PHC 7650 MINICOURSES
SPECIAL COURSE OFFERINGS FOR FALL, 2003
Each session will consist of 3 hours of lecture per week for 4 weeks and will be allotted 1 credit. Class meeting times will be arranged with the instructors. An organizational meeting for all courses will be held on Wednesday, September 3rd at 1:00 PM in the Pharmacology Library (6364 Scott Hall). Contact the listed instructors for course details or R. Yamazaki (ryamazak@med.wayne.edu) for general information.
Session 1
September 8 - October 3
Session 2
October 6 - October 31
Session 3
November 3 - December 5
Phototransduction: From proteomics to structure to a coordinated signaling pathway

Russell Yamazaki and Akio Yamazaki

Mon, Wed 4-5:30 6364 Scott

First meeting 9/10/03

Each student will be given a peptide sequence from a retinal phototransduction protein and will do the following:

  • BLAST search to identify the protein
  • Multiple sequence alignment of the protein family
  • Determination of secondary structure and 3-dimensional structure (where known)
  • Gather information from the literature about the function and regulation of the protein


All students will then work together to construct a coherent phototransduction signaling scheme for control of cGMP levels in the light and dark.


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Cellular and Molecular 
Basis of Addiction 

Dr. Eugene Schoener
Addiction Research Institute, 2761 East Jefferson Ave.
Phone (313) 993-1364 FAX 993-1381, email: eschoen@med.wayne.edu

Tues, 1-4 6364 Scott

This minicourse will provide the advanced graduate student in Pharmacology or related disciplines with an integrated understanding of neurochemical, molecular, pharmacologic, and behavioral mechanisms that underlie acute and chronic actions of drugs that are abused (ethanol, opioids, cocaine. cannabinoids, etc.) Over five weekly three-hour sessions, the course will focus on issues related to: a) the neurobiologic basis of reinforcement/reward and dependence, b) factors of individual vulnerability to addiction, c) clinical applications of pharmacogenetics in addiction, d) drug induced changes in gene expression, and e) cocaine—putting it all together. Each session will include lecture, seminar and journal club components. Students will be expected to complete reading and presentation assignments on each topic. No written exam will be held. Grades will be determined on the basis of student presentations, written assignments and class participation. 
 
 
 
 

 
Proteinase Mechanism and Inhibition

Grant Blouse

This course will present an introduction to the different classes of proteinases, their mechanism of action and regulation by inhibitors with an emphasis on proteinases of therapeutic interest.  The format of the course will be to incorporate short lectures with student-led discussions of applicable journal articles.  Each student will also present a small poster project at the end of the session characterizing the mechanism and therapeutic relevance of a specific proteinase-inhibitor pair.  Grading is based on class participation and the poster project.
 

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