School of Medicine

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The Adult Neuropsychology Program serves the Detroit metropolitan area with comprehensive neuropsychological evaluations. Whether the evaluation is needed for diagnostic purposes, treatment planning, educational special needs, or for a disability claim, we can provide professional and accurate assessments and reports. With a team of professional psychometricians, we conduct comprehensive neuropsychological evaluations and provide impartial evidence-based reports in three major areas: 1) the cognitive and psychological effects of neurological and medical disorders, such as epilepsy, brain tumors, stroke, multiple sclerosis, head injury, and learning disabilities; 2) identification of dementia and memory loss in the elderly; 3) objective determination of disability, competency, need for guardianship, and ability to return to work. We offer an accessible location, excellent appointment availability and rapid turnaround on evaluations and reports.

Joshua E. Adler, MD, PhD	Randall R. Benson, MD	Nurse Coordinator:
M. Maher Fakhouri, MD	Richard A. Lewis, MD	(313) 745-8953 phone
Kenneth Maiese, MD	Aashit K. Shah, MD	(313) 745-8958 fax
Jagdish R. Shah, MD	Renee Bailey Van Stavern, MD
Darren Fuerst, Ph.D		Appointment scheduling

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The new Dementia and Behavioral Neurology Clinic sees adolescent and adult patients with perceptuomotor or cognitive impairment resulting from a range of developmental, acquired and degenerative causes. The clinic offers comprehensive, multidisciplinary diagnostic evaluation by fellowship-trained and Board-certified clinicians using the most current neurological, neuropsychological, molecular-genetic and functional neuroimaging methods. As part of this comprehensive approach, meetings are scheduled with family members to discuss diagnosis, prognosis and therapeutic interventions. The clinic also offers select clinical and basic research protocols.

Joshua E. Adler, MD, PhD	Nurse Coordinator:
Randall R. Benson, MD	(313) 745-1416 phone
Darren R. Fuerst, PhD	(313) 745-4468 fax	Appointment scheduling

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The WSU/DMC Outpatient stroke clinic and inpatient services are staffed by neurologists with fellowship training in cerebrovascular disease. Patients can be seen following transient ischemic attacks, ischemic stroke, or cerebral hemorrhage. Stroke risk assessments can also be done for asymptomatic patients with carotid stenosis or unruptured cerebral aneurysms. The WSU/DMC stroke program is actively involved in clinical studies for primary and secondary prevention of stroke in patients with a preceding TIA or stroke. Current studies include a comparison of warfarin versus aspirin for patients with symptomatic intracranial stenosis. A complete listing of ongoing trials can be found at the stroke program website:

http://www.med.wayne.edu/stroke

The Department of Neurology cerebrovascular disease/stroke program has a national reputation and is actively involved in a number of multi-center clinical trials for primary and secondary prevention of stroke (Drs. Carhuapoma, Chaturvedi, Jacobs, and R. VanStavern). WSU is the USA's coordinating center for the world's largest study of carotid endarterectomy for stroke prevention in patients with internal carotid artery stenosis. Dr. Chaturvedi is the Director of the cerebrovascular disease program.

The neurotrauma/neurointensive care program (Drs. Carhuapoma, Coplin Kraus) works closely with the Departments of Neurosurgery, Emergency Medicine, Anatomy, and Physiology. The clinical program is based at Detroit Receiving Hospital (a large, urban, level I emergency trauma center) and has a number of ongoing clinical trials which include hemicraniectomy for acute/traumatic brain injury.

Seemant Chaturvedi, MD	Nurse Coordinator:
William Coplin, MD	(313) 745-8937 phone
Bradley Jacobs, MD	(313) 745-4273 fax
Jacqueline Kraus, M.D., Ph.D.
Renee Bailey Van Stavern, MD	Appointment scheduling

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The comprehensive Epilepsy program at WSU/DMC provides state of the art medical and surgical treatment for adults and children with epilepsy. We offer a full complement of advanced diagnostic tests to establish seizure classification, to assess response to medical therapy, and to evaluate patients for epilepsy surgery. The program provides comprehensive epilepsy care through a dedicated multidisciplinary team that includes neurologists/epileptologists, pediatric neurologists/epileptologists, adult and pediatric neurosurgeons, adult and pediatric neuropsychologists, neuroradiologists, and EEG technologists. For more information, visit the epilepsy website at:

http://www.med.wayne.edu/neurology/clin_programs/Labs/Epilepsy/epilepsy.html

Jeffrey Loeb, MD, PhD	Nurse Coordinator:
Darren R. Fuerst, PhD	(313) 745-1416 phone
Aashit K. Shah, MD	(313) 745-4273 fax
Jagdish R. Shah, MD
Craig Watson, MD, PhD	Appointment scheduling

