Welcome to the web site of the Department of Pharmacology at the Wayne State University School of Medicine in Detroit, Michigan. By following the links on this page, you can learn about the history of the Department, the current research interests of our faculty members (encompassing cancer biology, neuroscience, and other subdisciplines in pharmacology), the accomplishments of our current and past students, and resources of interest to pharmacologists. You will also find links to the many exciting activities to be found in Detroit and Michigan. We hope you enjoy your virtual tour of the Department and look forward to hearing from you.

Bonnie F. Sloane, Ph.D.
Distinguished Professor and Chair

Pharmacology in Michigan video

Graduate Program
Cool Research

Doral Cavallo-Medved, Ph.D. Adjunct Assistant Professor (Department of Biological Sciences, University of Windsor) is lead author of a new book aimed at students not majoring in biology. More...

Dr. Q. Ping Dou has been awarded a two year R21 grant, "Regulation of Metformin Response by Breast Cancer Associated Gene 2 (BCA2)" from NCI, NIH with Drs. Paul Stemmer and Lisa Polin as Co-Investigators.

Dr. Raymond Mattingly's application for membership to the Academy of Pharmacology Educators has been accepted by ASPET. The purpose of the Academy of Pharmacology Educators is to provide a means to recognize individuals who have made exemplary contributions to pharmacology education in one or more of the following areas, student-teacher interaction, innovative contributions, scholarly endeavors, and/or professional development and service. more..

Dr Carvallo-Medved, who trained under Dr. Bonnie Sloane, received a teaching excellence award from the University of Windsor, where she is now an Assistant Professor...more, photo.

Dr. Izabela Podgorski has been awarded a five year R01 grant from the National Cancer Institute to study the functional role of bone marrow adipocytes in metastatic prostate cancer.

Dr. Izabela Podgorski has also been awarded a one year Hypothesis Exploration Award ($75,000) from the DOD Prostate Cancer Research Program to study the role of obesity-induced tumor metabolic stress  in docetaxel resistance in metastatic prostate cancer. The title of this grant is “Targeting HO-1/FABP-4/IL-1Beta Axis in Metastatic Prostate Cancer: Therapeutic Implications of Overcoming Obesity-Induced Changes in Tumor Metabolism”

Dr. Sloane is featured in a recent University video highlighting Nanotechnology Reseach at Wayne State University. In particular this video focuses on Dr. Sloane's work supported by her NIH R21 grant.

During the period of 20-24 October 2013, delegates from 22 countries converged on the Spier Wine Estate outside Cape Town, South Africa for the 8th General Meeting of the International Proteolysis Society. Three training workshops on “Protease Kinetics,” “Imaging” and “Structural Biology” preceded the meeting and provided 35 members-in-training with hands-on, protease-specific training.  The “Imaging” Workshop was run by Dr. Bonnie Sloane (Photo), Dr. Kamiar Moin (sleeping with the lions in Kruger National Park) and Dr. Edith Elliott (a former Fulbright Scholar at WSU).

Dr.Karin List has been awarded $75,000 by the WSU grant Plus Program to support preliminary studies leading to the submission of another external grant with a different research thrust than that supported by her current funding.

Dr. Lawrence Lash has been appointed inaugural Editor in Chief of Toxicology Reports, a new Elsevier open access journal.

Dr. Stanley Terlecky was named Associate Dean of Graduate Programs for the WSU School of Medicine in July 2013. In this role, Dr. Terlecky oversees the graduate programs at the School of Medicine, the Interdisciplinary Biomedical Sciences curriculum, and other aspects of student training.

Wayne State University, along with McGill University in Canada and the Hong Kong Polytechnic University, have executed an exclusive worldwide license with Viteava Pharmaceutical Inc. for an intellectual property portfolio claiming composition of matter and/or methods of use of novel analogs and derivatives of the green tea flavonoid known as (-)epigallocatechin-3-gallate, or EGCG.This intellectual property resulted from a long-standing collaboration between Q. Ping Dou, Ph.D., professor of oncology, pharmacology and pathology at Wayne State University’s School of Medicine and the Karmanos Cancer Institute, and Tak-Hang Chan, Ph.D., professor emeritus of chemistry at McGill University and the Hong Kong Polytechnic University... More

Ryan Jackson, an undergraduate student working in the laboratory of Dr. Ray Mattingly won an Outstanding Presentation Award at the ABRCMS (Annual Biomedical Research Conference for Minority Students), Nashville, TN, November 2013

Dr. Karin List was an invited speaker at the ASBMB meeting on “Membrane-anchored serine proteases” in Potomac, MD, September 19–22, 2013. She was elected chair for the next meeting in 2015. Congratulations to Gina Zoratti, graduate student in the List lab, for winning the poster award at the same meeting.


