Undergraduate degree: B.S., Biological Sciences, Wayne State University, Detroit, MI, 1991.
Graduate degree: Ph.D., Cancer Biology, Wayne State University, Detroit, MI, 1991.
Post-doctoral Fellowship: Department
of Pathology, Medical College of Ohio, 3/97-6/98.
Department of Otolaryngology,
Wayne
State University, Detroit, MI, 7/98-7/00.
Research Interests: Molecular biology and genetics of head and neck cancer .
Academic office phone number: 313-745-4336
Email: piechock@karmanos.org
Selected Publications: Piechocki M.P., S. Kantak and J.M. Onoda.
TPA--induced differentiation of rat aortic endothelial cells is substrate
specific and receptor mediated. In: Angiogenesis:
Key Principles‑ Science- Technology Medicine. (R. Steineer, P.B.
Weisz and R. Langer, eds.), EXS 61:152-157, Birkhauser Verlag Basel/Switzerland,
1992.
Onoda,
J.M., Piechocki M.P., and Honn K.V.
Radiation-induced Increase in Expression of the aIIbb3
integrin in melanoma cells: Effects on metastatic potential. Radiation Research,
130(3): 281-288, 1992.
Onoda,
J.M., Piechocki M.P., R.G. Mihu, and
K.V. Honn. Calcium channel blockers
and cisplatin: synergistic antimetastatic effects.
In: New Concepts in Cancer: Metastasis, Oncogenes and Growth Factors (C.
Etievant, J. Cros, Y. Rustum, eds.), pp. 127-147, MacMillan Press, London. 1990.
Onoda,
J.M. and Piechocki M.P..
Radiation Enhanced Tumor Cell Receptor Expression and Metastasis. In:
Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury. (K.V.
Honn, L.J. Marnett, S. Nigam and T. Walden, eds.), pp. 153-160, Kluwer Academic
Publishers, Boston. 1991.
Liu,
W., Piechocki M.P., Shridhar V., G.
Lyles, S. Zheng, Y. Nakamura, H. Drabkin, J. Vance, and D.I. Smith. The
isolation of a yeast artificial chromosome (YAC) contig extending for 2
megabases in the vicinity of the von Hippel Lindau disease gene. Human Molecular Genetics, 2(8): 1177-1182, 1993.
Piechocki, M.P. and R.N. Hines. Oligonucleotide
Design and Optimized Protocol for Site-Directed Mutagenesis. BioTechniques,
16(4): 702-706, 1994.
Hines,
R.N., Piechocki M.P., and P.D.
Boucher. Molecular Mechanisms
Controlling Cyp1A Gene Expression. In:
Frontiers in Biotransformation (Volume 9) Regulation and Control of Complex
Biological Processes by Biotransformation. (K. Ruckpaul and H. Rein, eds.),
pp.85-111, Akademie Verlag, Berlin, 1994.
Boucher,
P.D., Piechocki, M.P. and
Hines, R.N. Partial characterization of the human CYP1A1
negatively acting transcription factor and mutational analysis of its cognate
DNA recognition sequence. Mol. Cell. Biol.,
15 (9) 5144-5151, 1995.
Piechocki, M.P. and R.N. Hines. Functional
characterization of the human CYP1A1
negative regulatory element; modulation of Ah receptor mediated transcriptional
activity. Carcinogenesis Vol 19 no. 5 pp. 771-780, 1998.
Ruch,
R., Cesen-Cummings, K., Piechocki, M.
and A. Malkinson. Role of altered gap Junctional intercellular communication in
lung neoplasia. In: Gap Junctions;
Proceedings of the 8th International Gap Junction Conference. (R. Werner, ed.),
pp. 362-366, IOS Press, Amsterdam. 1998.
Piechocki, M.P., Burk, R.D. and R.J. Ruch.
Regulation of Connexin32 and connexin43 gene expression by DNA
methylation in rat liver cells. Carcinogenesis,
Vol. 20, no. 3 pp. 401-406, 1999.
Piechocki, M.P., Toti, R., Fernstrom, M.J., Burk, R.D. and R.J. Ruch.
Liver cell-specific transcriptional regulation of Connexin32.
