WSU Department of Pharmacology Student Journal Club W2005

PHC 7700 STUDENT JOURNAL CLUB WINTER 2005
Room 6364 Scott, Wednesdays at noon Course Director: Dr. Nicholas Davis Phone: 577-8654 Email: ndavis@genetics.wayne.edu Description: Graduate student presentations of journal articles relating to a topic Link to PDF file for Journal Club guidelines: JClubguide.pdf Click on the authors for the PubMed abstract. If your location has full-text access, you will see a button with the journal name (Example: PNAS Online). Click on the button to get to the text. You can usually also get a PDF file for printing or saving by clicking on the line that says "Reprint (PDF) version of this article". For some journals, you may need to use Ovid to get access to full text. If you are accessing from off campus, you will need to use your WSU AccessID and password to authenticate your WSU affiliation to use Ovid and other proprietary databases that are licensed to the WSU Library. NEW! If you are logged on through WSU and cannot access full-text articles at Nature Publishing from PubMed, use the link to PubMed here. WSU PubMed

PHC 7700 STUDENT JOURNAL CLUB
WINTER 2005

Room 6364 Scott, Wednesdays at noon

Course Director: Dr. Nicholas Davis Phone: 577-8654
Email: ndavis@genetics.wayne.edu

Description: Graduate student presentations of journal articles relating to a topic

Link to PDF file for Journal Club guidelines: JClubguide.pdf
Click on the authors for the PubMed abstract. If your location has full-text access, you will see a button with the journal name (Example: PNAS Online). Click on the button to get to the text. You can usually also get a PDF file for printing or saving by clicking on the line that says "Reprint (PDF) version of this article".
For some journals, you may need to use Ovid to get access to full text. If you are accessing from off campus, you will need to use your WSU AccessID and password to authenticate your WSU affiliation to use Ovid and other proprietary databases that are licensed to the WSU Library.

NEW!
If you are logged on through WSU and cannot access full-text articles at Nature Publishing from PubMed, use the link to PubMed here. WSU PubMed

