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As Professor and Director of Neurosurgical Research, Dr. Pat McAllister plays a critical role in all research activities of the Department of Neurological Surgery and the Children's Hospital of Michigan. With joint appointments in the Department of Anatomy and Cell Biology and the Department of Physiology, Wayne State University School of Medicine, and an active membership in the Cellular and Clinical Neurobiology Training Program of the Department of Psychiatry and Behavioral Neurosciences, he is instrumental in guiding neurosurgical residents through their doctoral studies, and especially in "gluing" the basic research initiatives together with the clinical strengths of the Neurosurgery Department. For the past 3 years, he has also served as Director of the Cortical Implant Project in the Ligon Research Center of Vision. Dr. McAllister received his Ph.D. from Purdue University in 1976, and following postdoctoral training at the University of Vermont School of Medicine, he held staff positions at the UCLA Mental Retardation Research Center, Temple University School of Medicine, and the Cleveland Clinic Foundation before joining the Detroit Medical Center/Wayne State University in October, 1997.

Dr. McAllister has dedicated more than 18 years to the study of hydrocephalus. In addition to advancing our understanding of the neuronal damage that occurs in the gray matter of the cerebral cortex, his introduction of shunting experiments in the mid-eighties has contributed greatly to what is known about the potential for recovery after treatment. By working closely with pediatric neurosurgeons Alexa Canady, M.D., Steve Ham, M.D., and Sandeep Sood, M.D., and developmental neuroanatomist Yuchuan Ding, M.D., Ph.D., he has turned the current efforts in the lab towards treatments that could supplement shunting, and protect neurons or promote regeneration in the hydrocephalic brain. Dr. McAllister is also deeply committed to improving education and communication for patients and families that battle hydrocephalus, and thus questions or comments regarding hydrocephalus research are welcomed. It is important to emphasize that a significant portion of the support for our studies comes from the local support group STARS (Support Toward Advancing Research on Shunts).

 
   
     
    Education    
  B.A. (Biology), Earlham College, Richmond, IN   June/1970  
  Ph.D. (Neurobiology), Purdue University, West. Lafayette, IN   December/1976  
  Dr. Gopal D. Das, advisor      
 

Professional Publications (last Ten Years):

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2007        
    Tang H, Cao T, Wang A, Liang X, Salley SO, McAllister JP 2nd, Ng KY. Effect of surface modification of siliconeon Staphylococcus epidermidis adhesion and colonization. J Biomed Mater Res A. 2007 Mar 15;80(4):885-94. (MedLine).    
    McAllister JP II, Abdolvahabi RM, Walker ML, Mitchell JA, Jones HC: Effects of congenital hydrocephalus on the hypothalamic gonadotrophin-releasing hormone system. Neurosurgical Focus 22(4): E4, 2007.    
    Parthasarathy KS, Cheng Y-CN, McAllister JP II, Shen Y, Li J, Deren K, Haacke EM, Auner GW: Biocompatibilities of sapphire and borosilicate glass as cortical neuroprostheses. Magnetic Resonance Imaging. 2007 (MedLine).    
2006        
    Ng KS, Tang H, Cao T, Wang A, Liang X, Salley SO, McAllister JP 2nd. Polymer and protein surface coatings on silicone: effect on Staphylococcus epidermidis adhesion and colonization. Cerebrospinal Fluid Res. 2006 Dec 21;3 Suppl 1:S41. (MedLine)    
    McAllister JP 2nd, Miller JM. Aquaporin 4 and hydrocephalus. J Neurosurg. 2006 Dec;105(6):457-8; discussion 458. (MedLine)    
    Tang H, Wang A, Liang X, Cao T, Salley SO, McAllister JP 2nd, Ng KY. Effect of surface proteins on Staphylococcus epidermidis adhesion and colonization on silicone. Colloids Surf B Biointerfaces. 2006 Aug 1;51(1):16-24. (MedLine)    
    McAllister JP 2nd. Neuronal damage in hydrocephalus. J Neurosurg. 2006 May;104(5 Suppl):297-8; discussion 298. (MedLine)    
    Bergsneider M, Egnor MR, Johnston M, Kranz D, Madsen JR, McAllister JP 2nd, Stewart C, Walker ML, Williams MA. What we don't (but should) know about hydrocephalus. J Neurosurg. 2006 Mar;104(3 Suppl):157-9. (MedLine)    
    Miller JM, Kumar R, McAllister JP 2nd, Krause GS. Gene expression analysis of the development of congenital hydrocephalus in the H-Tx rat. Brain Res. 2006 Feb 23;1075(1):36-47. Epub 2006 (MedLine)    
    Wang A, Cao T, Tang H, Liang X, Black C, Salley SO, McAllister JP, Auner GW, Ng KY. Immobilization of polysaccharides on a fluorinated silicon surface. Colloids Surf B Biointerfaces. 2006 Jan 15;47(1):57-63. (MedLine)    
    Liang X, Wang A, Cao T, Tang H, McAllister JP 2nd, Salley SO, Ng KY. Effect of cast molded rifampicin/silicone on Staphylococcus epidermidis biofilm formation. J Biomed Mater Res A. 2006 Mar 1;76(3):580-8. (MedLine)    
   

