WSU Department of Pharmacology Student Journal ClubF2006

PHC 7700 STUDENT JOURNAL CLUB FALL 2006
Room 6364 Scott, Thursday at noon except where noted Course Director: Stanley Terlecky, 7302 Scott Hall, 577-3557, srterlecky@med.wayne.edu Description: Graduate student presentations of journal articles relating to a topic Link to PDF file for Journal Club guidelines: JClubguide.pdf Click on the authors for the PubMed abstract. If your location has full-text access, you will see a button with the journal name (Example: PNAS Online). Click on the button to get to the text. You can usually also get a PDF file for printing or saving by clicking on the line that says "Reprint (PDF) version of this article". If you are accessing from off campus, you will need to use your WSU AccessID and password to authenticate your WSU affiliation to access full-text articles and proprietary databases that are licensed to the WSU Library.

PHC 7700 STUDENT JOURNAL CLUB
FALL 2006

Room 6364 Scott, Thursday at noon except where noted

Course Director: Stanley Terlecky, 7302 Scott Hall, 577-3557, srterlecky@med.wayne.edu

Description: Graduate student presentations of journal articles relating to a topic

Link to PDF file for Journal Club guidelines: JClubguide.pdf
Click on the authors for the PubMed abstract. If your location has full-text access, you will see a button with the journal name (Example: PNAS Online). Click on the button to get to the text. You can usually also get a PDF file for printing or saving by clicking on the line that says "Reprint (PDF) version of this article".
If you are accessing from off campus, you will need to use your WSU AccessID and password to authenticate your WSU affiliation to access full-text articles and proprietary databases that are licensed to the WSU Library.

DATE	SPEAKER, TITLE AND REFERENCES
Wed, Sept 6	Organizational meeting
Wed, Sept 13	Summer rotation reports
Sept 21	Graduate Student Research Day - no meeting
Sept 28	Jonathan Wojtkowiak - Mitotic exit Paper: Potapova TA, Daum JR, Pittman BD, Hudson JR, Jones TN, Satinover DL, Stukenberg PT, Gorbsky GJ. The reversibility of mitotic exit in vertebrate cells. Nature. 2006 Apr 13;440(7086):954-8. Review: Murray AW. Recycling the cell cycle: cyclins revisited. Cell. 2004 Jan 23;116(2):221-34.
Oct 5	Tony Cimini - COX2, b-catenin and colon cancer Paper: Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS. Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science. 2005 Dec 2;310(5753):1504-10. Review: Clevers H. Colon cancer--understanding how NSAIDs work. N Engl J Med. 2006 Feb12 16;354(7):761-3.
Oct 12	Kadija Abounit - Protease inhibitors, kinase signaling and cancer Paper: Srirangam A, et al. Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer. Clin Cancer Res. 2006 Mar 15;12(6):1883-96. Review: Fresno Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, Gonzalez-Baron M.. PI3K/Akt signalling pathway and cancer. Cancer Treatment Reviews (2004) 30:193-204.
Oct 19	Heather McClung - Finding the way to the nucleus Paper: Arhel, N., et al. Quantitative four-dimensional tracking of cytoplasmic and nuclear HIV-1 complexes. Nature Methods 3, 817-824 (2006). Review: Bukrinsky, M. A hard way to the nucleus. Molecular Medicine 10, 1-5 (2004)
Oct 26	Pharmacology Departmental Retreat - no meeting
Nov 2	Irene Papanayotou - Polyglutamine-induced neurodegeneration Paper: Custer SK et al., Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport. Nat Neurosci. 2006 Oct;9(10):1302-11 Review:
Nov 9	Chris Jedeszko - Matrix Elasticity Paper: Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell. 2006 Aug 25;126(4):677-89. Review: Tissue cells feel and respond to the stiffness of their substrate. Discher DE, Janmey P, Wang YL. Science. 2005 Nov 18;310(5751):1139-43.
Nov 15	Komal Sane - Targeted Apoptosis Paper: Putt KS, Chen GW, Pearson JM, Sandhorst JS, Hoagland MS, Kwon JT, Hwang SK, Jin H, Churchwell MI, Cho, MH, Doerge DR, Helferich WG, Hergenrother PJ. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2006 Oct;2(10):543-50. Review: Bremer E, van Dam G, Kroesen BJ, de Leij L, Helfrich W. Targeted induction of apoptosis for cancer therapy: current progress and prospects. Trends Mol Med. 2006 Aug;12(8):382-93.
Nov 23	Thanksgiving break - no meeting
Nov 30	Nicole Najor - Inheritance of colorectal cancer Paper: Chan TL, Yuen ST, Kong CK, Chan YW, Chan AS, Ng WF, Tsui WY, Lo MW, Tam WY, Li VS, Leung SY. Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer, Nat Genet. 2006 Oct;38(10):1178-83. Review: Rowley PT. Inherited susceptibility to colorectal cancer. Annu Rev Med. 2005;56:539-54.
Dec 7	Eric Hales - c-myc expression Paper: Juhong Liu et al. The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression. 2006. EMBO J. 25. 2119-2130. Review: Hye-Jung Chung and David Levens. c-myc Expression: Keep the Noise Down! 2005. Mol. Cells. 20 (2). 157-166.
Dec 14	Qing Zhong - Resveratrol and mitochondrial function Paper: Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1alpha. Cell. 2006 Nov 15;127: 1-14 Reviews: Biskup S, Moore DJ. Detrimental deletions: mitochondria, aging and Parkinson's disease. Bioessays. 2006 Oct;28(10):963-7. Houten SM, Auwerx J. PGC-1alpha: turbocharging mitochondria. Cell. 2004 Oct 1;119(1):5-7.
Dec 14 following the above presentation	Lesley Lawrenson - Vaults Paper: Poderycki MJ, Kickhoefer VA, Kaddis CS, Raval-Fernandes S, Johansson E, Zink JI, Loo JA, Rome LH. Related Articles, Links The vault exterior shell is a dynamic structure that allows incorporation of vault-associated proteins into its interior. Biochemistry. 2006 Oct 3;45(39):12184-93. Review: Mossink MH, van Zon A, Scheper RJ, Sonneveld P, Wiemer EA. Vaults: a ribonucleoprotein particle involved in drug resistance? Oncogene. 2003 Oct 20;22(47):7458-67.