The comprehensive Epilepsy program at Children's Hospital of Michigan/Wayne State University provides state of the art family centered care for the treatment of Children with Epilepsy. This encompasses medical and surgical treatments. This program has an international reputation and has helped children from all parts of the globe. The program provides comprehensive epilepsy care through a dedicated team of pediatric neurologists, neuro-surgeons, neuropsychologist , nurses, pediatric and adult epilepotogists, and neuroradiologist and electroneurodiagnostic technologist. A full array of advanced diagnostic tests is offered to establish seizure classification, assess response to medical therapy, search for a possible seizure focus, which could indicate benefit form Epilepsy surgery. The pediatric neurology office also has on going research searching for the causes of Epilepsy.

The epilepsy program in the Division of Pediatric Neurology is internationally renowned. Referrals for epilepsy surgery come from national and international sources. Extramural support for the program includes five NIH grants. The clinical component of the epilepsy program is headed by Dr. Harry Chugani and includes PET neuroimaging and MR spectroscopy. Drs. A. Shah and J. Shah from the adult neurology program provide EEG expertise for pediatric epilepsy surgery and are collaborators on some studies.

Harry T. Chugani, MD	Nurse Coordinator:
	(313) 745-5788 phone
	(313) 745-5074 fax

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A typical visit to The Headache and Pain clinic at Wayne State University involves initial evaluation by a neurologist to establish the proper diagnosis and to provide the latest advanced management for headache and pain conditions. Complicated cases may require multidisplinary approach with affiliated psychologists, physical therapists, and anesthesiologists to provide the best effective treatment for headache and pain. The treatment options after establishing the diagnosis are, medications adjustment, nerve block, botox injection, and occasionally surgical intervention.

Joshua E. Adler, MD, PhD	Nurse Coordinator:
M. Maher Fakhouri, MD	(313) 745-1416 phone
	(313) 745-4273 fax	Appointment scheduling

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The Neuro Infectious Disease Division of the Department of Neurology has expertise in the diagnosis and management of viral infections of the nervous system. We have particular expertise in the diagnosis and
management of the neurological complications of HIV infection and participate in multicenter trials of new treatments in collaboration with our colleagues in the HIV clinic and in the Neuromuscular Clinic. We have a special interest in viral encephalitis and are participating, as part of the Collaborative Antiviral Study Group, in the planning and execution of studies of new ways of treating herpes simplex encephalitis.

Alexandros C. Tselis, MD, PhD	Nurse Coordinator:
	(313) 745-4280 phone
	(313) 745-4216 fax	Appointment scheduling

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Evaluation and treatment for a full range of movement disorders is offered, including Parkinson's disease and related syndromes, essential and other tremors, torticollis and other dystonias, restless legs syndrome, Tourette's, Huntington's and other choreas, Wilson's disease and spinocerebellar ataxias. Management of Parkinson's disease includes access to clinical trials as well as the latest approved medications for Parkinson's disease, and multidisciplinary evaluations including physical therapy, speech and swallowing therapy, psychiatry, occupational therapy and referral for Parkinson's surgery when indicated. Medical tremor therapy and evaluation for surgical tremor therapy are available. Botulinum toxin (Botox and Myobloc) therapy for torticollis and other dystonias, including limb dystonias and orofacial dystonias is performed with electromyographic (EMG) guidance. Evaluation, diagnosis and treatment of unusual movement disorders including Farr's disease and other calcifications of the basal ganglia, Stiff person syndrome and painful legs/moving toes is supplemented by access to research in these areas.

Edwin George, MD, PhD	Nurse Coordinator:
	(313) 745-4171 phone
	(313) 745-4468 fax	Appointment scheduling

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WSU/DMC has a very large and active comprehensive center for the evaluation and treatment of patients with multiple sclerosis (MS) and other demyelinating diseases of the central nervous system. In addition, we have considerable experience in evaluation and management of patients with neurologic manifestation of other autoimmune diseases.

WSU is also very active in clinical trials of new treatments for MS as well as in basic research relevant to this chronic illness. The clinic is part of the Consortium of Multiple Sclerosis Centers and is recognized by the National Multiple Sclerosis Society as a leading clinical, research, and educational center for multiple sclerosis (MS). Approximately 7,000 patients with MS reside in the metropolitan Detroit area. The clinic has participated and is currently participating in a number of multi-center therapeutic trials in MS.

