Basic
Neuroscience and Biomedical Engineering Research
Dr. McAllister
directs a comprehensive interdisciplinary research program whose
ultimate goal is to improve clinical treatments for hydrocephalus.
He has maintained this program for 23 years and enjoys an international
reputation as one of the main investigators in hydrocephalus research.
His program has expanded from initial characterizations of the
neuropathology associated with neonatal and infantile hydrocephalus
to current studies of the genetic causes of hydrocephalus, pharmacological
strategies for neuroprotection and recovery of function, biomedical
engineering improvements in the design of cerebrospinal fluid
drainage systems (shunts), development of implantable pressure
sensors, and clinical evaluations of patient outcome and new treatment
applications. The following projects illustrate the diversity
of the Center’s approach to hydrocephalus research as well
as the expectations for progress in specific areas of neuroscience.