Zhe Yang, Ph.D.


Assistant Professor


Area of interest: X-ray crystallography, Cancer, HIV, Epigenetics, Chromatin
Ph.D. Institute of Biophysics, Chinese Academy of Sciences, Beijing, P. R. China, 1999.

Lab

e-mail: zyang@med.wayne.edu
Tel: 313-577-1294



JW

Selected publications:

Horton JR, Zhang X, Maunus R, Yang Z, Wilson GG, Roberts RJ, Cheng X (2006). DNA nicking by HinP1I endonuclease: bending, base flipping and minor groove expansion. Nucleic Acids Res. 34:939-48.

Yang Z, Horton JR, Maunus R, Wilson GG, Roberts RJ, Cheng X (2005). Structure of HinP1I endonuclease reveals a striking similarity to the monomeric restriction enzyme MspI. Nucleic Acids Res. 33:1892-901.

Sawada K, Yang Z, Horton JR, Collins RE, Zhang X, Cheng X (2004). Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase. J Biol Chem. 279:43296-306.

Yang Z, Shipman L, Zhang M, Anton BP, Roberts RJ, Cheng X (2004). Structural characterization and comparative phylogenetic analysis of Escherichia coli HemK, a protein (N5)-glutamine methyltransferase. J Mol Biol. 340:695-706.

Yang Z, Horton JR, Zhou L, Zhang XJ, Dong A, Zhang X, Schlagman SL, Kossykh V, Hattman S, Cheng X (2003). Structure of the bacteriophage T4 DNA adenine methyltransferase. Nat Struct Biol. 10:849-55.

Zhang X, Yang Z, Khan SI, Horton JR, Tamaru H, Selker EU, Cheng X (2003). Structural basis for the product specificity of histone lysine methyltransferases. Mol Cell. 12:177-85.

Yang Z, Pandi L, Doolittle RF (2002). The crystal structure of fragment double-D from cross-linked lamprey fibrin reveals isopeptide linkages across an unexpected D-D interface. Biochemistry. 41:15610-7.

Yang Z, Spraggon G, Pandi L, Everse SJ, Riley M, Doolittle RF (2002). Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide. Biochemistry. 41:10218-24.

Yang Z, Kollman JM, Pandi L, Doolittle RF (2001). Crystal structure of native chicken fibrinogen at 2.7 A resolution. Biochemistry. 40:12515-23.

Doolittle RF, Yang Z, Mochalkin I (2001). Crystal structure studies on fibrinogen and fibrin. Ann N Y Acad Sci. 936:31-43. Review.

Yang Z, Mochalkin I, Doolittle RF (2000). A model of fibrin formation based on crystal structures of fibrinogen and fibrin fragments complexed with synthetic peptides. Proc Natl Acad Sci U S A. 97:14156-61.

Yang Z, Mochalkin I, Veerapandian L, Riley M, Doolittle RF (2000). Crystal structure of native chicken fibrinogen at 5.5-A resolution. Proc Natl Acad Sci U S A. 97:3907-12.



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