| PHC
7700 STUDENT JOURNAL CLUB FALL 2007 |
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Course Director: Stanley Terlecky, 7302 Scott Hall, 577-3557, srterlecky@med.wayne.edu Description: Graduate student presentations of journal articles relating to a topic Link to PDF file for Journal Club
guidelines: JClubguide.pdf
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Organizational meeting |
| Sept 12 |
Rotation
reports |
| Sept
19 |
Mary Irwin - Resistance to tumor kinase inhibitors Paper: Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Janne PA. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007 May 18;316(5827):1039-43. Reviews: Engelman JA, Cantley LC. The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors. Clin Cancer Res. 2006 Jul 15;12(14 Pt 2):4372s-4376s. Peschard P, Park M. From Tpr-Met to Met, tumorigenesis and tubes. Oncogene. 2007 Feb 26;26(9):1276-85 |
| Sept 26 |
Komal Sane - Pharmacological chaperones Paper: Wang Y, Loo TW, Bartlett MC, Clarke DM. Additive effect of multiple pharmacological chaperones on maturation of CFTR processing mutants. Biochem J. 2007 Sep 1;406(2):257-63. |
| Oct 3 |
Adelaida Segarra - Heat Shock Factors Paper: Dai C, Whitesell L, Rogers AB, Lindquist S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell. 2007 Sep 21;130(6):1005-18. Review: Pirkkala L, Nykanen P, Sistonen L. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J. 2001 May;15(7):1118-31. |
| Oct 10 | Kadija Abounit - Autophagy and Neurodegeneration Paper: Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3(6):331-8. Short review: He C, Klionsky DJ. Autophagy and neurodegeneration. ACS Chem Biol. 2006 May 23;1(4):211-3. Review: Ravikumar B, Rubinsztein DC. Role of autophagy in the clearance of mutant huntingtin: a step towards therapy? Mol Aspects Med. 2006 Oct-Dec;27(5-6):520-7. |
| Oct 17 | Heather
McClung - Microglia and multiple
sclerosis Paper: Adams RA, Bauer J, Flick MJ, Sikorski SL, Nuriel T, Lassmann H, Degen JL, Akassoglou K. The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med. 2007 Mar 19;204(3):571-82. Review: Jack C, Ruffini F, Bar-Or A, Antel JP. Microglia and multiple sclerosis. J Neurosci Res. 2005 Aug 1;81(3):363-73. |
| Oct 24 |
Irene
Papanayotou - Palmitoylation and
fas Paper: Chakrabandhu K, Herincs Z, Huault S, Dost B, Peng L, Conchonaud F, Marguet D, He HT, Hueber AO. Review: Greaves J, Chamberlain LH. Palmitoylation-dependent protein sorting. J Cell Biol. 2007 Jan 29;176(3):249-54. Palmitoylation is required for efficient Fas cell death signaling. EMBO J. 2007 Jan 10;26(1):209-20. |
| Oct 31 |
Claudio
Villalobos - Serotonin and
Depression Paper: Lucas G, Rymar VV, Du J, Mnie-Filali O, Bisgaard C, Manta S, Lambas-Senas L, Wiborg O, Haddjeri N, Pineyro G, Sadikot AF, Debonnel G. Serotonin(4) (5-HT(4)) receptor agonists are putative antidepressants with a rapid onset of action. Neuron. 2007 Sep 6;55(5):712-25. Review: Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM. Neurobiology of depression. Neuron. 2002 Mar 28;34(1):13-25. |
| Nov 7 |
Hitchintan Kaur - Role of mesenchymal stem cells in
metastasis Paper: Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 2007 Oct 4;449(7162):557-63. Review: Kaplan RN, Psaila B, Lyden D. Bone marrow cells in the 'pre-metastatic niche': within bone and beyond. Cancer Metastasis Rev. 2006 Dec;25(4):521-9. |
| Nov 14 |
Shelly
Yoshida - GTP-cyclohydrolase and
pain Paper: Kim H, Dionne RA. Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans. Mol Pain. 2007 Mar 7;3:6. Review: Montagna P. Recent advances in the pharmacogenomics of pain and headache. Neurol Sci. 2007 May;28 Suppl 2:S208-12. |
| Nov 21 |
Thanksgiving Break |
| Nov 28 |
Maggie Prior - Fragile X syndrome Paper: Zalfa F, Eleuteri B, Dickson KS, Mercaldo V, De Rubeis S, di Penta A, Tabolacci E, Chiurazzi P, Neri G, Grant SG, Bagni C. A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability. Nat Neurosci. 2007 May;10(5):578-87. Review: Bagni C, Greenough WT. From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome. Nat Rev Neurosci. 2005 May;6(5):376-87. |
| Dec 5 |
Nicole Najor - Alzheimer disease and Down syndrome Paper: Ryoo SR, Jeong HK, Radnaabazar C, Yoo JJ, Cho HJ, Lee HW, Kim IS, Cheon YH, Ahn YS, Chung SH, Song WJ. DYRK1A-mediated Hyperphosphorylation of Tau: A FUNCTIONAL LINK BETWEEN DOWN SYNDROME AND ALZHEIMER DISEASE. J Biol Chem. 2007 Nov 30;282(48):34850-34857. Review: Lott IT, Head E. Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiol Aging. 2005 Mar;26(3):383-9. |
| Dec 12 |
Neete
Benipal - Heme oxygenase-1
protection of kidney Paper: Goodman AI, Olszanecki R, Yang LM, Quan S, Li M, Omura S, Stec DE, Abraham NG. Heme oxygenase-1 protects against radiocontrast-induced acute kidney injury by regulating anti-apoptotic proteins. Kidney Int. 2007 Oct;72(8):945-53. Review: Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev. 2006 Apr;86(2):583-650. |
| Dec 19 | |
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Last updated 12/08/2007