DATE	SPEAKER, TITLE AND REFERENCES
Jan 11	Rotation reports
Jan 19	No meeting
Jan 26	Anthony Cimini - Protein palmitoylation: Add a little grease to move it Paper: Huang K, Yanai A, Kang R, Arstikaitis P, Singaraja RR, Metzler M, Mullard A, Haigh B, Gauthier-Campbell C, Gutekunst CA, Hayden MR, El-Husseini A. Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins. Neuron. 2004 Dec 16;44(6):977-86. Review: el-Husseini Ael-D, Bredt DS. Protein palmitoylation: a regulator of neuronal development and function. Nat Rev Neurosci. 2002 Oct;3(10):791-802
Feb 2	Eric Hales - E2F transcriptional regulation Paper: Wencheng Zhu, Paloma H Giangrande, and Joseph R Nevins. "E2Fs link the control of G1/S and G2/M transcription" EMBO J. 2004 Nov 24;23(23):4615-26. Review: Jeffrey M Trimarchi and Jacqueline A Lees. "Sibling Rivalry in the E2F Family" Nat Rev Mol Cell Biol. 2002 Jan;3(1):11-20
Feb 9	Chris Jedeszko - Galectins Paper: Califice S, Castronovo V, Bracke M, van den Brule F. Dual activities of galectin-3 in human prostate cancer: tumor suppression of nuclear galectin-3 vs tumor promotion of cytoplasmic galectin-3. Oncogene. 2004 Sep 30;23(45):7527-36. Review: Liu FT, Rabinovich GA. Galectins as modulators of tumour progression. Nat Rev Cancer. 2005 Jan;5(1):29-41.
Feb 16	Jay Koepke - Correcting misfolding Paper: Yam GH, Zuber C, Roth J. A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder. FASEB J. 2005 Jan;19(1):12-8. Review: Cohen FE, Kelly JW. Therapeutic approaches to protein-misfolding diseases. Nature. 2003 Dec 18;426(6968):905-9.
Feb 23	Heather McClung - Ghrelin Paper: Thompson NM, Gill DA, Davies R, Loveridge N, Houston PA, Robinson IC, Wells T. Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology. 2004 Jan;145(1):234-42. Review: Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB. Ghrelin--a hormone with multiple functions. Front Neuroendocrinol. 2004 Apr;25(1):27-68.
Mar 2	Irene Papanayotou - Kidney Cell Apoptosis Paper: Sinha D, Bannergee S, Schwartz JH, Lieberthal W, Levine JS. Inhibition of ligand-independent ERK1/2 activity in kidney proximal tubular cells deprived of soluble survival factors up-regulates Akt and prevents apoptosis. J Biol Chem. 2004 Mar 19;279(12):10962-72. Reviews: Wada T, Penninger JM. Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 2004 Apr 12;23(16):2838-49. Thompson JE, Thompson CB. Putting the rap on Akt. J Clin Oncol. 2004 Oct 15;22(20):4217-26.
Mar 9	Chris Wood - DNA repair and aging Paper: Szczesny B, Bhakat KK, Mitra S, Boldogh I. Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution. Mech Ageing Dev. 2004 Oct-Nov; 125(10-11): 755-65. Review: T. Izumi, L.R. Wiederhold, G. Roy, R. Roy, A. Jaiswal, K.K. Bhakat, S. Mitra and T.K. Hazra, Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage, Toxicology 193 (2003), pp. 43–65.
Mar 16	Spring Break
Mar 23	Jonathan Wojtkowiak - Visfatin Paper: Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, Matsuki Y, Murakami M, Ichisaka T, Murakami H, Watanabe E, Takagi T, Akiyoshi M, Ohtsubo T, Kihara S, Yamashita S, Makishima M, Funahashi T, Yamanaka S, Hiramatsu R, Matsuzawa Y, Shimomura I. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science. 2005 Jan 21;307(5708):426-30. supplemental material: http://www.sciencemag.org/cgi/content/full/1097243/DC1 Review: Van Gaal LF, Mertens IL, Abrams PJ. Health risks of lipodystrophy and abdominal fat accumulation: therapeutic possibilities with leptin and human growth hormone. Growth Horm IGF Res. 2003 Aug;13 Suppl A:S4-9.
Mar 30	Komal Sane - Ras signaling Paper: Caron RW, Yacoub A, Li M, Zhu X, Mitchell C, Hong Y, Hawkins W, Sasazuki T, Shirasawa S, Kozikowski AP, Dennis PA, Hagan MP, Grant S, Dent P. Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. Mol Cancer Ther. 2005 Feb;4(2):257-70. Review: Kim IA, Fernandes AT, Gupta AK, McKenna WG, Bernhard EJ. The influence of Ras pathway signaling on tumor radiosensitivity. Cancer Metastasis Rev. 2004 Aug-Dec;23(3-4):227-36.
Apr 6	Ravi Yedidi - New targets for anti-microtubular agents Paper: Horvath I, Harmat V, Perczel A, Palfi V, Nyitray L, Nagy A, Hlavanda E, Naray-Szabo G, Ovadi J. The structure of the complex of calmodulin with KAR-2: a novel mode of binding explains the unique pharmacology of the drug. J Biol Chem. 2005 Mar 4;280(9):8266-74. Review: Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer. 2004 Apr;4(4):253-65.
Apr 13	Qing Zhong - TNFa-induced apoptosis Paper: Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell. 2005 Mar 11;120(5):649-61. Review: Ding WX, Yin XM. Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury. J Cell Mol Med. 2004 Oct-Dec;8(4):445-54.
Apr 20	Josh Dilworth
Apr 27	Scott Payton
May 4	Beimeng Sun

DATE

SPEAKER, TITLE AND REFERENCES

Jan 11

Rotation reports

Jan 19

No meeting

Jan 26

Anthony Cimini - Protein palmitoylation: Add a little grease to move it
Paper: Huang K, Yanai A, Kang R, Arstikaitis P, Singaraja RR, Metzler M, Mullard A, Haigh B, Gauthier-Campbell C, Gutekunst CA, Hayden MR, El-Husseini A. Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins. Neuron. 2004 Dec 16;44(6):977-86.
Review: el-Husseini Ael-D, Bredt DS. Protein palmitoylation: a regulator of neuronal development and function. Nat Rev Neurosci. 2002 Oct;3(10):791-802

Feb 2

Eric Hales - E2F transcriptional regulation
Paper: Wencheng Zhu, Paloma H Giangrande, and Joseph R Nevins. "E2Fs link the control of G1/S and G2/M transcription" EMBO J. 2004 Nov 24;23(23):4615-26.
Review: Jeffrey M Trimarchi and Jacqueline A Lees. "Sibling Rivalry in the E2F Family"
Nat Rev Mol Cell Biol. 2002 Jan;3(1):11-20

Feb 9

Chris Jedeszko - Galectins
Paper: Califice S, Castronovo V, Bracke M, van den Brule F. Dual activities of galectin-3 in human prostate cancer: tumor suppression of nuclear galectin-3 vs tumor promotion of cytoplasmic galectin-3. Oncogene. 2004 Sep 30;23(45):7527-36.
Review: Liu FT, Rabinovich GA. Galectins as modulators of tumour progression. Nat Rev Cancer. 2005 Jan;5(1):29-41.

