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Publications | Other Links
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The Maiese lab is directed by Dr.
Kenneth Maiese who maintains appointments in the Departments of
Neurology and Anatomy & Cell Biology and the Centers for Molecular
Medicine and Genetics and the NIEHS Center for Molecular and Cellular Toxicology,
Wayne State University School
of Medicine, Detroit, Michigan. Send e-mail to the Maiese lab at:
kmaiese@med.wayne.edu,
or call us at (313) 577-6730 or fax us at (313) 577-6707.
The focus of the Maiese Lab is to evaluate the role of growth factors, signal transduction pathways, gene regulation, cellular metabolism, and metabotropic glutamate receptors in neuronal survival. The cellular and molecular mechanisms of neuronal protection by specific signal transduction pathways and growth factors have not been established. Neuronal injury also can lead to gene induction that may account for the increased susceptibility of hippocampal neurons to disease, such as during cerebral ischemia. We have begun to explore the protective effects of the peptide growth factors basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) during anoxia and nitric oxide (NO) toxicity and to characterize the cellular and molecular pathways of calcium, protein kinases, glutamate signalling and gene regulation during neuronal injury. Further evaluation of the protective mechanism of growth factors and the cellular processes that ultimately lead to neurodegeneration will provide the foundation for the therapeutic management of neurodegenerative disease.
Note: These sites are under continuous
modification. Please direct comments or questions to the editor, Kenneth
Maiese at kmaiese@med.wayne.edu