More news...

Jonathan Diedrich, a graduate student in the Cancer Biology Program at the Wayne State University School of Medicine, received the second place prize for his poster presentation at the Pharmacology Research Colloquium at the University of Toledo.Jonathan Diedrich, a graduate student in the Cancer Biology Program at the Wayne State University School of Medicine, received the second place prize for his poster presentation at the Pharmacology Research Colloquium at the University of Toledo. More

Congratulations to Cancer Biology graduate students Aimalie Hardaway and Andrew Murray for their awards at this year's Pharmacology Colloquium, an annual meeting of Pharmacology students and faculty from Wayne State University, University of Michigan, Michigan State University and the University of Toledo. Aimalie, who is doing her dissertation research in the Podgorski Lab, gave the first place podium presentation with a talk entitled, "Adipocyte-Derived Factors and Bone Degradation: The Role of CXCL1 and CXCL2 in Osteoclastogenesis". With this award, Wayne State proudly takes possession of the first place plaque, which hangs for the year in the Pharmacology Library (6364 Scott Hall). Andrew Murray, a student in the List Lab, earned a second place finish in the poster category for his work on "Expression and function of the TMPRSS13 protease in breast cancer".

Congratulations to Kelly McGregor (Andrade lab) for winning a 2 year PhRMA Foundation predoctoral fellowship.

Congratulations to Ms. Gina Zoratti (List Lab) for winning the first poster presentation award at the Tumor and Microenvironment Program Annual Retreat 2013. Photo.

Dr. John Lazo, President of ASPET, was the keynote speaker at the 40th Annual Pharmacology Research Colloquium, held at Wayne State on June 7th....[More]

"Congratulations to Aimalie Hardaway (Cancer Biology graduate student in Podgorski lab) for winning 1st place award for her podium presentation at the 2013 Graduate Student Research Day.  Her talk titled "Adipocyte-Derived Factors and Bone Degradation: The Role of CXCL1 and CXCL2 in Osteoclastogenesis" is part of her dissertation research."

Several current or former students received awards for their poster presentations at a recent retreat of the Molecular Therapeutics Program at Karmanos. Daniela Buac (Dou lab) and Julie Madden (Boerner lab) won first and second place, respectively, in the graduate student competition.  Eric Hales (a graduate of the Wu lab; now in the Matherly lab) won the postdoctoral fellow prize. More than 125 scientists and medical students from the School of Medicine, Karmanos Cancer Institute and Henry Ford Health System participated in the retreat. More...





Neurodegeneration. In a study published in Nature Communications, Sokol Todi outlines the discovery of a new molecular mechanism that illustrates how cells regulate the degradation of proteins, which could be used to treat or cure Spinocerebellar Ataxia Type 3, the most common dominantly inherited ataxia in the world…[More]

Cancer Research. Research done by Jenny Rothberg in the Sloane lab, in conjunction with former Wayne State Pharmacology student Jonathan Wojkowiak in the Gillies lab at the Moffitt Cancer Center, has determined that an acidic microenvironment can drive cancer cells to spread. The investigators propose that neutralizing pH would inhibit further invasion, providing a therapeutic opportunity to slow the progression of cancers...[More]

Cell biology and Neuroscience:
Reversible modifications provide an important means for regulating protein function, which is essential for cellular responses. Until recently, phosphorylation has been the major focus of such protein post-translational modification studies. A recent paper by Nick Davis and colleagues reveals another regulated proteome — neuronal proteins modified by the 16-carbon fatty acid palmitate. In a technical tour-de-force, they have detected not only the palmitoylated neuronal proteins identified previously, but several hundred new candidates, including proteins involved in neurotransmitter availability and responsiveness, the growth and retraction of neuronal processes, and synaptic adhesion.   More…