-2013. Currently medical student at Central Michigan University.
Esther Penick (nee Chapin). PhD, Cellular and Clinical Neurobiology, 2000. Currently Associate Professor, Department of Biology, Knox College.
Mays Imad. PhD, Cellular and Clinical Neurobiology, 2006. Currently Post doctoral fellow, Department of Neuroscience, University of Arizona.
Claudio Villalobos. PhD, Pharmacology, 2010. Currently Postdoctoral fellow, Instituto de Ciencias Biomedicas, Faculty of Medicine, University of Chile.
Yves Chaput, MD. 1988-1990. Professor, School of Medicine, McGill University (now retired from academic life).
Samir Haj-Dahmane, PhD. 1993-1997. Currently Principal Investigator, Research Institute on Addictions, University of Buffalo.
Roh-Yu Chen, PhD. 1996-1997. Currently Principal Investigator, Research Institute on Addictions, University of Buffalo.
Jean-Claude Beique, Ph.D. 2000-2004. Currently Assistant Professor, Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa.
Hai-Dun Yan, PhD. 2002-2005. Currently Research Scientist, Ion Channel Research Unit, Duke University School of Medicine.
Dr. Andrade is no longer taking PhD students.
Selected Recent Publications:
- Beique J.-C., Imad, M, L. Mladenovic, Gingrich, J.A. and R. Andrade (2007) Mechanism of 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex. Proc. Natl Acad Sci USA 104: 9870-9875.
- Yan, H.-D., Villalobos C. and R. Andrade (2009) TRPC channels mediate a muscarinic receptor-induced afterdepolarization in cerebral cortex. J, Neurosci., 29:10038-46.
- Villalobos, C. and R. Andrade (2010) Visinin-like neuronal calcium sensor proteins regulate the slow calcium-activated afterhyperpolarizing current in the rat cerebral cortex. J. Neurosci, 30:14361-14365.
- Villalobos, C, Foehring, R.C., Lee, J.C. and R. Andrade (2011) Essential role for PtdIns(4,5)P2 in the expression and regulation of the slow calcium-activated afterhyperpolarizing current in the cerebral cortex. J. Neurosci. 31:18303-12.
- Andrade R., Foehring R.C. and Tzingounis A.V. (2012) The calcium-activated slow AHP: cutting through the Gordian knot. Front. Cell. Neurosci. 6:47.doi: 10.3389/fncel.2012.00047
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