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Carol Brenner
My laboratory uses a non-human primate model as a clinical translational model to understand mechanisms that guide early development in a species close to humans. We are studying genes and proteins that regulate cell fate decisions during blastocyst formation and problems that arise during preimplantation development that impact chromosomal and mitochondrial integrity. The links below provide additional information concerning my current research: ·
Mitochondrial DNA, Oocyte Aging and Embryo Competence ·
Mitochondrial
Function in Preimplantation Embryos ·
Chromosomal Instability in Preimplantation Embyos ·
Properties
of Adult and Embryonic Stem Cells Recent Publications and Presentations ·
Curriculum
Vitae
of
Carol
Brenner
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We
are located on the Wayne State University School of Medicine campus and are
affiliated with the new Departments of Obstetrics & Gynecology and
Physiology's Reproductive Science program.|
Principal Investigator/Program Director (Last, First, Middle): |
Brenner, Carol, A. |
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BIOGRAPHICAL
SKETCH
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Brenner, Carol A |
POSITION TITLE Associate Professor |
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EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) |
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INSTITUTION AND LOCATION |
DEGREE (if applicable) |
YEAR(s) |
FIELD OF STUDY |
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Queen Mary
College, University of London |
BSc. |
1976 |
Genetics |
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Tufts University, Medford MA |
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Ph.D. |
1986 |
Molecular Embryology |
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University of
California, San Francisco, CA. |
post-doc |
1988 University of California, San
Francisco, CA. |
Molecular Embryology |
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A. Positions and Honors.
Positions and
Employment
1994 - 1996 Assistant Professor,
Harvard University, Faulkner Center for Human Reproduction, Boston, MA.
1996 - 2001 Director of Molecular Embryology, Institute
for Reproductive Medicine and Science of Saint Barnabas, West Orange, NJ.
1998 - 2001 Faculty Member in Human Molecular Embryology Program, Human
Embryology Master’s Program, University of Krems, Krems, Austria.
2000 -2007 Adjunct Associate Professor, Biology Department, Northeastern
University,
Boston, MA.
2002
- 2007 Greater New Orleans Endowed
Chair and Associate Professor in Biology, Dept. of Biological Sciences, University of New Orleans, LA.
2003 - 2004 Adjunct Professor, Department of
Obstetrics & Gynecology, Eastern Virginia Medical School, Norfolk, VA.
2007 - present Associate
Professor, Department’s of Physiology and Obstetrics and Gynecology, Wayne
State
Uniiversity, Detroit, MI.
Other Experience and Professional
Memberships
2007 Member, Cellular, Molecular, and
Integrative Reproduction Study Section, Center for Scientific Review
2005 Organizer for Pre-symposium IETS 2006 meeting for Orlando,
FL. Frontiers of Primate Stem Cell Research.
2004 Co-organizer, Symposium on “Supporting
Human ART through Basic Science” Portland, OR, January 9.
2001 Scientific
Committee for ALPHA Meeting, New York, NY, September 9-11.
Ad Hoc Reviewer Publications Reviewer
Guest Editor-in- Chief, Special Issue of
Animal
Reproduction Science
(Netherlands) 2005
Cloning and
Stem Cells (UK) 2004
Fertility and
Sterility (USA)
Human Reproduction (UK)
Biology of Reproduction (US)
Journal of Reproduction and Fertility
(now Reproduction) (UK)
Molecular Reproduction and Development (US)
Theriogenology (US)
Zygote (UK)
Reproduction Fertility and Development
(Australia).
Molecular Human Reproduction (UK)
Reproductive BioMedicine (UK)
BioTechniques (US)
B. Selected
peer-reviewed publications (representative of approximately 70
publications)
Research Articles:
Lonergan T, Bavister B, Brenner
C.(2007) Mitochondria in stem cells. Mitochondrion (Epub)
Gibson TC , Kubsich MH and
Brenner CA. (2006) Mitochondrial
deletions in primate embryonic and adult stem cells, Reprod. Biomed. Online
12:93-98.