Wang A, McAllister JP II, Finlayson PG, Li J, Brabant KE, Tang H, Black CE, Cao T, Liang X, Salley SO, Auner GW, Ng KYS: Short- and long-term neural biocompatibility of heparin coated sapphire implants. Materials Science and Engineering C (in press).

   
    Patel KR, Tang H, Grever WE, Simon Ng KY, Xiang J, Keep RF, Cao T, McAllister JP 2nd. Evaluation of polymer and self-assembled monolayer-coated silicone surfaces to reduce neural cell growth. Biomaterials. 2006 Mar;27(8):1519-26. (MedLine)    
    Miller JM, Shanku AG, Ham SD, McAllister JP 2nd. Inhibitory effects of minocycline on gliosis in the hydrocephalic H-Tx rat. Cerebrospinal Fluid Res. 2006 Dec 21;3 Suppl 1:S17. (MedLine)    
    Li J, Shen Y, Miller JM, Egnor MR, Wagshul M, Stewart C, Haacke EM, Walker ME, Ham SD, McAllister JP. Pathophysiology of communicating hydrocephalus in two novel animal models. Cerebrospinal Fluid Res. 2006 Dec 21;3 Suppl 1:S21. (MedLine)
   
2005   Ding YH, Young CN, Luan X, Li J, Rafols JA, Clark JC, McAllister JP 2nd, Ding Y: Exercise preconditioning ameliorates inflammatory injury in ischemic rats during reperfusion. Acta Neuropathol (Berl). 109:237-46,2005 [Epub ahead of print](MedLine)
   
    Schuhmann MU, Ostrowski KR, Draper EJ, Chu JW, Ham SD, Sood S, McAllister JP. The value of C-reactive protein in the management of shunt infections. J Neurosurg. 2005 Sep;103(3 Suppl):223-30. (MedLine)    
2004   Li J, Luan X, Lai Q, Clark JC, McAllister JP II, Fessler R, Diaz FG, Ding Y: Long-term neuroprotection induced by regional brain cooling with saline infusion into ischemic territory in rats: a behavioral analysis. Neurol Res. 2004 Sep;26(6):677-83 (MedLine)
   
