Kaladhar B. Reddy, Ph.D.
Associate Professor of Pathology
Breast Cancer Program

EDUCATION:
Osmania University, Hyderabad, India, 1978, B.Sc.
Osmania University, Hyderabad, India, 1980, M.Sc.
Osmania University, Hyderabad, India, 1984, Ph.D.
Postdoctoral Fellow, Department of Pathology, University of Medicine and Dentistry of New Jersey, Newark,, NJ, USA, 1987-1988
Postdoctoral Fellow, Department of Medicine/ Oncology, The University of Texas Health Science Center at San Antonio, TX, USA, 1988-1990

APPOINTMENTS:
Associate Professor, Dept. of Pathology, Wayne State University, Detroit MI, 1998 - Present.
Member, Karmanos Cancer Institute.
Assistant Professor, Dept. of Pathology, School of Medicine, Wayne State University, Detroit, MI, 1993- 1998
Instructor, Dept. of Medicine/ Oncology, The University of Texas Health Science Center at San Antonio, TX 1990-1993
Member, The Institute for Cancer Research and Care, San Antonio, TX 1991- 1993

RESEARCH INTERESTS:
Growth factor and hormone mediated signaling, Tumor Biology, Breast Cancer

REPRESENTATIVE PUBLICATIONS:

1. Krueger JS, Keshamouni VG, Atanaskova N, Reddy KB: Temporal and Quantitative regulation of MAP kinase activation modulates cell motility and invasion. Oncogene 20(31): 4209-4218, 2001.

2. Reddy KB, McGowen R, Schuger L, Visscher D, Sheng S: Maspin expression inversely correlates with breast tumor progression in MMTV/TGF-alpha transgenic mouse model. Oncogene 20: 6538-6543, 2001.

3. Atanaskova N, Keshamouni VG, Krueger JS, Schwartz JA, Miller F, and Reddy KB: MAP Kinase/ Estrogen Receptor cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer tamoxifen resistance. Oncogene 21:4000-4008, 2002.

4. Keshamouni VG, Mattingly RR and Reddy KB: Mechanism of 17-beta-Estradiol-Induced Erk1/2 Activation in Breast Cancer Cells: A Role for HER2 and PKC-delta. J Biol Chem 21: 22558-22565, 2002.

5. Reddy KB, Nabha S and Atanaskova N: Role of MAPK in tumor progression and invasion. Cancer and Metastasis Reviews 22:395-403, 2003.

6. Krueger JS, and Reddy KB: Distinct mechanisms mediate the initial and sustained phases of cell migration in EGFR overexpressing cells. Mol Cancer Res 11: 801-9, 2003.

7. Farhana L, Dawson MI, Huang Y, Zhang Y, Rishi AK, Reddy KB, Freeman RS, Fontana JA. Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities. Oncogene. 23:1874-84, 2004.

8. Nabha S, Glaros S, Hong M, Lykkesfeidt AE, Schiff R, Osborne CK, Reddy KB: Upregulation of PKC-delta contributes to anti-estrogen resistance in mammary tumor cells. Oncogene :1-11, 2005.