Lonergan T, Brenner CA and Bavister BD. (2006) Differentiation-related
changes in mitochondrial properties as indicators of stem cell competence. J.
Cell Physiol. 208:149-153.
Gibson TC , Kubisch MH and
Brenner CA.(2005) Mitochondrial
deletions in oocytes and embryos in rhesus macaque (Macaca mulatta). Mol. Hum. Reprod.,
11:785-789. Epub 2005 Dec 22.
Bavister BD, Wolf DP and Brenner CA. (2005) Challenges of primate embryonic stem cell research.
Cloning Stem Cells 7:1-13.
Nichols SM, Bavister BD, Brenner CA, Didier PJ, Harrison RM
and Kubisch HM. (2005) Ovarian senescence in the rhesus macaque (Macaca
mulatta). Hum. Reprod. 1:79-83.
Brenner CA, Pierce KE and
Kubisch HM. (2004) The role of the
mitochondrial genome in assisted reproductive technologies and embryonic stem
cell-based therapeutic cloning. Reprod. Fertil. Dev.16: 743-751.
Warner CM and Brenner CA. (2004) Soluble HLA-G
(sHLA-G) - A predictor of IVF outcome? J. Assist. Reprod. Genet. 9:315-316.
Bavister BD and Brenner CA. (2004) How can basic
science help human ART? The Clinical
Embryologist 7:6-11.
Brenner
CA and Bavister BD.
(2004) Invited Commentary: Stem cells – hope or hype? The Clinical Embryologist 7:3-7.
Brenner
CA, Nichols SM, Jacoby
ES and Bavister BD. (2004) Non-human primates as a model for reproductive
aging and human infertility. Gynecol.
Obstet. Invest. 57:21-23.
Brenner CA. (2004) Ooplasmic transplantation: more
questions than answers. Assist. Reprod. Genet. 14:59:1170-1171.
Barritt
J, Kokot M, Cohen J and Brenner
CA. (2002) Quantification of ooplasmic mitochondria.
Reprod. Biomed. Online 4: 243-247.
Warner CM, Tyas D, Goldstein C, Cohen J and Brenner CA. (2002) Genotyping the
HLA system and embryo development. Reprod. Biomed. Online 4:133-139.
Barritt JA, Brenner
CA, Malter HE and Cohen J.(2001) Rebuttal: interooplasmic transfer in
humans. Reprod. Biomed. Online 3:47-48.
Warner CM and Brenner
CA. (2001) Genetic regulation of preimplantation survival. Curr. Top.
Dev. Biol. 52:151-192.
Barritt JA, Brenner CA and Cohen J. (2001) Cytoplasmic transfer in assisted
reproduction. Hum. Reprod. Update 7:428-435.
Barritt JA, Brenner
CA, Malter H and Cohen J.(2001) Mitochondria in human offspring derived
from ooplasmic transplantation. Hum. Reprod. 15:207-217.
Steuerwald N, Cohen J, Herrera R and Brenner CA. (2001) Quantification of checkpoint transcripts in single human oocytes
by real time rapid cycle fluorescence monitored RT-PCR. Mol. Hum. Reprod.
7:101-109.
Brenner
CA and Barritt JA.
(2000) Mitochondrial heteroplasmy haunts the Romanov house. ALPHA Journal*.
29:1-3.
Barritt JA, Cohen J and Brenner CA. (2000) Mitochondrial DNA point mutation in human
oocytes is associated with maternal age. Reprod. Biomed. Online. 1:96-100.
Pierce KE, Rice J , Sanchez, A, Brenner CA and Wangh LJ. (2000) Precision PCR using molecular
beacons for accurate detection of the Y chromosome in single human
blastomeres. Mol. Hum. Reprod. 6:1155-1164.
