| PHC
7700 STUDENT JOURNAL CLUB
FALL 2002 |
|
Course Director: Dr. Hai-Young Wu
Phone: 577-2912 FAX: 577-6739
Description: Graduate student presentations of journal articles relating to a topic Link to PDF file for Journal Club guidelines: JClubguide.pdf Click on the authors for the PubMed abstract. If your location has full-text access, you will see a button with the journal name (Example: PNAS Online). Click on the button to get to the text. You can usually also get a PDF file for printing or saving by clicking on the line that says "Reprint (PDF) version of this article". For some journals, you may need to use Ovid to get access to full text. |
| DATE | SPEAKER, TITLE AND REFERENCES |
|
|
Noon - Organizational meeting in Pharm library |
| Sept 18 | Rotation research presentations - J. Dilworth, D. Cooley |
| Sept 25 | Grant
Blouse - "Protein Folding,
Chaperones and the Ribosome" or "Just Call Me Trigger Happy"
Primary paper: "L23 Protein Functions as a Chaperone Docking Site on the Ribosome", Kramer et al. (2002) Nature vol. 419, 171-174 Secondary paper: "The Structural Basis of Ribosome Activity in Peptide Bond Synthesis", Nissen et al. (2000) Science vol. 289, 920-930 Review: "Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein", Hartl et al. (2002) Science vol. 295, 1852-1858 |
| Oct 2 | Wei
Cao - The role of promyelocytic leukemia protein (PML) in tumor
suppression
Papers: Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, Chang KS. The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases. Mol Cell Biol. 2001 Apr;21(7):2259-68. Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Zhong S, Pandolfi PP, Ishii S. PML-RARalpha alleviates the transcriptional repression mediated by tumor suppressor Rb. J Biol Chem. 2001 Nov 23;276(47):43491-4. Review: Salomoni P, Pandolfi PP. The role of PML in tumor suppression. Cell. 2002 Jan 25;108(2):165-70. |
| Oct 9 | Sreenivasa
Chandana - Seeing is Believing!!! Non-invasive
imaging of gene expression and protein function in vivo with positron emission
tomography
Review:Sharma V, Luker GD, Piwnica-Worms D. J Magn Reson Imaging. 2002 Oct;16(4):336-51. Papers: Noninvasive imaging of protein-protein interactions in living animals. Luker GD, Sharma V, Pica CM, Dahlheimer JL, Li W, Ochesky J, Ryan CE, Piwnica-Worms H, Piwnica-Worms D. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6961-6. Adenovirus Biodistribution and Noninvasive Imaging of Gene Expression In Vivo by Positron Emission Tomography Using Human Sodium/Iodide Symporter as Reporter Gene Thomas Groot-Wassink; Eric O. Aboagye; Matthias Glaser; Nicholas R. Lemoine; Georges Vassaux Human Gene Therapy, 2002 september 20 13: 1723-1735 |
| Oct 16 | No JClub - Thesis defense Julie Legakis at 1:00 PM |
| Oct 23 | Chien-Chung
Chen - The biotechnological applications of ribozymes
Papers: Hartig JS, Najafi-Shoushtari SH, Grune I, Yan A, Ellington AD, Famulok M. Protein-dependent ribozymes report molecular interactions in real time. Nat Biotechnol. 2002 Jul;20(7):717-22. Vaish NK, Dong F, Andrews L, Schweppe RE, Ahn NG, Blatt L, Seiwert SD. Monitoring post-translational modification of proteins with allosteric ribozymes. Nat Biotechnol. 2002 Aug;20(8):810-5. Review: Breaker RR. Engineered allosteric ribozymes as biosensor components. Curr Opin Biotechnol. 2002 Feb;13(1):31-9. |
| Oct 30 | Desma
Cooley - Oligomerization of G Protein-coupled Receptors: Two heads
are better than one
Papers: Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer M, McAllister G, Guest PC. Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation. J Biol Chem. 2002 May 3;277(18):15482-5. Duthey B, Caudron S, Perroy J, Bettler B, Fagni L, Pin JP, Prezeau L. A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor. J Biol Chem. 2002 Feb 1;277(5):3236-41. Review: George SR, O'Dowd BF, Lee SP. G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat Rev Drug Discov. 2002 Oct;1(10):808-20. |
| Nov 6 | MIchelle
Milstein - Narcolepsy - a key role for the hypocretins/orexins
Papers: Hara J et al. Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 2001 May;30(2);345-54. Thannickal
TC et al. Reduced number of hypocretin neurons in human narcolepsy.
Neuron 2000 Sep;27(3):469-74.
Review:
Scammell
TE. Wakefulness: an eye-opening perspective on orexin neurons. Current
Biology 2001 Oct 2;11(19):R769-71.
|
| Nov 13 | Scott
Payton - RNA Interference with Regards to Possible Oncogenic Cancer
Therapy
Review: Hannon GJ. RNA interference. Nature. 2002 Jul 11;418(6894):244-51. Papers: Wilda M, Fuchs U, Wossmann W, Borkhardt A. Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi). Oncogene. 2002 Aug 22;21(37):5716-24. Brummelkamp T, Bernards R, Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell. 2002 Sep;2(3):243. |
| Nov 20 | Beimeng
Sun - The ENTH domain
Papers: Itoh
T, Koshiba S, Kigawa T, Kikuchi A, Yokoyama S, Takenawa T. Role of
the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis.
Science. 2001 Feb 9;291(5506):1047-51.
Ford
MG, Mills IG, Peter BJ, Vallis Y, Praefcke GJ, Evans PR, McMahon HT. Curvature
of clathrin-coated pits driven by epsin. Nature. 2002 Sep 26;419(6905):361-6.
Review: De
Camilli P, Chen H, Hyman J, Panepucci E, Bateman A, Brunger AT. The
ENTH domain. FEBS Lett. 2002 Feb 20;513(1):11-8
|
| Nov 27 | Cynthia
Chang - Small RNAs as ubiquitous regulators of gene
expression
Review: Why do miRNAs live in the miRNP? Schwarz DS, Zamore PD. Genes Dev 2002 May 1;16(9):1025-31 Papers: Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA.Llave C, Xie Z, Kasschau KD, Carrington JC. Science 2002 Sep 20;297(5589):2053-6 A microRNA in a multiple-turnover RNAi enzyme complex. Hutvagner G, Zamore PD. Science 2002 Sep 20;297(5589):2056-60 |
Trouble getting full text access?
Last updated 11/25/02