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My laboratory is currently investigating the molecular
interactions of trophoblast cells with growth factors and extracellular
matrices during blastocyst implantation and placentation. Efforts are also underway to delineate
the associated signal transduction pathways that regulate early mammalian
development and are responsible for reproductive disorders.
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My
laboratory uses a non-human primate model as a clinical translational model
to understand mechanisms that guide early development in a species close to
humans. We are studying genes and proteins that regulate cell fate
decisions during blastocyst formation and problems that arise during
preimplantation development that impact chromosomal and mitochondrial
integrity.
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