Brenner CA and Cohen J. (2000) The genetic revolution in artificial
reproduction: a view of the future. Hum. Reprod. 15:101-106.
Barritt J, Brenner CA, Willadsen S and Cohen J. (2000) Spontaneous and artificial
changes in human ooplasmic mitochondria. Hum. Reprod. 15 (suppl 2):207-217.
Brenner CA, Barritt J, Willadsen S and Cohen J. (2000)
Mitochondrial DNA heteroplasmy after human ooplasmic transplantation. Fertil.
Steril. 74:573-578.
Steuerwald N, Barritt J, Adler R, Malter
H, Schimmel T, Cohen J and Brenner CA. (2000) Quantification of mtDNA in single oocytes, polar
bodies and subcellular components by real- time rapid cycle fluorescence
monitored PCR. Zygote 9:209-215.
Steuerwald N, Cohen J, Herrera R and Brenner CA. (2000) Quantification of mRNA in single oocytes and
embryos by real-time rapid cycle fluorescence monitored RT-PCR. Mol. Hum.
Reprod. 6:448-453.
Steuerwald N, Cohen J, Herrera R and Brenner CA. (1999)
Analysis of gene expression in single oocytes and embryos by real-time rapid
cycle fluorescence monitored RT-PCR. Mol. Hum. Reprod. 5:1034-1039.
Barritt JA, Brenner CA, Cohen J and Matt DW. (1999) Mitochondrial DNA rearrangements
in human oocytes and embryos. Mol. Hum. Reprod. 5:927-933.
Brenner
CA, Wolny YM, Adler RR and Cohen J. (1999) Alternative splicing of
the telomerase catalytic subunit in human oocytes and embryos. Mol. Hum.
Reprod. 5:845-850.
Brenner
CA and Tomkin G. (1999) Telomeres, telomerase; is the
key to biological aging programmed in the human oocyte? ALPHA Journal*.
16:1-3.
Brenner CA. (1999) ART’s brave new world-designer
babies? The future of ART: micro arrays with macro consequences in
reproduction. ALPHA Journal*. 18: 1-3.
Cao W, Brenner CA, Alikani M,
Cohen J and Warner CM. (1999) Search for a human homologue of the mouse Ped
gene. Mol. Hum. Reprod. 5:541-547.
Brenner
CA, Wolny YM, Barritt
JA, Matt DW, Munne S and Cohen J. (1998) Mitochondrial deletion in human
oocytes and embryos. Mol. Hum. Reprod.
4:887-892.
Cohen J, Scott R, Alikani M, Schimmel T,
Munne S, Levron J, Wu L, Brenner C,
Warner C and Willadsen S. (1998) Ooplasmic transfer in mature human oocytes.
Mol. Hum. Reprod. 4:269-280.
Warner CM, Cao W, Exley GE, McElhinny
AS, Alikani M, Cohen J, Scott R and Brenner
CA. (1998) Genetic regulation of egg and embryo survival. Hum. Reprod.
13:178-190.
Brenner
CA, Scott RT and Cohen
J.(1997) Use of anucleate donor oocyte cytoplasm in recipient eggs. Lancet
350:961-963.
C. Research
Support
Ongoing Research Support
RO3 HD046553-01 A1 (PI: C. Brenner) 12/1/04
– 11/30/07
NICHD
“Chromosome
Anomalies in Macaque Monkey Oocytes”
The goals are
to examine defects in chromosomes of monkey oocytes and aging effects.
RO1 HD045966-01A2 (PI: C. Brenner 4/15/05
– 3/31/10
NICHD
“Defects in
Mitochondria Impacting Primate Oocyte Quality”
To examine
defects in mitochondrial DNA and function as a correlate of aging in oocytes.
R21 RR021881-01 (PI: C. Brenner) 7/1/05
– 6/30/08
NCRR
“Characterization
of Monkey Embryonic Stem Cells”.
Copyright ©2/29/2008, created and
continually maintained by Scott Morton