Chuan-pu "C.P." Lee, Ph.D.

Our research interest has been centered in the field of mitochondrial bioenergetics and mitochondrial pathophysiology. Mitochondrial diseases occupy at present a highly active area of investigation in both molecular and cell biology, and in clinical physiology and medicine. In recent years research in this field opened new insights, not only into the pathogenesis of such diseases, but also into the biological functions of mitochondria in general. In addition to the classical concept of mitochondria serving as the "powerhouse" of the cell, it is now evident that this organelle plays a crucial role in the genetic regulation of cellular energy metabolism, with important implications for various biological functions including electrolyte balance, calcium ion homeostasis, cellular signal transduction, antioxidant and immunologic defenses. There is growing evidence that a large number of pathological conditions, myo- and neuro-pathies, certain degenerative and autoimmune diseases, and even the physiological aging and turnover of cells and tissues, are likely to be related to mitochondrial functions.

Ye Xiong, Hong Lin, Ben D. Chen, Patti L. Peterson and Chuan-pu Lee. Appearance of shortened Bcl-2 and Bax proteins and lack of evidence of apoptosis in rat forebrain after severe experimental traumatic brain injury. Biochem. Biophys. Res. Commun. 286: 401-405, 2001.

Y. Xiong, P. L. Peterson and C. P. Lee. Alterations in cerebral energy metabolism induced by traumatic brain injury. J. Neurological Research 23: 129-138, 2001.

Y. Xiong, P. L. Peterson and C. P. Lee. Effect of N-acetylcystein on mitochondrial function following traumatic brain injury in rats. J. Neurotrauma 16: 1067-1082, 1999.

Y. Xiong, P. L. Peterson, B. H. Verweij, F. C. Vinas, P. L. Muizelaar and C. P. Lee. Mitochondrial dysfunction following experimental traumatic brain injury: Combined efficacy of SNX-111 and U-101033E. J. Neurotrauma 15: 531-544, 1998.

Y. Xiong, P. L. Peterson, J. P. Muizelaar and C. P. Lee. Amelioration of mitochondrial function by a novel antioxidant U-101033E following traumatic brain injury in rats. J. Neurotrauma 14: 907-917, 1997.

Y. Xiong, Q. Gu, P. L. Peterson, J. P. Muizelaar and C. P. Lee. Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury. J. Neurotrauma 14: 23-34, 1997.

M. Glinn, C. P. Lee and L. Ernster. Pro- and anti-oxidant activities of mitochondrial respiratory chain: Factors influencing the NAD(P)H-induced lipid peroxidation. Biochim. Biophys. Acta 1318: 246-254, 1997.