Darren R. Fuerst, PhD	Nurse Coordinator:
James Garbern, MD, PhD	(866) 263-1257 phone
John Kamholz, MD, PhD	(313) 745-4468 fax
Omar A. Khan, MD
Robert P. Lisak, MD
Alexandros C. Tselis, MD, PhD	Appointment scheduling

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The neurogenetics clinic specializes in treating patients and their families who have inherited disorders that have a neurologic component. In addition to evaluation, genetic testing and interpretation of results, we also provide genetic counseling for patients and their families so that they better understand their disease and the implications for everyone in the family. Common disorders for which we specialize include Huntington disease, the spinocerebellar ataxias, neurofibromatosis, Pelizaeus-Merzbacher disease, tuberous sclerosis, Charcot-Marie Tooth disease, Freidreich ataxia and myotonic dystrophy to name a few. We also have a protocol for testing at-risk individuals presymptomatically for adult onset inherited disorders such as Huntington disease or the spinocerebellar ataxias. This includes extensive counseling to make sure that a patient has made a careful decision and is prepared to cope with the results and all of the implications.

The neurogenetics clinic in the Department of Neurology is directed by Dr. Garbern. Karen Krajewski, a certified genetics counselor, can provide services such as genetic testing, education, and counseling for a wide variety of genetic disorders that affect the nervous system including Huntington disease, spinocerebellar ataxias, Pelizaeus-Merzbacher disease (PMD), and myotonic dystrophy. In addition, a multi-national consortium, with WSU as the coordinating center, has been developed to study patients PMD. For more information about PMD, go to:

PMD clinic

For more information regarding neurogenetics and Charcot-Marie Tooth disease, go to:

CMT clinic

James Garbern, MD, PhD	Nurse Coordinator:
John Kamholz, MD, PhD	(313) 577-9776 phone
Michael Shy, M.D.	(313) 577-7552 fax
Karen Krajewski, MS, CGC	Appointment scheduling
Dima El-Khechen, MS	Contact us

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The adult and pediatric neuromuscular clinics are both multidisciplinary clinics, which offer their patients therapeutic resources in addition to neurology, including pulmonary medicine, physical therapy and psychiatry. The adult neuromuscular clinic is involved in on-going research in ALS, demyelinating and hereditary neuropathies, myasthenia gravis, and myopathies. The two pediatric clinics treat approximately 40 different neuromuscular diseases affecting children.

Neuromuscular disease program: Drs Lisak and Lewis are a leading clinical investigator of acquired autoimmune myasthenia gravis (MG). They are in charge of clinical research programs in MG. Drs. Lisak and Ragheb collaborate on studies of the immune response to the acetylcholine receptor in blood and thymic specimens obtained from MG patients.

Hereditary neuropathies: Genotype/Phenotype correlations for the hereditary neuropathies, including Charcot-Marie-Tooth Disease (CMT), are done in collaboration with the neurogenetics research program.

Immune-mediated neuropathy: Drs. Lisak and Lewis are recognized clinical investigators of inflammatory demyelinating neuropathies such as Guillain-Barre Syndrome (GBS) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) are participating in a multi-center trial of interferon in CIDP.

Diabetic peripheral neuropathy: Drs. Lewis and Shy are involved in multi-center pharmaceutical trials of aldose reductase inhibitors.

Richard A. Lewis, MD	Nurse Coordinator:
Jun Li, MD, PhD	(313) 745-8937 phone
Robert P. Lisak, MD	(313) 745-4468 fax
James F. Selwa, MD
Michael E. Shy, MD	Appointment scheduling

An integral part of the neuromuscular evaluation process is the Inherited Neuropathies clinic. This multidisciplinary clinic at WSU is the only one of it kind in the country and is dedicated toward combining state of the art patient care and clinical research. A typical visit includes assessment by a neurologist, physiatrist, genetic counselor and other specialists, such as pediatric neurologists and pulmonary specialists, as needed. Information gathered from the clinic is used to help define the natural history of many of the inherited neuropathies, as well as establish geneotype-phenotype correlations and work toward effective treatments. For further information about services within the CMT program, go to:

CMT clinic

James Garbern, MD, PhD	Nurse Coordinator:
John Kamholz, MD, PhD	(313) 577-1689 phone
Karen Krajewski, MS, CGC	(313) 577-7552 fax
Richard A. Lewis, MD
Jun Li, MD, PhD
Michael E. Shy, MD	Appointment scheduling

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The neuro-oncology program and clinic is a multidisciplinary effort including specialists in neurology, radiation oncology, neurosurgery, medical oncology, neuroradiology, neuro-oncology, neuropathology, and molecular and glial biology. The neuro-oncology program provides diagnosis and management of metastatic and non-metastatic complications of systemic cancer and primary CNS tumors. It is an integral part of the Wertz Clinical Cancer Center and the Karmanos Cancer Institute. The clinical and research programs are multi-disciplinary with specialists in neuro-oncology, medical oncology, radiation oncology, neuroradiology, neurosurgery, neuropathology, and molecular and glial biology.

