School of Medicine

Graham C. Parker, Ph.D.
gparker@med.wayne.edu

Address:
Children's Hospital of Michigan
3901 Beaubien
Detroit,  MI 48201
Office Phone: 313-745-2400
Office Fax:        313-745-0282
Lab Address:  3N73 Children's Hospital of Michigan  

Education:
B.Sc. (Psychology), University of St. Andrews, UK
Ph.D. (Behavioral Neuroscience), University of St. Andrews, UK

Training:
Postdoctoral (Behavioral Pharmacology), McGill University, Montreal, Canada

Professional and Faculty Appointments:
Assistant Professor (Research), Dept. of Pediatrics, WSU School of Medicine

Major Research Interests:
The therapeutic potential and vulnerability of human stem cells; developmental models of neural disorders.

Current Research:
There is a dearth of information concerning the effects of commonly abused substances on the stem cell populations associated with the developing fetus. The blood supply is formed by hematopoietic and mesenchymal stem cells, both of which can be isolated from umbilical cord blood obtained after Caesarian delivery of full-term pregnancies. Such studies have implications for the gestational and future health of the growing child, as well as the viability of related stem cell populations.

Recent papers:
Chopra DP, Dombkowski AA, Stemmer PM, Parker GC (2009) Intestinal Epithelial cells In Vitro. Stem Cells Dev. Epub online

Parker GC, Acsadi G, Brenner CA (2009) Mitochondria: determinants of stem cell fate? Stem Cells Dev 18:803-806.

Acsadi G, Lee I, Li X, Khaidakov M, Pecinova A, Parker GC, Huttemann M (2009) Mitochondrial dysfunction in a neural cell model of spinal muscular atrophy. J Neurosci Res.

Parker GC (2008) Stem cells and development in the Far East. Stem Cells Dev 17:609-611.

Parker GC, Li X, Anguelov RA, Toth G, Cristescu A, Acsadi G (2008) Survival motor neuron protein regulates apoptosis in an in vitro model of spinal muscular atrophy. Neurotox Res 13:39-48.

Parker GC (2008) Engaging the media. Stem Cells Dev 17:389-390.

Vangipuram SD, Grever WE, Parker GC, Lyman WD (2008) Ethanol increases fetal human neurosphere size and alters adhesion molecule gene expression. Alcohol Clin Exp Res 32:339-347.

Magnus T, Liu Y, Parker GC, Rao MS (2008) Stem cell myths. Philos Trans R Soc Lond B Biol Sci 363:9-22.

Parker GC (2007) The critical values of rotation and expansion. Stem Cells Dev 16:515-516.

Parker GC (2007) Responsibility and discretion. Stem Cells Dev 16:345-346.

Parker GC (2007) Blood stem cells and non-hematological clinical practice: Pragmatics before therapeutics. Curr Pharmaceut Biotech 8:51-56.

Parker GC (2006) Embryonic Stem Cell Research: The State of the Union of "Those Who Create the Lines" and "Those Who Draw the Lines". Stem Cells Dev 15:623-629.

Parker GC (2006) Stem Cells Need Chemical Solutions. Aust J  Chem 59:481-484.

Parker GC, Anastassova-Kristeva M, Eisenberg LM, Rao MS, Williams MA, Sanberg PR, English D (2005) Stem Cells: Shibboleths of development, part II: Toward a functional definition. Stem Cells Dev 14:463-469.

Parker GC, Anastassova-Kristeva M, Broxmeyer HE, Dodge WH, Eisenberg LM, Gehling UM, Guenin LM, Huss R, Moldovan NI, Rao M, Srour EF, Yoder MC (2004) Stem Cells: Shibboleths of development. Stem Cells Dev 13:579-584.

Hao HN, Parker GC, Zhao J, Barami K, Lyman WD (2003) Differential responses of human neural and hematopoietic stem cells to ethanol exposure. J Hematother Stem Cell Res 12:389-399.

Hao HN, Parker GC, Zhao J, Barami K, Lyman WD (2003) Human neural stem cells are more sensitive than astrocytes to ethanol exposure. Alcohol Clin Exp Res 27:1310-1317.

Hao HN, Zhao J, Thomas RL, Parker GC, Lyman WD (2003) Fetal human hematopoietic stem cells can differentiate sequentially into neural stem cells and then astrocytes in vitro. J Hematother Stem Cell Res 12:23-32.