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Wayne State University School of Medicine










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Basic Neuroscience and Biomedical Engineering Research

Dr. McAllister directs a comprehensive interdisciplinary research program whose ultimate goal is to improve clinical treatments for hydrocephalus. He has maintained this program for 23 years and enjoys an international reputation as one of the main investigators in hydrocephalus research. His program has expanded from initial characterizations of the neuropathology associated with neonatal and infantile hydrocephalus to current studies of the genetic causes of hydrocephalus, pharmacological strategies for neuroprotection and recovery of function, biomedical engineering improvements in the design of cerebrospinal fluid drainage systems (shunts), development of implantable pressure sensors, and clinical evaluations of patient outcome and new treatment applications. The following projects illustrate the diversity of the Center’s approach to hydrocephalus research as well as the expectations for progress in specific areas of neuroscience.

Inhibition of Gliosis in Experimental Hydrocephalus
Pathophysiology of Communicating Hydrocephalus
Genetic Causes of Hydrocephalus in Experimental Aqueductal Stenosis
Development of "Smart" Shunts and Neural Sensors
Reduction of Tissue Obstruction and Bacterial Infection in Ventricular Catheters
Cellular Mechanisms for Reconstitution of the Cerebral Cortex Following CSF Shunting
Effects of Repeated Shunt Malfunction on the Pathophysiology of Hydrocephalus
Restoration of Neural Connections by Shunting in Experimental Hydrocephalus
Reproductive Effects of Hydrocephalus in HTx Rats
Development and Utilization of Animal Models for Experimental Hydrocephalus
The Role of Neuron Cell Death on Outcome
The Role of Glial "Scar" Formation on Outcome
Visual System Changes and Their Impact on Learning Disablities
Determining the Point of Irreversible Damage - Early vs. Late Shunting
Axonal Damage and Neuron Tolerance to Ischemia
Mathematical Modeling of CSF Changes in Communicating Hydrocephalus
Role of Osmotic Gradients in Hydrocephalus
 



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