| PHC
7700 STUDENT JOURNAL CLUB WINTER 2008 |
|
Course Director: Karin List, 577-1034, klist@med.wayne.edu Description: Graduate student presentations of journal articles relating to the topic "Animal Models of Human Disease" Link to PDF file for Journal Club
guidelines: JClubguide.pdf
|
|
|
|
|
|
Organizational meeting |
| Jan 16 |
Rotation
reports |
| Jan
23 |
Open |
| Jan 30 |
Nicole Najor - Entosis Paper: Overholtzer M, Mailleux AA, Mouneimne G, Normand G, Schnitt SJ, King RW, Cibas ES, Brugge JS. A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell. 2007 Nov 30;131(5):966-79. Background: Mailleux AA, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge JS. BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell. 2007 Feb;12(2):221-34 Review 1: Le Bot N. Entosis: cell death by invasion. Nat Cell Biol. 2007 Dec;9(12):1346. Review 2: White E. Entosis: it's a cell-eat-cell world. Cell. 2007 Nov 30;131(5):840-2. |
| Feb 6 |
Bavneet Benipal - Mouse models of diabetic retinopathy Paper: Sullivan KA, Hayes JM, Wiggin TD, Backus C, Su Oh S, Lentz SI, Brosius F 3rd, Feldman EL. Mouse models of diabetic neuropathy. Neurobiol Dis. 2007 Dec;28(3):276-85. Epub 2007 Jul 31. Review: Tomlinson DR, Gardiner NJ. Glucose neurotoxicity. Nat Rev Neurosci. 2008 Jan;9(1):36-45. |
| Feb 13 |
Kadija Abounit - Mouse models of acute ischemic stroke Paper: Shyu WC, Lin SZ, Chiang MF, Chen DC, Su CY, Wang HJ, Liu RS, Tsai CH, Li H. Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke. J Clin Invest. 2008 Jan;118(1):133-48. Review: Durukan A, Tatlisumak T. Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia. Pharmacol Biochem Behav. 2007 May;87(1):179-97. |
| Feb 20 |
Mary Irwin - Hsp90, EGFR mutants and sensitivity to
chemotherapeutic agents Paper: Sawai A, Chandarlapaty S, Greulich H, Gonen M, Ye Q, Arteaga CL, Sellers W, Rosen N, Solit DB. Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel. Cancer Res. 2008 Jan 15;68(2):589-96. Review: Mitsudomi T, Yatabe Y. Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer. Cancer Sci. 2007 Dec;98(12):1817-24. |
| Feb 27 |
No
meeting |
| Mar 5 |
Snow day - no meeting |
| Mar 12 |
Spring Break |
| Mar
19 |
Hitchintan Kaur - Mouse models for breast cancer Paper: Lahlou H, Sanguin-Gendreau V, Zuo D, Cardiff RD, McLean GW, Frame MC, Muller WJ. Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20302-7. Reviews: Hanahan D, Wagner EF, Palmiter RD. The origins of oncomice: a history of the first transgenic mice genetically engineered to develop cancer. Genes Dev. 2007 Sep 15;21(18):2258-70. Hennighausen L. Mouse models for breast cancer. Breast Cancer Res. 2000;2(1):2-7. Epub 1999 Dec 17. |
| Mar 26 |
Jian
Wang - Transgenic mouse model of
Alzheimer's disease Paper: Wilcock DM, Lewis MR, Van Nostrand WE, Davis J, Previti ML, Gharkholonarehe N, Vitek MP, Colton CA. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci. 2008 Feb 13;28(7):1537-45. Review: Rockenstein E, Crews L, Masliah E. Transgenic animal models of neurodegenerative diseases and their application to treatment development. Adv Drug Deliv Rev. 2007 Sep 30;59(11):1093-102. |
| Apr 2 |
Maggie Prior - Proteomic Analysis of Multiple Sclerosis Paper: Han MH, Hwang SI, Roy DB, Lundgren DH, Price JV, Ousman SS, Fernald GH, Gerlitz B, Robinson WH, Baranzini SE, Grinnell BW, Raine CS, Sobel RA, Han DK, Steinman L. Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature. 2008 Feb 28;451(7182):1076-81. Review: Baxter AG. The origin and application of experimental autoimmune encephalomyelitis. Nat Rev Immunol. 2007 Nov;7(11):904-12 |
| Apr 9 |
Main Maitah - p53 and skin cancer Paper: Tang X, Zhu Y, Han L, Kim AL, Kopelovich L, Bickers DR, Athar M. CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. J Clin Invest. 2007 Dec;117(12):3753-64. Review: Benjamin CL, Ananthaswamy HN. p53 and the pathogenesis of skin cancer. Toxicol Appl Pharmacol. 2007 Nov 1;224(3):241-8. |
| Apr 16 |
Claudio Villalobos - Emotion and Memory Paper: Hu H, Real E, Takamiya K, Kang MG, Ledoux J, Huganir RL, Malinow R. Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking. Cell. 2007 Oct 5;131(1):160-73. Reviews: Malinow R, Malenka RC. AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci. 2002;25:103-26. Richter-Levin G, Akirav I. Emotional tagging of memory formation--in the search for neural mechanisms. Brain Res Brain Res Rev. 2003 Dec;43(3):247-56. |
| Apr 23 |
Final
exam week |
| May 7 |
Heather
McClung - research presentation Jian Wang - rotation report |
| May 14 |
Irene
Papanayotou - research presentation Main Maitah - rotation report |
Trouble getting full text access?
Last updated 05/07/2008
