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Each course will consist of 3 hours of lecture per week for 4 weeks and will be allotted 1 credit. Class meeting times will be arranged with the instructors. An organizational meeting for all courses will be held on Thursday, September 6th at 1:00 PM in the Pharmacology Library (6364 Scott Hall) to determine enrollment and meeting days and times for each of the courses. Contact the listed instructors for course details or R. Yamazaki (ryamazak@med.wayne.edu) for general information. |
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September 10 - October 5 |
October 8 - November 2 |
November 5 - November 30 |
| Introduction to bioinformatics and structure Russell Yamazaki This course will
cover protein sequence searching, multiple sequence
alignments and viewing of protein structures using desktop computers.
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Human Diseases that Perturb Membrane Transport Ellen Tisdale A variety of
hereditary and autoimmune diseases are the result of a
defect(s) in some aspect of membrane transport. A better understanding
of the molecular basis that underlies these diseases will lead to
possible therapeutic intervention and treatments. For this minicourse,
students are expected to present and and critique journal articles
relevant to the topic. There will be no exam and the grade will be
based on oral presentation and discussion of journal articles.
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Endomorphins Over the past decade, we
have witnessed the discovery and characterization of a new endogenous
opioid system—the Endomorphins—that has shed new light on our
understanding of addiction and other aspects of opioid pharmacology.
Through critical reading, presentations and discussion, this seminar
course will examine physiological, pathological and therapeutic
implications of the Endomorphins and pharmacologic agents that
influence their actions. |
| Special Topics in Yeast Cell Biology Nicholas Davis The scientific
literature for several student-selected areas in yeast cell biology
will be reviewed in-depth. Possible focus areas include cell
cycle, sexual conjugation (signal transduction), membrane trafficking,
and ageing. Students will read assigned papers and participate in
leading biweekly discussions.
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Oxidants, Organelles, and Human Aging Stanley Terlecky This course will
examine how cellular organelles
produce and degrade various oxidants and will analyze the mechanisms in
place to assure a balance of these processes. The role of
reactive oxygen species in potentiating age-related disease and human
aging itself will also be covered. The course will focus on a
reading of primary literature and related class discussions/critiques.
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R7 family of Regulators of G Protein Signaling: Multifunctional Regulators of Cell Signaling Andrade, Bannon, and
Bouhamdan In the last decade
RGS proteins have emerged as important and ubiquitous regulators of
membrane signaling. These proteins are multidomain proteins
sharing a core domain that confers them the ability to as as GAPs
towards heterotrimeric G proteins but differ extensively outside this
domain. This has led to their classification into multiple subfamilies
which are though to subserve specific signaling functions within cells.
The R7 family of RGS proteins is
perhaps the best understood of these families and in this minicourse we will take a multidisciplinary look at these proteins and how their molecular properties underlie function and pathology. |