WSU Department of Pharmacology Student Journal Club W2005

PHC 7700 STUDENT JOURNAL CLUB FALL 2005
Room 6364 Scott, Thursdays at noon Course Director: Dr. Ellen Tisdale Phone: 577-1007 Email: etisdale@med.wayne.edu Description: Graduate student presentations of journal articles relating to a topic Link to PDF file for Journal Club guidelines: JClubguide.pdf Click on the authors for the PubMed abstract. If your location has full-text access, you will see a button with the journal name (Example: PNAS Online). Click on the button to get to the text. You can usually also get a PDF file for printing or saving by clicking on the line that says "Reprint (PDF) version of this article". If you are accessing from off campus, you will need to use your WSU AccessID and password to authenticate your WSU affiliation to access full-text articles and proprietary databases that are licensed to the WSU Library.

PHC 7700 STUDENT JOURNAL CLUB
FALL 2005

Room 6364 Scott, Thursdays at noon

Course Director: Dr. Ellen Tisdale Phone: 577-1007
Email: etisdale@med.wayne.edu

Description: Graduate student presentations of journal articles relating to a topic

Link to PDF file for Journal Club guidelines: JClubguide.pdf
Click on the authors for the PubMed abstract. If your location has full-text access, you will see a button with the journal name (Example: PNAS Online). Click on the button to get to the text. You can usually also get a PDF file for printing or saving by clicking on the line that says "Reprint (PDF) version of this article".
If you are accessing from off campus, you will need to use your WSU AccessID and password to authenticate your WSU affiliation to access full-text articles and proprietary databases that are licensed to the WSU Library.

DATE	SPEAKER, TITLE AND REFERENCES
Sept 8	Rotation report - Irene Papanayotou
Sept 15	No meeting
Sept 22	Graduate Student Research Symposium - no meeting
Sept 29	Komal Sane - p53 and Apoptosis Paper: Doumont G, Martoriati A, Beekman C, Bogaerts S, Mee PJ, Bureau F, Colombo E, Alcalay M, Bellefroid E, Marchesi F, Scanziani E, Pelicci PG, Marine JC. G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv. EMBO J. 2005 Sep 7;24(17):3093-103. Review: Yu J, Zhang L. The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun. 2005 Jun 10;331(3):851-8.
Oct 6	Jay Koepke - Mitochondrial reactive oxygen species Paper: Storz P, Doppler H, Toker A. Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species. Mol Cell Biol. 2005 Oct;25(19):8520-30 Review: Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol. 2003 Oct 15;552(Pt 2):335-44.
Oct 13	Chris Wood - 14-3-3 Proteins Paper: Faul C, Huttelmaier S, Oh J, Hachet V, Singer RH, Mundel P. Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3. J Cell Biol. 2005 May 9;169(3):415-24. Review: Bridges D, Moorhead GB. 14-3-3 proteins: a number of functions for a numbered protein. Sci STKE. 2005 Aug 9;2005(296):re10.
Oct 20	Jiang Zhu- GATA transcription Paper: Rath N, Wang Z, Lu MM, Morrisey EE. LMCD1/Dyxin Is a Novel Transcriptional Cofactor That Restricts GATA6 Function by Inhibiting DNA Binding. Mol Cell Biol. 2005 Oct;25(20):8864-73. Review: Heicklen-Klein A, McReynolds LJ, Evans T. Using the zebrafish model to study GATA transcription factors. Semin Cell Dev Biol. 2005 Feb;16(1):95-106.
Oct 27	Irene Papanayotou - Protein Palmitoylation Paper: Swarthout JT, Lobo S, Farh L, Croke MR, Greentree WK, Deschenes RJ, Linder ME. DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. J Biol Chem. 2005 Sep 2;280(35):31141-8. Review: Magee T, Seabra MC. Fatty acylation and prenylation of proteins: what's hot in fat. Curr Opin Cell Biol. 2005 Apr;17(2):190-6.
Nov 3	Eric Hales - p53 and MDM2 Paper: Wang C, et al (2005) MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J 24: 3279-3290 Review: Alarcon-Vargas D and Ronai Z (2002) p53-MDM2--the affair that never ends. Carcinogenesis 23: 541-547
Nov 10	Chris Jedeszko - MAGIC Paper : A Magnetic Nanoprobe Technology for Detecting Molecular Interactions in Live Cells, Jaejoon Won, Mina Kim, Yong-Weon Yi, Young Ho Kim, Neoncheol Jung, Tae Kook Kim. Science, Vol 309, Issue 5731, 121-125 , 1 July 2005. Link to Supporting Materials and Movie. Reviews: 1. Melton, L. Imaging: The big picture. Nature 437, 775-779 (29 September 2005) 2. van Roessel P, Brand AH. Imaging into the future: visualizing gene expression and protein interactions with fluorescent proteins. Nature Cell Biology 4: (2002): E15-E20
Nov 17	Qing Zhong - Oxidative stress responses Paper: Tapodi A, Debreceni B, Hanto K, Bognar Z, Wittmann I, Gallyas F Jr, Varbiro G, Sumegi B. Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress. J Biol Chem. 2005 Oct 21;280(42):35767-75. Review: Martindale JL, Holbrook NJ. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol. 2002 Jul;192(1):1-15.
Nov 24	*Thanksgiving Vacation - no meeting*
Dec 1	Jonathan Wojtkowiak - Snail Paper: Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero CP, Sterner CJ, Notorfrancesco KL, Cardiff RD, Chodosh LA. The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell. 2005 Sep;8(3):197-209. Review: Savagner P. Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition. BioEssays Volume 23, Issue 10, Pages 912 - 923
Dec 8	Anthony Cimini - Profiling yeast Paper: Schuldiner M, Collins SR, Thompson NJ, Denic V, Bhamidipati A, Punna T, Ihmels J, Andrews B, Boone C, Greenblatt JF, Weissman JS, Krogan NJ. Exploration of the function and organization of the yeast early secretory pathway through epistatic miniarray profile. Cell, Vol. 123, 507-519, 2005 Review: Ooi SL, Pan X, Peyser BD, Ye P, Meluh PB, Yuan DS, Irizarry RA, Bader JS, Spencer FA, Boeke JD. Global synthetic-lethality analysis and yeast functional profiling.TRENDS in Genetics. Article in Press , 2005
Dec 15	Heather McClung

