and
Anatomy & Cell Biology
Center for Molecular Medicine and Genetics
NIEHS Center for Molecular and Cellular Toxicology
Wayne State University School of Medicine
and
Anatomy & Cell Biology
Center for Molecular Medicine and Genetics
NIEHS Center for Molecular and Cellular Toxicology
Wayne State University School of Medicine
Kenneth Maiese is Professor
in the Departments of Neurology and Anatomy & Cell Biology and the
Centers for Molecular Medicine and Genetics and the NIEHS Center for Molecular
and Cellular Toxicology at Wayne State University School of Medicine. He
is Director of the Laboratory of Cellular and Molecular Cerebral Ischemia.
As a college undergraduate, he attended the University of Pennsylvania
and graduated Summa cum Laude with Distinction. He subsequently entered
Cornell University Medical College as a Joseph Collins Scholar and Teagle
Foundation Scholar. He was awarded the Doctorate of Medicine and obtained
his postgraduate training in Internal Medicine and Neurology at The New
York Hospital-Cornell University Medical Center. Following residency, Dr.
Maiese pursued his research interests in ischemic neurodegeneration and
trained in the Division of Neurobiology at Cornell University Medical College
and at the National Institute on Aging of the National Institutes of Health.
After the completion of his postdoctoral training, Dr. Maiese accepted
a position as Assistant Professor in the Department of Neurology and Neuroscience
of Cornell University Medical College and as Attending Neurologist of The
New York Hospital. Complementing his clinical interests in cerebrovascular
disease and neurointensive care management, Dr. Maiese's laboratory examined
the role of peptide growth factors and cellular signal transduction pathways
during ischemic neurodegeneration. In July, 1994, Dr. Maiese transferred
his laboratory to Wayne State University School of Medicine. Funded by
sources such as the National Institutes of Health, the American Heart Association,
the United Cerebral Palsy Foundation, Johnson & Johnson Focused Giving
Award, and the Alzheimer's Association, his laboratory focuses on the neuroprotective
mechanisms of peptide growth factors, the biological function of signal
transduction pathways in the ischemic cascade, and the molecular mechanisms
that mediate neuronal survival and neuronal injury. Experimental approaches
include cultures with primary hippocampal neurons, gene regulation, trophic
factor modulation, pharmacological manipulation of neuronal survival, and
global and focal animal stroke models.