Feb 16

Jay Koepke - Correcting misfolding
Paper: Yam GH, Zuber C, Roth J. A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder. FASEB J. 2005 Jan;19(1):12-8.
Review: Cohen FE, Kelly JW. Therapeutic approaches to protein-misfolding diseases. Nature. 2003 Dec 18;426(6968):905-9.

Feb 23

Heather McClung - Ghrelin
Paper: Thompson NM, Gill DA, Davies R, Loveridge N, Houston PA, Robinson IC, Wells T. Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology. 2004 Jan;145(1):234-42.
Review: Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB. Ghrelin--a hormone with multiple functions. Front Neuroendocrinol. 2004 Apr;25(1):27-68.

Mar 2

Irene Papanayotou - Kidney Cell Apoptosis
Paper: Sinha D, Bannergee S, Schwartz JH, Lieberthal W, Levine JS. Inhibition of ligand-independent ERK1/2 activity in kidney proximal tubular cells deprived of soluble survival factors up-regulates Akt and prevents apoptosis. J Biol Chem. 2004 Mar 19;279(12):10962-72.
Reviews: Wada T, Penninger JM. Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 2004 Apr 12;23(16):2838-49. Thompson JE, Thompson CB. Putting the rap on Akt. J Clin Oncol. 2004 Oct 15;22(20):4217-26.

Mar 9

Chris Wood - DNA repair and aging
Paper: Szczesny B, Bhakat KK, Mitra S, Boldogh I. Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution. Mech Ageing Dev. 2004 Oct-Nov; 125(10-11): 755-65.
Review: T. Izumi, L.R. Wiederhold, G. Roy, R. Roy, A. Jaiswal, K.K. Bhakat, S. Mitra and T.K. Hazra, Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage, Toxicology 193 (2003), pp. 43–65.

Mar 16

Spring Break

Mar 23

Jonathan Wojtkowiak - Visfatin
Paper: Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, Matsuki Y, Murakami M, Ichisaka T, Murakami H, Watanabe E, Takagi T, Akiyoshi M, Ohtsubo T, Kihara S, Yamashita S, Makishima M, Funahashi T, Yamanaka S, Hiramatsu R, Matsuzawa Y, Shimomura I. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science. 2005 Jan 21;307(5708):426-30.
supplemental material: http://www.sciencemag.org/cgi/content/full/1097243/DC1
Review: Van Gaal LF, Mertens IL, Abrams PJ. Health risks of lipodystrophy and abdominal fat accumulation: therapeutic possibilities with leptin and human growth hormone. Growth Horm IGF Res. 2003 Aug;13 Suppl A:S4-9.

Mar 30

Komal Sane - Ras signaling
Paper: Caron RW, Yacoub A, Li M, Zhu X, Mitchell C, Hong Y, Hawkins W, Sasazuki T, Shirasawa S, Kozikowski AP, Dennis PA, Hagan MP, Grant S, Dent P. Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. Mol Cancer Ther. 2005 Feb;4(2):257-70.
Review: Kim IA, Fernandes AT, Gupta AK, McKenna WG, Bernhard EJ. The influence of Ras pathway signaling on tumor radiosensitivity. Cancer Metastasis Rev. 2004 Aug-Dec;23(3-4):227-36.

Apr 6

Ravi Yedidi - New targets for anti-microtubular agents
Paper: Horvath I, Harmat V, Perczel A, Palfi V, Nyitray L, Nagy A, Hlavanda E, Naray-Szabo G, Ovadi J. The structure of the complex of calmodulin with KAR-2: a novel mode of binding explains the unique pharmacology of the drug. J Biol Chem. 2005 Mar 4;280(9):8266-74.
Review: Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer. 2004 Apr;4(4):253-65.

Apr 13

Qing Zhong - TNFa-induced apoptosis
Paper: Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell. 2005 Mar 11;120(5):649-61.
Review: Ding WX, Yin XM. Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury. J Cell Mol Med. 2004 Oct-Dec;8(4):445-54.

Apr 20

Josh Dilworth

Apr 27

Scott Payton

May 4

Beimeng Sun