Each session will consist of 3 hours of lecture per week for 4 weeks and will be allotted 1 credit. Class meeting times will be arranged with the instructors. An organizational meeting for all courses will be held on Thursday, January 11 at 1:00 PM in the Pharmacology Library (6364 Scott Hall). Contact the listed instructors for course details or R. Yamazaki (ryamazak@med.wayne.edu) for general information.

"Signaling in cell death and survival pathways"

John Reiners

Discussions of papers dealing with programmed cell death: autophagy, Bcl family members, non-apoptotic functions of caspases, and the role of mitochondria.

Mac McCauley

Not offered this semester

Ellen Tisdale

A variety of hereditary and autoimmune diseases are the result of a defect(s) in some aspect of membrane transport. A better understanding of the molecular basis that underlies these diseases will lead to possible therapeutic intervention and treatments. For this minicourse, students are expected to present and and critique journal articles relevant to the topic. There will be no exam and the grade will be based on oral presentation and discussion of journal articles.

"Proteomic analysis"

Paul Stemmer

This minicourse will cover selected methods used in protein fractionation and the analysis of proteomes. Material providing a theoretical basis for the analysis will be presented. Students will participate in discussions and in mass spectroscopic-based identification of proteins. This includes “hands on” work to generate spectra and to complete the analysis using internet-based software.

"DNA repair and human disease"

Gan Wang and Susan Xu

This minicourse will explore recent research progress in DNA repair and the role of DNA repair deficiency in human disease development. Individual DNA repair pathways, DNA damage-mediated cell cycle checkpoint regulation, and the consequences of DNA repair defects will be discussed. The minicourse will consist of eight sessions, with each session consisting of an introductory lecture followed by the discussion of a specific assigned paper.

Not offered this semester