| PHC
7700 STUDENT JOURNAL CLUB
FALL 2003 |
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Course Director: Dr.Nicholas Davis
Phone: 577-8654
Description: Graduate student presentations of journal articles relating to a topic Link to PDF file for Journal Club guidelines: JClubguide.pdf Click on the authors for the PubMed abstract. If your location has full-text access, you will see a button with the journal name (Example: PNAS Online). Click on the button to get to the text. You can usually also get a PDF file for printing or saving by clicking on the line that says "Reprint (PDF) version of this article". For some journals, you may need to use Ovid to get access to full text. |
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Christopher
Wood - "How Tiny Tim gets into the powerhouse"
Paper: Lutz T, Neupert W, Herrmann JM. Import of small Tim proteins into the mitochondrial intermembrane space. EMBO J. 2003 Sep 1;22(17):4400-8. Review: Koehler CM. Protein translocation pathways of the mitochondrion. FEBS Lett. 2000 Jun 30;476(1-2):27-31. |
| Sept 24 | Desma Cooley
- Regulators of G Protein Signaling (RGS) and RGS-like
Proteins
Paper: Rojkova AM, Woodard GE, Huang TC, Combs CA, Zhang JH, Simonds WF. Gg subunit-selective G protein b5 mutant defines regulators of G protein signaling protein binding requirement for nuclear localization. J Biol Chem. 2003 Apr 4;278(14):12507-12. Review: Ross EM, Wilkie TM. GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu Rev Biochem. 2000;69:795-827. |
| Oct 1 | Beimeng Sun
- COPII
Charles Barlowe, Molecular Recognition of Cargo by the COPII Complex: A Most Accommodating Coat. Cell 2003 114: 395-397. Elena Mossessova, Lincoln C. Bickford, and Jonathan Goldberg. SNARE Selectivity of the COPII Coat. Cell 2003 114: 483-495. |
| Oct 8 | Scott Payton
- New advances in the p53 story
Paper: Bronder JL, Moran RG. A defect in the p53 response pathway induced by de novo purine synthesis inhibition. J Biol Chem. 2003 Sep 29. Review: Appella E, Anderson CW. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem. 2001 May;268(10):2764-72. |
| Oct 15 | Joshua Dilworth
- Signaling crosstalk
Paper: "Proximal Events in Signaling by Plasma Membrane Estrogen Receptors," Razandi M et al, Journal of Biological Chemistry, Vol. 278: 2701-2712 (January 24, 2003) Review: "Estrogen action and cytoplasmic signaling cascades. Part 1: membrane-associated signaling complexes," Segars et al., Trends in Endocrinology and Metabolism, Vol. 13 No. 8, pp. 349-354 (October, 2002) |
| Oct 22 | Jeffrey Hartman
- Remodeling the scaffolding for the cellular gallows
Paper: Howard PL, Chia MC, Del Rizzo S, Liu FF, Pawson T. Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11267-72. Review: Tibbetts MD, Zheng L, Lenardo MJ. The death effector domain protein family: regulators of cellular homeostasis. Nat Immunol. 2003 May;4(5):404-9. Review. |
| Oct 29 | Soo Jin Oh
- Mechanism of BCL-2
Paper: Ruffolo SC, Shore GC. BCL-2 selectively interacts with the BID-induced open conformer of BAK, inhibiting BAK auto-oligomerization. J Biol Chem. 2003 Jul 4;278(27):25039-45 Review: Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer. 2002 Sep;2(9):647-56. |
| Nov 5 | Hua Teng -
S-Nitrosylation of NSF
Paper: Matsushita K, Morrell CN, Cambien B, Yang SX, Yamakuchi M, Bao C, Hara MR, Quick RA, Cao W, O'Rourke B, Lowenstein JM, Pevsner J, Wagner DD, Lowenstein CJ. Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Cell. 2003 Oct 17;115(2):139-50. Review: Sollner TH, Sequeira S. S-nitrosylation of NSF controls membrane trafficking. Cell. 2003 Oct 17;115(2):127-9. |
| Nov 12 |
Chien-Chung
Chen - Research Seminar
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| Nov 19 | Sreenivasa Chandana - Research Seminar |
| Nov 26 |
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| Dec 3 | |
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Last updated 10/30/03
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