DATE

SPEAKER, TITLE AND REFERENCES

Sept 8

Rotation report - Irene Papanayotou

Sept 15

No meeting

Sept 22

Graduate Student Research Symposium - no meeting

Sept 29

Komal Sane - p53 and Apoptosis
Paper: Doumont G, Martoriati A, Beekman C, Bogaerts S, Mee PJ, Bureau F, Colombo E, Alcalay M, Bellefroid E, Marchesi F, Scanziani E, Pelicci PG, Marine JC. G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv. EMBO J. 2005 Sep 7;24(17):3093-103.
Review: Yu J, Zhang L. The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun. 2005 Jun 10;331(3):851-8.

Oct 6

Jay Koepke - Mitochondrial reactive oxygen species
Paper: Storz P, Doppler H, Toker A. Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species. Mol Cell Biol. 2005 Oct;25(19):8520-30
Review: Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol. 2003 Oct 15;552(Pt 2):335-44.

Oct 13

Chris Wood - 14-3-3 Proteins
Paper: Faul C, Huttelmaier S, Oh J, Hachet V, Singer RH, Mundel P. Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3. J Cell Biol. 2005 May 9;169(3):415-24.
Review: Bridges D, Moorhead GB. 14-3-3 proteins: a number of functions for a numbered protein. Sci STKE. 2005 Aug 9;2005(296):re10.

Oct 20

Jiang Zhu- GATA transcription
Paper: Rath N, Wang Z, Lu MM, Morrisey EE. LMCD1/Dyxin Is a Novel Transcriptional Cofactor That Restricts GATA6 Function by Inhibiting DNA Binding. Mol Cell Biol. 2005 Oct;25(20):8864-73.
Review: Heicklen-Klein A, McReynolds LJ, Evans T. Using the zebrafish model to study GATA transcription factors. Semin Cell Dev Biol. 2005 Feb;16(1):95-106.

Oct 27

Irene Papanayotou - Protein Palmitoylation
Paper: Swarthout JT, Lobo S, Farh L, Croke MR, Greentree WK, Deschenes RJ, Linder ME. DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. J Biol Chem. 2005 Sep 2;280(35):31141-8.
Review: Magee T, Seabra MC. Fatty acylation and prenylation of proteins: what's hot in fat. Curr Opin Cell Biol. 2005 Apr;17(2):190-6.

Nov 3

Eric Hales - p53 and MDM2
Paper: Wang C, et al (2005) MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J 24: 3279-3290
Review: Alarcon-Vargas D and Ronai Z (2002) p53-MDM2--the affair that never ends. Carcinogenesis 23: 541-547

Nov 10

Chris Jedeszko - MAGIC
Paper : A Magnetic Nanoprobe Technology for Detecting Molecular Interactions in Live Cells, Jaejoon Won, Mina Kim, Yong-Weon Yi, Young Ho Kim, Neoncheol Jung, Tae Kook Kim. Science, Vol 309, Issue 5731, 121-125 , 1 July 2005. Link to Supporting Materials and Movie.
Reviews: 1. Melton, L. Imaging: The big picture. Nature 437, 775-779 (29 September 2005)
2. van Roessel P, Brand AH. Imaging into the future: visualizing gene expression and protein interactions with fluorescent proteins. Nature Cell Biology 4: (2002): E15-E20

Nov 17

Qing Zhong - Oxidative stress responses
Paper: Tapodi A, Debreceni B, Hanto K, Bognar Z, Wittmann I, Gallyas F Jr, Varbiro G, Sumegi B. Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress. J Biol Chem. 2005 Oct 21;280(42):35767-75.
Review: Martindale JL, Holbrook NJ. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol. 2002 Jul;192(1):1-15.

Nov 24

Thanksgiving Vacation - no meeting

Dec 1

Jonathan Wojtkowiak - Snail
Paper: Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero CP, Sterner CJ, Notorfrancesco KL, Cardiff RD, Chodosh LA. The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell. 2005 Sep;8(3):197-209.
Review: Savagner P. Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition. BioEssays Volume 23, Issue 10, Pages 912 - 923

Dec 8

Anthony Cimini - Profiling yeast
Paper: Schuldiner M, Collins SR, Thompson NJ, Denic V, Bhamidipati A, Punna T, Ihmels J, Andrews B, Boone C, Greenblatt JF, Weissman JS, Krogan NJ. Exploration of the function and organization of the yeast early secretory pathway through epistatic miniarray profile. Cell, Vol. 123, 507-519, 2005
Review: Ooi SL, Pan X, Peyser BD, Ye P, Meluh PB, Yuan DS, Irizarry RA, Bader JS, Spencer FA, Boeke JD. Global synthetic-lethality analysis and yeast functional profiling.TRENDS in Genetics. Article in Press , 2005

Dec 15

Heather McClung