Biochim Biophys Acta, 1491(1-3):107-122, 2000.
Wei, W-Z, Piechocki, M.P., Pilon, S. and C. Kelly. erbB-2 DNA
vaccines. Biotech lab international (January-February/2000 p.13-15).
Yoo GH; Washington J.; Piechocki
M; Shibuya TY; Ensley, JF; Oda D;
Wei WZ. Progression of Head and Neck
Cancer in an In-Vitro Model. Arch Otolaryngol
Head Neck Surg 126:1313-1318, 2000.
Pilon,
S., Piechocki, M.P. and Wei, W-Z.
Vaccination With Cytoplasmic ErbB-2 DNA protects mice from mammary tumor growth
without anti-ErbB-2 antibody. Journal
of Immunology 167: 3201-3206, 2001.
Christopherson,
I., Piechocki, M., Liu, G., Ratner,
S. and Galy A. Regulation of L-Selectin
expression by a dominant negative Ikaros protein. Journal of Leukocyte Biology
69: 675-683, 2001.
Ratner,
S., Piechocki, M.P. and A. Galy.
Role of Rho-family GTPase Cdc42 in polarized expression of lymphocyte
appendages. Blood (submitted).
Piechocki, M.P., Pilon, S.A., Kelly, C. and Wei, W-Z. Degradation
signals in ErbB-2 dictate proteasomal processing and immunogenicity and resist
protection by cis glycine-alanine repeat. Cellular Immunology In
Press, Vol. 216(2), 2001.
Piechocki,
M.P., Pilon,
S.A. and Wei, W-Z.
Quantitative measurement of anti-ErbB-2 antibody by flow cytometry and
ELISA. J. of Immunological Methods 259/1-2: 33-42, 2001.
Piechocki, M.P., Pilon, S.A. and Wei, W-Z. Complementary
anti-tumor immunity induced by plasmid DNA encoding secreted and cytoplasmic
human ErbB2. Journal of Immunology 167: 3367-3374, 2001.
Yoo
GH; Washington J.; Oliver, J., Piechocki
M; Shibuya TY; Ensley, JF.
Progression of Head and Neck Cancer in an In-Vitro Model. Cancer
In Press
Piechocki,
M.P., Lonardo,
F., Ensley, J.F., Nguyen, T., Foster-Nora, J., Kim, H. and Yoo, G.H.
Anticancer Activity of Docetaxel in Murine Salivary Gland Carcinoma.
Clinical Cancer Research (submitted).
Piechocki, M.P. Ho, Y-S. and Wei, W-Z.
Immune tolerance to ErbB-2 in transgenic mice expressing human ErbB-2
(Her-2) under the Whey acidic protein promoter (In preparation).
Ratner,
S., Piechocki, M.P. and A. Galy.
Role of Rho-family GTPase Cdc42 in polarized expression of lymphocyte
appendages. AAI/CIS Immunology 2000 #148.28.
Piechocki M.P., Pilon, S. and W-Z. Wei. ERBB-2 (E2) DNA vaccines containing EBV gly-ala or Pro-ala
repeat (GAr or PAr) sequence. Proceedings of AACR Vol. 41 March 2000 p.796
#5059.
Piechocki M.P, Pilon,S. and W-Z. Wei. ERBB-2 with glycine-alanine (GAr)
repeat insertion was processed by proteosome and induced tumor rejection.
AAI/CIS Immunology 2000 #53-21.
Piechocki M.P., Pilon, S. and W-Z. Wei. Development of ERBB2
(E2) DNA vaccines. .AAI/CIS Immunology 2000 #53.20.
Piechocki, M.P., Ho Y-S. and Wei, W-Z. Transgenic
mice expressing Human ErbB-2 (E2) under the Whey acidic protein promoter exhibit
immunological tolerance to E2. Proceedings
of AACR Vol. 42 March 2001 p.560 #3009.
Department Overview
| Full-time Faculty | Residency Program
| Fellowships
Residents | Medical Students | Clinical/Research Newsletters
Conference Schedules | Patient Services
| Research & Clinical Labs
Detroit Medical Center | Wayne
State University | WSU - School of Medicine
Return to WSU Otolaryngology Home Page