Associate ProfessorArea of interest: Molecular Enzymology M.D., Catholic University of Rome, Italy, 1982 Ph.D., University of Bari, Italy, 1987 WSU Crystallography page e-mail: mimo@boatman.med.wayne.edu Tel: 313-577-0620 |
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The study of enzymes and other biological macromolecules by a combination of tools including genetic engineering, steady- and pre-steady-state kinetics, circular dichroism, light scattering, X-ray crystallography and molecular modeling.
Selected publications:
Wang, J., Duewel, H.S., Stuckey, J.A., Woodard, R.W., Gatti, D.L. Function of His-185 in Aquifex aeolicus 3-Deoxy-D-manno-octulosonate 8-Phosphate Synthase. J. Mol. Biol., 324:205-214, 2002.
Wang, J., Ortiz-Maldonado, M., Entsch, B., Massey, V., Ballou, D.P. Gatti, D.L. Protein and ligand dynamics in 4-hydroxybenzoate hydroxylase. Proc. Natl. Acad. Sci, USA, 99:608-613, 2002.
Wang, J. Duewel, H.S., Woodard, R.W., Gatti, D.L. Structure of Aquifex aeolicus KDO8P synthase in complex with R5P and PEP and with a bi-substrate inhibitor: role of active site water in catalysis. Biochemistry, 40:15676-15683, 2001.
Zhou T, Radaev S, Rosen BP, Gatti DL. Conformational changes in four regions of the Escherichia coli ArsA ATPase link ATP hydrolysis to ion translocation. J Biol Chem 276:30414-30422, 2001.
Duewel, H.S., Radaev, S., Wang, J., Woodard, R.W. and Gatti, D.L. Substrate and Metal Complexes of 3-Deoxy-D-manno-octulosonate 8-Phosphate Synthase from Aquifex aeolicus at 1.9 Å Resolution. J. Biol. Chem., 276:8393-8402, 2001.
Zhou, T., Radaev, S., Rosen, B.P. and Gatti, D.L. Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump. EMBO J., 19:4838-4845, 2000.
Wang, Z.-G., Sheluho, D., Gatti, D.L. and Ackerman, S.H. The a subunit of the mitochondrial F1 ATPase interacts directly with the assembly factor Atp12p. EMBO J., 19:1486-1493, 2000.
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