Anxiety Disorders
Imaging Laboratory
Brain Imaging Research DivisionWayne State University
|
Anxiety Disorders
Brain Imaging Research Division |
|
Research InterestsResearch in this laboratory focuses on identifying the neural mechanisms that contribute to complex cognitive and emotional behaviors and neuropsychiatric disorders. Themes of interest include emotional salience, cognitive-emotion interactions and affective regulation, individual differences in emotional processing, and therapeutic intervention. These themes are explored using functional neuroimaging (e.g. fMRI, PET, ERP) which has allowed us to examine emotional processing in discreet brain circuits within individuals. This laboratory uses non-invasive brain imaging techniques to identify the neural substrates of emotion in normal human behavior and in anxiety disorders, such as social phobia and posttraumatic stress disorder. In addition, we have the ability to detect dynamic changes in brain activity during cognitive and affective processing within individual subjects during an ongoing imaging session with real-time fMRI, an innovative, state-of-the-art tool advancing our investigational themes. We aim to develop an integrative model for brain function and mental illness, and with that goal, we are engaged in collaborative efforts that combine fMRI with other human neuroscience methodologies, including neuropsychology, psychophysiologic and behavioral studies, functional genomics, neurochemical PET receptor imaging, structural/morphometric brain imaging, steady-state probe tomography, and magnetic resonance spectroscopy. |
Recent PublicationsPhan KL, Fitzgerald DA, Gao K, Moore GJ, Tancer ME, Posse S (In Press). Real-time fMRI of cortico-limbic brain activity during emotional processing. NeuroReport.Phan KL, Taylor SF, Welsh RC, Ho H-S, Britton JC, Liberzon I (In Press). Neural correlates of individual ratings of emotional salience: a trial-related functional magnetic resonance imaging study. NeuroImage. Taylor SF, Welsh RC, Wager TD, Phan KL, Fitzgerald KD, Gehring W (In Press). A functional neuroimaging study of motivation and executive function. NeuroImage. Phan KL, Wager TD, Taylor SF, Liberzon I (In Press). Functional brain imaging studies of human emotion. CNS Spectrums. Liberzon I, Britton JC, Phan KL (2003). Neural correlates of traumatic recall in posttraumatic stress disorder. Stress 6:151-156. Liberzon I, Phan KL (2003). Brain imaging studies of posttraumatic stress disorder. CNS Spectrums 8:625-634. Liberzon I, Phan KL, Khan S, Abelson JL. Role of GABA-A receptors in anxiety (2003). Evidence from animal models, clinical psychopharmacology, and neuroimaging studies. Current Neuropharmacology 1:267-283. Wager TD, Phan KL, Liberzon I, Taylor SF (2003). Valence, gender, and lateralization of functional brain anatomy in emotion: A meta-analysis of findings from neuroimaging. NeuroImage 19:513-531. Liberzon I, Phan KL, Decker LR, Taylor SF (2003). Extended amygdala and emotional salience: A PET investigation of positive and negative affect. Neuropsychopharmacology 28:726-733. Phan KL, Liberzon I, Welsh RC, Britton JC, Taylor SF (2003). Habituation of rostral anterior cingulate cortex to repeated emotionally salient pictures. Neuropsychopharmacology 28:1344-1350. Taylor SF, Phan KL, Decker LR, Liberzon I (2003). Subjective rating of emotionally salient stimuli modulates limbic activity. NeuroImage 18:650-659. Phan KL, Taylor SF, Welsh RC, Decker LR, Nichols TE, Noll DC, Britton JC, Liberzon I (2003). Activation of the Medial Prefrontal Cortex and Extended Amygdala by Individual Ratings of Emotional Arousal: An fMRI Study. Biological Psychiatry 53:211-215. Phan KL, Wager TD, Taylor SF, Liberzon (2002). Functional Neuroanatomy of Emotion: a Meta-Analysis of Emotion Activation Studies in PET and fMRI. NeuroImage 16:331-348. Liberzon I, Zubieta JK, Fig LM, Phan KL, Koeppe RA, Taylor SF (2002). Mu-Opiod receptors and limbic responses to aversive emotional stimuli. Proceedings of the National Academy of Sciences of the Unites States of America (PNAS) 99:7084-7089. |