Geoffrey R. Barger, MD	Nurse Coordinator:
	(313) 745-1515 phone
	(313) 577-4641 fax	Appointment scheduling

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Dr. Van Stavern is Director of the Neuro-Ophthalmology Service at Wayne State University. He sees patients with a variety of neuro-ophthalmic disorders, including optic neuritis, ischemic optic neuropathy, pseudotumor cerebri, migraine, cranial nerve palsies, myasthenia gravis and pituitary tumors, among others. He is actively involved in the WSU Multiple Sclerosis clinic, and has a particular interest in mitochondrial disorders and hereditary optic neuropathies. The Neuro-Ophthalmology Service is based at Kresge Eye Institute, and is involved in a number of clinical research studies.

Gregory Van Stavern, MD	Nurse Coordinator:
	(313) 745-4275 phone
	(313) 745-4468 fax	Appointment scheduling

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The Neurotrauma/Neurocritical Care program includes the areas of patient care, research and teaching in the acute/emergency care of patients with acute neurological/neurosurgical diseases. Patients with acute ischemic or hemorrhagic stroke, traumatic brain injury, status epilepticus, subarachnoid hemorrhage or neuromuscular diseases (Guillain Barre syndrome, myasthenia gravis) that require critical care are admitted to the 14 bed, fully staffed, specialized intensive care unit at Detroit Receiving Hospital. The faculty of the program is fully trained in neurological/neurosurgical intensive care. Current research interest involves several NIH funded multi-center trials such as hemicraniectomy for massive cerebral infarction and severe traumatic brain injury, balloon prophylaxis for patients at high risk for vasospasm after subarachnoid hemorrhage. The program is integrated with the Stroke program in the Department of Neurology and the Neurotrauma and Neuroendovascular programs within the department of Neurological Surgery.

William M. Coplin, MD
Jacqueline Kraus, M.D., Ph.D.	Appointment scheduling

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Development: A multidisciplinary team lead by a pediatric neurologist and nurse practitioner provide developmental assessment and diagnostic evaluations for infants and young children when there are concerns about development. The team combines therapists, community agencies and families to provide comprehensive family center care for infants and children with developmental delay.

Marianne Majkowski DO
Kathy Pawlik MSN, RN, CPNP
	Appointment scheduling

Neurogenetics and Metabolics: Teams of highly specialized neurologists work with diagnostic labs across the country to identify and work toward diagnosis and treatments for metabolic and genetic disorders in children such as mitochondrial, peroxosomal, and organic acid disorders, chromosomal deletions and syndromes involving neuropsychiatric problems such as autism. Ancillary services that work with families as needed include genetic counseling, nursing, dietician, social work, and occupational and physical therapy.

A.H.M. Mahbubul Huq MD, PhD
Gyula Acsadi MD, PhD	Appointment scheduling

Epilepsy program in the Division of Pediatric Neurology is internationally renowned. Referrals for epilepsy surgery come from national and international sources. Extramural support for the program includes five NIH grants. The clinical component of the epilepsy program is headed by Dr. Harry Chugani and includes PET neuroimaging and MR spectroscopy. Drs. A. Shah and J. Shah from the adult neurology program provide EEG expertise for pediatric epilepsy surgery and are collaborators on some studies.

Harry T. Chugani, MD	Nurse Coordinator:
Ahmad Kaddurah, MD	(313) 745-5788 phone	Appointment scheduling

Neuro/Behavioral Health: We provide a comprehensive approach to management of children with Neuro/Behavioral disorders, including autism, Tourette sydrome, Attention Deficit Disorders and Learning Disabilities. This group of physicians works closely with families, teachers and therapists to assist these children to meet their greatest learning potential with the use of medications and behavior plans. The Neurology Department and PET Center currently are involved in on going research in both Tourette Syndrome and autism.

Harry T. Chugani MD	Nurse Coordinator:
David Benjamins MD	(313) 993-2596 phone	Appointment scheduling

Neuromuscular: A team of dedicated neurologists; therapists and dietitians provide comprehensive multidisciplinary treatment approximately 40 different neuromuscular diseases affecting children. Utilizing the community resources of the Muscular Dystrophy Association at both national and local levels, this team works together with families to provide the most effective treatments for the care of children with neuromuscular disorders.

Gyula Acsadi MD, PhD	Nurse Coordinator:
Michael Nigro DO	(313) 745-5788 phone	Appointment scheduling

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