PHC 7700 STUDENT JOURNAL CLUB
FALL 2001
Room 6364 Scott, 12-1 pm Wednesdays (unless otherwise noted)

Course Director: Dr. Stanley Terlecky   Phone: 577-3557 FAX: 577-6739
                           Email: s.r.terlecky@wayne.edu

Description: Graduate student presentations of journal articles relating to a topic

Link to PDF file for Journal Club guidelines: J_Clubguide.pdf

Click on the authors for the PubMed abstract. If your location has full-text access, you will see a button with the journal name (Example: PNAS Online). Click on the button to get to the text. You can usually also get a PDF file for printing or saving by clicking on the line that says "Reprint (PDF) version of this article".
DATE
SPEAKER AND REFERENCES
 Thursday
Oct 11
 Julie Legakis - Prions and new treatment options for prion diseases
Papers: Peretz D, Williamson RA, Kaneko K, Vergara J, Leclerc E, Schmitt-Ulms G, Mehlhorn IR, Legname G, Wormald MR, Rudd PM, Dwek RA, Burton DR, Prusiner SB. Antibodies inhibit prion propagation and clear cell cultures of prion infectivity. Nature. 2001 Aug 16;412(6848):739-43.
Gilch S, Winklhofer KF, Groschup MH, Nunziante M, Lucassen R, Spielhaupter C, Muranyi W, Riesner D, Tatzelt J, Schatzl HM.  Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease.  EMBO J. 2001 Aug 1;20(15):3957-66.
Review: Caughey B. Transmissible spongiform encephalopathies, amyloidoses and yeast prions: common threads?
Nat Med. 2000 Jul;6(7):751-4.
Oct 17
 Ray Menard - Idiopathic pulmonary fibrosis and the role of TGF-b
Papers: Kolb M, Margetts PJ, Anthony DC, Pitossi F, Gauldie J.  Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis.  J Clin Invest. 2001 Jun;107(12):1529-36.
Eickelberg O, Pansky A, Koehler E, Bihl M, Tamm M, Hildebrand P, Perruchoud AP, Kashgarian M, Roth M.  Molecular mechanisms of TGF-(beta) antagonism by interferon (gamma) and cyclosporine A in lung fibroblasts. FASEB J. 2001 Mar;15(3):797-806.
Review: Gross TJ, Hunninghake GW.  Idiopathic pulmonary fibrosis. N Engl J Med. 2001 Aug 16;345(7):517-25.
 Oct 24
 Chien-Chung Chen - Nuclear Translation in Eukaryotic Cells
Papers:  Mangiarotti G. Coupling of transcription and translation in Dictyostelium discoideum nuclei. Biochemistry. 1999 Mar 30;38(13):3996-4000.
Iborra FJ, Jackson DA, Cook PR. Coupled transcription and translation within nuclei of mammalian cells. Science. 2001 Aug 10;293(5532):1139-42.
Perspective: Hentze MW. Protein synthesis. Believe it or not-translation in the nucleus. Science. 2001 Aug 10;293(5532):1058-9
Oct 31
 Sreenivasa Chandana - Role of a-synuclein in the pathogenesis of Parkinson's Disease
Papers: Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM. Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson
disease. Nat Med. 2001 Oct;7(10):1144-50
Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science. 2001 Jul 13;293(5528):263-9.
Review: Ciechanover A.  Linking ubiquitin, parkin and synphilin-1. Nat Med. 2001 Oct;7(10):1108-9.
Nov 7
 Wei Cao - Determining the substrate-binding site of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modifying techniques
Papers: Loo TW, Clarke DM. Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil. J Biol Chem. 2001 May 4;276(18):14972-9.
Loo TW, Clarke DM. Determining the dimensions of the drug-binding domain of human p-glycoprotein using thiol cross-linking compounds as molecular rulers. J Biol Chem. 2001 Oct 5;276(40):36877-80.
Review: Loo TW, Clarke DM. Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques. Biochim Biophys Acta. 1999 Dec 6;1461(2):315-25. 
 Nov 14
 Grant Blouse - Membrane-type serine proteases
Papers:  Takeuchi T, Shuman MA, Craik CS. Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue.  Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11054-61.
Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR, Craik CS. Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. J Biol Chem. 2000 Aug 25;275(34):26333-42.
Review: Hooper JD, Clements JA, Quigley JP, Antalis TM.  Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes. J Biol Chem. 2001 Jan 12;276(2):857-60
Nov 28
 Michelle Milstein - Role of gp120 in cardiac hypertrophy
Papers: Uozumi H, Hiroi Y, Zou Y, Takimoto E, Toko H, Niu P, Shimoyama M, Yazaki Y, Nagai R, Komuro I. gp130 plays a critical role in pressure overload-induced cardiac hypertrophy. J Biol Chem. 2001 Jun 22;276(25):23115-9.
Yasukawa H, Hoshijima M, Gu Y, Nakamura T, Pradervand S, Hanada T, Hanakawa Y, Yoshimura A, Ross J Jr, Chien KR. Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways. J Clin Invest. 2001 Nov 15;108(10):1459-1467.
Review: Ohtani T, Ishihara K, Atsumi T, Yoshida Y, Nishida K, Narimatsu M, Shirogane T, Hibi M, Hirano T. gp130-mediated signalling as a therapeutic target. Emerging Therapeutic Targets 4 (4): 1-21
Dec 5
 Ferdous Barlaskar - How to make a peroxisome
Papers: Otera H, Harano T, Honsho M, Ghaedi K, Mukai S, Tanaka A, Kawai A, Shimizu N, Fujiki Y. The mammalian peroxin Pex5pL, the longer isoform of the mobile peroxisome targeting signal (PTS) type 1 transporter, translocates the Pex7p.PTS2 protein complex into peroxisomes via its initial docking site, Pex14p. J Biol Chem. 2000 Jul 14;275(28):21703-14.
Matsumura T, Otera H, Fujiki Y. Disruption of the interaction of the longer isoform of Pex5p, Pex5pL, with Pex7p abolishes peroxisome targeting signal type 2 protein import in mammals. Study with a novel Pex5-impaired Chinese hamster ovary cell mutant. J Biol Chem. 2000 Jul 14;275(28):21715-21.
Review: Terlecky SR, Fransen M. How peroxisomes arise. Traffic. 2000 Jun;1(6):465-73

Last update 11/29/01

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