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Barry Bavister Received his B.A. degree
in Natural Sciences (Physiology) from the University of Cambridge in 1967,
and Ph.D. in the Marshall Laboratory of Reproduction, University of
Cambridge, in 1972. During graduate training, he collaborated with Professor
R.G. “Bob” Edwards in demonstrating for the first time the fertilization of
human ova in vitro, a discovery that paved the way for the birth of Louise
Brown in 1978. Post-doctoral training
(1974-1975) with Professor Ryuzo Yanagimachi at the University of Hawaii as a
Ford Foundation and Population Council Fellow followed by 2 years at the UCLA
School of Medicine in Torrance, California working on sperm motility factors,
and one year as Lecturer in Animal Physiology at the University of
California, Davis. From 1979 to 2000,
he was Assistant/Associate/Full Professor at the University of
Wisconsin-Madison and at the Wisconsin Regional Primate Research Center. In 2000, he became the Freeport-McMoRan
Endowed Chair of Reproductive and Conservation Biology in the Department of
Biological Sciences at the University of New Orleans. Research interests are the physiology
and biochemistry of gametes, fertilization and preimplantation embryogenesis
in mammals, and embryonic stem cell biology.
Key accomplishments of Dr. Bavister’s laboratory 1979-2000: Developing
the first reliable procedures for IVF in monkeys, which are now in use
worldwide, and production of the first genetically-documented IVF monkey
“Petri” in 1983; providing the first data implicating changes in intracellular
pH as regulators of early mammalian embryo development; demonstrated that
specific energy substrates and amino acids regulate embryo development, which
provided the basis for the formulation of sequential culture media; provided
the first evidence that timing of embryo development is critically important
for viability; showed that mitochondrial distribution and/or activity changes
during fertilization, and that these changes are perturbed in embryos that
have poor or no developmental competence - artificially perturbing pHi
produces similar developmental and subcellular changes. This work promises to provide new insights
into the relationships between embryos and their culture environment, that
will lead to improved culture media formulations. Dr. Bavister has authored or
co-authored 180 refereed journal articles, plus 27 book chapters and
proceedings of scientific meetings, and he has edited 3 books, all on the
topics of gamete biology, in vitro fertilization and embryo development.
Since 1982, he has been an invited speaker at almost 100 national and
international workshops, special lectures and symposia in 15 countries,
including Gordon Conferences, Serono Symposia, Organon Symposia, and American
Fertility Society/ American Society for Reproductive Medicine Post-Graduate
courses. He has most frequently been
asked to speak on the extrapolation of basic animal experimental data to the
improvement of human clinical IVF outcomes.
He has been the principal organizer/chairman for several national and
international conferences and workshops, including two Serono Symposia, the
International Embryo Transfer Society (IETS), and the Chinese Academy of
Sciences/Kunming Institute of Zoology.
He has served on the Editorial Boards of the journals Biology of
Reproduction; In Vitro Fertilization and Embryo Transfer; Gamete
Research/Molecular Reproduction and Development; and Reproduction,
Fertility and Development. He has
served on grant review panels for the National Institutes of Health and the
U.S. Department of Agriculture, and on the Board of Directors of the Society
for the Study of Reproduction, and the Board of Governors of the
International Embryo Transfer Society.
Dr. Bavister was elected vice-President of the International Embryo
Transfer Society in 2001, and in 2002 he served as President of this Society.
Sixteen students have received the M.S. and/or Ph.D. degrees in his
laboratory, and 10 more students have received post-doctoral training. His research has been continuously funded
by NIH since 1978. Representative Publications: Barnett DK,
Kimura J and Bavister BD. (1996) Translocation of active mitochondria during
hamster preimplantation embryo development studied by confocal laser scanning
microscopy. Dev Dynamics 205:64-72. Lane M, Baltz
JM, and Bavister BD. (1998)
Regulation of intracellular pH in hamster
preimplantation embryos by the Na+/H+
antiporter. Biol. Reprod
59:1483-1490. Squirrell JM,
Schramm RD, Paprocki AM, Wokosin DL and Bavister BD. (2003) Imaging
mitochondrial organization in living primate oocytes and embryos using
multiphoton microscopy. Microsc. Microanal. 9:190-201. Bavister BD,
Wolf DP, Brenner CA. Challenges of primate embryonic stem cell research.
(2005) Cloning Stem Cells 7:1-13. Nichols SM,
Bavister BD, Brenner CA, Didier PJ, Harrison RM, Kubisch HM. (2005) Ovarian
senescence in the rhesus macaque (Macaca mulatta). Hum. Reprod. 20:79-83. Lonergan T,
Brenner CA, Bavister BD. (2006) Differentiation-related changes in
mitochondrial properties as indicators of stem cell competence. J. Cell.
Physiol. 208:149-53. Bavister BD . (2006) The mitochondrial contribution to stem cell biology. Reprod. Fertil. Dev. 18:829–838. |
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