    Ding Y, Li J, Luan X, Lai Q, McAllister JP II, Phillis JW, Clark JC, Guthikonda M, Diaz FG: Local saline infusion into ischemic territory induces regional brain cooling and neuroprotection in rats with transient middle cerebral artery occlusion. Neurosurgery. 2004 Apr;54(4):956-64; discussion 964-5. (MedLine)    
    Luan X, Li J, McAllister JP II, Diaz FG, Clark JC, Fessler RD, Ding Y. Regional brain cooling induced by vascular saline infusion into ischemic territory reduces brain inflammation in stroke. Acta Neuropathol (Berl). 2004 Mar;107(3):227-34. (MedLine)    
    Eskandari R, McAllister JP II, Miller JM, Ding Y, Ham SD, Shearer DM, Way JS: Effects of hydrocephalus and ventriculoperitoneal shunting on afferent and efferent connections of the feline sensorimotor cortex. Journal of Neurosurgery – Pediatrics 101: 196-210, 2004. (MedLine)    
2003   Ding Y, Young CN, Li J, Luan X, McAllister JP II, Clark JD, Diaz FG: Reduced inflammatory mediator expression by pre-reperfusion infusion into ischemic territory in rats: a real-time polymerase chain reaction analysis. Neurosci Lett. 2003 Dec 26;353(3):173-6. (MedLine)    
2002   Ding Y, Yao B, Zhou Y, Park H, McAllister JP II, Diaz FG: Prereperfusion flushing of ischemic territory: a therapeutic study in which histological and behavioral assessments were used to measure ischemia-reperfusion injury in rats with stroke. J Neurosurg. 96(2):310-9, 2002 (MedLine)    
2001   Ding YC, Yao B, Lai Q, McAllister JP II: Impaired motor learning and diffuse axonal damage in motor and visual systems of the rat following traumatic brain injury. Neurological Research Special Issue on Neurotrauma 23: 193-202, 2001. (MedLine)    
  Ding YC, McAllister JP II, Yao B, Yan N, Canady AI: Neuron tolerance during hydrocephalus. Neuroscience, 106: s 659-667, 2001. (MedLine)    
  Ding YC, Lai Q, McAllister JP II, Canady AI: Impaired motor learning in children with hydrocephalus. Pediatric Neurosurgery 34: 182-189, 2001. (Abstract MedLine)    
  Ding Y, McAllister JP II, Yao B, Yan N, Canady AI: Axonal damage during hydrocephalus: A silver impregnation study. Neurological Research 23: 581-587, 2001 (MedLine)    
2000   Kriebel RM, McAllister JP II: The Pathology of the Hippocampus and Basal Forebrain Nuclei in Experimental Hydrocephalus. Neurological Research, 22: 29-36, 2000. (MedLine)    
  Abdolvahabi RM, McAllister JP II: A brief review of the effects of chronic hydrocephalus on the gonadotropin releasing hormone system: implications for amenorrhea and precocious puberty. Neurological Research, 22: 123-126, 2000. (MedLine)    
  McAllister JP II: Hydrocephalus Enters the New Millenium. Neurological Research, 22: 2-3, 2000. (MedLine)    
  McAllister JP II, Ding Y, Canady AI: Pathophysiology of Hydrocephalus: A Critical Review of Advances and Future Directions. In: Sainte-Rose C, Cinalli G (eds.), Neurosurgery of the Child, in preparation.   To Top
  Iezzi R, McAllister JP II, Abrams GW, Auner G, Johnson RR, Cortese JJ: A feline model for retinal stimulation and simultaneous recording from multiple electrode arrays. Poster presentation at the Association for Research in Vision and Ophthalmology (ARVO), Ft. Lauderdale, FL, 4/30-5/5/00.    
1999   Johnson MJ, Ayzman I, Wood AS, Tkach JA, Klauschie J, Skarupa DJ, McAllister JP II, Luciano MG: Development and Characterization of an Adult Model of Obstructive Hydrocephalus. Journal of Neuroscience Methods, 91: 55-65, 1999. (MedLine)   To Top
    McAllister JP II, Wood AS, Johnson MJ, Connelly RW, Skarupa DJ, Secic M, Luciano MG, Harris NG, Jones HC: Neuronal activation during the progression of experimental neonatal hydrocephalus. Neurosurgical Focus, 7: online, 1999.    
    Del Bigio MR, McAllister JP II: Pathophysiology of Hydrocephalus, In: Choux M, DiRocco CE, Hockley AD, Walker ML (eds.), Pediatric Neurosurgery, W.B. Saunders Co., Philadelphia, 217-236, 1999.    
1998   McAllister, J.P., II, Chovan, P: Neonatal hydrocephalus: mechanisms and consequences, In: Frim DM, Madsen JR (eds), Neurosurgery Clinics of North America. Neurosurgery of the Neonate, W.B. Saunders Co., Philadelphia, pp 73-93, January, 1998. (MedLine)    
  Bradley, N.K., Liakos, A.M., McAllister, J.P., II, Magram G, Kinsman S, Bradley MK: Maternal shunt dependency: implications for obstetric care, neurosurgical management, and pregnancy outcomes and a review of selected literature, Journal of Neurosurgery 43: 448-461, 1998. (MedLine)    
  Mangano, F.T., McAllister, J.P., II, Jones HC, Johnson MJ, Kriebel RM: The microglial response to progressive hydrocephalus in a model of inherited aqueductal stenosis. Neurological Research, 20: 697-704, 1998. (MedLine)    
  McAllister, J.P., II, Chovan, P., Steiner, C.P., Johnson, MJ., Luciano, M,G,, Ayzman, I., Wood, A.S., Tkach, J.A., Hahn, J.F: Differential Ventricular Expansion in Hydrocephalus. European Journal of Pediatric Surgery, 8: 39-42, 1998. (MedLine)    
1996   Harris NG, McAllister, J.P., II, Conaughty JM, Jones HC: The effect of inherited hydrocephalus and shunt treatment on cortical pyramidal cell dendrites in the infant H-Tx rat. Experimental Neurology, 141: 269-279, 1996. (MedLine)   To Top
   
   
 
Contact Information
 
 
Pat McAllister, Ph.D
Department of Neurological Surgery
Wayne State University School of Medicine
University Health Center,Suite 6E
4202 St. Antoine Detroit, MI 48201
Tel (313) 993-9294 or 993-0913
Fax (313) 745-4099
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