DATE

SPEAKER, TITLE AND REFERENCES

Wed,
Sept 6

Organizational meeting

Wed,
Sept 13

Summer rotation reports

Sept 21

Graduate Student Research Day - no meeting

Sept 28

Jonathan Wojtkowiak - Mitotic exit
Paper: Potapova TA, Daum JR, Pittman BD, Hudson JR, Jones TN, Satinover DL, Stukenberg PT, Gorbsky GJ. The reversibility of mitotic exit in vertebrate cells. Nature. 2006 Apr 13;440(7086):954-8.
Review: Murray AW. Recycling the cell cycle: cyclins revisited. Cell. 2004 Jan 23;116(2):221-34.

Oct 5

Tony Cimini - COX2, b-catenin and colon cancer
Paper: Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS. Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science. 2005 Dec 2;310(5753):1504-10.
Review: Clevers H. Colon cancer--understanding how NSAIDs work. N Engl J Med. 2006 Feb12 16;354(7):761-3.

Oct 12

Kadija Abounit - Protease inhibitors, kinase signaling and cancer

Paper: Srirangam A, et al. Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer. Clin Cancer Res. 2006 Mar 15;12(6):1883-96.

Review: Fresno Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, Gonzalez-Baron M.. PI3K/Akt signalling pathway and cancer. Cancer Treatment Reviews (2004) 30:193-204.

Oct 19

Heather McClung - Finding the way to the nucleus

Paper: Arhel, N., et al. Quantitative four-dimensional tracking of cytoplasmic and nuclear HIV-1 complexes. Nature Methods 3, 817-824 (2006).
Review: Bukrinsky, M. A hard way to the nucleus. Molecular Medicine 10, 1-5 (2004)

Oct 26

Pharmacology Departmental Retreat - no meeting

Nov 2

Irene Papanayotou - Polyglutamine-induced neurodegeneration
Paper: Custer SK et al., Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport. Nat Neurosci. 2006 Oct;9(10):1302-11
Review:

Nov 9

Chris Jedeszko - Matrix Elasticity
Paper: Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell. 2006 Aug 25;126(4):677-89.
Review: Tissue cells feel and respond to the stiffness of their substrate. Discher DE, Janmey P, Wang YL. Science. 2005 Nov 18;310(5751):1139-43.

Nov 15

Komal Sane - Targeted Apoptosis
Paper: Putt KS, Chen GW, Pearson JM, Sandhorst JS, Hoagland MS, Kwon JT, Hwang SK, Jin H, Churchwell MI, Cho, MH, Doerge DR, Helferich WG, Hergenrother PJ. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2006 Oct;2(10):543-50.
Review: Bremer E, van Dam G, Kroesen BJ, de Leij L, Helfrich W. Targeted induction of apoptosis for cancer therapy: current progress and prospects. Trends Mol Med. 2006 Aug;12(8):382-93.

Nov 23

Thanksgiving break - no meeting

Nov 30

Nicole Najor - Inheritance of colorectal cancer
Paper: Chan TL, Yuen ST, Kong CK, Chan YW, Chan AS, Ng WF, Tsui WY, Lo MW, Tam WY, Li VS, Leung SY. Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer, Nat Genet. 2006 Oct;38(10):1178-83.
Review: Rowley PT. Inherited susceptibility to colorectal cancer. Annu Rev Med. 2005;56:539-54.

Dec 7

Eric Hales - c-myc expression
Paper: Juhong Liu et al. The FUSE/FBP/FIR/TFIIH system is a molecular machine programming a pulse of c-myc expression. 2006. EMBO J. 25. 2119-2130.
Review: Hye-Jung Chung and David Levens. c-myc Expression: Keep the Noise Down! 2005. Mol. Cells. 20 (2). 157-166.

Dec 14

Qing Zhong - Resveratrol and mitochondrial function
Paper: Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1alpha. Cell. 2006 Nov 15;127: 1-14
Reviews: Biskup S, Moore DJ. Detrimental deletions: mitochondria, aging and Parkinson's disease. Bioessays. 2006 Oct;28(10):963-7. Houten SM, Auwerx J. PGC-1alpha: turbocharging mitochondria. Cell. 2004 Oct 1;119(1):5-7.

Dec 14
following the above presentation

Lesley Lawrenson - Vaults
Paper: Poderycki MJ, Kickhoefer VA, Kaddis CS, Raval-Fernandes S, Johansson E, Zink JI, Loo JA, Rome LH. Related Articles, Links The vault exterior shell is a dynamic structure that allows incorporation of vault-associated proteins into its interior. Biochemistry. 2006 Oct 3;45(39):12184-93.
Review: Mossink MH, van Zon A, Scheper RJ, Sonneveld P, Wiemer EA. Vaults: a ribonucleoprotein particle involved in drug resistance? Oncogene. 2003 Oct 20;22(47):7458-67.